J:International Journal of Inflammation

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT276964 Binding of Tlr1 and Tlr2 11 1 0.24 4.22 0.89
2 INT276988 Binding of Tlr6 and Tlr2 11 1 0.26 4.89 0.79
3 INT171901 Binding of TNF and Il1 2 1 0.18 1.07 0.7
4 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 1 0.06 1.33 0.37
5 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 1 0.05 1.33 0.37
6 INT350813 Binding of Apc and Crp 1 1 0.18 1.12 0.27
7 INT350815 Negative_regulation of Binding of TNF and Il1 1 1 0.05 0.37 0.16
8 INT329798 Binding of MYD88 and TICAM1 2 1 0.01 0.24 0.1
9 INT350802 Binding of MYD88 and TLR3 1 1 0.01 0 0.04
10 INT350800 Binding of TLR3 and TICAM1 1 1 0.01 0 0.04
11 INT350792 Binding of Hspd1 and Lsr1 1 1 0.00 0.25 0
12 INT350796 Binding of CEBPB and Hspd1 1 1 0.00 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
5 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
6 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
7 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
8 INT68684 Gene_expression of VEGFA 2 2371 0.78 1742.52 259.2
9 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
10 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
11 INT6354 Localization of Gabrg1 1 321 0.74 41.41 186.74
12 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
13 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
14 INT15516 Gene_expression of Crp 3 711 0.77 615.33 173.09
15 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
16 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
17 INT49439 Gene_expression of Cpox 5 508 0.73 326.97 130.17
18 INT17612 Gene_expression of CRP 11 676 0.78 580.61 119.03
19 INT118381 Gene_expression of Il17a 4 405 0.76 306.97 112.06
20 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
21 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
22 INT18009 Positive_regulation of CRP 8 518 0.70 553.03 103.74
23 INT60691 Gene_expression of Il12a 2 331 0.78 208.03 75.96
24 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
25 INT39565 Gene_expression of Ptger2 3 424 0.75 229.28 72.68
26 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
27 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
28 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
29 INT170332 Gene_expression of IFN1@ 1 477 0.75 275.21 69.65
30 INT46 Localization of Ren 3 233 0.81 46.15 62.44
31 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
32 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
33 INT117223 Gene_expression of TLR4 3 348 0.78 206.18 54.42
34 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
35 INT55670 Negative_regulation of Gene_expression of Tnf 1 83 0.59 57.16 46.33
36 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
37 INT27798 Gene_expression of Ntrk2 4 111 0.78 56.08 42.68
38 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
39 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
40 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
41 INT17381 Gene_expression of Tbxa2r 3 146 0.78 65.01 34.15
42 INT67039 Positive_regulation of Cpox 2 144 0.65 98.4 33.77
43 INT34729 Positive_regulation of IFN1@ 1 233 0.67 128.04 30.38
44 INT90792 Localization of Il10 1 144 0.80 87.88 30.03
45 INT21900 Gene_expression of Mthfd1 3 150 0.75 69.47 27.03
46 INT100861 Binding of CRP 2 179 0.48 175.2 26.45
47 INT130176 Positive_regulation of Gene_expression of CRP 3 125 0.66 137.06 25.9
48 INT70048 Positive_regulation of Gene_expression of IL10 1 90 0.55 71.34 25.66
49 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
50 INT151758 Gene_expression of PYCARD 1 91 0.63 14.54 24.27
51 INT142594 Gene_expression of Tlr2 5 165 0.78 139.73 22.26
52 INT69993 Positive_regulation of Gene_expression of Cpox 2 93 0.55 69.4 22.05
53 INT23257 Regulation of CRP 2 127 0.62 100.05 21.87
54 INT49985 Transcription of Il6 1 62 0.72 40.13 20.29
55 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
56 INT116978 Gene_expression of CCR6 2 53 0.78 56 17.73
57 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
58 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
59 INT75540 Positive_regulation of TH1L 1 62 0.67 43.45 15.02
60 INT53080 Positive_regulation of Ptgs1 1 42 0.42 23.58 14.37
61 INT161515 Positive_regulation of Gene_expression of Il17a 2 50 0.64 41.52 13.82
62 INT142593 Positive_regulation of Tlr2 2 85 0.70 75.9 13.62
63 INT117222 Positive_regulation of Gene_expression of TLR4 1 80 0.70 51.6 12.9
64 INT28420 Gene_expression of Ptgds 1 59 0.78 31.72 12.67
65 INT9832 Gene_expression of Shbg 1 96 0.75 56.71 12.19
66 INT87239 Localization of Il12a 1 51 0.75 31.95 12.05
67 INT83611 Negative_regulation of Gene_expression of Cpox 1 55 0.29 31.09 11.5
68 INT150540 Binding of TLR2 1 50 0.45 35.86 10.43
69 INT16404 Regulation of CD4 1 54 0.61 33.05 10.29
70 INT10019 Binding of CD8A 1 57 0.36 31.49 10.08
71 INT182137 Gene_expression of TLR9 2 137 0.78 48.48 9.05
72 INT6499 Localization of Ntrk2 1 44 0.79 11.78 8.75
73 INT97516 Binding of PYCARD 1 46 0.36 7.06 7.85
74 INT111607 Gene_expression of CDH1 2 103 0.75 90.45 7.77
75 INT103909 Gene_expression of NOD2 1 37 0.77 21.9 7.36
76 INT160562 Localization of Cd4 3 49 0.71 27.58 6.78
77 INT142596 Positive_regulation of Gene_expression of Tlr2 1 42 0.69 38.41 6.67
78 INT43721 Gene_expression of Vegfa 1 49 0.77 36.18 6.63
79 INT207892 Binding of Tlr9 1 35 0.46 26.66 6.61
80 INT23174 Gene_expression of NLRP3 1 51 0.72 35.49 6.47
81 INT39416 Gene_expression of Cd79a 2 81 0.64 45.17 6.08
82 INT17641 Gene_expression of NLRP1 1 33 0.73 8.85 6.02
83 INT53196 Binding of Cd4 1 44 0.47 27.28 5.85
84 INT49440 Localization of Cpox 1 27 0.53 11.26 5.79
85 INT56149 Localization of CD8A 2 56 0.74 30.41 5.75
86 INT81049 Positive_regulation of CASP1 1 44 0.67 19.97 5.69
87 INT145888 Negative_regulation of Mthfd1 1 27 0.41 8.98 5.4
88 INT174688 Binding of Tlr2 1 45 0.42 36.65 5.25
89 INT125005 Negative_regulation of SLPI 1 9 0.42 5.79 4.43
90 INT162249 Gene_expression of Hist1h2aa 1 8 0.12 6.46 4.35
91 INT137178 Gene_expression of TLR3 1 46 0.72 24.97 4.33
92 INT204529 Positive_regulation of TLR9 2 18 0.62 15.62 3.99
93 INT19158 Gene_expression of PAH 1 35 0.65 35.81 3.88
94 INT15982 Positive_regulation of NLRP3 1 25 0.65 23.19 3.57
95 INT53200 Binding of Ptgs2 1 11 0.48 5.08 3.54
96 INT148288 Gene_expression of CCL15 1 9 0.25 6.53 3.41
97 INT9110 Binding of PAH 2 32 0.41 42.1 3.1
98 INT90402 Positive_regulation of Gene_expression of Ptgs1 1 13 0.31 4.83 2.88
99 INT204524 Binding of TLR9 2 17 0.43 11.69 2.76
100 INT162792 Gene_expression of NOD1 1 19 0.71 6.11 2.71
101 INT204124 Transcription of CRP 1 14 0.69 20.79 2.71
102 INT11379 Positive_regulation of Negative_regulation of IL1B 1 9 0.49 7.2 2.64
103 INT127458 Positive_regulation of PAH 2 24 0.58 27.25 2.53
104 INT200217 Localization of PAH 1 10 0.36 15.51 2.46
105 INT24740 Positive_regulation of Cd79a 2 36 0.48 14.71 2.17
106 INT101985 Positive_regulation of Positive_regulation of Ptgs1 1 4 0.15 4.13 1.98
107 INT24453 Binding of NLRP3 1 18 0.48 13.7 1.93
108 INT122195 Regulation of Localization of VEGFA 1 13 0.57 10.61 1.92
109 INT64959 Positive_regulation of Negative_regulation of IL6 1 5 0.42 5.16 1.86
110 INT181523 Gene_expression of Ifnar1 1 16 0.67 7.79 1.72
111 INT110028 Transcription of Il12a 2 6 0.49 1.48 1.51
112 INT190367 Gene_expression of Defa1 6 10 0.75 8.92 1.5
113 INT256598 Gene_expression of DEFB103A 3 8 0.65 5.06 1.49
114 INT71918 Gene_expression of ACTA1 1 16 0.75 7.73 1.45
115 INT117219 Positive_regulation of NOD2 2 9 0.69 4.66 1.31
116 INT204766 Gene_expression of Nod2 3 4 0.75 4.14 1.3
117 INT139237 Negative_regulation of Gene_expression of CDH1 1 23 0.57 24.31 1.28
118 INT244123 Localization of Defa1 2 5 0.78 3.42 1.23
119 INT263019 Gene_expression of DEFA6 5 4 0.25 4.14 1.17
120 INT91658 Localization of CASP1 1 5 0.77 0.89 1.04
121 INT213501 Negative_regulation of Gene_expression of Defa1 2 4 0.42 4.74 0.93
122 INT263027 Positive_regulation of DEFB103A 2 5 0.45 2.89 0.92
123 INT250645 Gene_expression of Samsn1 1 6 0.33 9.95 0.86
124 INT294787 Localization of TLR9 1 2 0.67 2.35 0.75
125 INT264973 Binding of MYD88 2 4 0.35 1.2 0.74
126 INT279202 Positive_regulation of Localization of CRP 1 3 0.69 2.45 0.72
127 INT244161 Positive_regulation of NOD1 1 4 0.64 1.83 0.62
128 INT282380 Binding of Atg16l1 1 4 0.38 2.06 0.58
129 INT195160 Binding of TLR5 4 8 0.24 5.83 0.53
130 INT207614 Binding of Hspd1 1 4 0.18 1.16 0.5
131 INT195161 Gene_expression of TLR5 2 7 0.49 3.96 0.47
132 INT186290 Binding of Pvrl1 2 8 0.11 4.82 0.46
133 INT204781 Positive_regulation of Nod2 2 6 0.45 2.79 0.46
134 INT213502 Negative_regulation of Defa1 1 2 0.02 1.97 0.41
135 INT195450 Binding of SAT1 1 3 0.37 4.11 0.39
136 INT125006 Gene_expression of DEFA5 5 2 0.05 3.38 0.38
137 INT163489 Binding of CDH1 1 13 0.19 8.63 0.35
138 INT164192 Localization of SLPI 1 4 0.73 1.51 0.32
139 INT346906 Negative_regulation of Localization of SLPI 1 1 0.22 0.68 0.32
140 INT263025 Positive_regulation of Gene_expression of DEFA6 1 2 0.16 1 0.28
141 INT346895 Positive_regulation of Gene_expression of Nod2 2 1 0.33 0.74 0.28
142 INT292006 Gene_expression of ADSL 2 8 0.22 2.55 0.26
143 INT346896 Binding of Nod2 1 1 0.21 0.72 0.26
144 INT346903 Gene_expression of DEFB104B 1 1 0.58 0.78 0.23
145 INT346899 Regulation of Positive_regulation of Nod2 1 1 0.18 0.75 0.22
146 INT201196 Negative_regulation of Gene_expression of PAH 1 2 0.30 3.11 0.19
147 INT346897 Positive_regulation of Atg16l1 1 1 0.16 0.57 0.19
148 INT346898 Regulation of Binding of Atg16l1 1 1 0.09 0.75 0.19
149 INT350810 Localization of Cd276 1 1 0.01 1.19 0.17
150 INT346902 Gene_expression of CCL14 1 1 0.22 0.41 0.17
151 INT350812 Positive_regulation of Localization of Cd276 1 1 0.01 1.2 0.17
152 INT350779 Positive_regulation of Positive_regulation of TLR9 2 1 0.08 0.8 0.15
153 INT285439 Positive_regulation of TLR5 2 6 0.38 1.06 0.13
154 INT88416 Positive_regulation of Gene_expression of ACTA1 1 2 0.67 1.05 0.13
155 INT345424 Phosphorylation of PAH 1 1 0.05 1.55 0.11
156 INT346908 Negative_regulation of DEFA5 1 1 0.03 0.41 0.11
157 INT333625 Positive_regulation of IRF3 1 7 0.61 3.49 0.09
158 INT125009 Gene_expression of HDAC5 1 3 0.44 0.22 0.09
159 INT181528 Positive_regulation of Gene_expression of Ifnar1 1 4 0.43 1.06 0.08
160 INT346905 Binding of DEFA5 1 1 0.02 0.2 0.08
161 INT350780 Positive_regulation of Positive_regulation of TLR5 2 1 0.17 0.41 0.07
162 INT299866 Gene_expression of Prox1 1 12 0.76 1.12 0.06
163 INT299864 Transcription of Prox1 1 4 0.52 1.13 0.06
164 INT346907 Positive_regulation of Gene_expression of DEFA5 1 1 0.04 1.03 0.06
165 INT346900 Gene_expression of HDAC6 1 1 0.13 0.17 0.06
166 INT346901 Regulation of Gene_expression of DEFA5 1 1 0.02 1.04 0.06
167 INT350811 Regulation of Transcription of Il12a 1 1 0.11 0.2 0.04
168 INT346893 Negative_regulation of Gene_expression of Nod2 1 1 0.28 0.13 0.04
169 INT302535 Gene_expression of NLRP2 1 3 0.65 2.14 0.03
170 INT309269 Binding of Defa1 1 3 0.36 0.28 0.03
171 INT244145 Gene_expression of NLRP4 1 2 0.57 0.38 0.03
172 INT350784 Positive_regulation of TICAM1 1 1 0.05 0 0.03
173 INT350778 Regulation of Binding of CDH1 1 1 0.02 0.29 0
174 INT350773 Binding of Muc2 2 1 0.10 0.23 0
175 INT346894 Gene_expression of Defa5 1 1 0.22 0.56 0
176 INT346904 Negative_regulation of Gene_expression of DEFA5 1 1 0.03 0.58 0
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