J:International Journal of Medical Sciences

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT182635 Binding of CCR5 and CCL5 2 1 0.09 4.19 3
2 INT182636 Binding of TNFSF11 and TNFRSF11A 16 1 0.29 17.5 0.84
3 INT238641 Binding of TNF and Ifx 1 1 0.07 0.86 0.84
4 INT238642 Binding of TNF and Ada 1 1 0.03 0.86 0.84
5 INT313993 Ros1 Positive_regulation of Nfkb1 1 2 0.05 1.61 0.68
6 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 1 0.01 0.97 0.46
7 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 1 0.04 0.85 0.45
8 INT182606 Binding of MSH2 and MSH3 1 2 0.12 1.4 0.21
9 INT182634 Binding of CCR5 and MIP 2 1 0.39 1.29 0.2
10 INT182607 Binding of MLH1 and MSH3 1 1 0.04 0.81 0.11
11 INT182644 Binding of CXCR4 and Cxcr4 1 1 0.10 0.66 0.09
12 INT235640 Binding of GATA3 and Mrgpre 1 3 0.01 0.8 0.04
13 INT194483 Binding of Apoe and Chol1 1 1 0.24 0.51 0.03
14 INT194481 Binding of Apoe and Apob 1 1 0.07 0.51 0.03
15 INT194486 Binding of SNRNP70 and Apob 1 1 0.00 0.64 0.03
16 INT194484 Binding of SNRNP70 and Chol1 1 1 0.00 0.64 0.03
17 INT194485 SNRNP70 Regulation of Ppara 1 1 0.00 0.53 0
18 INT235649 TP73 Regulation of EFNA1 1 1 0.09 0.97 0
19 INT194482 Binding of Rare1 and Hdl1 1 2 0.00 1.73 0
20 INT235645 TP53 Regulation of EPHA2 1 1 0.10 0.97 0
21 INT206824 Binding of Muc5b and Gopc 1 1 0.07 0.05 0
22 INT235648 Binding of EFNA1 and EPHA2 1 2 0.23 1.3 0
23 INT235647 TP63 Regulation of EPHA2 1 1 0.15 0.97 0
24 INT235650 TP53 Regulation of EFNA1 1 1 0.06 0.97 0
25 INT206825 Binding of Muc2 and Gopc 1 1 0.08 0.05 0
26 INT235646 TP63 Regulation of EFNA1 1 1 0.09 0.97 0
27 INT235651 TP73 Regulation of EPHA2 1 1 0.15 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 7 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 5 1050 0.70 896.51 322.81
5 INT9158 Gene_expression of Tnf 5 722 0.78 522.01 277.68
6 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
8 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
9 INT6481 Binding of TNF 5 624 0.48 510.2 214.82
10 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
11 INT48955 Gene_expression of Nos2 2 753 0.78 403.87 208.08
12 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
13 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
14 INT120811 Gene_expression of Gopc 8 1174 0.59 428.49 150.55
15 INT812 Localization of INS 1 1026 0.81 515.6 145.31
16 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
17 INT115386 Gene_expression of Ppara 18 779 0.77 549.99 128.36
18 INT65054 Positive_regulation of Nfkb1 2 285 0.70 149.33 126.73
19 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 6 1138 0.72 311.58 119.18
20 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
21 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
22 INT5940 Negative_regulation of Avp 4 236 0.59 67.86 101.2
23 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
24 INT65500 Gene_expression of App 1 605 0.78 429.94 98.31
25 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
26 INT48408 Gene_expression of ICAM1 6 494 0.78 340.08 88.6
27 INT84546 Positive_regulation of Ppara 4 481 0.70 334.21 83.45
28 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
29 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
30 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
31 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
32 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
33 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
34 INT102546 Gene_expression of Ccl2 1 197 0.78 192.8 67.41
35 INT11318 Gene_expression of Gtf3a 2 274 0.52 183.82 60.89
36 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
37 INT169926 Positive_regulation of Gopc 3 416 0.46 157.8 58.67
38 INT96937 Gene_expression of Mmp9 6 191 0.75 150.3 56.01
39 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
40 INT62543 Gene_expression of Icam1 9 231 0.78 187.58 52.71
41 INT72182 Gene_expression of Mcpt1 7 167 0.75 123.7 52.15
42 INT122041 Binding of Ppara 5 308 0.48 189.17 51.48
43 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
44 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
45 INT49520 Gene_expression of P2rx3 1 121 0.78 61.15 49.24
46 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
47 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
48 INT5307 Regulation of Tnf 2 87 0.62 78.71 43.4
49 INT25383 Gene_expression of Csf2 1 222 0.76 152.93 43.32
50 INT115384 Positive_regulation of Mmp9 5 121 0.68 94.74 43.02
51 INT29496 Gene_expression of MMP3 4 136 0.75 49.49 41.78
52 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
53 INT77307 Gene_expression of Bcl2 7 399 0.77 319.77 38
54 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
55 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
56 INT84260 Positive_regulation of Mapk8 1 124 0.69 72.84 35.98
57 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
58 INT1624 Gene_expression of Cea 4 212 0.76 180.44 34.21
59 INT11325 Gene_expression of HLA-E 1 209 0.76 98.05 33.72
60 INT234 Binding of Alb 2 151 0.48 52.34 32.97
61 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
62 INT122039 Positive_regulation of Gene_expression of Ppara 2 144 0.68 113.55 28.55
63 INT118734 Gene_expression of Tlr4 13 70 0.78 55.7 28.19
64 INT116861 Gene_expression of Apoe 4 182 0.78 100.41 27.26
65 INT129956 Gene_expression of MMP13 1 145 0.72 60.48 26.98
66 INT65537 Positive_regulation of Positive_regulation of Nfkb1 4 52 0.67 30.6 26.35
67 INT89662 Positive_regulation of Gene_expression of App 1 169 0.70 133.36 25.62
68 INT93626 Gene_expression of Fasl 4 118 0.75 115.24 25.11
69 INT58192 Positive_regulation of MRI1 1 86 0.61 53.81 24.68
70 INT100423 Gene_expression of Bax 5 141 0.75 98.43 24.48
71 INT151758 Gene_expression of PYCARD 1 91 0.63 14.54 24.27
72 INT22708 Gene_expression of MUC1 5 297 0.78 232.71 24.19
73 INT9155 Gene_expression of Glul 2 60 0.77 17.97 23.95
74 INT44954 Gene_expression of APP 1 191 0.78 105.86 23.9
75 INT8640 Positive_regulation of HSD11B1 3 332 0.67 377.84 22.36
76 INT2911 Positive_regulation of Glul 2 36 0.70 11.09 22.07
77 INT8483 Positive_regulation of Positive_regulation of TNF 1 73 0.67 60.35 22.03
78 INT170444 Binding of Gopc 1 172 0.39 45.05 20.71
79 INT63340 Positive_regulation of Gene_expression of ICAM1 2 109 0.70 90.82 20.61
80 INT96269 Positive_regulation of Mcpt1 6 71 0.61 52.38 20.4
81 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 3 134 0.61 34.87 20.15
82 INT93663 Positive_regulation of MMP1 1 72 0.67 33.38 19.86
83 INT712 Positive_regulation of LDHA 1 160 0.70 175.25 19.11
84 INT56749 Gene_expression of PCNA 1 219 0.77 111.25 18.42
85 INT4420 Positive_regulation of GOT1 1 103 0.64 88.4 18.38
86 INT62826 Negative_regulation of Gene_expression of ICAM1 1 75 0.58 46.39 17.72
87 INT132997 Localization of Mmp9 1 59 0.80 45.9 17.61
88 INT95767 Negative_regulation of Mmp9 2 72 0.57 49.14 17.1
89 INT62546 Positive_regulation of Gene_expression of Icam1 1 60 0.70 59.52 16.9
90 INT110767 Localization of Mcpt1 1 43 0.68 24.3 16.74
91 INT23657 Positive_regulation of APP 1 64 0.70 39.76 16.68
92 INT26314 Positive_regulation of MMP3 1 48 0.67 22.14 16.17
93 INT56447 Positive_regulation of Icam1 2 64 0.64 64.14 16.16
94 INT9220 Gene_expression of Ighg1 2 125 0.77 85.74 15.92
95 INT102680 Protein_catabolism of COL7A1 1 49 0.69 34.68 15.78
96 INT69652 Regulation of P2rx3 1 26 0.61 17.17 15.4
97 INT16167 Negative_regulation of DMD 9 186 0.57 108.71 15.25
98 INT81486 Localization of MMP3 8 31 0.81 12.94 15.21
99 INT24798 Negative_regulation of Glul 18 52 0.55 27.25 15.17
100 INT16166 Positive_regulation of DMD 2 348 0.67 133.22 15.06
101 INT12891 Negative_regulation of MMP3 1 41 0.58 17.99 15.06
102 INT7475 Positive_regulation of Hdl1 2 138 0.67 175.81 15.05
103 INT74098 Negative_regulation of Gene_expression of Nos1 1 36 0.59 16.25 14.82
104 INT151120 Negative_regulation of Tlr4 6 18 0.59 21.09 14.46
105 INT39507 Positive_regulation of TXNRD1 1 37 0.68 12.47 14.25
106 INT78480 Localization of Nfkb1 1 39 0.80 23.14 13.64
107 INT78472 Gene_expression of CDKN2A 1 223 0.78 173.76 13.61
108 INT14572 Binding of INS 1 205 0.48 175.43 13.38
109 INT80222 Negative_regulation of Bcl2 2 82 0.58 69.16 13.18
110 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
111 INT194462 Localization of Ppara 1 94 0.78 68.33 12.09
112 INT36287 Binding of CD4 1 96 0.47 58.93 11.88
113 INT53038 Positive_regulation of Agtr1a 1 35 0.67 23.76 11.68
114 INT65713 Localization of ICAM1 1 42 0.81 39.55 11.49
115 INT118742 Positive_regulation of Tlr4 2 32 0.69 27.55 11.09
116 INT96271 Positive_regulation of Gene_expression of Mcpt1 1 30 0.53 21.34 11.06
117 INT94438 Gene_expression of OLR1 1 86 0.78 80.38 11.03
118 INT13240 Gene_expression of TF 1 94 0.76 57.81 10.99
119 INT6515 Gene_expression of BGLAP 1 110 0.75 45.13 10.81
120 INT83886 Negative_regulation of HMOX2 1 27 0.43 11.69 10.78
121 INT1734 Negative_regulation of HSD11B1 1 116 0.57 125.13 10.52
122 INT35460 Gene_expression of IL16 1 45 0.75 48.71 10.5
123 INT15888 Positive_regulation of Nbr1 1 42 0.69 35.76 10.48
124 INT130867 Gene_expression of TNFSF11 1 106 0.77 45.15 10.34
125 INT74828 Regulation of Slc1a2 1 12 0.61 3.92 10.3
126 INT80036 Positive_regulation of FAS 1 42 0.67 42.22 9.4
127 INT102106 Positive_regulation of Bax 1 48 0.67 30.62 9.28
128 INT28312 Gene_expression of ABCA1 1 85 0.72 37.69 9.27
129 INT49802 Localization of MUC1 2 75 0.81 44.74 8.87
130 INT36449 Negative_regulation of G6PD 1 74 0.59 54.15 8.85
131 INT80420 Gene_expression of IFI27 1 145 0.78 63.61 8.83
132 INT146991 Positive_regulation of Gene_expression of Tlr4 4 21 0.69 20.76 8.69
133 INT89292 Positive_regulation of CCR5 1 27 0.70 15.12 8.59
134 INT112967 Regulation of Mcpt1 2 15 0.54 13.03 8.58
135 INT129962 Positive_regulation of Gene_expression of MMP13 1 41 0.65 20.74 8.54
136 INT44003 Gene_expression of F3 2 40 0.75 27.92 8.29
137 INT17250 Negative_regulation of BGLAP 2 35 0.57 21 8.26
138 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 1 61 0.55 13.63 8.17
139 INT75932 Binding of Csf2 1 45 0.37 33.2 8.01
140 INT24799 Regulation of Glul 3 22 0.45 8.3 8
141 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
142 INT77306 Negative_regulation of Gene_expression of Bcl2 2 46 0.58 38.05 7.71
143 INT182440 Gene_expression of CCNE2 1 39 0.53 22.07 7.44
144 INT102107 Negative_regulation of Gene_expression of Bax 1 30 0.57 29.48 7.33
145 INT6511 Positive_regulation of AFP 1 76 0.70 70.15 7.28
146 INT50212 Gene_expression of Ifx 1 33 0.75 32.17 7.26
147 INT121752 Gene_expression of IL11 1 54 0.62 18.05 7.16
148 INT144945 Negative_regulation of Icam1 1 27 0.50 26.23 7.08
149 INT76120 Gene_expression of Ptprc 1 102 0.59 30.42 7.02
150 INT142264 Positive_regulation of Apoe 1 47 0.50 26.35 6.94
151 INT99942 Positive_regulation of Fasl 1 37 0.68 32.61 6.92
152 INT168600 Binding of Mmp9 1 14 0.44 12.79 6.92
153 INT138799 Regulation of Gene_expression of Ppara 6 40 0.60 29.42 6.89
154 INT295467 Negative_regulation of Gene_expression of Tlr4 2 11 0.58 7.94 6.83
155 INT194479 Phosphorylation of Ppara 1 47 0.81 30.36 6.6
156 INT50633 Regulation of Gene_expression of Glul 2 12 0.60 1.64 6.59
157 INT8683 Positive_regulation of F3 1 31 0.67 42.89 6.21
158 INT17086 Binding of HSD11B1 20 84 0.47 122.28 6.16
159 INT17913 Regulation of HSD11B1 1 87 0.60 93.23 6.04
160 INT63042 Binding of Apoe 1 59 0.48 31.23 5.88
161 INT56160 Binding of Ifx 2 14 0.36 11.39 5.74
162 INT91147 Positive_regulation of Positive_regulation of Ppara 1 30 0.69 19.31 5.56
163 INT168279 Regulation of Tlr4 2 17 0.54 8.97 5.5
164 INT13396 Gene_expression of DMD 1 125 0.75 57.81 5.45
165 INT144946 Localization of Icam1 1 21 0.75 21.84 5.33
166 INT56445 Regulation of Icam1 2 14 0.39 15.4 5.32
167 INT99823 Positive_regulation of Gene_expression of APP 1 31 0.70 21.52 5.09
168 INT44608 Gene_expression of C2 1 45 0.75 15.84 5.05
169 INT180379 Gene_expression of Olr1 5 31 0.36 36.46 4.84
170 INT14470 Gene_expression of HCC 1 83 0.67 110.55 4.61
171 INT160914 Positive_regulation of Positive_regulation of Mmp9 1 7 0.57 4.69 4.52
172 INT57592 Negative_regulation of TAs 2 17 0.33 9.49 4.51
173 INT133231 Regulation of PYCARD 1 18 0.39 5.02 4.44
174 INT48411 Gene_expression of Cd44 1 35 0.77 27.05 4.29
175 INT30610 Localization of PCa 1 35 0.65 13.91 4.25
176 INT91158 Regulation of Ros1 1 26 0.25 17 4.23
177 INT58003 Localization of APP 1 32 0.80 13.75 4.2
178 INT93016 Binding of TNFRSF11A 1 29 0.47 19.67 4.17
179 INT170738 Binding of Icam1 2 23 0.37 25.49 4.09
180 INT20672 Gene_expression of CDS1 2 19 0.76 8.19 4.08
181 INT33951 Regulation of TXNRD1 1 18 0.51 6.97 4.02
182 INT152552 Gene_expression of Muc5ac 5 24 0.73 19.44 4
183 INT59836 Positive_regulation of Upf1 9 24 0.02 4.42 3.99
184 INT144302 Protein_catabolism of MMP3 3 7 0.86 7.43 3.98
185 INT126477 Gene_expression of Sdf2l1 1 43 0.66 22.02 3.97
186 INT28060 Positive_regulation of Hdlcl1 1 48 0.66 37.31 3.79
187 INT26233 Binding of GSR 1 45 0.46 18.22 3.74
188 INT149614 Localization of MMP13 1 13 0.81 6.12 3.65
189 INT173849 Positive_regulation of Localization of MMP3 2 7 0.49 4.6 3.65
190 INT16165 Regulation of DMD 2 114 0.60 35.13 3.64
191 INT44015 Binding of Cd86 1 16 0.31 5.92 3.58
192 INT100384 Regulation of SNRNP70 1 24 0.60 11 3.56
193 INT50648 Negative_regulation of Gene_expression of Glul 2 9 0.58 2.7 3.53
194 INT5609 Regulation of Ifx 2 6 0.60 5.73 3.5
195 INT72798 Binding of ADA 1 12 0.47 7.84 3.39
196 INT171998 Binding of DMD 3 58 0.47 38.13 3.35
197 INT158978 Localization of TNFRSF11B 2 19 0.78 11.8 3.32
198 INT3403 Positive_regulation of BCAR1 7 18 0.63 18.95 3.23
199 INT28130 Positive_regulation of ABCA1 1 18 0.61 7.08 3.22
200 INT19392 Gene_expression of Ada 1 9 0.77 7.4 3.17
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