J:J. Biol. Chem.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 2 0.54 8.87 18.3
2 INT51205 Binding of OPRK1 and PDYN 7 1 0.00 2.01 7.8
3 INT20133 Trh Positive_regulation of Localization of Prl 23 2 0.78 2.04 5.44
4 INT34444 Binding of Oprl1 and Ptprg 4 1 0.03 0.18 4.58
5 INT64480 Binding of OPRL1 and PNOC 2 1 0.33 0.23 4.38
6 INT29240 Binding of POMC and YY1 5 1 0.40 0.17 4.06
7 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 1 0.00 0.63 3.1
8 INT41152 Binding of Penk and Slc3a1 3 1 0.12 0.11 2.91
9 INT69665 Binding of Oprd1 and Pnoc 5 1 0.35 0.4 2.5
10 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 2 0.07 1.35 2.18
11 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 1 0.18 0.3 2.08
12 INT51199 Binding of OPRM1 and PDYN 2 1 0.13 0.3 2.08
13 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 2 0.19 1.34 2.08
14 INT107738 Binding of Pld2 and Oprm1 1 5 0.23 0 1.93
15 INT24817 Binding of POMC and VTN 8 8 0.42 0.39 1.71
16 INT111076 Psen1 Regulation of Psenen 1 2 0.17 0.76 1.58
17 INT41652 Binding of Pomc and Oprl1 3 3 0.16 0 1.57
18 INT117008 Sfpi1 Regulation of Oprm1 1 3 0.56 0.56 1.49
19 INT144452 Binding of GPM6A and GPM6B 1 2 0.28 0 1.46
20 INT144454 Binding of DMPK and GPM6A 1 2 0.00 0 1.45
21 INT2641 Binding of Pomc and Lct 2 1 0.31 0.57 1.32
22 INT91305 Binding of Npff and Npffr2 2 1 0.31 0.64 1.32
23 INT148778 Binding of Usf1 and Rtn1 1 2 0.40 0.85 1.3
24 INT148775 Binding of Calca and Usf1 1 2 0.43 0.85 1.29
25 INT136200 Binding of Penk and NUP37 1 2 0.04 0 1.28
26 INT100816 PPP1R14C Regulation of Ppp1cc 1 2 0.08 0 1.27
27 INT71109 Binding of INSRR and MC1R 1 3 0.01 0 1.27
28 INT116892 Binding of TRPV1 and Phax 4 2 0.00 0.1 1.24
29 INT18324 Sst Negative_regulation of Localization of Ins1 2 2 0.46 1.09 1.24
30 INT140238 HELQ Regulation of MC1R 1 2 0.01 0.5 1.2
31 INT124157 Oprm1 Negative_regulation of Gnb5 1 2 0.25 0.4 1.19
32 INT57824 Binding of Trim13 and Slc25a2 1 1 0.01 0.08 1.19
33 INT57822 Binding of Slc25a2 and Atxn2l 1 1 0.00 0.08 1.17
34 INT57823 Binding of Trim13 and Atxn2l 1 1 0.00 0.08 1.17
35 INT113540 Binding of OPRM1 and Tac1 1 2 0.04 0.1 1.1
36 INT81788 Binding of AGRP and MC4R 4 3 0.51 0 1.09
37 INT101715 PLAT Positive_regulation of NFKB1 2 2 0.11 0.99 1.09
38 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 1 0.40 0 1.05
39 INT97011 Binding of CALM3 and OPRM1 1 1 0.35 0 1.05
40 INT144661 Dnm1 Negative_regulation of Binding of Hbegf 1 2 0.24 0 1.01
41 INT113453 Ngf Positive_regulation of JUN 1 1 0.27 0.6 1.01
42 INT60213 Binding of Ptgs1 and Ptgs2 2 1 0.37 0.5 0.97
43 INT122144 Binding of Trpv1 and Prkd1 1 4 0.02 0.39 0.96
44 INT141373 Ier3 Positive_regulation of CREM 1 2 0.00 0 0.95
45 INT148772 Usf1 Regulation of Calca 1 2 0.40 0.69 0.95
46 INT33976 Trmt2a Negative_regulation of Binding of Fads1 1 1 0.00 0 0.94
47 INT117005 Sfpi1 Positive_regulation of Oprm1 1 2 0.52 0.56 0.94
48 INT81329 Binding of ARRB1 and OPRK1 1 2 0.05 0.1 0.93
49 INT42798 Gtf3a Positive_regulation of Penk 1 1 0.11 0.1 0.91
50 INT124160 Binding of Rgs9 and Mors1 1 1 0.23 0.28 0.9
51 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 1 0.01 0.28 0.88
52 INT62956 CXCR2 Positive_regulation of IL8 1 2 0.30 0 0.88
53 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 1 0.02 0.54 0.87
54 INT117572 Binding of SEMA6B and SEMA6A 1 1 0.00 0.18 0.86
55 INT120820 Binding of ASIC3 and Dlg4 3 2 0.02 0.11 0.84
56 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 1 0.01 0.08 0.84
57 INT80878 PCDHB17 Negative_regulation of ADCY1 1 1 0.01 0.08 0.84
58 INT1583 PENK Negative_regulation of Binding of PENK and POMC 1 1 0.08 0 0.83
59 INT1582 Binding of PENK and POMC 1 1 0.16 0 0.83
60 INT97012 Binding of CALM1 and OPRM1 1 1 0.18 0 0.82
61 INT77393 Binding of ARRB1 and OPRM1 1 1 0.15 0 0.82
62 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 1 0.34 0 0.8
63 INT42797 Egf Regulation of Gene_expression of Penk 1 1 0.21 0.07 0.8
64 INT107739 Prkcg Negative_regulation of Positive_regulation of Pld2 1 1 0.46 0 0.79
65 INT42796 Ngf Positive_regulation of Binding of Penk 1 1 0.56 0.08 0.79
66 INT115147 TGM7 Positive_regulation of Gene_expression of GDF15 1 4 0.28 1.15 0.77
67 INT125523 PLAT Positive_regulation of GDF15 1 3 0.13 1.33 0.75
68 INT111194 Binding of NEUROD1 and Pck1 1 1 0.39 0 0.75
69 INT144455 Binding of CNR1 and GPM6A 1 1 0.02 0 0.74
70 INT144453 Binding of GPM6A and SSTR2 1 1 0.02 0 0.74
71 INT136199 Hnrpd Regulation of Gene_expression of Penk 1 1 0.46 0 0.74
72 INT106527 Akt1 Positive_regulation of Jun 1 4 0.05 0.53 0.74
73 INT120819 Binding of ASIC3 and Lin7b 1 2 0.01 0 0.73
74 INT157063 SLC12A1 Negative_regulation of CALCRL 1 1 0.00 0.34 0.73
75 INT117012 Binding of OPRD1 and TCN2 1 3 0.02 0 0.72
76 INT120818 Lin7b Positive_regulation of ASIC3 1 2 0.01 0 0.71
77 INT82759 Binding of IGHG3 and OPRM1 2 1 0.06 0 0.7
78 INT117806 Binding of TRPV1 and Syt9 1 2 0.11 0.37 0.7
79 INT107741 Binding of OPRM1 and Pld2 1 2 0.01 0 0.69
80 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 1 0.39 0.58 0.69
81 INT81787 Binding of AGRP and MC1R 1 6 0.53 0 0.69
82 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 1 0.46 0.31 0.68
83 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 1 0.52 0.31 0.68
84 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 1 0.52 0.31 0.68
85 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 1 0.46 0.31 0.68
86 INT144459 Binding of GPM6A and INSRR 1 1 0.00 0 0.67
87 INT33274 Binding of Oprd1 and Igh-6 1 1 0.12 0 0.66
88 INT144457 GPM6A Regulation of MRGPRX1 1 1 0.06 0 0.65
89 INT100806 Ppp1r14a Regulation of Ppp1cc 1 1 0.05 0 0.65
90 INT104858 Prkaca Negative_regulation of Negative_regulation of TRPV1 2 1 0.10 0.41 0.64
91 INT148773 Binding of Calca and Usf2 1 1 0.46 0.42 0.64
92 INT151783 Regulation of Binding of Calca and P2rx1 1 1 0.42 0.51 0.64
93 INT151778 Binding of Calca and P2rx1 1 1 0.35 0.5 0.64
94 INT148776 Binding of Usf2 and Rtn1 1 1 0.38 0.42 0.64
95 INT117007 Binding of Oprm1 and Sfpi1 1 1 0.50 0.07 0.63
96 INT124158 Binding of Oprm1 and Rgs7 1 1 0.30 0.18 0.62
97 INT148780 Binding of Usf2 and Usf1 1 1 0.40 0.41 0.62
98 INT52478 Binding of Adarb1 and Ift172 1 2 0.00 0 0.62
99 INT124161 Binding of Rgs7 and Rgs11 1 1 0.29 0.18 0.62
100 INT59687 Gene_expression of Opcml Regulation of Binding of Oprd1 1 1 0.00 0.54 0.62
101 INT124159 Binding of Oprm1 and Rgs11 1 1 0.31 0.18 0.62
102 INT151780 Calca Positive_regulation of Camkk2 1 1 0.01 0.48 0.61
103 INT91306 Binding of Npff and Npffr1 1 1 0.23 0.17 0.6
104 INT148779 Usf1 Negative_regulation of Calca 1 1 0.44 0.4 0.59
105 INT111184 Binding of GIPC1 and CHCHD8 1 1 0.00 0 0.59
106 INT148771 Usf2 Negative_regulation of Calca 1 1 0.42 0.4 0.59
107 INT115146 MAPK1 Positive_regulation of EGR1 3 1 0.13 2.43 0.57
108 INT71110 Binding of MC1R and NDP 1 1 0.10 0 0.57
109 INT141362 EP300 Negative_regulation of Transcription of IL2 1 1 0.17 0 0.56
110 INT77394 Binding of ARRB1 and GIPC1 1 1 0.01 0 0.56
111 INT81792 AGRP Negative_regulation of INSRR 3 2 0.01 0 0.55
112 INT141371 Positive_regulation of CREM Negative_regulation of Crem 1 1 0.00 0 0.54
113 INT49358 Binding of DHCR24 and Pdyn 1 2 0.00 0 0.53
114 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 2 0.18 0 0.53
115 INT79593 Binding of Reg1 and LMTK2 1 2 0.00 0.32 0.53
116 INT141372 CREM Negative_regulation of Crem 1 1 0.00 0 0.53
117 INT60759 Ikbip Regulation of Gene_expression of Oprd1 1 1 0.01 0 0.52
118 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 1 0.18 0.44 0.52
119 INT138353 Foxm1 Positive_regulation of Phosphorylation of Trpv1 1 1 0.10 0.31 0.51
120 INT138352 Foxm1 Positive_regulation of Trpa1 1 1 0.05 0.33 0.51
121 INT144456 Binding of GPM6A and OPRM1 1 1 0.07 0 0.5
122 INT117006 Sfpi1 Negative_regulation of Oprm1 1 1 0.39 0.29 0.49
123 INT81331 ADRBK1 Regulation of OPRK1 1 1 0.03 0.09 0.48
124 INT58578 Binding of RPA1 and TACR1 1 2 0.01 0 0.48
125 INT81330 ARRB1 Regulation of OPRK1 1 1 0.04 0.09 0.47
126 INT81333 Binding of OPRK1 and SNORD50A 1 1 0.07 0.09 0.46
127 INT81335 Negative_regulation of Binding of OPRK1 and SNORD50A 1 1 0.08 0.1 0.46
128 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 1 0.41 0.07 0.44
129 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 1 0.50 0.07 0.44
130 INT130975 Binding of ASIC3 and Slc9a3r1 1 1 0.06 0.26 0.43
131 INT83567 Matk Negative_regulation of Oprl1 1 1 0.00 0 0.42
132 INT53139 Binding of Htr1a and Kcnj3 1 1 0.37 0 0.42
133 INT125520 PLAT Positive_regulation of Gene_expression of GDF15 1 2 0.13 0.74 0.42
134 INT113537 Binding of OPRM1 and TACR1 1 1 0.01 0.1 0.42
135 INT117011 Binding of TCN2 and TP53INP2 1 2 0.00 0 0.42
136 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 1 0.14 0.34 0.41
137 INT106114 Binding of ASIC2 and Pick1 1 1 0.14 0.1 0.4
138 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 1 0.01 0 0.4
139 INT79577 APP Negative_regulation of PENK 1 2 0.12 0.35 0.4
140 INT106116 Binding of ASIC1 and Pick1 1 1 0.04 0.1 0.4
141 INT106115 Pick1 Positive_regulation of Phosphorylation of ASIC2 1 1 0.13 0.07 0.39
142 INT33713 Binding of ITPR3 and Trh 1 2 0.00 0.86 0.39
143 INT106117 Pick1 Positive_regulation of ASIC2 1 1 0.14 0.09 0.39
144 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 1 0.06 0.57 0.38
145 INT113289 TRPV1 Regulation of Phosphorylation of Prkaca 1 1 0.02 0.1 0.37
146 INT80444 Binding of EDNRA and SPR 1 1 0.05 0.1 0.36
147 INT120821 Dlg4 Positive_regulation of ASIC3 1 1 0.02 0 0.36
148 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 1 0.08 0.29 0.36
149 INT114903 POMC Regulation of Gene_expression of COL7A1 1 2 0.06 0.2 0.36
150 INT53257 CALCRL Negative_regulation of Binding of Agt 1 1 0.00 0 0.36
151 INT29292 POMC Negative_regulation of HP 1 1 0.01 0 0.34
152 INT24530 Gal Negative_regulation of Localization of Ins1 1 2 0.16 0.18 0.34
153 INT120817 Binding of Dlg4 and Lin7b 1 1 0.00 0 0.34
154 INT98292 IL4 Regulation of Transcription of OPRM1 1 1 0.05 0 0.33
155 INT34449 Binding of Ca2 and Pck1 1 1 0.17 0.18 0.33
156 INT98291 FAIM3 Regulation of IL4 1 1 0.02 0 0.32
157 INT117010 Binding of OPRD1 and UTS2D 1 1 0.02 0 0.32
158 INT147434 Psenen Positive_regulation of APP 1 1 0.01 0.58 0.32
159 INT31276 Oxt Negative_regulation of Cpe 1 1 0.01 0 0.31
160 INT31275 Avp Negative_regulation of Cpe 1 1 0.00 0 0.31
161 INT62207 Binding of PTGS1 and PTGS2 3 3 0.06 0.07 0.29
162 INT83569 Grk5 Regulation of Oprk1 1 1 0.02 0 0.29
163 INT98293 IL4 Positive_regulation of Transcription of FAIM3 1 1 0.02 0 0.29
164 INT31277 Penk Negative_regulation of Cpe 1 1 0.12 0 0.29
165 INT59684 Binding of Gmfb and Cyp2c6 1 1 0.00 0 0.29
166 INT59682 Hps6 Positive_regulation of Binding of Chrna7 1 1 0.02 0 0.29
167 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 1 0.03 0 0.29
168 INT137684 Binding of Cyp27b1 and Prkca 1 1 0.02 0 0.29
169 INT83568 Adrbk2 Regulation of Oprk1 1 1 0.02 0 0.29
170 INT81791 AGRP Negative_regulation of MC1R 2 1 0.47 0 0.28
171 INT49904 Gtf3a Regulation of Dpys 1 1 0.02 0.06 0.28
172 INT49918 Gtf3a Regulation of FCRLB 1 1 0.00 0.06 0.28
173 INT156640 ATF4 Regulation of Gene_expression of S100P 1 1 0.44 0.88 0.28
174 INT148774 Usf2 Regulation of Calca 1 1 0.11 0.24 0.27
175 INT96788 Binding of SP3 and NR2F2 1 2 0.24 0.27 0.27
176 INT96789 Binding of SP1 and NR2F2 1 2 0.24 0.27 0.27
177 INT79592 Binding of APP and Reg1 1 1 0.01 0.16 0.27
178 INT96787 SP1 Positive_regulation of GDF15 1 2 0.08 0.27 0.27
179 INT101371 Inadl Positive_regulation of Gene_expression of ASIC3 1 1 0.02 0.46 0.27
180 INT96790 SP3 Positive_regulation of GDF15 1 2 0.20 0.26 0.27
181 INT125515 SP1 Regulation of GDF15 1 1 0.14 0.47 0.26
182 INT101630 Binding of OPRM1 and SST 1 1 0.34 0 0.26
183 INT125522 PLAT Regulation of Gene_expression of GDF15 1 1 0.08 0.46 0.26
184 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 1 0.07 0.44 0.26
185 INT125513 PLAT Positive_regulation of Transcription of GDF15 1 1 0.12 0.44 0.26
186 INT53951 Negative_regulation of Trib3 Negative_regulation of Gene_expression of Ptgs1 1 1 0.01 0.43 0.26
187 INT125521 EGR1 Regulation of GDF15 1 1 0.13 0.47 0.26
188 INT125516 TP53 Regulation of GDF15 1 1 0.10 0.47 0.26
189 INT59683 Binding of Chrna7 and Evi2a 1 1 0.03 0 0.25
190 INT24529 Gal Regulation of Localization of Ins1 1 1 0.23 0.1 0.25
191 INT125517 Negative_regulation of PLAT Positive_regulation of GDF15 1 1 0.12 0.46 0.25
192 INT125512 Gene_expression of NFKB1 Positive_regulation of GDF15 1 1 0.32 0.42 0.25
193 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 3 0.61 0.77 0.25
194 INT59685 Hps6 Positive_regulation of Binding of Chrna7 and Evi2a 1 1 0.00 0 0.25
195 INT118419 Binding of Gata1 and Tac2 1 3 0.31 0.7 0.24
196 INT125518 Binding of NFKB1 and GDF15 1 1 0.33 0.41 0.24
197 INT125519 Regulation of PLAT Positive_regulation of NFKB1 1 1 0.07 0.44 0.24
198 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 1 0.36 0.59 0.24
199 INT140376 TGM1 Positive_regulation of Rhoa 1 1 0.01 0 0.24
200 INT101312 Samhd1 Positive_regulation of Gene_expression of Aif1 1 1 0.03 0.38 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 22 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 9 2431 0.81 378.96 952.2
3 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
4 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
5 INT292 Localization of Penk 3 876 0.81 88.44 669.14
6 INT58061 Gene_expression of Trpv1 15 1117 0.78 451.54 637.59
7 INT728 Positive_regulation of Penk 8 1068 0.70 186.9 636.87
8 INT797 Regulation of Penk 3 812 0.62 111.13 542.24
9 INT443 Localization of POMC 3 1020 0.81 284.52 443.17
10 INT50058 Negative_regulation of Cpox 4 907 0.58 426.28 428.29
11 INT5895 Gene_expression of Oprm1 13 525 0.78 120.67 407.29
12 INT64202 Positive_regulation of Trpv1 13 643 0.70 249.66 397.42
13 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
14 INT1395 Negative_regulation of Penk 3 537 0.59 87.33 389.81
15 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
16 INT2540 Negative_regulation of Calca 2 538 0.59 172.11 384.38
17 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
18 INT157 Positive_regulation of Localization of Prl 2 790 0.70 104.54 374.78
19 INT720 Positive_regulation of POMC 3 807 0.70 237.37 353.83
20 INT5660 Binding of Oprd1 6 477 0.48 71.86 342.06
21 INT16260 Gene_expression of Bdnf 2 671 0.78 283.44 339.1
22 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
23 INT5059 Positive_regulation of TNF 4 1050 0.70 896.51 322.81
24 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
25 INT5979 Gene_expression of Oprd1 6 428 0.78 75.64 320.32
26 INT34869 Negative_regulation of PTGS2 5 778 0.59 366.76 319.85
27 INT5540 Positive_regulation of Oprm1 9 344 0.70 76.77 319.71
28 INT5680 Gene_expression of Ngf 1 530 0.78 264.29 310.56
29 INT4941 Positive_regulation of Oprd1 7 345 0.70 74.26 304.41
30 INT9131 Positive_regulation of Prkcg 2 431 0.70 130.8 302.41
31 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
32 INT886 Gene_expression of Pomc 6 676 0.78 129.87 295.98
33 INT11624 Gene_expression of OPRM1 19 445 0.78 72.36 294.36
34 INT5379 Gene_expression of Fos 1 656 0.78 255.5 292.54
35 INT9381 Positive_regulation of TRPV1 31 523 0.70 187.4 276.05
36 INT94450 Gene_expression of Nav1 5 359 0.78 131.85 275.46
37 INT49750 Negative_regulation of CPOX 4 735 0.58 360.06 274.19
38 INT1396 Binding of Penk 6 355 0.48 22.79 269.65
39 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
40 INT87687 Positive_regulation of Trpv1 4 409 0.70 210.24 257.59
41 INT5501 Regulation of Oprd1 3 283 0.62 55.1 249.9
42 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
43 INT5597 Gene_expression of Pdyn 11 433 0.78 62.97 235.47
44 INT6406 Binding of Oprm1 9 280 0.48 40.54 226.26
45 INT1212 Binding of Oprl1 6 312 0.48 28.6 225.15
46 INT95787 Positive_regulation of Mapk1 2 568 0.70 226.51 220.94
47 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
48 INT6293 Gene_expression of Oprm1 4 312 0.78 48.73 215.61
49 INT4893 Gene_expression of Tacr1 1 366 0.78 129.67 213.92
50 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
51 INT2391 Negative_regulation of PTGS1 23 501 0.59 207.62 205.6
52 INT50670 Gene_expression of CPOX 4 763 0.76 442.13 195.02
53 INT156 Negative_regulation of Prl 2 542 0.59 131.97 192.24
54 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
55 INT94952 Positive_regulation of Mapk14 1 305 0.70 197.83 186.61
56 INT1652 Regulation of Pomc 3 387 0.62 61.01 186.51
57 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
58 INT12602 Negative_regulation of Oprm1 5 190 0.59 36.11 177.85
59 INT49441 Negative_regulation of Cpox 3 494 0.59 303.22 177.46
60 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
61 INT26472 Regulation of Oprm1 2 191 0.62 35.84 173.1
62 INT5930 Positive_regulation of Oprm1 9 221 0.70 31.19 172.93
63 INT159 Negative_regulation of Localization of Prl 5 416 0.59 55.34 171.8
64 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
65 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
66 INT1114 Localization of Ins1 7 748 0.80 192.95 165.48
67 INT4768 Positive_regulation of OPRM1 4 212 0.70 31.09 164.28
68 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
69 INT51921 Gene_expression of Cpox 6 501 0.73 229.81 157.81
70 INT21185 Binding of Ptprg 2 213 0.47 13.49 157.75
71 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
72 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
73 INT6042 Binding of Oprm1 4 248 0.48 31.77 154.34
74 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
75 INT1033 Positive_regulation of Ca2 4 507 0.68 131.76 147.64
76 INT5116 Gene_expression of IL2 4 670 0.78 291.13 146.69
77 INT2780 Regulation of Gene_expression of Penk 6 265 0.62 32.45 143.88
78 INT9660 Regulation of TNF 4 363 0.62 312.94 139.99
79 INT4658 Binding of OPRM1 17 188 0.48 25.96 136.24
80 INT60126 Regulation of Trpv1 3 186 0.62 85.53 133.4
81 INT11012 Positive_regulation of Creb1 2 258 0.70 84.4 132
82 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
83 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
84 INT49439 Gene_expression of Cpox 4 508 0.73 326.97 130.17
85 INT5595 Positive_regulation of Pdyn 4 223 0.70 48.37 130.14
86 INT64161 Positive_regulation of Prkca 3 213 0.70 85.06 129.91
87 INT115386 Gene_expression of Ppara 1 779 0.77 549.99 128.36
88 INT1614 Gene_expression of Oprl1 2 164 0.78 31.43 127.74
89 INT1878 Binding of HLA-B 15 440 0.48 321.16 127.36
90 INT695 Binding of POMC 20 304 0.48 56.66 126.85
91 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
92 INT6822 Gene_expression of Pdyn 5 215 0.78 35.99 125.76
93 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
94 INT64201 Negative_regulation of Trpv1 4 203 0.59 79.18 119.75
95 INT5010 Gene_expression of Calca 1 197 0.78 85.76 118.75
96 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
97 INT50674 Gene_expression of PTGS2 4 459 0.78 253.33 118.51
98 INT16253 Positive_regulation of Gene_expression of Bdnf 1 196 0.70 92.67 113.01
99 INT48923 Gene_expression of Ephb1 1 211 0.77 106.23 109.9
100 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
101 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
102 INT47243 Gene_expression of Prkcg 2 195 0.78 58.05 108.44
103 INT4742 Gene_expression of Tac1 2 177 0.78 69.99 102.66
104 INT89054 Positive_regulation of Gene_expression of Trpv1 3 156 0.70 90.78 102.03
105 INT10838 Positive_regulation of IL8 4 381 0.70 295.51 101.62
106 INT5906 Negative_regulation of Oprm1 6 125 0.59 19.58 101.57
107 INT397 Localization of SST 3 232 0.81 58.05 101.19
108 INT97701 Phosphorylation of Mapk14 2 191 0.82 115.33 100.46
109 INT293 Protein_catabolism of Penk 2 161 1.00 11.71 98.45
110 INT65500 Gene_expression of App 13 605 0.78 429.94 98.31
111 INT56130 Gene_expression of MC1R 5 259 0.78 62.7 97.55
112 INT4822 Localization of Ca2 4 417 0.80 99.57 96.45
113 INT940 Negative_regulation of Ptgs1 9 219 0.59 104.34 95.97
114 INT29971 Gene_expression of Oprk1 4 126 0.78 35.32 93.97
115 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
116 INT86024 Gene_expression of PPARA 1 736 0.78 497.93 91.14
117 INT38731 Localization of Trpv1 2 138 0.81 52.73 90.49
118 INT6437 Binding of YY1 8 154 0.47 26.3 90.46
119 INT1639 Negative_regulation of OPRM1 4 107 0.59 13.86 90.37
120 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
121 INT18032 Positive_regulation of Oprk1 3 108 0.70 30.78 89.7
122 INT12763 Phosphorylation of Prkcg 7 167 0.82 38.91 89.63
123 INT71789 Positive_regulation of MAPK1 4 396 0.70 234.44 89.27
124 INT7180 Negative_regulation of Trib3 3 180 0.51 68.48 88.01
125 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
126 INT54571 Positive_regulation of NFKB1 5 263 0.70 138.99 87.32
127 INT5594 Regulation of Pdyn 1 137 0.62 27.04 86.63
128 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
129 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
130 INT4830 Binding of Trpv1 4 158 0.48 45.11 84.2
131 INT2520 Negative_regulation of Ca2 3 271 0.57 72.13 83.71
132 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
133 INT10534 Positive_regulation of Trib3 2 209 0.60 78.75 81.48
134 INT403 Localization of Trh 2 241 0.81 28.55 81.45
135 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
136 INT7528 Regulation of OPRM1 4 100 0.62 20.63 80.57
137 INT64636 Positive_regulation of Gene_expression of Nos2 2 242 0.70 147.52 79.53
138 INT2289 Gene_expression of PENK 6 203 0.78 55.62 79.49
139 INT3214 Localization of Ins1 24 527 0.80 196.9 79.26
140 INT749 Gene_expression of HLA-B 3 341 0.75 224.12 77.37
141 INT17546 Negative_regulation of Ngf 1 135 0.59 60.28 77.19
142 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
143 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
144 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
145 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
146 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
147 INT5593 Positive_regulation of Gene_expression of Pdyn 3 114 0.70 29.1 74.46
148 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
149 INT1080 Negative_regulation of Ache 5 343 0.59 108.51 72.4
150 INT6656 Gene_expression of YY1 5 135 0.75 24.73 72.16
151 INT8962 Gene_expression of Cpe 3 110 0.71 39.67 71.67
152 INT57380 Phosphorylation of Creb1 2 213 0.82 66.8 71.26
153 INT5852 Gene_expression of Penk 3 167 0.78 44.44 71.13
154 INT6490 Negative_regulation of ADCY1 8 145 0.58 26.25 70.96
155 INT8346 Gene_expression of Qrfp 2 136 0.70 19.49 70.21
156 INT1376 Binding of Trh 8 121 0.48 20 69.86
157 INT1377 Positive_regulation of Trh 4 172 0.70 40.55 69.83
158 INT53964 Negative_regulation of Prkaca 2 131 0.58 38.76 69.52
159 INT7534 Gene_expression of Ifng 1 193 0.78 111.02 68.6
160 INT9484 Gene_expression of Jun 2 175 0.78 34.89 68.54
161 INT1988 Positive_regulation of Localization of Ins1 3 254 0.69 59.25 68.37
162 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
163 INT6489 Positive_regulation of Gene_expression of Tnf 2 140 0.70 92.31 67.85
164 INT4637 Binding of Adarb1 2 132 0.41 14.48 67.76
165 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
166 INT6824 Regulation of Gene_expression of Pdyn 2 114 0.62 9.48 66.73
167 INT1603 Negative_regulation of Rtcd1 11 131 0.51 29.99 66.66
168 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
169 INT1425 Gene_expression of Rbm39 2 143 0.58 51.32 65.44
170 INT1599 Positive_regulation of ADCY1 3 146 0.67 30.05 64.9
171 INT8733 Localization of Oprm1 1 61 0.75 7.55 64.61
172 INT83419 Gene_expression of Mors1 1 57 0.68 12.11 63.66
173 INT67614 Positive_regulation of PPARA 4 438 0.68 293.28 63.61
174 INT9657 Positive_regulation of Gene_expression of Il6 2 237 0.70 180.45 63.6
175 INT6894 Gene_expression of CNR1 3 168 0.78 74.07 62.84
176 INT12175 Positive_regulation of PDYN 2 86 0.69 18.27 62.04
177 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
178 INT39153 Positive_regulation of PTGS2 2 182 0.70 96.16 60.6
179 INT9196 Gene_expression of PTGS1 9 215 0.77 96.99 60.5
180 INT66779 Binding of Pnoc 2 79 0.48 6.43 60.46
181 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
182 INT14740 Gene_expression of TGFB1 1 272 0.78 168.48 60.18
183 INT546 Binding of ALB 1 311 0.48 85.98 60.14
184 INT50672 Positive_regulation of CPOX 2 205 0.44 125.93 60.06
185 INT109431 Gene_expression of Trpa1 3 123 0.78 51.84 59.98
186 INT1536 Negative_regulation of NA 3 244 0.55 52.67 59.79
187 INT102020 Gene_expression of Creb1 1 190 0.78 57.31 59.77
188 INT6623 Gene_expression of NA 5 231 0.78 45.78 59.36
189 INT62960 Gene_expression of P2rx2 1 149 0.77 58.31 59.16
190 INT7032 Positive_regulation of Pdyn 2 94 0.66 26.51 58.83
191 INT8732 Positive_regulation of Gene_expression of Oprm1 2 76 0.70 22.59 58.83
192 INT7491 Localization of Pdyn 1 80 0.81 3.94 58.77
193 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
194 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
195 INT20964 Gene_expression of OPRK1 1 96 0.78 23.54 58.18
196 INT68813 Transcription of Oprm1 2 93 0.71 20.11 57.65
197 INT20266 Positive_regulation of Bdkrb1 1 60 0.69 63.64 56.59
198 INT21737 Binding of MC1R 2 129 0.48 45.45 56.54
199 INT1510 Binding of PDYN 2 94 0.48 4.68 56.44
200 INT83602 Positive_regulation of Gene_expression of TRPV1 5 114 0.70 51.19 56.35
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