J:J. Comp. Neurol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 1 0.54 5.93 32.4
2 INT10268 Binding of PDYN and POMC 11 1 0.39 0.08 10.36
3 INT74159 Ngf Regulation of Gene_expression of Calca 2 1 0.60 1.66 3.22
4 INT102284 Binding of Grin1 and Grin2a 5 1 0.27 1.79 3.01
5 INT128044 Bdnf Positive_regulation of Ephb1 2 2 0.31 1.89 2.57
6 INT65025 Binding of Oprm1 and Hps4 1 2 0.01 0 1.93
7 INT42928 Penk Negative_regulation of Localization of Oxt 2 2 0.03 0 1.57
8 INT89011 Lep Positive_regulation of Insr 1 6 0.19 2.41 1.57
9 INT121096 Binding of Calca and Trpv1 3 2 0.37 1.23 1.29
10 INT87375 Binding of Gabrg1 and Oprm1 1 1 0.00 0.83 1.25
11 INT65024 Binding of Oprm1 and Penk 1 1 0.03 0 0.93
12 INT72917 Binding of Crh and Crhr1 4 2 0.32 0.73 0.91
13 INT122687 Binding of Galr2 and Th 1 1 0.13 0.07 0.83
14 INT122688 Binding of Galr1 and Th 1 1 0.14 0.07 0.83
15 INT122686 Binding of Galr3 and Th 1 1 0.14 0.07 0.83
16 INT122191 Binding of Crh and Ucn 4 1 0.36 0.79 0.82
17 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 1 0.22 0.2 0.8
18 INT128041 Bdnf Positive_regulation of Trib3 1 1 0.10 0.29 0.79
19 INT87513 Binding of Tac2 and Abat 1 1 0.09 0.26 0.78
20 INT125626 Binding of Calca and Atp8a2 1 1 0.00 0.4 0.76
21 INT83838 Binding of CEACAM6 and Il1b 1 1 0.05 0 0.71
22 INT89009 Lep Positive_regulation of Cck 2 1 0.67 0.43 0.69
23 INT122190 Binding of Crhr1 and Ucn 4 2 0.49 0.65 0.67
24 INT23576 Binding of Penk and Crh 2 1 0.18 0 0.62
25 INT89010 Arc Positive_regulation of Insr 1 2 0.08 0.86 0.59
26 INT89012 DST Positive_regulation of Insr 1 2 0.01 0.86 0.59
27 INT98815 Binding of Crhr2 and Ucn 3 1 0.32 0.5 0.56
28 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 1 0.07 0.34 0.45
29 INT69163 Tlr4 Positive_regulation of Ptgs1 1 1 0.02 0.08 0.44
30 INT126979 Penk Negative_regulation of Localization of AVP 1 1 0.00 0 0.41
31 INT126975 Penk Negative_regulation of Localization of Avp 1 1 0.00 0 0.41
32 INT148514 Binding of Gad2 and Penk 1 1 0.25 0 0.4
33 INT140869 Binding of Gdnf and Trib3 1 2 0.04 0.15 0.37
34 INT144343 Binding of Npffr2 and Qrfp 1 1 0.37 0 0.37
35 INT140802 Accn2 Regulation of Transcription of Accn1 1 1 0.24 0 0.36
36 INT148515 Binding of Penk and Slc17a7 1 1 0.21 0 0.36
37 INT117789 Binding of CALCA and Slc17a7 1 1 0.09 0 0.35
38 INT144344 Binding of Npvf and Qrfp 1 1 0.16 0 0.34
39 INT144345 Binding of Qrfpr and Qrfp 1 1 0.40 0 0.34
40 INT55087 Binding of Gad1 and Penk 1 1 0.08 0 0.32
41 INT115413 Binding of Penk and Oxtr 1 1 0.00 0 0.25
42 INT105542 PTGES Positive_regulation of DNTT 1 1 0.00 0.62 0.25
43 INT102283 Binding of Grin2d and Nr2c2 1 1 0.03 0.08 0.24
44 INT143394 Ucn Regulation of Crh 1 1 0.44 0.19 0.2
45 INT140870 Binding of Trib3 and Gtf3a 1 1 0.00 0.07 0.18
46 INT139558 Chrna4 Regulation of Neurod1 1 1 0.17 0 0.1
47 INT102587 Npff Positive_regulation of Gene_expression of Nts 1 1 0.37 0.07 0.1
48 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 1 0.17 0 0.1
49 INT80067 Penk Positive_regulation of Gene_expression of Glb1 1 1 0.07 0.1 0.05
50 INT121772 Rps6ka1 Regulation of Phosphorylation of USHBP1 1 2 0.00 0 0
51 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
2 INT3439 Localization of Abat 3 1017 0.78 112.39 727.06
3 INT58061 Gene_expression of Trpv1 18 1117 0.78 451.54 637.59
4 INT728 Positive_regulation of Penk 13 1068 0.70 186.9 636.87
5 INT2543 Positive_regulation of Calca 3 787 0.70 331.13 592.08
6 INT797 Regulation of Penk 25 812 0.62 111.13 542.24
7 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
8 INT64202 Positive_regulation of Trpv1 3 643 0.70 249.66 397.42
9 INT467 Gene_expression of POMC 8 1048 0.78 332.8 394.16
10 INT1395 Negative_regulation of Penk 3 537 0.59 87.33 389.81
11 INT6056 Negative_regulation of Gene_expression of Fos 9 601 0.59 193.05 386.84
12 INT2540 Negative_regulation of Calca 6 538 0.59 172.11 384.38
13 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
14 INT287 Localization of Cck 3 518 0.81 86.84 364.04
15 INT439 Localization of Gnrh1 3 976 0.81 100.96 363.25
16 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
17 INT16260 Gene_expression of Bdnf 2 671 0.78 283.44 339.1
18 INT2649 Regulation of Calca 8 433 0.62 146.05 330.95
19 INT5979 Gene_expression of Oprd1 11 428 0.78 75.64 320.32
20 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
21 INT477 Localization of Avp 3 813 0.81 131.58 300.4
22 INT63932 Positive_regulation of Ephb1 1 537 0.70 259.67 296.14
23 INT886 Gene_expression of Pomc 2 676 0.78 129.87 295.98
24 INT11624 Gene_expression of OPRM1 4 445 0.78 72.36 294.36
25 INT5379 Gene_expression of Fos 2 656 0.78 255.5 292.54
26 INT3579 Localization of Oxt 2 555 0.81 43.35 292.44
27 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
28 INT2365 Positive_regulation of Cck 9 354 0.70 87.8 277.41
29 INT9381 Positive_regulation of TRPV1 1 523 0.70 187.4 276.05
30 INT5591 Regulation of Gene_expression of Fos 11 425 0.62 129.06 265.78
31 INT3948 Regulation of Cck 3 291 0.62 58.07 255.88
32 INT5501 Regulation of Oprd1 3 283 0.62 55.1 249.9
33 INT1005 Localization of Sst 4 385 0.81 26.31 244.56
34 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
35 INT1902 Gene_expression of Cck 19 348 0.78 70.33 241.92
36 INT1562 Localization of Crh 10 499 0.81 126.74 236.68
37 INT5597 Gene_expression of Pdyn 16 433 0.78 62.97 235.47
38 INT1665 Positive_regulation of Pag1 6 270 0.68 186.63 229.87
39 INT1212 Binding of Oprl1 6 312 0.48 28.6 225.15
40 INT11009 Phosphorylation of Creb1 8 458 0.82 111.34 221.97
41 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
42 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
43 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
44 INT63934 Phosphorylation of Ephb1 2 377 0.82 150.52 188.66
45 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
46 INT24326 Gene_expression of Ngf 5 346 0.78 218.67 184.71
47 INT4803 Transcription of Penk 15 435 0.72 59.09 182.4
48 INT3440 Negative_regulation of Localization of Abat 1 221 0.57 33.94 180.36
49 INT1429 Gene_expression of PDYN 11 308 0.78 61.33 175.65
50 INT943 Negative_regulation of Cck 2 205 0.59 38.42 174.78
51 INT26472 Regulation of Oprm1 7 191 0.62 35.84 173.1
52 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
53 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
54 INT51921 Gene_expression of Cpox 3 501 0.73 229.81 157.81
55 INT21185 Binding of Ptprg 18 213 0.47 13.49 157.75
56 INT6042 Binding of Oprm1 4 248 0.48 31.77 154.34
57 INT4740 Gene_expression of Th 13 298 0.78 61.27 154.03
58 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
59 INT6108 Gene_expression of Npy 2 292 0.78 110.65 148.21
60 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
61 INT2780 Regulation of Gene_expression of Penk 4 265 0.62 32.45 143.88
62 INT1414 Regulation of Oprl1 2 169 0.62 32.05 139.99
63 INT90910 Phosphorylation of Grin1 5 150 0.82 68.23 139.24
64 INT14843 Gene_expression of Gabrg1 3 301 0.77 62.63 139.16
65 INT1273 Gene_expression of Avp 14 356 0.78 90.56 138.7
66 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
67 INT4658 Binding of OPRM1 5 188 0.48 25.96 136.24
68 INT60126 Regulation of Trpv1 1 186 0.62 85.53 133.4
69 INT11012 Positive_regulation of Creb1 1 258 0.70 84.4 132
70 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
71 INT5595 Positive_regulation of Pdyn 5 223 0.70 48.37 130.14
72 INT1614 Gene_expression of Oprl1 7 164 0.78 31.43 127.74
73 INT5842 Gene_expression of Gfap 1 372 0.78 153.71 127.71
74 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
75 INT218 Positive_regulation of Th 6 245 0.70 40.5 120.1
76 INT12501 Positive_regulation of Adarb1 3 166 0.58 36.94 118.92
77 INT5010 Gene_expression of Calca 7 197 0.78 85.76 118.75
78 INT4207 Regulation of Avp 2 267 0.62 63.72 115.33
79 INT16253 Positive_regulation of Gene_expression of Bdnf 2 196 0.70 92.67 113.01
80 INT90 Localization of Gast 3 400 0.81 137.67 113
81 INT49651 Gene_expression of Creb1 3 276 0.78 114.77 111.96
82 INT7362 Gene_expression of Sst 11 185 0.78 41.73 111.37
83 INT7327 Regulation of Th 3 164 0.62 29.67 110.14
84 INT5283 Positive_regulation of Npy 4 191 0.70 66.77 109.2
85 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
86 INT4936 Localization of Tacr1 1 125 0.80 35.7 107.7
87 INT9012 Localization of Vip 5 283 0.81 31.71 106.16
88 INT49171 Gene_expression of Nos1 1 241 0.78 140.7 104.76
89 INT12569 Localization of Oprd1 3 94 0.81 23.81 104.56
90 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
91 INT4742 Gene_expression of Tac1 4 177 0.78 69.99 102.66
92 INT1898 Regulation of Crh 3 220 0.62 61.33 102.64
93 INT89054 Positive_regulation of Gene_expression of Trpv1 1 156 0.70 90.78 102.03
94 INT397 Localization of SST 1 232 0.81 58.05 101.19
95 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
96 INT1351 Gene_expression of Pag1 3 131 0.57 89.48 98.76
97 INT4860 Positive_regulation of CALCA 3 148 0.00 73.35 97.61
98 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
99 INT18755 Positive_regulation of Rvm 3 79 0.60 60 92.93
100 INT2122 Negative_regulation of Localization of Gnrh1 1 226 0.59 26.92 92.04
101 INT214 Localization of AVP 1 370 0.81 208.51 91.09
102 INT9516 Negative_regulation of Gabrg1 1 149 0.53 27.83 91.02
103 INT38731 Localization of Trpv1 3 138 0.81 52.73 90.49
104 INT1639 Negative_regulation of OPRM1 4 107 0.59 13.86 90.37
105 INT67682 Localization of Bdnf 1 204 0.81 72.36 88.92
106 INT1635 Gene_expression of Vip 4 245 0.78 53.36 88.13
107 INT5594 Regulation of Pdyn 3 137 0.62 27.04 86.63
108 INT5610 Positive_regulation of Insr 2 140 0.69 37.26 86.24
109 INT4798 Gene_expression of Nts 11 169 0.77 29.56 86.04
110 INT21793 Positive_regulation of Ngf 1 154 0.70 94.78 85.27
111 INT5780 Regulation of Gene_expression of Calca 1 90 0.62 59.52 85.03
112 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
113 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
114 INT4631 Positive_regulation of Sst 2 127 0.70 17.37 83.29
115 INT8650 Gene_expression of Gal 2 152 0.78 61.97 81.72
116 INT6107 Localization of Npy 2 180 0.81 26.76 81.67
117 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
118 INT403 Localization of Trh 1 241 0.81 28.55 81.45
119 INT2289 Gene_expression of PENK 4 203 0.78 55.62 79.49
120 INT2893 Localization of Oxt 2 219 0.80 28.96 79.43
121 INT2155 Negative_regulation of Sst 2 111 0.59 16.58 77.74
122 INT29708 Gene_expression of Gria1 2 177 0.78 56.36 77.37
123 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
124 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
125 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
126 INT5593 Positive_regulation of Gene_expression of Pdyn 1 114 0.70 29.1 74.46
127 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
128 INT7028 Localization of Pdyn 2 90 0.81 8.89 73.54
129 INT79506 Gene_expression of Grin2b 2 122 0.78 43.71 73.42
130 INT63936 Positive_regulation of Phosphorylation of Ephb1 3 131 0.70 49.38 73.16
131 INT7886 Regulation of Localization of Avp 1 146 0.62 14.53 72.99
132 INT442 Localization of PDYN 6 99 0.81 11.87 72.75
133 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
134 INT6656 Gene_expression of YY1 2 135 0.75 24.73 72.16
135 INT5852 Gene_expression of Penk 7 167 0.78 44.44 71.13
136 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
137 INT5993 Positive_regulation of Nts 8 122 0.70 26.82 70.45
138 INT8346 Gene_expression of Qrfp 5 136 0.70 19.49 70.21
139 INT1376 Binding of Trh 1 121 0.48 20 69.86
140 INT1377 Positive_regulation of Trh 1 172 0.70 40.55 69.83
141 INT14624 Gene_expression of Pax3 1 100 0.38 33.22 69.47
142 INT451 Regulation of Oxt 1 142 0.62 22.07 69.42
143 INT66416 Regulation of Pnoc 5 66 0.61 17.32 68.91
144 INT7344 Gene_expression of TAC1 3 132 0.75 35.48 68.26
145 INT5861 Gene_expression of Egr1 2 203 0.78 49.35 68.13
146 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
147 INT5941 Gene_expression of Oxt 2 164 0.76 22.63 65.47
148 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
149 INT66531 Gene_expression of Pnoc 6 88 0.78 22.9 65.11
150 INT6926 Regulation of Pag1 3 72 0.39 55.79 65.09
151 INT13286 Gene_expression of Ca2 1 317 0.67 71.58 65.01
152 INT5573 Negative_regulation of Gene_expression of Penk 2 113 0.59 21.83 64.66
153 INT8733 Localization of Oprm1 11 61 0.75 7.55 64.61
154 INT83419 Gene_expression of Mors1 1 57 0.68 12.11 63.66
155 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
156 INT8363 Localization of Nts 6 135 0.81 14.29 61.71
157 INT18981 Gene_expression of ABAT 1 78 0.68 38.35 61.36
158 INT2761 Regulation of Gabrg1 3 119 0.61 18.8 60.52
159 INT66779 Binding of Pnoc 2 79 0.48 6.43 60.46
160 INT1430 Regulation of PDYN 3 88 0.60 16.99 60.32
161 INT4760 Negative_regulation of Gene_expression of Calca 1 93 0.59 34.19 60.3
162 INT90911 Positive_regulation of Phosphorylation of Grin1 2 62 0.70 27.45 59.26
163 INT62960 Gene_expression of P2rx2 1 149 0.77 58.31 59.16
164 INT7491 Localization of Pdyn 8 80 0.81 3.94 58.77
165 INT6436 Positive_regulation of Positive_regulation of Fos 2 101 0.70 18.71 57.96
166 INT5819 Regulation of Localization of Penk 1 64 0.62 6.69 57.68
167 INT6669 Negative_regulation of Positive_regulation of Fos 1 98 0.59 23.5 56.82
168 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
169 INT1510 Binding of PDYN 2 94 0.48 4.68 56.44
170 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
171 INT6826 Transcription of Pdyn 2 130 0.71 22.19 54.88
172 INT5034 Negative_regulation of Insr 3 100 0.55 28.08 54.5
173 INT6073 Negative_regulation of Localization of Penk 1 63 0.59 8.67 53.95
174 INT49747 Transcription of Oprm1 4 68 0.72 9.01 53.78
175 INT4891 Transcription of Calca 3 81 0.72 35.27 53.75
176 INT7800 Localization of Pag1 1 51 0.56 33.06 53.74
177 INT7898 Gene_expression of Homer1 2 123 0.78 31.52 53.67
178 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
179 INT929 Positive_regulation of Oprl1 1 64 0.70 14.67 52.84
180 INT27954 Positive_regulation of Gene_expression of Ngf 5 87 0.70 57.91 51.96
181 INT6034 Binding of Gabrg1 2 115 0.47 17.48 51.92
182 INT5858 Positive_regulation of Drd1a 1 66 0.69 4.51 51.73
183 INT5338 Regulation of Npy 3 92 0.62 25.54 51.24
184 INT5136 Negative_regulation of PDYN 1 71 0.59 11.22 51.14
185 INT8690 Localization of Tac1 5 71 0.80 22.98 50.75
186 INT2197 Gene_expression of Gnrh1 2 184 0.78 40.04 50.57
187 INT7287 Positive_regulation of Transcription of Penk 3 103 0.70 19.81 50.37
188 INT2323 Gene_expression of Trh 5 146 0.78 29.92 49.5
189 INT10304 Binding of OPRK1 2 89 0.48 9.28 49.42
190 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
191 INT17915 Gene_expression of Insr 5 141 0.75 47.45 48.59
192 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
193 INT32718 Gene_expression of OPRD1 1 82 0.76 9.43 48.38
194 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
195 INT29144 Gene_expression of Rvm 1 41 0.52 29.23 47.76
196 INT51627 Gene_expression of Grin2a 2 82 0.76 25.09 47.6
197 INT5025 Positive_regulation of Gene_expression of Cck 1 63 0.70 10.96 47.11
198 INT5337 Negative_regulation of Npy 1 87 0.59 19.6 46.75
199 INT8713 Regulation of Tac1 1 56 0.60 25.29 45.94
200 INT2783 Gene_expression of Slc3a1 7 86 0.65 8.84 45.4
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