J:J. Endocrinol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 4 0.73 0.87 14.34
2 INT29446 Crh Positive_regulation of Localization of POMC 8 1 0.38 1.87 2.58
3 INT9786 Gnrh1 Regulation of LH 7 1 0.40 0.58 1.82
4 INT27788 Gnrh1 Positive_regulation of Positive_regulation of LH 3 1 0.55 0.17 1.72
5 INT94270 Pomc Regulation of Transcription of Crh 1 2 0.17 0.67 1.6
6 INT94271 Pomc Regulation of Avp 1 2 0.20 0.67 1.57
7 INT3575 Sst Regulation of Localization of Gnrhr 2 1 0.24 0 1.24
8 INT55873 Binding of ADRA1D and GNRH1 1 1 0.08 0 0.54
9 INT55872 Binding of ADRA1D and CRH 1 1 0.26 0 0.54
10 INT113040 IHH Regulation of Gene_expression of INS 1 1 0.12 0.37 0.37
11 INT26071 Adarb1 Regulation of Localization of Crh 1 1 0.01 0.21 0.32
12 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 1 0.02 0 0.26
13 INT110373 CYP4A11 Positive_regulation of PPARG 1 3 0.00 0.94 0.26
14 INT86634 POMC Positive_regulation of TYR 2 1 0.42 0 0.24
15 INT3592 INS Positive_regulation of AVP 1 1 0.05 0.28 0.2
16 INT3591 Negative_regulation of INS Positive_regulation of AVP 1 1 0.04 0.28 0.2
17 INT59459 Binding of OXTR and ISYNA1 1 2 0.05 0.47 0.2
18 INT116382 Lox Positive_regulation of Binding of Alox5 1 1 0.12 0.25 0.14
19 INT131603 POMC Regulation of TYR 1 1 0.52 0 0.13
20 INT80586 Oxt Positive_regulation of Localization of Avp 1 1 0.30 0 0.13
21 INT36216 Avp Negative_regulation of Positive_regulation of CGA 1 1 0.03 0 0.11
22 INT59462 F2 Negative_regulation of Binding of OXTR and ISYNA1 1 1 0.02 0.24 0.1
23 INT59463 ANTXR1 Negative_regulation of Binding of OXTR and ISYNA1 1 1 0.00 0.24 0.1
24 INT32303 Ptger2 Regulation of Ptgfr 1 1 0.03 0.1 0.1
25 INT52893 Ins1 Positive_regulation of Localization of Sst 1 1 0.29 0.17 0.09
26 INT52894 Gcg Negative_regulation of Ins1 1 1 0.16 0.18 0.09
27 INT110377 Binding of Ncoa1 and Pparg 1 1 0.02 0.26 0.08
28 INT99770 Thbs1 Regulation of PGR 1 1 0.01 0 0
29 INT99768 Oxtr Regulation of PGR 1 2 0.20 0 0
30 INT99769 Thbs1 Regulation of THBS1 1 1 0.00 0 0
31 INT59458 GTPBP4 Positive_regulation of Gene_expression of ISYNA1 1 1 0.02 0.14 0
32 INT99772 Pgr Regulation of THBS1 1 1 0.00 0 0
33 INT99771 Oxtr Regulation of THBS1 1 2 0.01 0 0
34 INT59460 F2 Positive_regulation of Gene_expression of ISYNA1 1 1 0.06 0.14 0
35 INT59461 OXTR Positive_regulation of Gene_expression of ISYNA1 1 1 0.07 0.14 0
36 INT99773 Pgr Regulation of PGR 1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 75 2431 0.81 378.96 952.2
3 INT292 Localization of Penk 10 876 0.81 88.44 669.14
4 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
5 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
6 INT155 Positive_regulation of Prl 34 1233 0.70 317.93 457.82
7 INT1045 Localization of LH 60 1211 0.81 87.04 456.25
8 INT443 Localization of POMC 7 1020 0.81 284.52 443.17
9 INT5895 Gene_expression of Oprm1 3 525 0.78 120.67 407.29
10 INT467 Gene_expression of POMC 7 1048 0.78 332.8 394.16
11 INT157 Positive_regulation of Localization of Prl 22 790 0.70 104.54 374.78
12 INT439 Localization of Gnrh1 19 976 0.81 100.96 363.25
13 INT720 Positive_regulation of POMC 10 807 0.70 237.37 353.83
14 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
15 INT876 Localization of Gh1 31 843 0.80 67.75 340.82
16 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
17 INT162 Regulation of Prl 37 794 0.62 165.01 322.24
18 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
19 INT5540 Positive_regulation of Oprm1 1 344 0.70 76.77 319.71
20 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
21 INT477 Localization of Avp 28 813 0.81 131.58 300.4
22 INT161 Regulation of Localization of Prl 40 615 0.62 65.37 298.66
23 INT886 Gene_expression of Pomc 7 676 0.78 129.87 295.98
24 INT3579 Localization of Oxt 40 555 0.81 43.35 292.44
25 INT1893 Localization of Gh 6 1041 0.79 340.23 256.58
26 INT5501 Regulation of Oprd1 2 283 0.62 55.1 249.9
27 INT1005 Localization of Sst 9 385 0.81 26.31 244.56
28 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
29 INT1562 Localization of Crh 9 499 0.81 126.74 236.68
30 INT1308 Localization of Pomc 3 457 0.81 66.83 217.5
31 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
32 INT2651 Positive_regulation of Pomc 9 403 0.70 95.72 206.24
33 INT156 Negative_regulation of Prl 13 542 0.59 131.97 192.24
34 INT528 Gene_expression of Prl 8 693 0.78 217.18 192.2
35 INT2085 Positive_regulation of LH 21 441 0.70 60.15 191.02
36 INT1652 Regulation of Pomc 5 387 0.62 61.01 186.51
37 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
38 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
39 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
40 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
41 INT159 Negative_regulation of Localization of Prl 11 416 0.59 55.34 171.8
42 INT438 Gene_expression of Crh 3 376 0.78 159.11 169.17
43 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
44 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
45 INT5127 Localization of Lhb 24 488 0.80 50.48 162.66
46 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
47 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
48 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
49 INT1044 Negative_regulation of Localization of LH 23 358 0.59 25.95 151.31
50 INT880 Positive_regulation of Localization of Gh1 15 304 0.70 14.79 150.23
51 INT425 Localization of PRL 3 455 0.81 189.64 144.8
52 INT2379 Positive_regulation of Localization of LH 19 349 0.70 27.86 144.53
53 INT1273 Gene_expression of Avp 4 356 0.78 90.56 138.7
54 INT1047 Negative_regulation of LH 7 314 0.59 53.71 135.89
55 INT5497 Positive_regulation of Crh 5 299 0.70 125.54 131.14
56 INT1614 Gene_expression of Oprl1 1 164 0.78 31.43 127.74
57 INT695 Binding of POMC 4 304 0.48 56.66 126.85
58 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
59 INT6822 Gene_expression of Pdyn 1 215 0.78 35.99 125.76
60 INT416 Regulation of LH 15 253 0.62 31.48 125.55
61 INT2106 Regulation of Localization of LH 18 279 0.62 22.37 122.77
62 INT252 Localization of GH1 9 529 0.80 227.4 122.05
63 INT6128 Positive_regulation of Localization of POMC 1 256 0.70 68.77 121.64
64 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
65 INT7395 Localization of GNRH1 3 399 0.81 62.88 117.68
66 INT1438 Localization of Pomc 2 360 0.81 101.26 116.47
67 INT4207 Regulation of Avp 8 267 0.62 63.72 115.33
68 INT1793 Localization of CGA 5 379 0.81 67.38 114.69
69 INT1530 Regulation of Gh 3 382 0.61 115.96 112.47
70 INT7362 Gene_expression of Sst 2 185 0.78 41.73 111.37
71 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
72 INT12569 Localization of Oprd1 2 94 0.81 23.81 104.56
73 INT1898 Regulation of Crh 2 220 0.62 61.33 102.64
74 INT397 Localization of SST 1 232 0.81 58.05 101.19
75 INT2159 Regulation of Localization of Gnrh1 5 200 0.62 13.28 99.07
76 INT293 Protein_catabolism of Penk 1 161 1.00 11.71 98.45
77 INT874 Positive_regulation of Gh1 15 244 0.70 27.17 97.98
78 INT1004 Regulation of Sst 3 140 0.62 18.52 94.84
79 INT5865 Positive_regulation of Localization of Gh 2 282 0.69 84.86 93.5
80 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
81 INT2122 Negative_regulation of Localization of Gnrh1 6 226 0.59 26.92 92.04
82 INT214 Localization of AVP 1 370 0.81 208.51 91.09
83 INT7885 Positive_regulation of Localization of Oxt 9 160 0.70 14.36 87.7
84 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
85 INT2149 Positive_regulation of Oxt 10 181 0.70 24.8 85.43
86 INT875 Regulation of Localization of Gh1 11 166 0.62 12.87 84.97
87 INT4289 Positive_regulation of Localization of Gnrh1 3 202 0.70 12.3 84.01
88 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
89 INT4631 Positive_regulation of Sst 5 127 0.70 17.37 83.29
90 INT6107 Localization of Npy 1 180 0.81 26.76 81.67
91 INT1309 Positive_regulation of Localization of Gnrhr 4 152 0.69 24.25 81.56
92 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
93 INT403 Localization of Trh 11 241 0.81 28.55 81.45
94 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
95 INT2289 Gene_expression of PENK 1 203 0.78 55.62 79.49
96 INT2893 Localization of Oxt 6 219 0.80 28.96 79.43
97 INT920 Localization of PLOD1 1 223 0.81 42.25 78.7
98 INT2155 Negative_regulation of Sst 2 111 0.59 16.58 77.74
99 INT4358 Positive_regulation of Localization of Avp 8 195 0.70 30.79 77.58
100 INT881 Negative_regulation of Localization of Gh1 7 164 0.58 15.1 75.28
101 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
102 INT7886 Regulation of Localization of Avp 8 146 0.62 14.53 72.99
103 INT5128 Positive_regulation of Lhb 11 232 0.69 44.23 71.26
104 INT2055 Regulation of Gnrh1 9 185 0.62 23.65 71.26
105 INT1377 Positive_regulation of Trh 2 172 0.70 40.55 69.83
106 INT451 Regulation of Oxt 4 142 0.62 22.07 69.42
107 INT2123 Positive_regulation of Gnrh1 5 209 0.70 24.2 68.97
108 INT4637 Binding of Adarb1 2 132 0.41 14.48 67.76
109 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
110 INT1046 Gene_expression of LH 5 180 0.77 29.75 66.87
111 INT7468 Negative_regulation of Localization of Oxt 16 109 0.59 9.46 66.79
112 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
113 INT5941 Gene_expression of Oxt 2 164 0.76 22.63 65.47
114 INT480 Negative_regulation of Localization of Avp 5 151 0.59 27.64 63.72
115 INT7280 Positive_regulation of Localization of Sst 5 97 0.70 5.64 63.37
116 INT2056 Negative_regulation of Gnrh1 3 175 0.59 33.43 63.32
117 INT5095 Localization of Ghrh 2 185 0.81 28.09 62.08
118 INT8363 Localization of Nts 2 135 0.81 14.29 61.71
119 INT7884 Regulation of Localization of Oxt 8 102 0.62 7.95 61.71
120 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
121 INT5016 Negative_regulation of Crh 5 129 0.59 36.74 59.28
122 INT1794 Regulation of Localization of CGA 4 136 0.57 13.39 59.07
123 INT8732 Positive_regulation of Gene_expression of Oprm1 2 76 0.70 22.59 58.83
124 INT5710 Negative_regulation of Localization of Lhb 5 146 0.57 20.51 58.33
125 INT5819 Regulation of Localization of Penk 1 64 0.62 6.69 57.68
126 INT68813 Transcription of Oprm1 1 93 0.71 20.11 57.65
127 INT2148 Negative_regulation of Oxt 3 105 0.59 11.42 57
128 INT33567 Gene_expression of CALM1 1 139 0.67 48.85 56.14
129 INT1782 Regulation of Gh1 3 125 0.62 22 55.74
130 INT19 Regulation of Gnrhr 3 131 0.62 36.4 55.66
131 INT2421 Positive_regulation of Positive_regulation of Penk 1 97 0.69 13.38 55.32
132 INT251 Regulation of INS 1 398 0.62 232.47 55.04
133 INT6826 Transcription of Pdyn 1 130 0.71 22.19 54.88
134 INT5506 Positive_regulation of Gene_expression of Pomc 3 132 0.70 26.78 54.3
135 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
136 INT6116 Regulation of Gene_expression of Oprd1 1 69 0.62 16.43 54
137 INT5509 Positive_regulation of Localization of Crh 3 91 0.70 30.65 53.92
138 INT49747 Transcription of Oprm1 2 68 0.72 9.01 53.78
139 INT771 Regulation of Nts 1 93 0.61 13.13 53.57
140 INT1781 Negative_regulation of Gh1 5 127 0.59 16.94 51.77
141 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
142 INT5098 Negative_regulation of Localization of Sst 2 70 0.58 3.56 51.17
143 INT10304 Binding of OPRK1 1 89 0.48 9.28 49.42
144 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
145 INT6299 Regulation of Localization of Lhb 14 104 0.61 8.98 48.79
146 INT1197 Negative_regulation of Localization of POMC 1 109 0.59 28.29 48.02
147 INT1977 Negative_regulation of Positive_regulation of Prl 5 98 0.59 17.06 47.88
148 INT873 Gene_expression of Gh1 2 130 0.76 26.15 46.75
149 INT847 Regulation of Lhb 8 131 0.61 22.08 46.54
150 INT619 Positive_regulation of Positive_regulation of Prl 7 116 0.70 22.69 45.06
151 INT2262 Negative_regulation of Lhb 9 142 0.59 25.47 44.81
152 INT989 Negative_regulation of Trh 2 90 0.59 15.45 43.63
153 INT1894 Negative_regulation of Localization of Gh 1 168 0.58 64.12 43.56
154 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
155 INT1319 Gene_expression of Oprl1 4 65 0.78 9.34 42.41
156 INT5502 Positive_regulation of Gene_expression of Crh 1 69 0.70 43.06 42.23
157 INT5130 Regulation of GNRH1 1 139 0.62 31.95 42.08
158 INT7029 Regulation of Pdyn 1 51 0.61 12.89 40.34
159 INT918 Positive_regulation of Localization of PRL 2 90 0.70 23.97 40.3
160 INT685 Regulation of AVP 1 124 0.62 34.9 39.91
161 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
162 INT2782 Regulation of Gene_expression of Pomc 1 75 0.62 15.04 38.97
163 INT916 Regulation of Localization of PRL 1 92 0.62 22.98 38.13
164 INT5711 Positive_regulation of Localization of Lhb 6 90 0.70 10.92 36.76
165 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
166 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
167 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
168 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
169 INT59466 Gene_expression of ISYNA1 1 204 0.77 112.57 35.48
170 INT255 Regulation of Localization of GH1 2 89 0.62 18.71 35.3
171 INT5743 Localization of NA 4 104 0.59 14.35 35.29
172 INT7282 Regulation of Localization of Sst 3 58 0.62 1.92 34.83
173 INT67613 Positive_regulation of PPARG 2 94 0.70 69.15 34.38
174 INT14559 Gene_expression of Igf1 1 254 0.78 112 34.17
175 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
176 INT3117 Regulation of Oxt 7 103 0.61 17.93 32.28
177 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
178 INT7396 Regulation of Localization of GNRH1 2 81 0.62 6.57 31.31
179 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
180 INT5507 Regulation of Localization of Crh 3 57 0.61 8.43 30.26
181 INT5100 Positive_regulation of Ghrh 3 100 0.64 24.2 30.21
182 INT7397 Negative_regulation of Localization of GNRH1 1 86 0.59 15.45 29.78
183 INT5514 Negative_regulation of Localization of Crh 1 64 0.58 8.12 29.29
184 INT5300 Regulation of Insr 2 54 0.60 11.33 29.26
185 INT6765 Localization of Oprl1 1 49 0.81 5.11 28.87
186 INT1196 Positive_regulation of Positive_regulation of POMC 3 51 0.70 15.99 28.58
187 INT4861 Localization of GRP 1 84 0.80 8.26 28.03
188 INT21379 Transcription of Crh 5 65 0.72 15.64 27.92
189 INT7565 Transcription of Pomc 6 69 0.72 14.46 27.41
190 INT6382 Regulation of Binding of Oprd1 1 36 0.61 7 26.48
191 INT2261 Gene_expression of Lhb 2 121 0.77 42.78 26.04
192 INT13415 Positive_regulation of Hpse 2 58 0.70 24.9 25.53
193 INT3028 Negative_regulation of Oxt 2 76 0.58 18.52 24.4
194 INT18400 Localization of Glp1r 16 97 0.80 11.96 24.32
195 INT14556 Positive_regulation of Igf1 1 105 0.69 52.21 24.04
196 INT5131 Gene_expression of GNRH1 1 109 0.78 28.79 23.94
197 INT682 Negative_regulation of AVP 2 97 0.59 50.67 23.91
198 INT5511 Negative_regulation of Gene_expression of Pomc 1 47 0.59 12.08 23.02
199 INT917 Positive_regulation of Localization of PLOD1 1 51 0.69 8.53 22.87
200 INT4612 Positive_regulation of Localization of CGA 1 64 0.64 8.51 22.39
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