J:J. Endocrinol. Invest.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 2 0.64 2.12 14.2
2 INT10844 Ghrh Regulation of Gh 13 2 0.13 4.77 4.71
3 INT1390 Trh Positive_regulation of Prl 14 2 0.67 4.42 4.39
4 INT20411 Ghrh Positive_regulation of Gh1 6 1 0.56 0.62 2.47
5 INT7367 Ghrh Regulation of Localization of Gh1 5 1 0.49 1.55 2.25
6 INT32482 Ghrh Positive_regulation of Prl 3 1 0.18 0.26 1.62
7 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 2 0.35 0 1.15
8 INT22176 Calca Regulation of Localization of Prl 4 2 0.69 0.39 1.11
9 INT52562 Lhb Positive_regulation of Prl 3 2 0.00 1.09 1.02
10 INT25155 TRH Positive_regulation of PRL 2 1 0.50 0.4 1
11 INT64106 Oprl1 Positive_regulation of Localization of Gnrh1 1 1 0.03 0 0.88
12 INT132318 Ghrl Positive_regulation of Localization of GH1 5 1 0.32 4.49 0.84
13 INT29847 INS Regulation of Localization of AVP 1 1 0.23 0.24 0.59
14 INT25156 TRH Regulation of PRL 2 1 0.27 0.81 0.56
15 INT32484 Gnrhr Regulation of GHRH 1 1 0.01 0 0.55
16 INT32486 Gh1 Regulation of Ghrh Positive_regulation of Gh1 1 1 0.14 0 0.55
17 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 1 0.28 0 0.55
18 INT32485 Ghrh Regulation of Ghrh Positive_regulation of Gh1 1 1 0.21 0 0.55
19 INT70244 POMC Positive_regulation of Localization of PLOD1 1 1 0.21 0 0.53
20 INT34368 TRH Positive_regulation of GHRH 1 1 0.23 0.4 0.53
21 INT32479 Gh1 Negative_regulation of Dbi 1 1 0.01 0 0.51
22 INT39181 NPL Regulation of Prl 1 1 0.16 0 0.47
23 INT39178 NPL Regulation of FSHR 1 1 0.03 0 0.46
24 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 2 0.04 0.55 0.39
25 INT17091 Il1b Negative_regulation of Localization of Ins1 1 3 0.32 0.28 0.28
26 INT20029 Ghrh Positive_regulation of Negative_regulation of Gh 1 1 0.05 0.14 0.26
27 INT20030 Negative_regulation of SST Positive_regulation of Ghrh 1 1 0.01 0.16 0.23
28 INT20031 Negative_regulation of SST Positive_regulation of Gh 1 1 0.00 0.16 0.23
29 INT73168 Lhb Positive_regulation of Gh 2 2 0.00 0.95 0.2
30 INT73165 Gh Positive_regulation of Prl 2 2 0.00 0.95 0.2
31 INT17092 Il1b Regulation of Localization of Ins1 1 2 0.46 0.13 0.15
32 INT59379 Calca Negative_regulation of Vip 1 1 0.12 0.67 0.12
33 INT33323 Regulation of Trh Positive_regulation of Prl 1 1 0.30 0 0.1
34 INT73167 Regulation of Lhb Positive_regulation of Gh 1 1 0.00 0.48 0.1
35 INT27844 Binding of INS and Gh 1 1 0.03 0.1 0.1
36 INT27841 Binding of INS and GAL 1 1 0.04 0.1 0.1
37 INT33324 Regulation of Binding of Prl and Trh 1 1 0.50 0 0.08
38 INT33325 Binding of Prl and Trh 1 1 0.42 0 0.08
39 INT88054 ABL2 Regulation of Gh 1 1 0.02 0.57 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT158 Localization of Prl 34 2431 0.81 378.96 952.2
3 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
4 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
5 INT155 Positive_regulation of Prl 12 1233 0.70 317.93 457.82
6 INT1045 Localization of LH 5 1211 0.81 87.04 456.25
7 INT443 Localization of POMC 4 1020 0.81 284.52 443.17
8 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
9 INT467 Gene_expression of POMC 5 1048 0.78 332.8 394.16
10 INT157 Positive_regulation of Localization of Prl 12 790 0.70 104.54 374.78
11 INT439 Localization of Gnrh1 4 976 0.81 100.96 363.25
12 INT720 Positive_regulation of POMC 4 807 0.70 237.37 353.83
13 INT876 Localization of Gh1 2 843 0.80 67.75 340.82
14 INT162 Regulation of Prl 17 794 0.62 165.01 322.24
15 INT477 Localization of Avp 1 813 0.81 131.58 300.4
16 INT161 Regulation of Localization of Prl 3 615 0.62 65.37 298.66
17 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
18 INT1893 Localization of Gh 12 1041 0.79 340.23 256.58
19 INT16868 Gene_expression of Il6 4 807 0.78 499.48 256.57
20 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
21 INT767 Localization of Gnrhr 5 565 0.80 106.68 214.57
22 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
23 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
24 INT156 Negative_regulation of Prl 9 542 0.59 131.97 192.24
25 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
26 INT1652 Regulation of Pomc 6 387 0.62 61.01 186.51
27 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
28 INT159 Negative_regulation of Localization of Prl 4 416 0.59 55.34 171.8
29 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
30 INT1114 Localization of Ins1 5 748 0.80 192.95 165.48
31 INT5127 Localization of Lhb 5 488 0.80 50.48 162.66
32 INT3448 Positive_regulation of Gh 16 521 0.69 180.03 161.18
33 INT2640 Gene_expression of Pomc 2 424 0.78 120.72 155.37
34 INT1044 Negative_regulation of Localization of LH 1 358 0.59 25.95 151.31
35 INT880 Positive_regulation of Localization of Gh1 2 304 0.70 14.79 150.23
36 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
37 INT812 Localization of INS 5 1026 0.81 515.6 145.31
38 INT425 Localization of PRL 15 455 0.81 189.64 144.8
39 INT2379 Positive_regulation of Localization of LH 3 349 0.70 27.86 144.53
40 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
41 INT2867 Gene_expression of CALCA 2 247 0.78 78.78 138.47
42 INT5497 Positive_regulation of Crh 2 299 0.70 125.54 131.14
43 INT695 Binding of POMC 3 304 0.48 56.66 126.85
44 INT2106 Regulation of Localization of LH 3 279 0.62 22.37 122.77
45 INT7395 Localization of GNRH1 1 399 0.81 62.88 117.68
46 INT4207 Regulation of Avp 4 267 0.62 63.72 115.33
47 INT1793 Localization of CGA 5 379 0.81 67.38 114.69
48 INT1530 Regulation of Gh 21 382 0.61 115.96 112.47
49 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
50 INT915 Positive_regulation of PRL 8 342 0.70 141.96 104.31
51 INT397 Localization of SST 1 232 0.81 58.05 101.19
52 INT874 Positive_regulation of Gh1 1 244 0.70 27.17 97.98
53 INT5865 Positive_regulation of Localization of Gh 3 282 0.69 84.86 93.5
54 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
55 INT214 Localization of AVP 2 370 0.81 208.51 91.09
56 INT4289 Positive_regulation of Localization of Gnrh1 2 202 0.70 12.3 84.01
57 INT339 Regulation of Trh 2 156 0.62 39.27 83.55
58 INT148 Positive_regulation of Gnrhr 3 182 0.70 47.44 79.64
59 INT920 Localization of PLOD1 8 223 0.81 42.25 78.7
60 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
61 INT1497 Negative_regulation of Gh 17 415 0.59 192.95 74.71
62 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
63 INT5128 Positive_regulation of Lhb 1 232 0.69 44.23 71.26
64 INT1377 Positive_regulation of Trh 1 172 0.70 40.55 69.83
65 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
66 INT8388 Positive_regulation of Vip 1 142 0.70 39.72 67.61
67 INT65733 Positive_regulation of Cnr1 1 125 0.70 40.27 67.33
68 INT462 Regulation of Pomc 2 157 0.62 41.67 67.27
69 INT253 Regulation of PRL 7 184 0.62 47.27 65.79
70 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
71 INT17401 Gene_expression of IGF1 2 475 0.78 232.18 62.07
72 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
73 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
74 INT1794 Regulation of Localization of CGA 3 136 0.57 13.39 59.07
75 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
76 INT1782 Regulation of Gh1 2 125 0.62 22 55.74
77 INT1579 Gene_expression of PRL 2 279 0.78 119.2 55.41
78 INT251 Regulation of INS 1 398 0.62 232.47 55.04
79 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
80 INT249 Localization of GHRH 7 215 0.80 78.02 51.87
81 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
82 INT6299 Regulation of Localization of Lhb 4 104 0.61 8.98 48.79
83 INT1197 Negative_regulation of Localization of POMC 1 109 0.59 28.29 48.02
84 INT847 Regulation of Lhb 4 131 0.61 22.08 46.54
85 INT531 Gene_expression of GH1 3 376 0.75 193.45 46.24
86 INT2275 Negative_regulation of Localization of Ins1 3 183 0.59 51.02 44.94
87 INT2262 Negative_regulation of Lhb 1 142 0.59 25.47 44.81
88 INT5130 Regulation of GNRH1 2 139 0.62 31.95 42.08
89 INT3933 Positive_regulation of PLOD1 10 128 0.70 30.76 42.03
90 INT5454 Localization of CRH 1 124 0.79 79.18 41.53
91 INT957 Positive_regulation of GHRH 8 136 0.70 36.84 40.52
92 INT918 Positive_regulation of Localization of PRL 3 90 0.70 23.97 40.3
93 INT685 Regulation of AVP 1 124 0.62 34.9 39.91
94 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
95 INT916 Regulation of Localization of PRL 6 92 0.62 22.98 38.13
96 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
97 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
98 INT2296 Positive_regulation of Gene_expression of Prl 2 137 0.70 36.96 35.39
99 INT255 Regulation of Localization of GH1 10 89 0.62 18.71 35.3
100 INT2274 Regulation of Localization of INS 4 101 0.62 41.55 34.79
101 INT692 Negative_regulation of SST 2 72 0.59 28.68 34.52
102 INT1116 Regulation of Ren 1 103 0.62 27.66 33.26
103 INT5868 Positive_regulation of GNRH1 1 122 0.69 20.96 32.8
104 INT913 Regulation of Localization of PLOD1 4 71 0.62 8.64 32.72
105 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
106 INT3117 Regulation of Oxt 4 103 0.61 17.93 32.28
107 INT7396 Regulation of Localization of GNRH1 1 81 0.62 6.57 31.31
108 INT7975 Regulation of PLOD1 5 97 0.62 20.9 30.51
109 INT5100 Positive_regulation of Ghrh 5 100 0.64 24.2 30.21
110 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
111 INT5135 Negative_regulation of GNRH1 1 106 0.58 36.63 27.71
112 INT6174 Regulation of Gene_expression of POMC 1 49 0.61 9.75 27.69
113 INT7894 Negative_regulation of Vip 2 59 0.59 11.76 27.36
114 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
115 INT1638 Negative_regulation of PLOD1 1 92 0.59 21.69 26.61
116 INT9682 Positive_regulation of IGF1 4 238 0.70 120.03 26.36
117 INT2261 Gene_expression of Lhb 2 121 0.77 42.78 26.04
118 INT6441 Positive_regulation of CRH 1 98 0.69 57.22 24.12
119 INT5131 Gene_expression of GNRH1 1 109 0.78 28.79 23.94
120 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
121 INT7113 Negative_regulation of Localization of CGA 1 71 0.51 17.7 23.42
122 INT250 Regulation of GHRH 5 65 0.61 17.46 23.19
123 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
124 INT917 Positive_regulation of Localization of PLOD1 1 51 0.69 8.53 22.87
125 INT4612 Positive_regulation of Localization of CGA 2 64 0.64 8.51 22.39
126 INT693 Negative_regulation of Localization of SST 1 46 0.59 8.57 21.75
127 INT1644 Regulation of FSHR 3 77 0.55 15.62 21.49
128 INT6127 Regulation of Localization of AVP 2 60 0.62 15.12 20.84
129 INT955 Gene_expression of GHRH 2 126 0.78 59.91 20.74
130 INT7364 Regulation of Ghrh 1 49 0.58 8.05 19.05
131 INT5372 Localization of LHB 2 55 0.68 9.47 19
132 INT1975 Regulation of Regulation of Prl 3 32 0.59 5.78 18.53
133 INT13454 Positive_regulation of Positive_regulation of Gh 1 49 0.68 14.53 18.49
134 INT1642 Negative_regulation of Localization of PLOD1 1 40 0.58 10.67 17.95
135 INT871 Negative_regulation of Gene_expression of Prl 1 53 0.58 18.89 17.79
136 INT1578 Negative_regulation of Localization of PRL 1 52 0.59 20.62 17.18
137 INT10841 Positive_regulation of Gene_expression of Gh 2 101 0.59 45.39 16.96
138 INT984 Positive_regulation of Localization of GHRH 2 58 0.70 12.66 16.51
139 INT28950 Positive_regulation of Gene_expression of IGF1 3 99 0.69 46.9 16.47
140 INT1261 Localization of Adh1 2 63 0.81 19.36 16.09
141 INT7970 Gene_expression of PLOD1 1 120 0.71 44.42 15.54
142 INT61893 Gene_expression of Ghrl 2 125 0.75 71.49 15.14
143 INT6278 Negative_regulation of Gene_expression of Pomc 1 35 0.59 11.07 14.8
144 INT7366 Negative_regulation of Ghrh 1 42 0.58 7.72 14.45
145 INT7587 Localization of GAL 1 27 0.78 4.79 14.29
146 INT16530 Gene_expression of Ghrh 5 45 0.77 6.22 13.44
147 INT9678 Positive_regulation of Positive_regulation of GH1 1 32 0.68 8.14 12.97
148 INT27242 Gene_expression of PGR 2 153 0.75 98.77 12.79
149 INT3104 Negative_regulation of CGA 1 76 0.54 29.81 12.23
150 INT744 Positive_regulation of PTH 1 130 0.70 95.02 11.7
151 INT254 Regulation of Localization of GHRH 3 30 0.60 5.17 11.46
152 INT987 Localization of TRH 1 37 0.78 10.53 11.1
153 INT9946 Regulation of Localization of LHB 1 27 0.52 2.47 11.08
154 INT10009 Positive_regulation of TRH 1 31 0.67 8.94 11.03
155 INT6515 Gene_expression of BGLAP 1 110 0.75 45.13 10.81
156 INT1378 Negative_regulation of Regulation of Prl 2 27 0.43 9.16 9.9
157 INT11729 Regulation of IGF1 2 71 0.61 44.58 9.71
158 INT15722 Positive_regulation of PPAP2A 2 25 0.43 4.83 9.65
159 INT2059 Positive_regulation of Negative_regulation of Prl 1 24 0.70 5.7 9.37
160 INT684 Binding of AVP 2 38 0.48 13.9 8.85
161 INT4991 Positive_regulation of Vim 1 74 0.69 69.84 8.33
162 INT12292 Negative_regulation of Positive_regulation of GH1 2 22 0.58 5.02 8.28
163 INT17250 Negative_regulation of BGLAP 1 35 0.57 21 8.26
164 INT48725 Gene_expression of IGFBP3 2 128 0.78 78.83 8.19
165 INT953 Positive_regulation of Positive_regulation of GHRH 1 17 0.67 2.38 8.18
166 INT4563 Positive_regulation of Regulation of Prl 1 20 0.70 4.2 8.1
167 INT4487 Positive_regulation of Positive_regulation of PRL 1 27 0.70 8.06 8.09
168 INT764 Gene_expression of OLAH 1 25 0.67 25.58 8.07
169 INT34741 Positive_regulation of Gene_expression of GH1 1 58 0.67 35.06 7.8
170 INT5311 Regulation of Negative_regulation of Oprd1 1 11 0.43 0.99 7.23
171 INT7138 Regulation of Regulation of Avp 1 10 0.36 1.99 6.37
172 INT4144 Gene_expression of SHBG 1 64 0.68 39.94 6.08
173 INT10843 Regulation of Regulation of Gh 3 14 0.22 5.56 5.93
174 INT18443 Positive_regulation of ADRA2C 1 12 0.69 2.61 5.48
175 INT13735 Negative_regulation of Regulation of GH1 1 14 0.42 4.35 5.39
176 INT21067 Regulation of Regulation of PRL 1 11 0.60 2 5.31
177 INT5126 Positive_regulation of Positive_regulation of Lhb 1 16 0.48 2.12 5.23
178 INT21901 Negative_regulation of Egf 1 25 0.58 10.46 4.99
179 INT38087 Regulation of Adh1 1 15 0.61 4.56 4.83
180 INT49130 Positive_regulation of IGFBP3 4 49 0.63 27.55 4.78
181 INT8340 Negative_regulation of SHBG 1 49 0.57 35.96 4.73
182 INT16220 Negative_regulation of Regulation of Gh 2 13 0.42 3.59 4.33
183 INT32569 Localization of GGH 4 18 0.80 2.46 4.3
184 INT5219 Negative_regulation of DBP 1 43 0.57 23.35 4.26
185 INT23480 Regulation of PPAP2A 2 13 0.39 3.51 4.13
186 INT11370 Positive_regulation of LHB 1 15 0.28 5.45 4.01
187 INT75869 Gene_expression of Acsl1 1 24 0.45 27.76 3.66
188 INT18920 Binding of Egf 1 24 0.48 9.43 3.57
189 INT132317 Positive_regulation of Gene_expression of Ghrl 1 20 0.49 21 3.57
190 INT48499 Transcription of GNRH1 3 11 0.67 0.74 3.48
191 INT5345 Positive_regulation of BRD2 2 14 0.67 6.72 3.43
192 INT20179 Positive_regulation of Regulation of Gh 1 12 0.54 3.99 3.42
193 INT949 Negative_regulation of TRH 1 12 0.43 3.06 3.4
194 INT15609 Positive_regulation of Gene_expression of GNRH1 1 17 0.49 5.15 3.34
195 INT57252 Negative_regulation of PGR 1 22 0.43 12.95 3.33
196 INT66191 Gene_expression of DBP 2 42 0.66 22.25 3.18
197 INT986 Negative_regulation of Localization of GHRH 1 16 0.58 8.57 3.16
198 INT33717 Regulation of Localization of Adh1 1 15 0.54 3.3 2.91
199 INT69641 Positive_regulation of ADCY2 1 5 0.32 0.18 2.87
200 INT919 Regulation of Positive_regulation of GH1 1 7 0.47 1.09 2.75
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