J:J. Invest. Dermatol.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT69872	Binding of MC1R and POMC	52	4	0.54	8.87	18.3
2	INT86637	POMC Regulation of Gene_expression of KRT16	2	2	0.47	1.22	1.61
3	INT86636	POMC Positive_regulation of Gene_expression of KRT16	2	2	0.39	0.83	1.28
4	INT107938	POMC Positive_regulation of Gene_expression of TGFBR2	1	1	0.42	1.09	1.07
5	INT69874	POMC Negative_regulation of TYRP1	1	2	0.13	0	1.07
6	INT69871	ASIP Negative_regulation of TYRP1	1	2	0.36	0	1.07
7	INT101381	POMC Regulation of Localization of IL8	1	2	0.28	1.49	1.02
8	INT69870	ASIP Negative_regulation of Binding of MC1R and POMC	1	2	0.37	0	0.9
9	INT107937	POMC Regulation of Gene_expression of TGFBR2	1	1	0.28	0.82	0.81
10	INT86638	POMC Negative_regulation of Gene_expression of OPRM1	1	1	0.34	0.33	0.68
11	INT97655	Binding of RBM25 and Mc1r	1	1	0.00	0.44	0.58
12	INT119281	Pnoc Regulation of Oprl1	1	1	0.31	0.29	0.56
13	INT69873	ASIP Negative_regulation of Binding of POMC	1	1	0.35	0	0.45
14	INT58969	TNF Regulation of Regulation of RPS6KA6	1	2	0.35	0.34	0.38
15	INT58967	TNF Regulation of RPS6KA6	1	2	0.18	0.33	0.38
16	INT69881	Positive_regulation of Gtf3a Positive_regulation of Gene_expression of TNF	1	1	0.03	0.6	0.31
17	INT101510	PPARA Regulation of IL6	1	1	0.31	0.53	0.27
18	INT101508	PPARA Regulation of IL8	1	1	0.31	0.53	0.27
19	INT101509	PPARA Regulation of Gene_expression of IL8	1	1	0.31	0.53	0.27
20	INT101511	PPARA Regulation of Gene_expression of IL6	1	1	0.31	0.53	0.27
21	INT38711	CYSLTR1 Positive_regulation of Gene_expression of PTGS1	1	1	0.08	0.14	0.25
22	INT86634	POMC Positive_regulation of TYR	2	1	0.42	0	0.24
23	INT58968	TNF Positive_regulation of Gene_expression of RPS6KA6	1	1	0.36	0.2	0.21
24	INT58966	TNF Regulation of TNF Regulation of RPS6KA6	1	1	0.19	0.17	0.19
25	INT58970	TNF Regulation of BHLHE23	1	1	0.28	0.17	0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT6483	Gene_expression of TNF	10	3152	0.78	2515.62	929.82
2	INT1912	Gene_expression of Calca	1	1152	0.78	453.25	739.84
3	INT443	Localization of POMC	2	1020	0.81	284.52	443.17
4	INT9238	Gene_expression of IL6	2	1575	0.78	1135.66	424.22
5	INT467	Gene_expression of POMC	19	1048	0.78	332.8	394.16
6	INT2540	Negative_regulation of Calca	1	538	0.59	172.11	384.38
7	INT720	Positive_regulation of POMC	11	807	0.70	237.37	353.83
8	INT34869	Negative_regulation of PTGS2	1	778	0.59	366.76	319.85
9	INT11624	Gene_expression of OPRM1	15	445	0.78	72.36	294.36
10	INT9158	Gene_expression of Tnf	1	722	0.78	522.01	277.68
11	INT10832	Gene_expression of IL8	2	1050	0.78	698.72	270
12	INT5972	Gene_expression of IL1B	2	948	0.78	510.91	263.97
13	INT16868	Gene_expression of Il6	3	807	0.78	499.48	256.57
14	INT738	Regulation of POMC	3	459	0.62	111.19	243.74
15	INT6482	Positive_regulation of Gene_expression of TNF	7	659	0.70	569.88	210
16	INT2391	Negative_regulation of PTGS1	2	501	0.59	207.62	205.6
17	INT11313	Positive_regulation of Il6	1	526	0.70	331.27	201.59
18	INT24326	Gene_expression of Ngf	7	346	0.78	218.67	184.71
19	INT739	Negative_regulation of POMC	1	358	0.59	102.28	166.77
20	INT4768	Positive_regulation of OPRM1	1	212	0.70	31.09	164.28
21	INT5116	Gene_expression of IL2	1	670	0.78	291.13	146.69
22	INT48895	Gene_expression of Il10	4	333	0.78	221.2	138.52
23	INT695	Binding of POMC	7	304	0.48	56.66	126.85
24	INT9235	Negative_regulation of Gene_expression of TNF	1	346	0.59	252.98	118.61
25	INT50674	Gene_expression of PTGS2	2	459	0.78	253.33	118.51
26	INT12339	Localization of IL8	3	437	0.81	251.87	117.39
27	INT27096	Positive_regulation of Nfkb1	1	325	0.70	195.11	109.06
28	INT10838	Positive_regulation of IL8	1	381	0.70	295.51	101.62
29	INT4860	Positive_regulation of CALCA	1	148	0.00	73.35	97.61
30	INT21793	Positive_regulation of Ngf	2	154	0.70	94.78	85.27
31	INT7528	Regulation of OPRM1	1	100	0.62	20.63	80.57
32	INT48244	Gene_expression of Il4	4	172	0.76	132.38	73.42
33	INT58400	Negative_regulation of Tnf	1	182	0.59	129.97	71
34	INT11318	Gene_expression of Gtf3a	1	274	0.52	183.82	60.89
35	INT9196	Gene_expression of PTGS1	2	215	0.77	96.99	60.5
36	INT14740	Gene_expression of TGFB1	3	272	0.78	168.48	60.18
37	INT647	Gene_expression of SGCG	2	211	0.75	78.46	55.82
38	INT69876	Negative_regulation of Nfkb1	1	147	0.58	89.81	55.5
39	INT52800	Negative_regulation of Gene_expression of Tnf	1	142	0.59	92.27	55.47
40	INT9234	Negative_regulation of Gene_expression of IL6	1	171	0.59	101.61	53.15
41	INT27954	Positive_regulation of Gene_expression of Ngf	2	87	0.70	57.91	51.96
42	INT52264	Gene_expression of IK	1	180	0.77	90.87	51.87
43	INT5781	Gene_expression of Edn1	1	190	0.78	99.1	46
44	INT73502	Positive_regulation of IL10	2	154	0.69	124.87	43.5
45	INT1319	Gene_expression of Oprl1	2	65	0.78	9.34	42.41
46	INT13354	Transcription of TNF	1	108	0.72	85.81	42.32
47	INT64440	Gene_expression of Pnoc	3	66	0.78	13.61	41.76
48	INT9094	Gene_expression of COL7A1	5	277	0.77	143.42	38.73
49	INT1931	Positive_regulation of Gene_expression of POMC	4	116	0.70	37.26	38.67
50	INT20210	Localization of Ngf	1	69	0.79	46.22	38.57
51	INT65889	Gene_expression of RETNLB	2	73	0.34	60.98	38.3
52	INT48222	Positive_regulation of Localization of IL8	1	123	0.59	78.04	37.2
53	INT77407	Regulation of Gene_expression of OPRM1	1	51	0.62	12.58	35.75
54	INT7675	Gene_expression of ENG	1	146	0.77	45.35	34.6
55	INT11764	Positive_regulation of ENG	1	78	0.61	27.65	33.69
56	INT9694	Positive_regulation of Csf2	1	102	0.68	70.09	33.07
57	INT56290	Negative_regulation of Gene_expression of Il6	1	79	0.59	47.98	31.07
58	INT69483	Transcription of OPRM1	4	45	0.72	7.31	30.22
59	INT77652	Negative_regulation of Gene_expression of IL8	1	99	0.59	67.57	30.21
60	INT651	Positive_regulation of PTGS1	1	93	0.69	37.27	29.18
61	INT1196	Positive_regulation of Positive_regulation of POMC	2	51	0.70	15.99	28.58
62	INT6364	Gene_expression of Edn1	1	123	0.78	73.76	28.43
63	INT6174	Regulation of Gene_expression of POMC	1	49	0.61	9.75	27.69
64	INT16428	Positive_regulation of Gtf3a	3	135	0.20	106.44	26.67
65	INT48240	Binding of Ngf	1	46	0.46	23.51	24.42
66	INT7383	Localization of VIP	2	53	0.81	17.7	22.65
67	INT14731	Positive_regulation of TGFB1	1	78	0.67	52.57	22.23
68	INT14733	Positive_regulation of Gene_expression of TGFB1	1	71	0.69	49.89	22.2
69	INT14700	Regulation of IFNA1	2	111	0.45	66.16	21.52
70	INT101517	Negative_regulation of PPARA	1	168	0.57	112.24	21.41
71	INT52106	Negative_regulation of Localization of IL8	1	57	0.52	22.81	20.8
72	INT69877	Positive_regulation of Positive_regulation of Nfkb1	1	53	0.68	31.44	20.7
73	INT14701	Negative_regulation of IFNA1	2	118	0.54	84.19	20.08
74	INT69304	Negative_regulation of Il10	1	47	0.59	36.88	19.79
75	INT74286	Regulation of Il10	1	42	0.44	28.06	19.44
76	INT14737	Gene_expression of FN1	1	117	0.78	78.74	18.99
77	INT89594	Gene_expression of Ccl5	3	44	0.54	24.08	18.62
78	INT10833	Regulation of Gene_expression of IL8	1	68	0.62	38.74	18.46
79	INT36054	Transcription of IL1B	1	53	0.72	32.64	17.31
80	INT48892	Transcription of Il10	1	31	0.71	27.26	16.77
81	INT48238	Regulation of Gene_expression of Ngf	4	25	0.62	11.48	16.42
82	INT75929	Gene_expression of IL9	3	61	0.43	24.71	16.17
83	INT9783	Gene_expression of INSRR	1	81	0.50	32.99	15.52
84	INT1416	Transcription of POMC	2	40	0.72	10.71	15.38
85	INT73351	Negative_regulation of Pnoc	1	13	0.42	5.71	14.17
86	INT76863	Negative_regulation of Gene_expression of OPRM1	4	21	0.57	6.56	13.69
87	INT69878	Positive_regulation of Gene_expression of Gtf3a	1	48	0.29	36.78	13.57
88	INT91817	Positive_regulation of RETNLB	1	22	0.34	21.4	13.12
89	INT86950	Negative_regulation of Gene_expression of Il10	1	26	0.42	18.92	12.73
90	INT51014	Transcription of IL2	1	42	0.71	21.56	12.7
91	INT67213	Transcription of Pnoc	1	18	0.67	4.66	12.17
92	INT65304	Positive_regulation of Gene_expression of MC1R	6	34	0.70	11.32	12.09
93	INT50933	Transcription of Il6	1	38	0.72	24.31	11.58
94	INT62464	Gene_expression of Ogfr	2	21	0.78	20.39	10.82
95	INT701	Localization of IGHE	1	87	0.80	40.5	10.62
96	INT1321	Localization of Oprl1	1	18	0.76	1.74	9.56
97	INT81264	Positive_regulation of Localization of Ngf	1	13	0.58	9.82	9.53
98	INT13435	Positive_regulation of RTCA	1	31	0.60	7.19	8.5
99	INT68971	Localization of Pnoc	1	10	0.73	2.95	8.43
100	INT1591	Negative_regulation of Binding of POMC	1	18	0.59	1.74	7.91
101	INT86639	Gene_expression of KRT16	9	19	0.68	12.44	7.79
102	INT101721	Positive_regulation of Transcription of OPRM1	1	8	0.48	1.22	7.74
103	INT89589	Negative_regulation of Ccl5	1	9	0.40	4.62	7.39
104	INT91609	Regulation of Gene_expression of MC1R	1	11	0.62	2.75	7.34
105	INT14732	Positive_regulation of FN1	1	46	0.69	31.17	7.33
106	INT15490	Negative_regulation of Gene_expression of COL7A1	1	40	0.58	25.97	7.18
107	INT60527	Transcription of IL10	1	16	0.56	13.57	6.42
108	INT9695	Negative_regulation of Csf2	1	41	0.57	31.65	6.28
109	INT24191	Binding of VIP	1	14	0.40	2.16	6.2
110	INT67397	Transcription of Il4	2	15	0.54	11.36	6.06
111	INT85417	Positive_regulation of Gene_expression of IK	1	17	0.09	9.38	5.73
112	INT67214	Transcription of Oprl1	1	9	0.69	1.8	5.66
113	INT75833	Negative_regulation of Positive_regulation of IL8	1	15	0.53	6.69	5.59
114	INT27952	Transcription of Ngf	1	12	0.72	5.34	5.43
115	INT58972	Gene_expression of BHLHE23	2	10	0.65	2.97	5.1
116	INT85413	Negative_regulation of IL9	1	5	0.47	4.42	4.77
117	INT85415	Positive_regulation of IL9	1	10	0.28	6.93	4.71
118	INT21254	Regulation of Positive_regulation of POMC	2	12	0.61	3.64	4.67
119	INT30160	Positive_regulation of ADRA2B	1	14	0.29	1.92	4.37
120	INT81750	Regulation of Ntrk1	1	13	0.52	6.03	4.37
121	INT25503	Gene_expression of C5AR1	2	22	0.75	21.88	4.16
122	INT92653	Gene_expression of IL12B	1	21	0.75	17.28	3.89
123	INT16723	Regulation of GBE1	1	16	0.11	4.3	3.7
124	INT31528	Regulation of TYR	2	6	0.44	0.83	3.63
125	INT12083	Regulation of TGFB1	1	22	0.53	15.4	3.6
126	INT14947	Localization of SPARCL1	1	7	0.46	11.97	3.6
127	INT15489	Negative_regulation of Gene_expression of SGCG	1	10	0.42	4.78	3.18
128	INT82879	Regulation of Ccl5	1	9	0.30	6.19	3.17
129	INT86640	Positive_regulation of Gene_expression of KRT16	4	5	0.61	2.5	2.99
130	INT95105	Gene_expression of TGFBR2	2	15	0.64	16.36	2.74
131	INT19646	Binding of KLRD1	2	9	0.04	4.27	2.35
132	INT91442	Binding of PTGDR2	1	6	0.46	1.5	2.2
133	INT101516	Positive_regulation of PPARD	1	8	0.49	4.75	2.19
134	INT92648	Positive_regulation of IL12B	1	7	0.20	4.55	2.19
135	INT60943	Positive_regulation of Transcription of Ngf	1	3	0.50	2.15	1.99
136	INT117116	Positive_regulation of Positive_regulation of MC1R	1	7	0.49	1.57	1.91
137	INT28679	Gene_expression of Tnfsf13b	2	5	0.60	2.75	1.53
138	INT28681	Gene_expression of Il1rl1	1	4	0.55	3.04	1.46
139	INT91441	Binding of MINOS1	1	3	0.03	0.31	1.35
140	INT128004	Negative_regulation of Gene_expression of MINOS1	1	4	0.04	0.51	1.31
141	INT14946	Binding of SPARCL1	1	5	0.31	6.57	1.29
142	INT14727	Regulation of FN1	1	13	0.45	5.95	1.26
143	INT69875	Negative_regulation of Binding of MC1R	1	2	0.39	0.37	1.26
144	INT128001	Gene_expression of MINOS1	1	3	0.07	0.36	1.24
145	INT26659	Regulation of HESX1	1	4	0.42	1.52	1.2
146	INT2972	Negative_regulation of Olfr525	1	3	0.36	0.95	1.2
147	INT41143	Localization of VIPR1	1	4	0.78	1.57	1.16
148	INT92654	Transcription of RETNLB	1	3	0.01	3.33	1.12
149	INT28680	Positive_regulation of Tnfsf13b	2	5	0.39	6.46	1.1
150	INT41142	Binding of VIPR1	1	5	0.20	0.07	1.02
151	INT95641	Regulation of Fbn1	1	3	0.45	3.67	0.91
152	INT80024	Negative_regulation of KLRD1	1	3	0.04	0.91	0.88
153	INT92649	Negative_regulation of Gene_expression of IL12B	1	3	0.03	2.23	0.86
154	INT135299	Binding of PTCH1	2	10	0.48	12.16	0.84
155	INT107939	Regulation of TGFBR2	1	1	0.37	0.98	0.84
156	INT6602	Gene_expression of RPS6KA6	4	3	0.56	1.75	0.82
157	INT80023	Positive_regulation of Negative_regulation of KLRD1	1	1	0.04	0.17	0.81
158	INT28682	Negative_regulation of Gene_expression of Il1rl1	1	2	0.42	0.31	0.75
159	INT86641	Regulation of Gene_expression of KRT16	1	1	0.40	0.42	0.74
160	INT101923	Binding of MICA	3	6	0.48	5.44	0.71
161	INT28684	Positive_regulation of Gene_expression of Tnfsf13b	1	1	0.39	0	0.7
162	INT28685	Negative_regulation of Gene_expression of Tnfsf13b	1	1	0.33	0	0.7
163	INT44118	Binding of CD209	5	10	0.35	8.83	0.69
164	INT69880	Positive_regulation of Positive_regulation of Gtf3a	2	8	0.03	5.25	0.68
165	INT97654	Gene_expression of RBM25	1	1	0.00	0.59	0.65
166	INT75054	Binding of MC2R	1	3	0.09	0.63	0.63
167	INT25506	Protein_catabolism of RERE	1	3	0.57	0.31	0.52
168	INT119280	Gene_expression of HFM	1	1	0.34	0.08	0.52
169	INT45338	Gene_expression of RICTOR	1	4	0.52	0.89	0.48
170	INT101515	Negative_regulation of Positive_regulation of PPARD	1	2	0.35	0.68	0.47
171	INT44156	Regulation of Scl1	2	1	0.00	0.91	0.46
172	INT13434	Positive_regulation of Positive_regulation of RTCA	1	4	0.41	0.39	0.44
173	INT92650	Regulation of Gene_expression of IL9	1	2	0.25	0.76	0.41
174	INT28683	Regulation of Gene_expression of Tnfsf13b	1	1	0.35	0	0.4
175	INT58976	Positive_regulation of RPS6KA6	2	1	0.36	0.32	0.39
176	INT58974	Regulation of BHLHE23	1	2	0.19	0.42	0.38
177	INT92651	Negative_regulation of Positive_regulation of IL9	1	1	0.00	0.8	0.38
178	INT58975	Regulation of RPS6KA6	2	1	0.33	0.33	0.37
179	INT92652	Negative_regulation of Positive_regulation of IL12B	1	1	0.03	0.99	0.36
180	INT25502	Gene_expression of RERE	1	6	0.53	1.74	0.32
181	INT81752	Binding of BPIFA4P	1	8	0.37	2.87	0.29
182	INT117115	Regulation of Positive_regulation of MC1R	1	1	0.33	0.38	0.29
183	INT25505	Protein_catabolism of C5AR1	1	2	0.64	1.29	0.24
184	INT14735	Positive_regulation of COL6A2	2	3	0.42	3.13	0.22
185	INT69879	Regulation of Positive_regulation of Gtf3a	1	2	0.03	1.59	0.22
186	INT58973	Positive_regulation of Gene_expression of RPS6KA6	1	1	0.36	0.2	0.21
187	INT131619	Positive_regulation of Positive_regulation of Dgat1	1	1	0.13	0.41	0.21
188	INT131620	Positive_regulation of Dgat1	1	1	0.18	0.4	0.2
189	INT86632	Gene_expression of 5,6,7,8	1	1	0.00	0	0.19
190	INT101922	Regulation of MICA	1	2	0.39	2.64	0.15
191	INT9693	Localization of Entpd4	1	1	0.19	0.21	0.14
192	INT14736	Gene_expression of COL6A2	2	2	0.47	1.65	0.13
193	INT14728	Positive_regulation of Gene_expression of COL6A2	1	1	0.30	0.85	0.13
194	INT25504	Protein_catabolism of DES	1	1	0.96	0.31	0.11
195	INT131616	Regulation of Olfr525	1	1	0.00	0.21	0.11
196	INT14948	Localization of CORIN	1	1	0.33	0.19	0.1
197	INT14738	Negative_regulation of Regulation of TGFB1	1	2	0.41	0.81	0.09
198	INT95640	Transcription of Fbn1	1	1	0.53	0.21	0.08
199	INT14729	Positive_regulation of Positive_regulation of COL6A2	1	1	0.30	0.71	0.04
200	INT14739	Negative_regulation of Regulation of COL6A2	1	1	0.26	0.75	0.03