J:J. Lab. Clin. Med.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 1 0.22 0 4.47
2 INT42579 SOD1 Negative_regulation of POMC 1 1 0.16 0.43 1.27
3 INT42580 CAT Negative_regulation of POMC 1 1 0.20 0.42 1.26
4 INT103031 Calca Positive_regulation of Ptgs1 2 1 0.46 0.98 1.22
5 INT96089 Binding of F2 and Pf4 1 2 0.00 1.31 0.56
6 INT96098 Binding of PPBP and F2 1 2 0.00 1.31 0.56
7 INT103032 Calca Positive_regulation of Calca Positive_regulation of Nos3 1 1 0.24 0.41 0.46
8 INT103025 Calca Positive_regulation of Nos3 1 1 0.25 0.41 0.46
9 INT39870 Odc1 Negative_regulation of Tk1 1 2 0.36 0.8 0.46
10 INT103027 Ptgis Positive_regulation of Nos3 1 1 0.06 0.42 0.46
11 INT96103 Binding of PPBP and Selp 1 2 0.00 1.22 0.46
12 INT103026 Ptgis Positive_regulation of Ptgs1 1 1 0.02 0.42 0.46
13 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 1 0.12 0.41 0.46
14 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 1 0.26 0.41 0.46
15 INT96083 Binding of PPBP and SELP 1 2 0.02 1.21 0.46
16 INT96095 Binding of Selp and Pf4 1 2 0.01 1.2 0.45
17 INT96097 Binding of SELP and Pf4 1 2 0.13 1.2 0.45
18 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 1 0.17 0.58 0.44
19 INT32445 Pomc Positive_regulation of Il1f5 1 1 0.21 0 0.34
20 INT96096 Binding of Serpinc1 and Selp 1 1 0.00 0.69 0.3
21 INT96102 Binding of TAT and Selp 1 1 0.04 0.7 0.3
22 INT96082 Binding of SELP and TAT 1 1 0.40 0.69 0.3
23 INT96100 Binding of SELP and F2 1 1 0.01 0.67 0.29
24 INT96101 Binding of SELP and Serpinc1 1 1 0.01 0.69 0.29
25 INT96094 Binding of Selp and F2 1 1 0.00 0.67 0.29
26 INT96099 Binding of TAT and F2 1 1 0.01 0.68 0.29
27 INT96093 Binding of Serpinc1 and F2 1 1 0.00 0.68 0.29
28 INT58588 IFNG Positive_regulation of ARHGAP4 1 3 0.31 1.22 0.19
29 INT83514 SERPINC1 Negative_regulation of F2 2 1 0.16 0.62 0.16
30 INT83512 F2 Negative_regulation of PLAU 1 1 0.27 0.57 0.16
31 INT83513 Negative_regulation of SERPINC1 Negative_regulation of F2 1 1 0.16 0.64 0.16
32 INT83515 F2 Positive_regulation of PLAU 1 1 0.31 0.57 0.16
33 INT83511 F2 Negative_regulation of PRH1 1 1 0.01 0.6 0.15
34 INT58586 IFNG Positive_regulation of Gene_expression of PLG 1 1 0.41 0.38 0.06

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 9 1902 0.78 275.47 1057.59
2 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
3 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
5 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
6 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
7 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
8 INT9158 Gene_expression of Tnf 3 722 0.78 522.01 277.68
9 INT48955 Gene_expression of Nos2 4 753 0.78 403.87 208.08
10 INT798 Positive_regulation of Gene_expression of Penk 1 394 0.70 78.53 203.07
11 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
12 INT1114 Localization of Ins1 2 748 0.80 192.95 165.48
13 INT6108 Gene_expression of Npy 1 292 0.78 110.65 148.21
14 INT13353 Positive_regulation of Tnf 3 332 0.70 248.75 148.1
15 INT812 Localization of INS 1 1026 0.81 515.6 145.31
16 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
17 INT5283 Positive_regulation of Npy 1 191 0.70 66.77 109.2
18 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
19 INT148 Positive_regulation of Gnrhr 4 182 0.70 47.44 79.64
20 INT64636 Positive_regulation of Gene_expression of Nos2 2 242 0.70 147.52 79.53
21 INT2431 Positive_regulation of Mpo 3 275 0.70 211.99 78.47
22 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
23 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
24 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
25 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
26 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
27 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
28 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
29 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
30 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
31 INT5759 Positive_regulation of Ptgs1 2 127 0.69 53.45 53.04
32 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
33 INT2463 Localization of CCK 3 101 0.81 37.54 47.59
34 INT2406 Gene_expression of CCK 1 85 0.78 28.04 46.67
35 INT2275 Negative_regulation of Localization of Ins1 2 183 0.59 51.02 44.94
36 INT1474 Regulation of Localization of Ins1 2 132 0.61 25.96 43.07
37 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
38 INT47939 Gene_expression of Selp 3 171 0.76 87.54 39.03
39 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
40 INT326 Gene_expression of Gnrhr 4 105 0.76 35.87 34.93
41 INT2884 Positive_regulation of CCK 1 66 0.69 25.25 30.6
42 INT2671 Positive_regulation of Odc1 1 82 0.70 11.03 29
43 INT91775 Gene_expression of Slc6a4 1 102 0.78 26.45 28.23
44 INT3076 Regulation of KNG1 2 52 0.60 20.39 27.89
45 INT74726 Negative_regulation of Slc6a4 1 61 0.59 21.01 27.84
46 INT2569 Gene_expression of Ache 2 120 0.78 26.29 26.89
47 INT5650 Gene_expression of Mpo 2 117 0.77 80.27 26.42
48 INT49141 Gene_expression of Selp 2 157 0.78 85.22 24.78
49 INT2290 Protein_catabolism of POMC 5 41 0.99 4.86 23.36
50 INT11829 Negative_regulation of Odc1 3 54 0.59 7.03 23.03
51 INT66753 Negative_regulation of Positive_regulation of Tnf 1 45 0.59 35.28 22.33
52 INT21503 Binding of Ptgs1 1 45 0.48 15.6 22.29
53 INT8580 Gene_expression of ELANE 1 132 0.75 62.98 21.79
54 INT9079 Gene_expression of PPBP 1 52 0.75 31.2 21.52
55 INT3952 Negative_regulation of ALB 2 116 0.59 72.18 18.35
56 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
57 INT8056 Regulation of Positive_regulation of Penk 1 34 0.59 4.71 17.66
58 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
59 INT1154 Negative_regulation of CCK 2 24 0.59 9.3 15.32
60 INT22276 Gene_expression of TBXA2R 1 65 0.77 23.22 14.21
61 INT11069 Positive_regulation of Pf4 1 35 0.68 27.7 13.96
62 INT2336 Negative_regulation of Lct 2 51 0.58 33.79 13.73
63 INT3112 Regulation of Odc1 3 39 0.62 4.73 13.69
64 INT11071 Positive_regulation of PPBP 1 43 0.68 26.85 13.43
65 INT5649 Negative_regulation of Positive_regulation of Mpo 1 31 0.59 26.62 11.92
66 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
67 INT49142 Gene_expression of SELP 1 94 0.75 54.61 11.64
68 INT14204 Protein_catabolism of KNG1 1 41 0.96 20.94 11.47
69 INT19944 Negative_regulation of IFNG 2 39 0.58 22.35 10.91
70 INT14962 Gene_expression of Pf4 1 27 0.76 22.48 10.88
71 INT66303 Regulation of Slc6a4 1 10 0.45 4.82 10.55
72 INT32581 Positive_regulation of C4B 1 9 0.45 11.17 9.05
73 INT2885 Positive_regulation of Localization of CCK 2 19 0.70 9.92 8.94
74 INT15705 Negative_regulation of co 1 46 0.42 7.9 8.18
75 INT32579 Binding of C4B 1 14 0.36 14.99 7.79
76 INT32580 Gene_expression of C4B 2 24 0.75 17.95 7.75
77 INT6335 Binding of TSPO 1 39 0.44 10.88 7.66
78 INT17501 Negative_regulation of F2 1 70 0.58 32.23 7.51
79 INT63169 Positive_regulation of Gene_expression of Selp 1 35 0.69 21.95 7.16
80 INT21138 Binding of ADRA2A 1 16 0.48 5.57 6.8
81 INT63170 Positive_regulation of Selp 1 27 0.68 24.1 6.3
82 INT14258 Regulation of TSPO 1 32 0.60 10.16 6.24
83 INT4561 Gene_expression of PLG 1 32 0.75 17.59 6.21
84 INT17086 Binding of HSD11B1 1 84 0.47 122.28 6.16
85 INT8866 Positive_regulation of TAT 2 30 0.67 18.06 5.57
86 INT13295 Positive_regulation of Cdkn2a 2 18 0.68 13.02 5.47
87 INT40638 Binding of HRH1 1 14 0.44 5.81 5.09
88 INT18345 Positive_regulation of Positive_regulation of Gnrhr 2 16 0.42 4.99 4.91
89 INT12104 Positive_regulation of PLG 1 45 0.68 28.94 4.81
90 INT30444 Negative_regulation of Protein_catabolism of POMC 1 4 0.51 2.11 4.53
91 INT44578 Binding of Hbb 2 19 0.48 3.12 4.2
92 INT4530 Regulation of Ggh 1 9 0.54 2.5 3.96
93 INT66242 Gene_expression of Ptgis 4 15 0.64 6.73 3.84
94 INT103021 Transcription of Slc6a4 1 16 0.70 3.93 3.77
95 INT5320 Gene_expression of PTGFR 1 18 0.59 12.99 3.7
96 INT33739 Gene_expression of ITGA2B 2 25 0.75 8.19 3.6
97 INT13878 Negative_regulation of Ugt1a2 1 9 0.33 2.85 3.48
98 INT42581 Regulation of Gene_expression of ELANE 1 11 0.38 9.25 3.38
99 INT16588 Positive_regulation of Gene_expression of Gnrhr 2 14 0.62 4.76 3.35
100 INT31450 Binding of HIST1H1B 1 20 0.37 10.21 2.84
101 INT10141 Gene_expression of A2M 1 11 0.35 9.37 2.75
102 INT96092 Binding of ANXA5 1 24 0.36 14.51 2.6
103 INT25449 Positive_regulation of Gene_expression of PPBP 1 5 0.46 3.77 2.57
104 INT16964 Binding of IFNG 2 27 0.48 14.31 2.45
105 INT96084 Binding of Selp 1 12 0.48 8.41 2.16
106 INT64676 Gene_expression of ANXA5 1 11 0.75 13.48 2.11
107 INT42583 Protein_catabolism of ELANE 1 8 0.89 4.33 2.11
108 INT17268 Localization of PLG 1 9 0.78 11.71 2.06
109 INT35146 Negative_regulation of PLG 3 27 0.57 17.63 1.98
110 INT66237 Positive_regulation of Ptgis 2 5 0.33 1.49 1.96
111 INT38268 Positive_regulation of BEST1 2 16 0.17 14.54 1.93
112 INT78960 Binding of SOAT1 1 9 0.36 2.56 1.92
113 INT21487 Negative_regulation of HCC 1 18 0.49 29.81 1.88
114 INT103024 Positive_regulation of Gene_expression of Ptgis 2 5 0.48 4.02 1.83
115 INT21813 Gene_expression of Apoa2 1 10 0.61 3.68 1.81
116 INT37758 Gene_expression of GC 1 10 0.75 7.09 1.75
117 INT26451 Gene_expression of KLK1 2 14 0.75 5.79 1.66
118 INT21962 Localization of KLK1 1 15 0.78 3.54 1.61
119 INT20509 Positive_regulation of Negative_regulation of Ins1 1 7 0.48 2.8 1.46
120 INT42959 Negative_regulation of Vom2r2 1 3 0.06 0.56 1.43
121 INT14205 Regulation of KLK1 1 10 0.60 4.38 1.28
122 INT7991 Gene_expression of SPANXA1 1 8 0.67 3.41 1.2
123 INT35104 Positive_regulation of GC 1 6 0.11 4.99 1.08
124 INT42104 Regulation of Cdkn2a 1 4 0.44 5.67 1.06
125 INT98992 Binding of Vcam1 1 13 0.34 12.97 1.04
126 INT28066 Regulation of fut10 1 4 0.10 2.01 0.96
127 INT7614 Regulation of Vom2r2 1 2 0.04 0.87 0.89
128 INT40639 Binding of CHRM1 1 2 0.26 0.43 0.87
129 INT3086 Binding of Pf4 1 14 0.47 7.1 0.86
130 INT18146 Gene_expression of lt 2 6 0.66 2.88 0.84
131 INT28885 Regulation of Tk1 3 6 0.47 2.53 0.82
132 INT103023 Positive_regulation of Positive_regulation of Ptgis 1 1 0.18 0.7 0.8
133 INT23629 Negative_regulation of fut10 3 6 0.40 1.81 0.77
134 INT30429 Positive_regulation of Binding of OR2H2 1 1 0.21 0.58 0.66
135 INT30430 Binding of OR2H2 1 1 0.15 0.57 0.65
136 INT28886 Negative_regulation of Tk1 3 5 0.45 1.66 0.64
137 INT50016 Positive_regulation of ARHGAP4 1 3 0.49 1.8 0.58
138 INT23630 Gene_expression of fut10 1 5 0.62 0.9 0.54
139 INT28065 Negative_regulation of Gene_expression of fut10 1 2 0.04 0.53 0.53
140 INT30428 Positive_regulation of Binding of ADRA2A 1 1 0.34 0.59 0.53
141 INT10983 Binding of Apoa2 2 7 0.45 4.21 0.52
142 INT58591 Negative_regulation of Positive_regulation of PLG 1 4 0.42 2.46 0.51
143 INT15715 Positive_regulation of LTB 1 2 0.67 1.4 0.45
144 INT42105 Regulation of Positive_regulation of Cdkn2a 1 1 0.44 0.33 0.42
145 INT40640 Binding of BAP1 1 1 0.05 0.09 0.39
146 INT50014 Negative_regulation of ARHGAP4 3 2 0.27 1.59 0.32
147 INT84920 Regulation of Gene_expression of lt 1 1 0.03 0.5 0.22
148 INT103022 Positive_regulation of Transcription of Slc6a4 1 2 0.44 0.52 0.21
149 INT58589 Regulation of F12 1 3 0.39 1.9 0.16
150 INT58590 Protein_catabolism of IFNG 1 2 0.84 0.75 0.1
151 INT58594 Regulation of ARHGAP4 1 1 0.21 0.65 0.1
152 INT58593 Regulation of Negative_regulation of ARHGAP4 1 1 0.21 0.53 0.07
153 INT58592 Negative_regulation of Protein_catabolism of IFNG 1 1 0.40 0.51 0.07
154 INT35144 Negative_regulation of Gene_expression of PLG 1 3 0.29 0.98 0.06
155 INT34916 Positive_regulation of Localization of Hdlcl1 1 1 0.02 1.64 0
156 INT101924 Positive_regulation of Procr 1 1 0.07 0.69 0
157 INT34915 Localization of Hdlcl1 1 1 0.03 1.61 0
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