J:J. Med. Chem.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT50889 Binding of HTR1A and HTR1D 2 1 0.40 0.31 1.05
2 INT111078 Binding of Cnr1 and Cnr2 2 1 0.05 0 0.92
3 INT112842 Positive_regulation of Binding of Pdyn and Oprd1 1 2 0.00 0 0.81
4 INT112841 Binding of Pdyn and Oprd1 1 2 0.00 0 0.81
5 INT40610 Binding of Prkaca and Oprl1 1 1 0.02 0.09 0.8
6 INT21543 Binding of Oprd1 and Cish 2 1 0.09 0.15 0.78
7 INT70058 Binding of Pnoc and Insrr 1 1 0.01 0.09 0.77
8 INT99335 Binding of Agrp and Mc1r 1 1 0.30 0 0.77
9 INT72416 Binding of PDYN and El2 1 1 0.45 0 0.58
10 INT41250 Binding of Adra2a and Eef1a1 1 1 0.06 0.4 0.56
11 INT31818 Negative_regulation of Binding of Sst and Oprm1 1 1 0.26 0.3 0.48
12 INT31817 Positive_regulation of Binding of Sst and Oprm1 1 1 0.30 0.3 0.48
13 INT31816 Binding of Sst and Oprm1 1 1 0.22 0.3 0.48
14 INT112843 Binding of OPRK1 and Nfatc4 1 1 0.00 0 0.48
15 INT6020 Och Regulation of Penk 1 1 0.00 0.05 0.43
16 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 2 0.10 0.36 0.4
17 INT15104 Binding of Pax3 and Penk 1 1 0.01 0 0.37
18 INT102341 Binding of Slc6a3 and Flvcr2 2 1 0.06 0 0.34
19 INT102338 Binding of Sert1 and Flvcr2 1 1 0.08 0 0.34
20 INT102340 Binding of Slc6a3 and Sert1 1 1 0.18 0 0.34
21 INT108637 Binding of MC1R and NCOR2 1 1 0.00 0.1 0.32
22 INT150200 Regulation of Binding of Cnr1 and Cnr2 1 1 0.01 0 0.3
23 INT126006 Binding of ALB and IL8 1 3 0.41 0.28 0.28
24 INT72419 Positive_regulation of Binding of Cnr1 and Cnr2 1 1 0.55 0 0.25
25 INT6641 Negative_regulation of Binding of Avpr2 and Oxtr 1 1 0.04 0.06 0.23
26 INT6642 Binding of Avpr2 and Oxtr 1 1 0.03 0.06 0.23
27 INT6644 Binding of Avpr1a and Oxtr 1 1 0.14 0.05 0.23
28 INT57171 Binding of RYBP and Cyp1a1 1 1 0.01 0 0.23
29 INT6643 Negative_regulation of Binding of Avpr1a and Oxtr 1 1 0.16 0.05 0.23
30 INT57172 Binding of RYBP and Cyp2b1 1 1 0.02 0 0.23
31 INT25907 Binding of PRLR and Cish 1 1 0.00 0 0.23
32 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 1 0.03 0.18 0.2
33 INT50886 HTR2A Positive_regulation of HTR1D 1 1 0.54 0.07 0.2
34 INT68510 Binding of ATM and PRLR 1 1 0.01 0 0.19
35 INT126007 Negative_regulation of Binding of ALB and IL8 1 2 0.37 0.18 0.18
36 INT57170 Binding of Cyp1a1 and Cyp2b1 1 1 0.39 0 0.13
37 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 1 0.02 0 0.1
38 INT83831 Binding of PNMT and Adrb1 1 1 0.02 0 0.1
39 INT83828 Binding of Adrb1 and Pnmt 1 1 0.01 0 0.1
40 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 1 0.02 0 0.1
41 INT126005 Binding of IL8 and OXA1L 1 1 0.30 0.1 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 3 1902 0.78 275.47 1057.59
2 INT58061 Gene_expression of Trpv1 11 1117 0.78 451.54 637.59
3 INT50058 Negative_regulation of Cpox 7 907 0.58 426.28 428.29
4 INT5895 Gene_expression of Oprm1 1 525 0.78 120.67 407.29
5 INT467 Gene_expression of POMC 4 1048 0.78 332.8 394.16
6 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
7 INT18357 Gene_expression of TRPV1 6 825 0.78 307.11 382.81
8 INT6580 Negative_regulation of Ptgs1 17 929 0.59 381.53 376.26
9 INT5660 Binding of Oprd1 19 477 0.48 71.86 342.06
10 INT34869 Negative_regulation of PTGS2 9 778 0.59 366.76 319.85
11 INT5540 Positive_regulation of Oprm1 6 344 0.70 76.77 319.71
12 INT46460 Gene_expression of NAV1 1 288 0.78 135.51 305.75
13 INT4941 Positive_regulation of Oprd1 5 345 0.70 74.26 304.41
14 INT9381 Positive_regulation of TRPV1 5 523 0.70 187.4 276.05
15 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
16 INT5501 Regulation of Oprd1 5 283 0.62 55.1 249.9
17 INT6406 Binding of Oprm1 5 280 0.48 40.54 226.26
18 INT1212 Binding of Oprl1 10 312 0.48 28.6 225.15
19 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
20 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
21 INT6293 Gene_expression of Oprm1 3 312 0.78 48.73 215.61
22 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
23 INT1429 Gene_expression of PDYN 2 308 0.78 61.33 175.65
24 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
25 INT5930 Positive_regulation of Oprm1 3 221 0.70 31.19 172.93
26 INT4937 Negative_regulation of Oprd1 4 224 0.59 44.51 171.11
27 INT4768 Positive_regulation of OPRM1 2 212 0.70 31.09 164.28
28 INT2366 Binding of Cck 2 192 0.48 30.64 163.46
29 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
30 INT21185 Binding of Ptprg 1 213 0.47 13.49 157.75
31 INT6042 Binding of Oprm1 9 248 0.48 31.77 154.34
32 INT14843 Gene_expression of Gabrg1 4 301 0.77 62.63 139.16
33 INT5061 Negative_regulation of Mme 12 306 0.59 51.97 136.9
34 INT4658 Binding of OPRM1 4 188 0.48 25.96 136.24
35 INT1614 Gene_expression of Oprl1 3 164 0.78 31.43 127.74
36 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
37 INT6822 Gene_expression of Pdyn 5 215 0.78 35.99 125.76
38 INT50674 Gene_expression of PTGS2 4 459 0.78 253.33 118.51
39 INT7362 Gene_expression of Sst 1 185 0.78 41.73 111.37
40 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
41 INT114 Binding of Oprl1 10 139 0.48 23 103.35
42 INT10838 Positive_regulation of IL8 2 381 0.70 295.51 101.62
43 INT5906 Negative_regulation of Oprm1 1 125 0.59 19.58 101.57
44 INT4860 Positive_regulation of CALCA 2 148 0.00 73.35 97.61
45 INT56130 Gene_expression of MC1R 1 259 0.78 62.7 97.55
46 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
47 INT6437 Binding of YY1 4 154 0.47 26.3 90.46
48 INT6585 Positive_regulation of Insrr 5 110 0.52 40.67 89.9
49 INT6214 Negative_regulation of Adarb1 2 123 0.50 26.39 89.57
50 INT403 Localization of Trh 1 241 0.81 28.55 81.45
51 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
52 INT25363 Negative_regulation of Trpv1 1 144 0.59 64.78 75.7
53 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
54 INT1724 Negative_regulation of ACE 3 437 0.59 315.64 74.48
55 INT6656 Gene_expression of YY1 2 135 0.75 24.73 72.16
56 INT4153 Binding of Insrr 7 109 0.40 17.99 72.15
57 INT8962 Gene_expression of Cpe 2 110 0.71 39.67 71.67
58 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
59 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
60 INT6761 Binding of CALCA 1 100 0.48 26.71 62.05
61 INT39153 Positive_regulation of PTGS2 2 182 0.70 96.16 60.6
62 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
63 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
64 INT21737 Binding of MC1R 1 129 0.48 45.45 56.54
65 INT1510 Binding of PDYN 1 94 0.48 4.68 56.44
66 INT31186 Negative_regulation of Insrr 1 81 0.37 24.91 55.94
67 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
68 INT52692 Gene_expression of Ptgs2 2 160 0.78 85.06 55.73
69 INT5770 Binding of Rbm39 8 88 0.41 13.23 55.5
70 INT49436 Binding of TRPV1 4 145 0.48 38.35 55.08
71 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
72 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
73 INT929 Positive_regulation of Oprl1 3 64 0.70 14.67 52.84
74 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
75 INT62630 Positive_regulation of CNR1 1 86 0.70 40.34 51.51
76 INT5957 Positive_regulation of Cpe 2 65 0.69 21.07 51.22
77 INT9556 Negative_regulation of NAV1 1 47 0.59 28.49 49.33
78 INT12471 Regulation of Insrr 3 52 0.35 17.8 48.31
79 INT789 Positive_regulation of YY1 1 69 0.67 14.07 47.06
80 INT29105 Positive_regulation of OPRK1 1 68 0.70 7.06 44.69
81 INT7828 Positive_regulation of Oprd1 1 55 0.69 14.11 42.86
82 INT4913 Binding of Pax3 1 52 0.28 9.57 42.67
83 INT11180 Binding of RYBP 1 52 0.46 13.86 42.53
84 INT1319 Gene_expression of Oprl1 3 65 0.78 9.34 42.41
85 INT4850 Binding of Tac1 3 57 0.47 14.25 42.17
86 INT5539 Negative_regulation of Mme 6 75 0.59 28.91 41.84
87 INT61925 Negative_regulation of Adk 11 53 0.59 22.46 40.38
88 INT72011 Positive_regulation of Binding of Ptprg 1 42 0.50 2.72 39.89
89 INT16194 Binding of CNR1 5 82 0.48 20.75 39.59
90 INT1596 Negative_regulation of Oprl1 3 61 0.57 13.5 38.41
91 INT18774 Gene_expression of RYBP 1 67 0.65 47.66 37.59
92 INT95646 Negative_regulation of Faah 3 63 0.59 25.61 36.78
93 INT4843 Gene_expression of Npff 2 50 0.78 12.92 36.37
94 INT11292 Gene_expression of Mme 1 77 0.78 20.98 35.85
95 INT23330 Binding of Chrna7 3 79 0.48 10.06 35.5
96 INT66005 Regulation of Cnr1 1 47 0.61 19.21 34.52
97 INT34465 Regulation of Oprd1 1 34 0.45 7.14 34.29
98 INT21560 Positive_regulation of Binding of Oprm1 1 30 0.50 7.16 32.95
99 INT4727 Regulation of TAC1 1 60 0.47 6.74 32.83
100 INT9796 Gene_expression of Cck 2 63 0.78 11.44 32.09
101 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
102 INT10285 Binding of ADRA1D 2 102 0.47 25.82 31.11
103 INT49110 Regulation of Grip2 1 46 0.61 13.57 30.87
104 INT6177 Binding of Htr1a 1 65 0.47 17.65 30.59
105 INT7845 Regulation of OPRK1 2 44 0.62 4.54 30.49
106 INT12502 Regulation of Adarb1 1 50 0.53 7.58 30.01
107 INT9053 Negative_regulation of ALOX5 2 97 0.58 40.34 29.94
108 INT15296 Regulation of Rbm39 1 45 0.29 10.66 29.27
109 INT651 Positive_regulation of PTGS1 2 93 0.69 37.27 29.18
110 INT5771 Binding of Oprd1 1 37 0.48 2.6 27.54
111 INT7717 Positive_regulation of Adra2a 1 62 0.70 17.68 27.32
112 INT6594 Gene_expression of HTR1D 1 60 0.75 10.15 27.13
113 INT5232 Negative_regulation of Enpep 4 56 0.57 3.25 26.7
114 INT76621 Positive_regulation of Cnr2 1 32 0.69 17.77 26.57
115 INT48832 Positive_regulation of Grip2 1 48 0.69 12.13 25.99
116 INT5426 Negative_regulation of RTCA 1 58 0.51 12.34 25.74
117 INT6934 Binding of OPRD1 2 51 0.48 7.72 25.73
118 INT11773 Gene_expression of Tac1 1 56 0.77 10 25.72
119 INT9781 Binding of INSRR 3 64 0.31 19.1 25.2
120 INT6179 Binding of Oprk1 1 37 0.48 9.24 24.83
121 INT74377 Regulation of Cnr1 1 38 0.59 16.93 24.77
122 INT10836 Negative_regulation of IL8 2 95 0.59 52.59 24.71
123 INT27933 Gene_expression of NCOR2 1 65 0.72 31.35 24.23
124 INT9355 Binding of pcp 7 81 0.46 10.41 24.22
125 INT47741 Negative_regulation of Flvcr2 1 43 0.51 5.72 23.37
126 INT30386 Negative_regulation of OPRD1 1 33 0.52 4.34 23.06
127 INT6270 Binding of HTR1D 3 55 0.47 9.54 22.86
128 INT21503 Binding of Ptgs1 2 45 0.48 15.6 22.29
129 INT8248 Binding of Adra2a 1 43 0.48 6.72 22.17
130 INT8048 Gene_expression of Nts 2 45 0.74 8.9 21.84
131 INT1334 Negative_regulation of Binding of Oprl1 1 29 0.59 3.03 20.62
132 INT17848 Binding of PTGS2 1 70 0.46 32.1 20.6
133 INT13108 Binding of MTG1 2 35 0.47 6.36 20.5
134 INT7487 Gene_expression of Htr1a 1 36 0.75 11.08 20.05
135 INT6848 Gene_expression of BDKRB2 2 40 0.75 17.19 20.04
136 INT47876 Binding of Pnoc 1 20 0.47 4.99 20.01
137 INT77902 Negative_regulation of Positive_regulation of TRPV1 1 30 0.59 9.36 19.2
138 INT40811 Binding of OPRL1 1 26 0.48 2.76 18.68
139 INT12269 Gene_expression of Chrna9 1 39 0.73 6.98 18.44
140 INT12360 Regulation of Tac1 1 31 0.61 5.9 18
141 INT73362 Negative_regulation of Abcb1a 1 46 0.59 8.78 17.81
142 INT13790 Binding of HTR1A 1 52 0.47 18.83 17.59
143 INT23784 Gene_expression of FAIM3 1 25 0.55 2.89 17.14
144 INT1721 Negative_regulation of HP 1 148 0.42 86.82 16.89
145 INT32753 Positive_regulation of Positive_regulation of OPRM1 1 19 0.62 3.3 16.73
146 INT32648 Gene_expression of Tyrp1 2 80 0.66 17.9 16.59
147 INT78749 Gene_expression of SCN10A 1 25 0.75 9.23 16.5
148 INT49263 Binding of Grip2 1 31 0.41 9.86 16.38
149 INT9197 Binding of PTGS1 1 44 0.48 18.48 16.26
150 INT8571 Gene_expression of B3GAT1 2 54 0.75 36.85 15.98
151 INT47742 Binding of Flvcr2 1 26 0.42 3.28 15.87
152 INT13400 Negative_regulation of Enpep 2 30 0.50 4.23 15.86
153 INT1752 Negative_regulation of Ache 4 109 0.59 42.05 15.73
154 INT52591 Gene_expression of KCNMA1 1 78 0.76 13.95 15.55
155 INT9783 Gene_expression of INSRR 1 81 0.50 32.99 15.52
156 INT12837 Binding of SIGMAR1 3 57 0.48 5.31 15.49
157 INT15102 Gene_expression of Trim13 4 18 0.67 0.43 15.49
158 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
159 INT1850 Binding of OXA1L 2 77 0.48 7.61 15.22
160 INT29086 Negative_regulation of Sert1 3 37 0.58 7.49 14.98
161 INT170 Negative_regulation of Adrb1 3 52 0.55 13.46 14.78
162 INT127046 Gene_expression of P2RX7 1 65 0.78 34.28 14.76
163 INT7523 Regulation of ADRA1D 1 42 0.45 11.63 14.52
164 INT20665 Gene_expression of ACE 1 87 0.78 51.71 14.19
165 INT20071 Positive_regulation of HTR2A 1 33 0.67 10.89 14
166 INT6645 Positive_regulation of BDKRB1 2 14 0.66 12.17 13.79
167 INT18658 Regulation of Adra1a 1 34 0.62 5.69 13.78
168 INT7057 Binding of FAIM3 2 19 0.48 4.02 13.78
169 INT13498 Gene_expression of Atxn2l 2 16 0.52 1.24 13.73
170 INT4842 Regulation of Npff 1 13 0.54 4.59 13.62
171 INT7031 Transcription of Pdyn 1 43 0.71 5.82 13.58
172 INT20881 Negative_regulation of OPRK1 2 20 0.43 3.73 13.37
173 INT9231 Binding of Htr3a 1 27 0.47 7.29 13.04
174 INT57580 Positive_regulation of TACR1 1 18 0.69 9.35 12.47
175 INT49975 Binding of SLC6A3 1 34 0.47 9.86 12.41
176 INT3699 Gene_expression of H2-Ab1 1 24 0.74 12.06 11.82
177 INT99336 Negative_regulation of FOLH1 16 30 0.57 8.83 11.53
178 INT7350 Negative_regulation of Anpep 5 30 0.59 2.89 11.28
179 INT85017 Positive_regulation of Mc4r 1 13 0.67 7.56 10.86
180 INT8966 Regulation of Trh 1 12 0.62 2.73 10.79
181 INT17349 Negative_regulation of Akr1b1 1 41 0.59 27.03 10.65
182 INT15054 Gene_expression of Mme 2 48 0.77 42.52 10.63
183 INT93281 Negative_regulation of Folh1 2 12 0.50 5.55 10.63
184 INT7411 Localization of FGFR3 3 40 0.78 4.77 10.24
185 INT67048 Gene_expression of ITGA4 1 58 0.75 28.93 10.16
186 INT50615 Positive_regulation of Positive_regulation of Insrr 2 11 0.19 5.5 10.05
187 INT1617 Positive_regulation of Binding of Oprl1 1 10 0.59 0.63 9.79
188 INT4391 Gene_expression of SERPINA1 1 47 0.78 41.43 9.7
189 INT12367 Binding of PRLR 2 17 0.03 2.05 9.69
190 INT85144 Binding of Cnr2 2 14 0.47 6.41 9.49
191 INT53547 Binding of TACR1 2 22 0.48 5.03 9.48
192 INT40609 Binding of Prkaca 1 23 0.36 3.42 9.19
193 INT51837 Negative_regulation of TACR1 1 17 0.43 6.5 9.12
194 INT32692 Positive_regulation of Aif1 1 33 0.35 13.29 9.03
195 INT113734 Gene_expression of Agrp 1 31 0.77 11.04 9.02
196 INT7090 Gene_expression of pcp 2 50 0.66 13.54 8.96
197 INT3922 Negative_regulation of Pnmt 4 29 0.59 3.18 8.96
198 INT33209 Positive_regulation of Binding of OPRM1 1 8 0.68 0.63 8.95
199 INT82839 Negative_regulation of ABCB1 1 61 0.59 16.09 8.83
200 INT49205 Positive_regulation of B3GAT1 1 20 0.67 10.28 8.71
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