J:J. Neurochem.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT51205 Binding of OPRK1 and PDYN 7 2 0.00 2.01 7.8
2 INT106559 Binding of Bdnf and Ntrk2 23 1 0.43 11.09 7.33
3 INT26824 Crh Positive_regulation of Localization of Penk 7 3 0.54 0.42 6.49
4 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 5 0.74 4.31 6.1
5 INT15842 Crh Positive_regulation of Localization of Pomc 15 1 0.73 5 5.05
6 INT125407 Binding of OPRL1 and PTPRM 1 9 0.03 0.72 4.67
7 INT7022 Drd1a Positive_regulation of Npr1 6 2 0.05 0.26 4.32
8 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 1 0.27 0.43 3.88
9 INT122349 Ngf Regulation of Trpv1 3 1 0.64 1.55 3.79
10 INT141254 Ngf Regulation of Transcription of Trpv1 1 3 0.53 1.37 3.74
11 INT134284 Binding of OPRM1 and PLD2 1 8 0.52 0 3.72
12 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 2 0.47 0.72 3.63
13 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 2 0.11 0 3.28
14 INT87267 Binding of BMP8B and KRIT1 1 2 0.06 0.16 2.69
15 INT124547 Trib3 Regulation of Regulation of Th 1 2 0.02 0.79 2.64
16 INT12140 Ngf Regulation of Chat 1 5 0.44 1.67 2.18
17 INT5486 Oprd1 Regulation of Cck 1 2 0.21 0 2.16
18 INT39108 Binding of PDYN and YY1 2 1 0.50 0.44 2.14
19 INT18593 Binding of Sst and Fdft1 2 1 0.11 0.08 2.12
20 INT133946 Binding of DNM2 and OPRK1 1 3 0.11 0 2.1
21 INT17299 Prss12 Regulation of Localization of Acot1 3 1 0.05 0 2.07
22 INT21261 Penk Negative_regulation of Npr1 1 2 0.02 0 2
23 INT23755 Mptp1 Regulation of PDYN 1 3 0.01 2.27 1.98
24 INT146099 Binding of Oprm1 and Rgs9 1 2 0.48 0 1.95
25 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 1 0.05 0.1 1.81
26 INT115443 Regulation of Binding of Cpox and Defb40 1 2 0.00 1.28 1.76
27 INT115435 Binding of Cpox and Defb40 Positive_regulation of Localization of Defb42 1 2 0.00 1.28 1.76
28 INT115442 Binding of Cpox and Defb40 1 2 0.00 1.28 1.76
29 INT18592 Sst Regulation of Localization of Acot1 2 1 0.22 0 1.61
30 INT32937 Binding of Pgrmc1 and Dtnb 1 2 0.20 0 1.61
31 INT141907 F2r Regulation of Plat 1 1 0.46 0 1.59
32 INT130839 Gfap Positive_regulation of S100B 1 1 0.51 1.9 1.56
33 INT130838 Gfap Positive_regulation of Aqp4 1 1 0.51 1.9 1.56
34 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 2 0.17 3.36 1.53
35 INT133937 Binding of OPRK1 and ARFGEF1 1 2 0.01 0 1.39
36 INT133933 Binding of DNM2 and TP53INP2 1 2 0.00 0 1.38
37 INT50706 Phax Positive_regulation of Localization of Trib3 1 2 0.04 0.28 1.38
38 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 1 0.05 0.07 1.37
39 INT143999 IK Regulation of Gene_expression of Penk 1 2 0.04 0 1.33
40 INT136603 Calca Positive_regulation of Localization of Il6 1 1 0.67 0.78 1.32
41 INT94367 Binding of ARRB1 and TP53INP2 1 2 0.25 0 1.3
42 INT20530 Nts Regulation of Prss12 5 3 0.24 0.74 1.23
43 INT42554 Oprl1 Regulation of Npr1 2 1 0.06 0 1.22
44 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 1 0.00 0.08 1.22
45 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 1 0.02 0.08 1.22
46 INT49955 OPRM1 Positive_regulation of ADCY1 1 2 0.21 0.31 1.19
47 INT49956 OPRM1 Positive_regulation of SGCG 1 2 0.53 0.3 1.18
48 INT88778 Binding of Oprm1 and Pomc 3 2 0.21 0.56 1.14
49 INT18596 Fdft1 Regulation of Localization of Acot1 1 1 0.06 0 1.14
50 INT130471 Prkcg Regulation of Regulation of Fos 1 1 0.45 0.27 1.12
51 INT110522 Oprm1 Positive_regulation of Oprk1 1 1 0.11 0 1.12
52 INT21267 Cck Negative_regulation of Binding of Oprd1 1 1 0.50 0 1.12
53 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 1 0.11 0 1.11
54 INT125405 PTPRM Positive_regulation of Binding of OPRL1 and PTPRM 1 2 0.00 0.16 1.07
55 INT60047 Oprl1 Negative_regulation of Phosphorylation of Syn1 1 1 0.05 0.17 1.05
56 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 1 0.28 0 1.04
57 INT65986 IL1B Positive_regulation of PTGS2 3 1 0.32 2.05 1.03
58 INT146098 Binding of Rgs9 and Arrb2 1 1 0.19 0 1.03
59 INT33142 Pck1 Positive_regulation of Npr1 4 3 0.01 0.5 1.02
60 INT56743 LIF Positive_regulation of Cck 1 2 0.08 0.18 1.02
61 INT12138 Ins1 Negative_regulation of Chat 1 2 0.27 0.71 1.01
62 INT47163 Penk Regulation of Rtcd1 1 1 0.00 0 1.01
63 INT12141 Igf1 Negative_regulation of Chat 1 2 0.32 0.63 1
64 INT63803 RGD1560349 Positive_regulation of Penk 1 1 0.04 0 1
65 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 1 0.24 0 0.98
66 INT56742 LIF Positive_regulation of Chat 1 2 0.02 0.2 0.98
67 INT136420 Binding of DeltaFosB and Rorb 1 1 0.03 0.66 0.97
68 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 1 0.08 0 0.96
69 INT18597 Sst Positive_regulation of Localization of Acot1 1 1 0.29 0 0.96
70 INT146096 Positive_regulation of Binding of Oprm1 and Rgs9 1 1 0.44 0 0.94
71 INT34457 AGT Positive_regulation of POMC 1 1 0.01 0 0.91
72 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 1 0.13 1.31 0.91
73 INT7292 Binding of Drd1a and Penk 1 2 0.14 0 0.9
74 INT52759 Oprd1 Regulation of Sptan1 1 1 0.03 0 0.9
75 INT52760 Oprd1 Regulation of Drd1a 1 1 0.02 0 0.9
76 INT52761 Dll1 Regulation of Sptan1 1 1 0.07 0 0.89
77 INT52762 Dll1 Regulation of Drd1a 1 1 0.10 0 0.89
78 INT116269 Binding of Myc and Mycbp2 1 2 0.19 0.5 0.87
79 INT115444 Cpox Positive_regulation of Localization of Defb42 1 1 0.00 0.64 0.87
80 INT52390 OPRD1 Regulation of ADCY1 1 1 0.09 0.13 0.86
81 INT126384 Binding of Bdnf and Ntrk2 Positive_regulation of Prkca 1 1 0.49 0.63 0.85
82 INT12142 Ins1 Regulation of Chat 1 2 0.24 0.69 0.84
83 INT12137 Ngf Regulation of Gad1 1 2 0.27 0.67 0.83
84 INT127545 Gria1 Positive_regulation of Gene_expression of Gnptab 1 2 0.00 0.7 0.83
85 INT106312 NFKB1 Regulation of S100A4 1 2 0.14 1.1 0.83
86 INT84717 Il1b Regulation of Cpox 1 1 0.00 0.37 0.83
87 INT89529 OPRM1 Regulation of CALM1 1 1 0.27 0 0.81
88 INT123492 TIAF1 Positive_regulation of Gene_expression of CCL4 1 2 0.00 1.45 0.81
89 INT34458 AGT Negative_regulation of PENK 1 1 0.00 0 0.81
90 INT55923 Penk Regulation of Transcription of Oprm1 1 1 0.26 0 0.78
91 INT90750 Oprd1 Regulation of Positive_regulation of Gpd1 1 1 0.10 0.25 0.78
92 INT55922 Penk Regulation of Oprm1 1 1 0.26 0 0.78
93 INT50708 Phax Positive_regulation of Trib3 1 1 0.03 0.07 0.77
94 INT16933 Tsc22d3 Positive_regulation of Localization of Penk 2 1 0.24 0 0.76
95 INT66580 Binding of Ap1s1 and Rare2 1 1 0.00 0.07 0.76
96 INT133941 ARFGEF1 Positive_regulation of OPRK1 1 1 0.02 0 0.76
97 INT133935 DNM2 Positive_regulation of OPRK1 1 1 0.11 0 0.76
98 INT140790 Positive_regulation of Ptger3 Negative_regulation of Negative_regulation of Bdkrb2 1 1 0.00 0.07 0.76
99 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 1 0.05 0 0.76
100 INT28620 Penk Regulation of Crh 2 2 0.40 0.25 0.75
101 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 1 0.21 0.46 0.74
102 INT57658 ASNA1 Positive_regulation of Npr1 1 1 0.00 0.15 0.74
103 INT50707 Phax Positive_regulation of Positive_regulation of Trib3 1 1 0.04 0.16 0.74
104 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 1 0.23 0.46 0.74
105 INT133940 Binding of OPRD1 and ARFGEF1 1 1 0.02 0 0.73
106 INT133938 Binding of OPRL1 and ARFGEF1 1 1 0.00 0 0.73
107 INT133939 Binding of OPRL1 and PDYN 1 1 0.00 0 0.73
108 INT133934 Binding of OPRD1 and PDYN 1 1 0.02 0 0.73
109 INT133943 Binding of DNM2 and OPRL1 1 1 0.00 0 0.73
110 INT87274 CALM1 Regulation of Oprd1 1 1 0.01 0.08 0.72
111 INT87275 KRIT1 Regulation of Oprd1 1 1 0.01 0.08 0.72
112 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 1 0.23 2.62 0.71
113 INT123494 Binding of Egr1 and Ccr5 1 2 0.04 0.94 0.71
114 INT51433 Gria1 Positive_regulation of Eif3g 1 2 0.03 0 0.7
115 INT66581 Binding of JUN and Rare2 1 1 0.00 0.07 0.69
116 INT133942 Binding of YY1 and ARFGEF1 1 1 0.05 0 0.69
117 INT133944 Binding of PDYN and TP53INP2 1 1 0.00 0 0.69
118 INT71595 Camk2a Regulation of Negative_regulation of Oprm1 1 2 0.04 0 0.69
119 INT133936 Binding of DNM2 and YY1 1 1 0.29 0 0.69
120 INT66582 Binding of FOS and Rare2 1 1 0.00 0.07 0.69
121 INT134286 PLD2 Regulation of Regulation of EDNRA 1 1 0.10 0 0.67
122 INT40180 Regulation of Binding of Oprl1 and Scn7a 1 1 0.02 0 0.67
123 INT40179 Binding of Oprl1 and Scn7a 1 1 0.03 0 0.67
124 INT134287 PLD2 Regulation of Regulation of MRGPRX1 1 1 0.31 0 0.67
125 INT94366 Binding of ARRB1 and OPRD1 1 1 0.11 0 0.67
126 INT144000 Binding of IK and Regulation of Gene_expression of Penk 1 1 0.04 0 0.67
127 INT128276 ecs Regulation of Transcription of Slc17a7 1 1 0.01 0.29 0.65
128 INT134281 Calca Positive_regulation of Nfat5 1 1 0.36 0.14 0.65
129 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 1 0.27 0.1 0.64
130 INT128275 Slc17a7 Positive_regulation of Transcription of Slc17a6 1 1 0.39 0.27 0.63
131 INT45638 Cck Positive_regulation of Localization of Melm1 1 1 0.02 0 0.62
132 INT45637 Cck Positive_regulation of Melm1 1 1 0.02 0 0.62
133 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 1 0.19 0.37 0.61
134 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 1 0.16 0.37 0.61
135 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 1 0.06 0.35 0.61
136 INT109256 PDYN Positive_regulation of Binding of CRYGS 1 1 0.00 0.1 0.61
137 INT126615 Binding of Oprd1 and Stat5a 1 1 0.28 0.07 0.61
138 INT56859 Oprd1 Positive_regulation of OPRD1 1 1 0.01 0.22 0.61
139 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 1 0.02 0.37 0.61
140 INT55919 Binding of Sigmar1 and Ap2s1 1 1 0.02 0.84 0.6
141 INT117707 Oprm1 Positive_regulation of PIK3CG 1 1 0.00 0.08 0.6
142 INT59925 Pdyn Regulation of Positive_regulation of Penk 1 1 0.10 0.09 0.59
143 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 1 0.04 0.31 0.59
144 INT131072 Cc2d1b Negative_regulation of Prkcg 1 1 0.01 0 0.58
145 INT30989 Pgrmc1 Positive_regulation of Penk 1 1 0.00 0 0.57
146 INT92974 Creb1 Regulation of Positive_regulation of Galr1 1 1 0.32 0 0.57
147 INT60665 Il1b Regulation of Oprd1 1 1 0.05 0 0.57
148 INT42300 Guca2a Negative_regulation of Rtcd1 1 1 0.00 0.79 0.56
149 INT146112 Binding of Il1b and Tnf 1 1 0.32 1.19 0.56
150 INT106374 Olr833 Negative_regulation of Abcb1a 1 1 0.00 0 0.56
151 INT125404 OPRL1 Positive_regulation of Binding of OPRL1 and PTPRM 1 1 0.03 0.08 0.54
152 INT34459 AGT Negative_regulation of MBTPS1 1 1 0.01 0 0.54
153 INT143864 Ngf Regulation of Ngf Positive_regulation of Nfatc4 1 1 0.00 0.62 0.53
154 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 1 0.38 0 0.53
155 INT143853 Ngf Positive_regulation of Nfatc4 1 1 0.02 0.62 0.53
156 INT5631 Ubqln1 Positive_regulation of Pdpk1 1 1 0.05 0 0.53
157 INT143854 Ngf Regulation of Transcription of Bdnf 1 1 0.09 0.61 0.53
158 INT143855 Ngf Regulation of Positive_regulation of Nfatc4 1 1 0.02 0.62 0.53
159 INT143863 Ngf Positive_regulation of Nfatc4 Regulation of Transcription of Bdnf 1 1 0.01 0.62 0.53
160 INT143862 Bdnf Positive_regulation of Gene_expression of NUP214 1 1 0.27 0.61 0.52
161 INT143861 Nfatc1 Regulation of Gene_expression of NUP214 1 1 0.00 0.61 0.52
162 INT30987 Pgrmc1 Positive_regulation of Pdyn 1 1 0.01 0 0.52
163 INT143859 Bdnf Positive_regulation of Gene_expression of Nfatc1 1 1 0.00 0.61 0.52
164 INT30028 Ins1 Regulation of Odc1 2 1 0.11 0 0.51
165 INT60658 Grip2 Positive_regulation of Localization of Sst 1 1 0.04 0 0.51
166 INT56744 CNTF Positive_regulation of Cck 1 1 0.08 0.09 0.51
167 INT130469 Tubgcp2 Negative_regulation of Naalad2 1 1 0.05 0.44 0.5
168 INT115800 Positive_regulation of HRASLS Positive_regulation of Positive_regulation of OPRM1 1 1 0.11 0 0.49
169 INT12143 Ngf Positive_regulation of Chat 1 1 0.45 0.29 0.49
170 INT56736 Cntf Positive_regulation of Chat 1 1 0.00 0.1 0.49
171 INT56745 CNTF Positive_regulation of Chat 1 1 0.02 0.1 0.49
172 INT146113 Binding of Adra2a and Lrp1 1 1 0.01 1.07 0.48
173 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 1 0.42 0.21 0.48
174 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 1 0.38 0.21 0.48
175 INT7291 Akr1d1 Regulation of Regulation of Penk 1 1 0.01 0 0.48
176 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 1 0.14 0.2 0.47
177 INT121614 Cfp Regulation of Enc1 1 1 0.00 0 0.47
178 INT121615 Enc1 Regulation of Cfp 1 1 0.00 0 0.47
179 INT131507 Ngf Positive_regulation of Mapk14 1 1 0.13 0.2 0.47
180 INT121616 Casp3 Regulation of Enc1 Regulation of Cfp 1 1 0.00 0 0.47
181 INT72928 Magel2 Negative_regulation of Positive_regulation of NOS1 1 1 0.01 0 0.47
182 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 1 0.01 0.08 0.47
183 INT69638 Binding of TF and Zfp354a 1 1 0.00 0 0.46
184 INT28619 Negative_regulation of Penk Regulation of Crh 1 1 0.41 0 0.46
185 INT95469 P2ry6 Positive_regulation of Positive_regulation of Pdpk1 1 1 0.15 0 0.46
186 INT131312 Binding of Nts and Datd 1 1 0.10 0.74 0.46
187 INT69637 Binding of CAV1 and Zfp354a 1 1 0.00 0 0.46
188 INT67528 PTGER2 Positive_regulation of Gene_expression of IL6 2 1 0.10 1.38 0.45
189 INT67527 MRXS5 Positive_regulation of Gene_expression of IL6 1 1 0.21 1.5 0.45
190 INT52383 Binding of Gs and Ptprg 1 1 0.00 0.48 0.44
191 INT80231 PCDHB17 Negative_regulation of Positive_regulation of RTCA 1 1 0.00 0 0.44
192 INT94362 OPRD1 Positive_regulation of PPP1R1A 1 1 0.29 0.16 0.44
193 INT80230 PCDHB17 Negative_regulation of RTCA 1 1 0.00 0 0.44
194 INT127543 Gria1 Positive_regulation of Gene_expression of Cryge 1 1 0.00 0.35 0.42
195 INT12139 Ins1 Regulation of Gad1 1 1 0.15 0.33 0.42
196 INT127546 Gria1 Positive_regulation of Gene_expression of Kcnab3 1 1 0.02 0.35 0.42
197 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 1 0.19 0.39 0.42
198 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 1 0.55 0.39 0.42
199 INT68526 Binding of ADCY1 and DIO2 1 1 0.01 0.07 0.41
200 INT80233 Positive_regulation of OPRM1 Positive_regulation of GNAI1 1 1 0.23 0 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 9 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 54 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 7 2431 0.81 378.96 952.2
4 INT6483 Gene_expression of TNF 8 3152 0.78 2515.62 929.82
5 INT1912 Gene_expression of Calca 5 1152 0.78 453.25 739.84
6 INT292 Localization of Penk 37 876 0.81 88.44 669.14
7 INT728 Positive_regulation of Penk 33 1068 0.70 186.9 636.87
8 INT2543 Positive_regulation of Calca 8 787 0.70 331.13 592.08
9 INT5228 Positive_regulation of Fos 5 934 0.70 209.8 503.87
10 INT443 Localization of POMC 7 1020 0.81 284.52 443.17
11 INT50058 Negative_regulation of Cpox 6 907 0.58 426.28 428.29
12 INT9238 Gene_expression of IL6 5 1575 0.78 1135.66 424.22
13 INT4758 Positive_regulation of Localization of Calca 4 557 0.70 138.55 411.04
14 INT467 Gene_expression of POMC 9 1048 0.78 332.8 394.16
15 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
16 INT6580 Negative_regulation of Ptgs1 4 929 0.59 381.53 376.26
17 INT157 Positive_regulation of Localization of Prl 2 790 0.70 104.54 374.78
18 INT287 Localization of Cck 23 518 0.81 86.84 364.04
19 INT720 Positive_regulation of POMC 3 807 0.70 237.37 353.83
20 INT5660 Binding of Oprd1 14 477 0.48 71.86 342.06
21 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
22 INT2649 Regulation of Calca 2 433 0.62 146.05 330.95
23 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
24 INT5979 Gene_expression of Oprd1 7 428 0.78 75.64 320.32
25 INT5680 Gene_expression of Ngf 8 530 0.78 264.29 310.56
26 INT477 Localization of Avp 4 813 0.81 131.58 300.4
27 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
28 INT1352 Localization of Acot1 51 728 0.80 73.01 296.01
29 INT886 Gene_expression of Pomc 9 676 0.78 129.87 295.98
30 INT5379 Gene_expression of Fos 3 656 0.78 255.5 292.54
31 INT3579 Localization of Oxt 2 555 0.81 43.35 292.44
32 INT2365 Positive_regulation of Cck 8 354 0.70 87.8 277.41
33 INT9381 Positive_regulation of TRPV1 9 523 0.70 187.4 276.05
34 INT94450 Gene_expression of Nav1 6 359 0.78 131.85 275.46
35 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
36 INT5591 Regulation of Gene_expression of Fos 9 425 0.62 129.06 265.78
37 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
38 INT3948 Regulation of Cck 8 291 0.62 58.07 255.88
39 INT5501 Regulation of Oprd1 9 283 0.62 55.1 249.9
40 INT1005 Localization of Sst 19 385 0.81 26.31 244.56
41 INT738 Regulation of POMC 8 459 0.62 111.19 243.74
42 INT1902 Gene_expression of Cck 3 348 0.78 70.33 241.92
43 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
44 INT1562 Localization of Crh 4 499 0.81 126.74 236.68
45 INT5597 Gene_expression of Pdyn 10 433 0.78 62.97 235.47
46 INT1665 Positive_regulation of Pag1 5 270 0.68 186.63 229.87
47 INT9987 Gene_expression of Abat 1 296 0.78 95.46 226.34
48 INT6406 Binding of Oprm1 3 280 0.48 40.54 226.26
49 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
50 INT95787 Positive_regulation of Mapk1 6 568 0.70 226.51 220.94
51 INT6665 Gene_expression of FOS 6 520 0.77 165.31 217.66
52 INT1308 Localization of Pomc 7 457 0.81 66.83 217.5
53 INT4893 Gene_expression of Tacr1 3 366 0.78 129.67 213.92
54 INT6482 Positive_regulation of Gene_expression of TNF 6 659 0.70 569.88 210
55 INT48955 Gene_expression of Nos2 14 753 0.78 403.87 208.08
56 INT2651 Positive_regulation of Pomc 6 403 0.70 95.72 206.24
57 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
58 INT798 Positive_regulation of Gene_expression of Penk 11 394 0.70 78.53 203.07
59 INT50670 Gene_expression of CPOX 6 763 0.76 442.13 195.02
60 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
61 INT6354 Localization of Gabrg1 15 321 0.74 41.41 186.74
62 INT94952 Positive_regulation of Mapk14 4 305 0.70 197.83 186.61
63 INT1652 Regulation of Pomc 13 387 0.62 61.01 186.51
64 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
65 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
66 INT4803 Transcription of Penk 25 435 0.72 59.09 182.4
67 INT12602 Negative_regulation of Oprm1 2 190 0.59 36.11 177.85
68 INT49441 Negative_regulation of Cpox 5 494 0.59 303.22 177.46
69 INT1429 Gene_expression of PDYN 5 308 0.78 61.33 175.65
70 INT943 Negative_regulation of Cck 2 205 0.59 38.42 174.78
71 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
72 INT4937 Negative_regulation of Oprd1 2 224 0.59 44.51 171.11
73 INT739 Negative_regulation of POMC 3 358 0.59 102.28 166.77
74 INT55879 Gene_expression of CCL2 2 421 0.78 240.74 166.02
75 INT1114 Localization of Ins1 2 748 0.80 192.95 165.48
76 INT4768 Positive_regulation of OPRM1 6 212 0.70 31.09 164.28
77 INT2366 Binding of Cck 2 192 0.48 30.64 163.46
78 INT5513 Negative_regulation of Pomc 8 295 0.59 60.9 158.63
79 INT51921 Gene_expression of Cpox 4 501 0.73 229.81 157.81
80 INT21185 Binding of Ptprg 20 213 0.47 13.49 157.75
81 INT768 Positive_regulation of Oprl1 15 179 0.70 40.05 156.93
82 INT1303 Negative_regulation of Npr1 29 278 0.55 35.1 156.78
83 INT2640 Gene_expression of Pomc 12 424 0.78 120.72 155.37
84 INT6042 Binding of Oprm1 9 248 0.48 31.77 154.34
85 INT2910 Regulation of Abat 2 169 0.62 36.95 153.53
86 INT4829 Positive_regulation of Localization of Abat 12 199 0.55 20.91 150.48
87 INT5050 Regulation of Localization of Calca 2 149 0.62 41.25 148.57
88 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
89 INT2451 Positive_regulation of Avp 5 355 0.70 102.66 147.69
90 INT1033 Positive_regulation of Ca2 3 507 0.68 131.76 147.64
91 INT3300 Positive_regulation of Gene_expression of Calca 2 179 0.70 77.76 144.2
92 INT2780 Regulation of Gene_expression of Penk 7 265 0.62 32.45 143.88
93 INT1414 Regulation of Oprl1 4 169 0.62 32.05 139.99
94 INT90910 Phosphorylation of Grin1 1 150 0.82 68.23 139.24
95 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
96 INT5061 Negative_regulation of Mme 2 306 0.59 51.97 136.9
97 INT48953 Positive_regulation of Nos2 4 486 0.70 239.85 131.87
98 INT5380 Positive_regulation of Gene_expression of Fos 2 243 0.70 105.65 131.05
99 INT5595 Positive_regulation of Pdyn 10 223 0.70 48.37 130.14
100 INT64161 Positive_regulation of Prkca 4 213 0.70 85.06 129.91
101 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
102 INT1614 Gene_expression of Oprl1 6 164 0.78 31.43 127.74
103 INT695 Binding of POMC 5 304 0.48 56.66 126.85
104 INT6822 Gene_expression of Pdyn 11 215 0.78 35.99 125.76
105 INT4824 Positive_regulation of Tacr1 4 169 0.70 66.1 123.46
106 INT4259 Positive_regulation of Npr1 26 262 0.70 49.37 123.11
107 INT64201 Negative_regulation of Trpv1 1 203 0.59 79.18 119.75
108 INT2555 Positive_regulation of Localization of Penk 3 116 0.70 24.35 119.73
109 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
110 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
111 INT7341 Positive_regulation of Grin1 5 169 0.70 65.86 118.38
112 INT1438 Localization of Pomc 4 360 0.81 101.26 116.47
113 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
114 INT7362 Gene_expression of Sst 5 185 0.78 41.73 111.37
115 INT11051 Positive_regulation of Gene_expression of IL6 3 415 0.69 319.21 109.3
116 INT5283 Positive_regulation of Npy 3 191 0.70 66.77 109.2
117 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
118 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
119 INT114 Binding of Oprl1 4 139 0.48 23 103.35
120 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
121 INT4742 Gene_expression of Tac1 3 177 0.78 69.99 102.66
122 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
123 INT5906 Negative_regulation of Oprm1 10 125 0.59 19.58 101.57
124 INT74826 Gene_expression of Slc1a2 5 131 0.78 61.83 100.84
125 INT97701 Phosphorylation of Mapk14 5 191 0.82 115.33 100.46
126 INT5587 Regulation of Fos 5 191 0.62 40.81 99.7
127 INT52651 Positive_regulation of Prkaca 4 136 0.67 40.82 99.16
128 INT293 Protein_catabolism of Penk 5 161 1.00 11.71 98.45
129 INT7944 Positive_regulation of Fos 3 193 0.70 60.69 98.31
130 INT4822 Localization of Ca2 11 417 0.80 99.57 96.45
131 INT17459 Positive_regulation of Gene_expression of FOS 4 182 0.67 53.45 96.38
132 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
133 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
134 INT2862 Positive_regulation of Localization of Cck 12 108 0.70 20.75 94.25
135 INT18755 Positive_regulation of Rvm 2 79 0.60 60 92.93
136 INT203 Positive_regulation of Pomc 3 257 0.70 90.56 92.84
137 INT1281 Negative_regulation of Maoa 13 203 0.59 22.47 91.66
138 INT94953 Negative_regulation of Mapk14 7 156 0.59 104.77 91.51
139 INT69764 Positive_regulation of Cnr1 2 126 0.70 67.8 91.49
140 INT6437 Binding of YY1 1 154 0.47 26.3 90.46
141 INT1639 Negative_regulation of OPRM1 5 107 0.59 13.86 90.37
142 INT74376 Gene_expression of Cnr1 1 173 0.78 73.43 89.7
143 INT18032 Positive_regulation of Oprk1 1 108 0.70 30.78 89.7
144 INT12763 Phosphorylation of Prkcg 5 167 0.82 38.91 89.63
145 INT71789 Positive_regulation of MAPK1 6 396 0.70 234.44 89.27
146 INT67682 Localization of Bdnf 12 204 0.81 72.36 88.92
147 INT96917 Positive_regulation of Mapk14 1 261 0.70 173.29 88.79
148 INT64158 Negative_regulation of Prkca 2 121 0.59 29.8 88.66
149 INT7885 Positive_regulation of Localization of Oxt 1 160 0.70 14.36 87.7
150 INT3441 Regulation of Localization of Abat 6 117 0.38 8.67 87.59
151 INT15898 Positive_regulation of Prkaca 4 199 0.70 50.89 87.54
152 INT54571 Positive_regulation of NFKB1 3 263 0.70 138.99 87.32
153 INT5594 Regulation of Pdyn 4 137 0.62 27.04 86.63
154 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
155 INT2149 Positive_regulation of Oxt 1 181 0.70 24.8 85.43
156 INT3766 Positive_regulation of Localization of Acot1 23 192 0.69 21.8 85.35
157 INT73340 Negative_regulation of Faah 5 134 0.59 38.67 85.03
158 INT2520 Negative_regulation of Ca2 11 271 0.57 72.13 83.71
159 INT339 Regulation of Trh 5 156 0.62 39.27 83.55
160 INT92434 Phosphorylation of Mapk1 4 287 0.82 91.65 83.46
161 INT4631 Positive_regulation of Sst 2 127 0.70 17.37 83.29
162 INT16254 Positive_regulation of Gene_expression of Ngf 2 144 0.70 80.61 82.08
163 INT55944 Positive_regulation of Cpox 3 214 0.57 105.14 81.4
164 INT7528 Regulation of OPRM1 6 100 0.62 20.63 80.57
165 INT99070 Gene_expression of Mapk14 6 147 0.78 103.99 79.59
166 INT64636 Positive_regulation of Gene_expression of Nos2 6 242 0.70 147.52 79.53
167 INT2289 Gene_expression of PENK 6 203 0.78 55.62 79.49
168 INT12476 Negative_regulation of TRPV1 1 124 0.59 47.95 77.98
169 INT2155 Negative_regulation of Sst 3 111 0.59 16.58 77.74
170 INT4358 Positive_regulation of Localization of Avp 3 195 0.70 30.79 77.58
171 INT29708 Gene_expression of Gria1 4 177 0.78 56.36 77.37
172 INT1335 Negative_regulation of Oprl1 2 123 0.59 18.02 77.13
173 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
174 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
175 INT1353 Negative_regulation of Localization of Acot1 6 153 0.53 15.05 75.17
176 INT12536 Localization of Prkcg 6 101 0.80 36.37 73.81
177 INT10274 Positive_regulation of Il1b 5 123 0.70 79.76 73.56
178 INT7028 Localization of Pdyn 6 90 0.81 8.89 73.54
179 INT63936 Positive_regulation of Phosphorylation of Ephb1 2 131 0.70 49.38 73.16
180 INT9236 Regulation of Gene_expression of TNF 2 204 0.62 162.66 72.99
181 INT4153 Binding of Insrr 3 109 0.40 17.99 72.15
182 INT31774 Positive_regulation of Vta1 2 67 0.44 14.52 71.79
183 INT49111 Negative_regulation of Prkaca 4 102 0.59 27.44 71.77
184 INT8962 Gene_expression of Cpe 1 110 0.71 39.67 71.67
185 INT57380 Phosphorylation of Creb1 2 213 0.82 66.8 71.26
186 INT6490 Negative_regulation of ADCY1 10 145 0.58 26.25 70.96
187 INT5843 Positive_regulation of Gfap 4 184 0.70 108.2 70.21
188 INT8346 Gene_expression of Qrfp 1 136 0.70 19.49 70.21
189 INT1376 Binding of Trh 2 121 0.48 20 69.86
190 INT1377 Positive_regulation of Trh 9 172 0.70 40.55 69.83
191 INT53964 Negative_regulation of Prkaca 2 131 0.58 38.76 69.52
192 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
193 INT9484 Gene_expression of Jun 8 175 0.78 34.89 68.54
194 INT39777 Regulation of Prkcg 2 90 0.62 31.52 68.17
195 INT5861 Gene_expression of Egr1 2 203 0.78 49.35 68.13
196 INT7134 Localization of KNG1 6 127 0.79 65.73 67.97
197 INT4637 Binding of Adarb1 2 132 0.41 14.48 67.76
198 INT19511 Localization of Il6 8 212 0.81 118.17 67.67
199 INT7468 Negative_regulation of Localization of Oxt 1 109 0.59 9.46 66.79
200 INT6824 Regulation of Gene_expression of Pdyn 1 114 0.62 9.48 66.73
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