J:J. Pharmacol. Exp. Ther.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 1 0.54 5.93 32.4
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 1 0.51 0 15.49
3 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 1 0.64 2.12 14.2
4 INT106676 Binding of Trpv1 and Phax 18 1 0.34 4.19 12.36
5 INT9546 Binding of Adarb1 and Penk 5 1 0.03 0 5.1
6 INT64756 oh Negative_regulation of Gpi1 1 7 0.03 0 4.09
7 INT34220 Binding of POMC and Oprl1 4 1 0.01 0.25 4.05
8 INT127128 Binding of CNR1 and CNR2 8 1 0.39 3.98 3.97
9 INT82023 Binding of Ntrk1 and Ngf 5 2 0.53 3.48 3.92
10 INT107331 Binding of PPBP and Adarb1 1 3 0.01 0 3.67
11 INT73071 Binding of Cpe and Insrr 3 2 0.01 0.33 3.38
12 INT48162 RIMS3 Regulation of Localization of LTC4S 1 6 0.10 2.14 3.25
13 INT114126 Binding of APLNR and OPRL1 1 2 0.01 0.47 2.85
14 INT32656 Pomc Positive_regulation of Rbm39 1 2 0.08 0.42 2.84
15 INT114134 Penk Positive_regulation of Oprm1 2 1 0.24 1.48 2.68
16 INT30345 Pomc Regulation of Localization of Penk 3 1 0.31 0 2.61
17 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 2 0.13 1.64 2.5
18 INT113714 Em Positive_regulation of tf 1 1 0.32 0 2.5
19 INT92182 Mir702 Negative_regulation of Adk 1 3 0.07 1.29 2.47
20 INT113715 Msh3 Positive_regulation of tf 1 1 0.11 0 2.47
21 INT21520 Crh Regulation of Pomc 3 2 0.22 0.4 2.45
22 INT56726 Cpe Negative_regulation of Pomc 1 1 0.07 0 2.41
23 INT14781 Cck Regulation of Gast 3 1 0.38 0.28 2.3
24 INT76776 Binding of Pnoc and Ptprg 2 1 0.02 0 2.29
25 INT32586 H2-Ab1 Regulation of Pomc 1 1 0.03 0.14 2.19
26 INT63919 Binding of Cck and Insrr 1 1 0.01 0 2.08
27 INT64750 Binding of Oprm1 and Pck1 2 1 0.41 0.51 2.07
28 INT63918 Binding of Cck and Ripk2 1 1 0.28 0 2.07
29 INT26222 Calca Positive_regulation of Calca Regulation of Gt(pU21)50Imeg 1 1 0.01 0 2.02
30 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 1 0.01 0 2.02
31 INT32585 H2-Ab1 Negative_regulation of Pomc 1 1 0.03 0.13 2
32 INT13430 Abat Positive_regulation of Localization of Sst 2 1 0.33 0 1.94
33 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 2 0.00 0 1.94
34 INT6320 Binding of Rbm39 and Scq1 1 1 0.03 0 1.92
35 INT30146 Binding of Adarb1 and Pdyn 1 1 0.01 0.17 1.91
36 INT113572 Binding of DMRT1 and OPRM1 1 4 0.01 0 1.9
37 INT66504 Binding of Agt and Agtr1a 8 1 0.39 3.78 1.78
38 INT37840 Binding of Cyp27b1 and Oprd1 1 2 0.01 0 1.73
39 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 1 0.39 0.39 1.72
40 INT10202 Agt Positive_regulation of Avp 3 3 0.70 0 1.69
41 INT105917 Binding of SLC22A6 and SLC22A8 2 1 0.31 0.34 1.67
42 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 2 0.41 0.63 1.66
43 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 1 0.09 0.31 1.65
44 INT144213 Nppa Positive_regulation of Localization of Calca 1 3 0.71 2.8 1.65
45 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 1 0.03 0 1.63
46 INT109525 Binding of DMRT1 and Oprm1 1 2 0.08 0 1.62
47 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 1 0.02 0 1.59
48 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 2 0.37 0.78 1.56
49 INT66713 Binding of BDKRB1 and KNG1 2 1 0.22 0.39 1.53
50 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 1 1 0.04 0 1.52
51 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 1 0.03 0 1.52
52 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 1 0.08 0.22 1.51
53 INT29093 Binding of H2-Ab1 and Rbm39 1 1 0.06 0 1.5
54 INT76770 Binding of HTR1E and Gs 1 2 0.00 0.87 1.42
55 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 1 0.65 0 1.4
56 INT73377 Npy Regulation of Adarb1 2 1 0.03 0.15 1.38
57 INT6466 Binding of Npr1 and Oprd1 1 2 0.01 0 1.37
58 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 2 0.47 0.64 1.37
59 INT75807 Gpm6a Positive_regulation of Localization of Penk 1 1 0.04 0 1.35
60 INT19633 GNRH1 Regulation of Localization of CGA 4 1 0.44 0.82 1.33
61 INT24378 Penk Regulation of Oprl1 1 1 0.10 0 1.29
62 INT22501 Binding of Calca and Pth 1 1 0.21 0.07 1.28
63 INT105295 WAS Regulation of PTGS1 1 1 0.02 0.13 1.27
64 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 1 0.47 0.21 1.27
65 INT71989 Binding of Pdyn and Insrr 1 1 0.01 0 1.27
66 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 1 0.01 0 1.27
67 INT46853 POMC Regulation of GAST 1 1 0.11 0.07 1.26
68 INT110542 SIGMAR1 Regulation of OPRM1 1 1 0.04 0.33 1.25
69 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 1 0.04 0.33 1.25
70 INT64758 Negative_regulation of oh Negative_regulation of Gpi1 1 2 0.03 0 1.24
71 INT56881 Ppbp Regulation of Vip 1 1 0.00 0 1.22
72 INT105918 Binding of FUT1 and SLC9A3R2 1 1 0.00 0.14 1.2
73 INT3302 Penk Positive_regulation of Slc43a3 1 1 0.01 0.09 1.19
74 INT73075 Adarb1 Regulation of Fos 1 1 0.01 0.07 1.18
75 INT66488 Binding of Oprl1 and Cbm4 1 1 0.01 0 1.17
76 INT65373 Notch1 Regulation of Oprd1 1 1 0.09 0 1.16
77 INT95045 Binding of Commd3 and Oprl1 1 1 0.34 0 1.16
78 INT19535 Binding of ADRA1D and ALB 3 1 0.42 0.8 1.15
79 INT56882 Binding of YY1 and Ppbp 1 1 0.01 0 1.11
80 INT2457 Agt Positive_regulation of Localization of Avp 5 1 0.59 0.2 1.09
81 INT75806 Cyp2a5 Negative_regulation of Cyp2g1 1 1 0.48 0.08 1.09
82 INT60783 Binding of Oprd1 and Cck 1 1 0.26 0.47 1.09
83 INT21331 Binding of Adarb1 and Gm5195 1 1 0.00 0.26 1.08
84 INT121089 Binding of Oprd1 and Adarb1 2 1 0.06 0 1.07
85 INT79094 PDYN Positive_regulation of PRL 1 1 0.35 0.09 1.07
86 INT87222 Nrg1 Regulation of Oprd1 1 1 0.00 0 1.07
87 INT21329 Binding of Man2a2 and Gm5195 1 1 0.00 0.26 1.06
88 INT82024 Binding of Ngfr and Ngf 2 1 0.33 1.48 1.05
89 INT57509 Trh Negative_regulation of Adarb1 1 1 0.02 0.22 1.05
90 INT57508 Pomc Negative_regulation of Adarb1 1 1 0.01 0.22 1.05
91 INT60794 Binding of TREH and Chrna9 1 2 0.00 0 1.04
92 INT128700 BBS9 Negative_regulation of Il12a 1 1 0.47 0.76 1.03
93 INT101317 Binding of Selplg and Selp 1 4 0.02 3.72 1.01
94 INT64759 oh Positive_regulation of oh Negative_regulation of Gpi1 1 2 0.01 0 1.01
95 INT54737 PPBP Regulation of NCOR2 1 1 0.01 0.15 1.01
96 INT117311 HP Positive_regulation of Lep 1 2 0.00 1.78 1.01
97 INT21332 Binding of Drd2 and Gm5195 1 1 0.01 0.26 1
98 INT46645 Binding of Gabrg1 and Chrm5 1 1 0.29 0.09 1
99 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 1 0.01 0.66 0.99
100 INT21330 Binding of Htr1f and Gm5195 1 1 0.00 0.26 0.99
101 INT52806 CYP2E1 Positive_regulation of RYBP 1 1 0.43 0.24 0.95
102 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 1 0.27 0.58 0.94
103 INT144282 ACP1 Negative_regulation of Positive_regulation of PHOSPHO2 1 1 0.05 0.58 0.94
104 INT144285 ACP1 Negative_regulation of MAPK1 1 1 0.37 0.58 0.93
105 INT144284 ACP1 Negative_regulation of PHOSPHO2 1 1 0.05 0.58 0.93
106 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 2 0.28 0.35 0.93
107 INT118204 ST14 Regulation of YY1 1 1 0.04 0 0.93
108 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 1 0.02 0 0.93
109 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 1 0.01 0 0.91
110 INT34273 WAS Regulation of Oprd1 1 1 0.00 0 0.91
111 INT34272 WAS Positive_regulation of Oprd1 1 1 0.01 0 0.91
112 INT138862 ABCC2 Negative_regulation of ABCC4 1 1 0.63 0.24 0.9
113 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 1 0.03 0.56 0.9
114 INT59503 Binding of Oprd1 and Insrr 1 1 0.00 0 0.89
115 INT56431 Vta1 Regulation of Regulation of Oprl1 1 1 0.07 0 0.89
116 INT71408 Binding of Rvm and Nts 2 1 0.27 1.21 0.87
117 INT32898 Binding of Htr1f and Man2a2 1 1 0.03 0.16 0.87
118 INT80792 Prkcg Regulation of Oprd1 1 1 0.19 0.2 0.86
119 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 1 0.01 0 0.86
120 INT104126 STAT3 Regulation of Phospho1 1 1 0.00 0.06 0.86
121 INT128701 Ednra Regulation of EDNRB 1 1 0.17 0.58 0.84
122 INT128702 Ednra Regulation of EDNRA 1 1 0.00 0.58 0.84
123 INT29781 PDYN Negative_regulation of Npr1 1 1 0.00 0.22 0.84
124 INT80793 Prkcg Regulation of Pkm2 1 1 0.29 0.2 0.83
125 INT79617 Htr1a Positive_regulation of Localization of POMC 1 2 0.38 0 0.83
126 INT116250 Vta1 Positive_regulation of Casp3 1 1 0.01 0 0.82
127 INT144283 ACP1 Positive_regulation of ABCB1 1 1 0.63 0.6 0.81
128 INT70422 Binding of Htr1a and Adarb1 1 1 0.01 0.37 0.81
129 INT78348 Binding of GALR1 and GAL 4 1 0.41 1.47 0.8
130 INT72418 Binding of Cnr1 and Cnr2 3 1 0.42 0.07 0.79
131 INT13427 Positive_regulation of Abat Positive_regulation of Localization of Sst 1 1 0.33 0 0.79
132 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 1 0.22 0 0.79
133 INT13428 Gabrd Regulation of Localization of Sstr2 1 1 0.31 0 0.79
134 INT128180 Gna12 Regulation of Regulation of RHOA 1 1 0.00 0 0.78
135 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 1 0.45 0.39 0.78
136 INT72017 Binding of Adora2a and Ptprg 2 3 0.07 0 0.77
137 INT56895 Binding of GNRH1 and NCOR2 1 1 0.02 0 0.76
138 INT106691 Ngf Positive_regulation of SIGMAR1 1 1 0.04 0 0.74
139 INT116251 Vta1 Positive_regulation of Localization of Pdyn 1 1 0.01 0 0.74
140 INT13344 Binding of Npy and Adarb1 2 1 0.02 0.41 0.73
141 INT30838 Crh Negative_regulation of D230030E09Rik 1 1 0.17 0.1 0.73
142 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 1 0.00 0.33 0.73
143 INT61165 Binding of Pag1 and Pcyt1a 1 1 0.01 0.33 0.73
144 INT76769 Negative_regulation of Binding of HTR1E and Gs 1 1 0.00 0.44 0.72
145 INT70011 Binding of Hrh1 and Insrr 1 2 0.00 0.4 0.72
146 INT72689 Binding of Oprd1 and Ptprg 1 1 0.00 0.38 0.71
147 INT104110 Negative_regulation of Adrbk2 Negative_regulation of Oprm1 1 1 0.00 0 0.71
148 INT84605 Binding of Avp and Avp Regulation of Aqp2 1 2 0.07 0 0.7
149 INT104102 Negative_regulation of Adrbk2 Negative_regulation of Oprl1 1 1 0.06 0 0.7
150 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 1 0.24 0.49 0.7
151 INT82497 Binding of CRX and Nts 1 2 0.05 1.54 0.7
152 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 1 0.29 0.32 0.69
153 INT82022 Binding of Trib3 and Ngf 1 1 0.08 0.31 0.68
154 INT71988 Drd1a Regulation of Npr1 1 1 0.10 0 0.68
155 INT82020 Negative_regulation of Binding of Trib3 and Ngf 1 1 0.07 0.31 0.68
156 INT117677 Binding of MATN3 and OPRL1 1 1 0.26 0.07 0.68
157 INT47145 Penk Negative_regulation of Agt 1 1 0.06 0 0.66
158 INT115764 Binding of Rbm39 and Tat 1 1 0.00 0 0.66
159 INT62250 Fdft1 Regulation of Adrb1 1 1 0.00 0 0.65
160 INT107330 Binding of Adarb1 and Trh 1 1 0.01 0 0.65
161 INT115811 Binding of Slc22a6 and Mtx1 1 1 0.02 0.17 0.65
162 INT115812 Binding of Slc22a8 and Mtx1 1 1 0.08 0.17 0.65
163 INT18231 Binding of ADRA1D and HP 2 1 0.14 0.17 0.64
164 INT128599 Binding of P2rx3 and Ppip5k1 1 1 0.05 0.41 0.64
165 INT6464 Sst Regulation of Negative_regulation of Npr1 1 1 0.01 0 0.64
166 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 5 0.01 0 0.64
167 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 1 0.01 0 0.63
168 INT6465 Trh Regulation of Negative_regulation of Npr1 1 1 0.01 0 0.63
169 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 1 0.24 0.34 0.63
170 INT23555 POMC Positive_regulation of Penk 1 1 0.56 0 0.63
171 INT73381 Npy5r Positive_regulation of Positive_regulation of Npy 1 1 0.12 0 0.63
172 INT23554 POMC Positive_regulation of Localization of Penk 1 1 0.56 0 0.63
173 INT128598 Ppip5k1 Negative_regulation of P2rx3 1 1 0.05 0.49 0.62
174 INT62249 Ghrh Regulation of Adrb1 1 1 0.00 0 0.62
175 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 1 0.03 0.2 0.62
176 INT108020 Binding of Adrb1 and Clec4d 1 2 0.00 1.19 0.61
177 INT61164 Binding of Pomc and Pcyt1a 1 1 0.17 0.24 0.61
178 INT64755 Regulation of oh Negative_regulation of Gpi1 1 1 0.02 0 0.61
179 INT112869 Aap Positive_regulation of Gpt 2 1 0.26 0.75 0.6
180 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 1 0.01 0.72 0.6
181 INT114506 Hmmr Positive_regulation of Casp3 1 1 0.01 0.72 0.6
182 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 1 0.00 0.09 0.6
183 INT108018 Binding of Slc37a4 and Clec4d 1 2 0.00 1.18 0.6
184 INT77376 Tmie Negative_regulation of Mastl 1 1 0.01 0 0.59
185 INT77379 Tmie Negative_regulation of Ebp 1 1 0.03 0 0.59
186 INT32755 Binding of Gabrg1 and Abat 1 1 0.10 0 0.59
187 INT77380 Tmie Negative_regulation of Fbln5 1 1 0.01 0 0.59
188 INT73073 Binding of Cd3e and Oprk1 1 1 0.28 0.06 0.59
189 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 1 0.19 1.38 0.58
190 INT120348 Negative_regulation of Binding of DES and MYC 1 1 0.06 0.18 0.58
191 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 1 0.19 1.32 0.58
192 INT120349 Binding of BDKRB1 and DES 1 1 0.05 0.17 0.58
193 INT120350 Binding of DES and MYC 1 1 0.05 0.17 0.58
194 INT120347 Binding of KNG1 and MYC 1 1 0.21 0.17 0.58
195 INT73368 Ang1 Negative_regulation of Fabp6 1 1 0.00 0.44 0.56
196 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 1 0.00 0 0.56
197 INT117199 Rgs1 Regulation of Rgs19 1 1 0.02 0.16 0.56
198 INT108021 Binding of Pomc and Mc4r 1 2 0.00 0.97 0.55
199 INT113628 Binding of OPRD1 and RHD 1 2 0.01 0 0.54
200 INT64744 OR5D2P Negative_regulation of ADCY1 1 1 0.00 0 0.54

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 14 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 21 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 54 2431 0.81 378.96 952.2
4 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
5 INT3439 Localization of Abat 52 1017 0.78 112.39 727.06
6 INT5202 Positive_regulation of Gene_expression of Fos 3 1163 0.70 319.28 684
7 INT292 Localization of Penk 38 876 0.81 88.44 669.14
8 INT728 Positive_regulation of Penk 32 1068 0.70 186.9 636.87
9 INT797 Regulation of Penk 27 812 0.62 111.13 542.24
10 INT5228 Positive_regulation of Fos 6 934 0.70 209.8 503.87
11 INT155 Positive_regulation of Prl 24 1233 0.70 317.93 457.82
12 INT1045 Localization of LH 13 1211 0.81 87.04 456.25
13 INT443 Localization of POMC 35 1020 0.81 284.52 443.17
14 INT4758 Positive_regulation of Localization of Calca 13 557 0.70 138.55 411.04
15 INT467 Gene_expression of POMC 9 1048 0.78 332.8 394.16
16 INT1395 Negative_regulation of Penk 11 537 0.59 87.33 389.81
17 INT6056 Negative_regulation of Gene_expression of Fos 4 601 0.59 193.05 386.84
18 INT76660 Gene_expression of Trpv1 11 691 0.78 329.46 386.42
19 INT2540 Negative_regulation of Calca 16 538 0.59 172.11 384.38
20 INT18357 Gene_expression of TRPV1 18 825 0.78 307.11 382.81
21 INT6580 Negative_regulation of Ptgs1 24 929 0.59 381.53 376.26
22 INT157 Positive_regulation of Localization of Prl 21 790 0.70 104.54 374.78
23 INT287 Localization of Cck 6 518 0.81 86.84 364.04
24 INT439 Localization of Gnrh1 19 976 0.81 100.96 363.25
25 INT720 Positive_regulation of POMC 18 807 0.70 237.37 353.83
26 INT5660 Binding of Oprd1 18 477 0.48 71.86 342.06
27 INT876 Localization of Gh1 15 843 0.80 67.75 340.82
28 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
29 INT2649 Regulation of Calca 17 433 0.62 146.05 330.95
30 INT162 Regulation of Prl 16 794 0.62 165.01 322.24
31 INT5979 Gene_expression of Oprd1 19 428 0.78 75.64 320.32
32 INT34869 Negative_regulation of PTGS2 8 778 0.59 366.76 319.85
33 INT5540 Positive_regulation of Oprm1 12 344 0.70 76.77 319.71
34 INT5680 Gene_expression of Ngf 2 530 0.78 264.29 310.56
35 INT9131 Positive_regulation of Prkcg 7 431 0.70 130.8 302.41
36 INT477 Localization of Avp 34 813 0.81 131.58 300.4
37 INT161 Regulation of Localization of Prl 18 615 0.62 65.37 298.66
38 INT1352 Localization of Acot1 71 728 0.80 73.01 296.01
39 INT886 Gene_expression of Pomc 11 676 0.78 129.87 295.98
40 INT11624 Gene_expression of OPRM1 9 445 0.78 72.36 294.36
41 INT5379 Gene_expression of Fos 1 656 0.78 255.5 292.54
42 INT2365 Positive_regulation of Cck 7 354 0.70 87.8 277.41
43 INT9381 Positive_regulation of TRPV1 16 523 0.70 187.4 276.05
44 INT49750 Negative_regulation of CPOX 14 735 0.58 360.06 274.19
45 INT6852 Localization of TNF 9 883 0.81 705.95 270.84
46 INT1396 Binding of Penk 11 355 0.48 22.79 269.65
47 INT5591 Regulation of Gene_expression of Fos 2 425 0.62 129.06 265.78
48 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
49 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
50 INT2909 Positive_regulation of Abat 15 334 0.70 62.1 256.43
51 INT3948 Regulation of Cck 9 291 0.62 58.07 255.88
52 INT5501 Regulation of Oprd1 19 283 0.62 55.1 249.9
53 INT1005 Localization of Sst 7 385 0.81 26.31 244.56
54 INT738 Regulation of POMC 7 459 0.62 111.19 243.74
55 INT1902 Gene_expression of Cck 4 348 0.78 70.33 241.92
56 INT11377 Positive_regulation of Ngf 3 331 0.70 206.5 238
57 INT1562 Localization of Crh 5 499 0.81 126.74 236.68
58 INT5597 Gene_expression of Pdyn 5 433 0.78 62.97 235.47
59 INT9987 Gene_expression of Abat 11 296 0.78 95.46 226.34
60 INT6406 Binding of Oprm1 22 280 0.48 40.54 226.26
61 INT1212 Binding of Oprl1 14 312 0.48 28.6 225.15
62 INT95787 Positive_regulation of Mapk1 6 568 0.70 226.51 220.94
63 INT1308 Localization of Pomc 18 457 0.81 66.83 217.5
64 INT6293 Gene_expression of Oprm1 25 312 0.78 48.73 215.61
65 INT767 Localization of Gnrhr 8 565 0.80 106.68 214.57
66 INT4893 Gene_expression of Tacr1 4 366 0.78 129.67 213.92
67 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
68 INT48955 Gene_expression of Nos2 12 753 0.78 403.87 208.08
69 INT2651 Positive_regulation of Pomc 14 403 0.70 95.72 206.24
70 INT2391 Negative_regulation of PTGS1 16 501 0.59 207.62 205.6
71 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
72 INT11313 Positive_regulation of Il6 8 526 0.70 331.27 201.59
73 INT2211 Negative_regulation of Abat 6 267 0.59 66.51 200.98
74 INT156 Negative_regulation of Prl 8 542 0.59 131.97 192.24
75 INT528 Gene_expression of Prl 9 693 0.78 217.18 192.2
76 INT2085 Positive_regulation of LH 23 441 0.70 60.15 191.02
77 INT63934 Phosphorylation of Ephb1 5 377 0.82 150.52 188.66
78 INT6354 Localization of Gabrg1 19 321 0.74 41.41 186.74
79 INT94952 Positive_regulation of Mapk14 2 305 0.70 197.83 186.61
80 INT1652 Regulation of Pomc 8 387 0.62 61.01 186.51
81 INT24326 Gene_expression of Ngf 4 346 0.78 218.67 184.71
82 INT4803 Transcription of Penk 7 435 0.72 59.09 182.4
83 INT3440 Negative_regulation of Localization of Abat 6 221 0.57 33.94 180.36
84 INT12602 Negative_regulation of Oprm1 8 190 0.59 36.11 177.85
85 INT1429 Gene_expression of PDYN 8 308 0.78 61.33 175.65
86 INT943 Negative_regulation of Cck 10 205 0.59 38.42 174.78
87 INT26472 Regulation of Oprm1 15 191 0.62 35.84 173.1
88 INT5930 Positive_regulation of Oprm1 13 221 0.70 31.19 172.93
89 INT159 Negative_regulation of Localization of Prl 12 416 0.59 55.34 171.8
90 INT4937 Negative_regulation of Oprd1 10 224 0.59 44.51 171.11
91 INT438 Gene_expression of Crh 4 376 0.78 159.11 169.17
92 INT739 Negative_regulation of POMC 12 358 0.59 102.28 166.77
93 INT1114 Localization of Ins1 15 748 0.80 192.95 165.48
94 INT4768 Positive_regulation of OPRM1 10 212 0.70 31.09 164.28
95 INT2366 Binding of Cck 4 192 0.48 30.64 163.46
96 INT5513 Negative_regulation of Pomc 2 295 0.59 60.9 158.63
97 INT51921 Gene_expression of Cpox 21 501 0.73 229.81 157.81
98 INT21185 Binding of Ptprg 36 213 0.47 13.49 157.75
99 INT768 Positive_regulation of Oprl1 10 179 0.70 40.05 156.93
100 INT1303 Negative_regulation of Npr1 29 278 0.55 35.1 156.78
101 INT2640 Gene_expression of Pomc 7 424 0.78 120.72 155.37
102 INT6042 Binding of Oprm1 28 248 0.48 31.77 154.34
103 INT2910 Regulation of Abat 8 169 0.62 36.95 153.53
104 INT1044 Negative_regulation of Localization of LH 4 358 0.59 25.95 151.31
105 INT4829 Positive_regulation of Localization of Abat 15 199 0.55 20.91 150.48
106 INT880 Positive_regulation of Localization of Gh1 9 304 0.70 14.79 150.23
107 INT49134 Gene_expression of Grin1 3 270 0.78 84.78 148.61
108 INT5050 Regulation of Localization of Calca 3 149 0.62 41.25 148.57
109 INT6108 Gene_expression of Npy 1 292 0.78 110.65 148.21
110 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
111 INT2451 Positive_regulation of Avp 16 355 0.70 102.66 147.69
112 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
113 INT9852 Positive_regulation of Gpt 8 563 0.70 364.64 146.82
114 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
115 INT425 Localization of PRL 1 455 0.81 189.64 144.8
116 INT2379 Positive_regulation of Localization of LH 2 349 0.70 27.86 144.53
117 INT2780 Regulation of Gene_expression of Penk 9 265 0.62 32.45 143.88
118 INT1414 Regulation of Oprl1 12 169 0.62 32.05 139.99
119 INT1273 Gene_expression of Avp 6 356 0.78 90.56 138.7
120 INT5061 Negative_regulation of Mme 14 306 0.59 51.97 136.9
121 INT4658 Binding of OPRM1 7 188 0.48 25.96 136.24
122 INT1047 Negative_regulation of LH 9 314 0.59 53.71 135.89
123 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
124 INT48953 Positive_regulation of Nos2 13 486 0.70 239.85 131.87
125 INT5497 Positive_regulation of Crh 8 299 0.70 125.54 131.14
126 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
127 INT5595 Positive_regulation of Pdyn 1 223 0.70 48.37 130.14
128 INT64161 Positive_regulation of Prkca 2 213 0.70 85.06 129.91
129 INT115386 Gene_expression of Ppara 3 779 0.77 549.99 128.36
130 INT1614 Gene_expression of Oprl1 6 164 0.78 31.43 127.74
131 INT695 Binding of POMC 5 304 0.48 56.66 126.85
132 INT65054 Positive_regulation of Nfkb1 2 285 0.70 149.33 126.73
133 INT5931 Regulation of Oprm1 9 149 0.62 18.15 125.93
134 INT416 Regulation of LH 15 253 0.62 31.48 125.55
135 INT5008 Localization of Calca 2 204 0.81 80.35 125.16
136 INT6323 Positive_regulation of Gabrg1 7 213 0.70 45.08 124.34
137 INT4824 Positive_regulation of Tacr1 3 169 0.70 66.1 123.46
138 INT4259 Positive_regulation of Npr1 18 262 0.70 49.37 123.11
139 INT2106 Regulation of Localization of LH 4 279 0.62 22.37 122.77
140 INT6128 Positive_regulation of Localization of POMC 7 256 0.70 68.77 121.64
141 INT14151 Gene_expression of Casp3 5 311 0.78 140.26 120.68
142 INT218 Positive_regulation of Th 7 245 0.70 40.5 120.1
143 INT2555 Positive_regulation of Localization of Penk 10 116 0.70 24.35 119.73
144 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
145 INT12501 Positive_regulation of Adarb1 8 166 0.58 36.94 118.92
146 INT5010 Gene_expression of Calca 6 197 0.78 85.76 118.75
147 INT7341 Positive_regulation of Grin1 3 169 0.70 65.86 118.38
148 INT7395 Localization of GNRH1 2 399 0.81 62.88 117.68
149 INT12339 Localization of IL8 2 437 0.81 251.87 117.39
150 INT92669 Gene_expression of Bdnf 3 309 0.78 178.26 116.68
151 INT1438 Localization of Pomc 4 360 0.81 101.26 116.47
152 INT4207 Regulation of Avp 16 267 0.62 63.72 115.33
153 INT1793 Localization of CGA 9 379 0.81 67.38 114.69
154 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
155 INT16253 Positive_regulation of Gene_expression of Bdnf 2 196 0.70 92.67 113.01
156 INT90 Localization of Gast 1 400 0.81 137.67 113
157 INT49651 Gene_expression of Creb1 3 276 0.78 114.77 111.96
158 INT7327 Regulation of Th 1 164 0.62 29.67 110.14
159 INT65731 Gene_expression of Cnr1 1 234 0.78 63.82 109.34
160 INT5283 Positive_regulation of Npy 2 191 0.70 66.77 109.2
161 INT27096 Positive_regulation of Nfkb1 14 325 0.70 195.11 109.06
162 INT47243 Gene_expression of Prkcg 5 195 0.78 58.05 108.44
163 INT4936 Localization of Tacr1 10 125 0.80 35.7 107.7
164 INT9012 Localization of Vip 6 283 0.81 31.71 106.16
165 INT12569 Localization of Oprd1 2 94 0.81 23.81 104.56
166 INT915 Positive_regulation of PRL 9 342 0.70 141.96 104.31
167 INT114 Binding of Oprl1 20 139 0.48 23 103.35
168 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
169 INT4742 Gene_expression of Tac1 2 177 0.78 69.99 102.66
170 INT1898 Regulation of Crh 9 220 0.62 61.33 102.64
171 INT89054 Positive_regulation of Gene_expression of Trpv1 2 156 0.70 90.78 102.03
172 INT5906 Negative_regulation of Oprm1 9 125 0.59 19.58 101.57
173 INT5940 Negative_regulation of Avp 23 236 0.59 67.86 101.2
174 INT5587 Regulation of Fos 1 191 0.62 40.81 99.7
175 INT2159 Regulation of Localization of Gnrh1 5 200 0.62 13.28 99.07
176 INT1351 Gene_expression of Pag1 1 131 0.57 89.48 98.76
177 INT293 Protein_catabolism of Penk 18 161 1.00 11.71 98.45
178 INT7944 Positive_regulation of Fos 3 193 0.70 60.69 98.31
179 INT874 Positive_regulation of Gh1 6 244 0.70 27.17 97.98
180 INT1004 Regulation of Sst 5 140 0.62 18.52 94.84
181 INT29971 Gene_expression of Oprk1 9 126 0.78 35.32 93.97
182 INT18755 Positive_regulation of Rvm 3 79 0.60 60 92.93
183 INT203 Positive_regulation of Pomc 4 257 0.70 90.56 92.84
184 INT81417 Gene_expression of PAG1 1 94 0.58 90.85 92.79
185 INT2122 Negative_regulation of Localization of Gnrh1 5 226 0.59 26.92 92.04
186 INT69764 Positive_regulation of Cnr1 2 126 0.70 67.8 91.49
187 INT214 Localization of AVP 4 370 0.81 208.51 91.09
188 INT9516 Negative_regulation of Gabrg1 4 149 0.53 27.83 91.02
189 INT38731 Localization of Trpv1 5 138 0.81 52.73 90.49
190 INT6437 Binding of YY1 5 154 0.47 26.3 90.46
191 INT1639 Negative_regulation of OPRM1 9 107 0.59 13.86 90.37
192 INT48767 Negative_regulation of NOS1 5 312 0.59 154.25 90.32
193 INT1160 Positive_regulation of Rbm39 20 122 0.57 28.19 90.28
194 INT6585 Positive_regulation of Insrr 11 110 0.52 40.67 89.9
195 INT74376 Gene_expression of Cnr1 2 173 0.78 73.43 89.7
196 INT18032 Positive_regulation of Oprk1 6 108 0.70 30.78 89.7
197 INT6214 Negative_regulation of Adarb1 7 123 0.50 26.39 89.57
198 INT96917 Positive_regulation of Mapk14 2 261 0.70 173.29 88.79
199 INT10166 Localization of Tnf 7 237 0.81 153.95 88.64
200 INT3441 Regulation of Localization of Abat 6 117 0.38 8.67 87.59
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