J:J. Physiol. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT117871 Sct Positive_regulation of Pes1 1 2 0.10 0 1.36
2 INT117870 Positive_regulation of Sct Positive_regulation of Pes1 1 1 0.09 0 0.71
3 INT117872 Negative_regulation of Sct Positive_regulation of Pes1 1 1 0.10 0 0.66
4 INT167983 Mapk8 Negative_regulation of gr 1 1 0.02 0.5 0.31
5 INT167982 Mapk14 Negative_regulation of gr 1 1 0.02 0.45 0.29
6 INT117857 Mln Positive_regulation of Localization of Gnrhr 1 1 0.14 0 0.12
7 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 1 0.45 0.1 0.09
8 INT123866 Lep Negative_regulation of Olfr544 1 1 0.00 0.09 0.08
9 INT158391 Oxt Positive_regulation of Localization of Nppa 2 1 0.27 0.64 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 2 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 6 2008 0.81 518.3 1408.65
3 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
4 INT292 Localization of Penk 1 876 0.81 88.44 669.14
5 INT4758 Positive_regulation of Localization of Calca 2 557 0.70 138.55 411.04
6 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
7 INT6580 Negative_regulation of Ptgs1 5 929 0.59 381.53 376.26
8 INT287 Localization of Cck 4 518 0.81 86.84 364.04
9 INT876 Localization of Gh1 2 843 0.80 67.75 340.82
10 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
11 INT477 Localization of Avp 6 813 0.81 131.58 300.4
12 INT3579 Localization of Oxt 3 555 0.81 43.35 292.44
13 INT9158 Gene_expression of Tnf 8 722 0.78 522.01 277.68
14 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
15 INT1902 Gene_expression of Cck 1 348 0.78 70.33 241.92
16 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
17 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
18 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
19 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
20 INT48955 Gene_expression of Nos2 7 753 0.78 403.87 208.08
21 INT2391 Negative_regulation of PTGS1 9 501 0.59 207.62 205.6
22 INT50670 Gene_expression of CPOX 3 763 0.76 442.13 195.02
23 INT63934 Phosphorylation of Ephb1 2 377 0.82 150.52 188.66
24 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
25 INT5127 Localization of Lhb 6 488 0.80 50.48 162.66
26 INT51921 Gene_expression of Cpox 13 501 0.73 229.81 157.81
27 INT13353 Positive_regulation of Tnf 5 332 0.70 248.75 148.1
28 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
29 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
30 INT14151 Gene_expression of Casp3 2 311 0.78 140.26 120.68
31 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
32 INT48923 Gene_expression of Ephb1 2 211 0.77 106.23 109.9
33 INT8413 Gene_expression of Ptgs1 4 248 0.78 110.17 108.58
34 INT10272 Gene_expression of Il1b 2 194 0.78 121.02 103.03
35 INT97701 Phosphorylation of Mapk14 1 191 0.82 115.33 100.46
36 INT293 Protein_catabolism of Penk 1 161 1.00 11.71 98.45
37 INT4860 Positive_regulation of CALCA 1 148 0.00 73.35 97.61
38 INT2862 Positive_regulation of Localization of Cck 1 108 0.70 20.75 94.25
39 INT94953 Negative_regulation of Mapk14 3 156 0.59 104.77 91.51
40 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
41 INT7885 Positive_regulation of Localization of Oxt 2 160 0.70 14.36 87.7
42 INT875 Regulation of Localization of Gh1 1 166 0.62 12.87 84.97
43 INT5617 Localization of Nppa 2 266 0.81 83.51 83.89
44 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
45 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
46 INT64636 Positive_regulation of Gene_expression of Nos2 2 242 0.70 147.52 79.53
47 INT2431 Positive_regulation of Mpo 2 275 0.70 211.99 78.47
48 INT4358 Positive_regulation of Localization of Avp 4 195 0.70 30.79 77.58
49 INT15769 Gene_expression of Il1b 4 146 0.78 114.51 75.35
50 INT10274 Positive_regulation of Il1b 3 123 0.70 79.76 73.56
51 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
52 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
53 INT5941 Gene_expression of Oxt 1 164 0.76 22.63 65.47
54 INT9196 Gene_expression of PTGS1 2 215 0.77 96.99 60.5
55 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
56 INT770 Regulation of Localization of Gnrhr 1 127 0.61 17.91 58.23
57 INT2148 Negative_regulation of Oxt 2 105 0.59 11.42 57
58 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
59 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
60 INT5759 Positive_regulation of Ptgs1 8 127 0.69 53.45 53.04
61 INT49017 Negative_regulation of Gene_expression of Nos2 1 169 0.59 80.64 52.67
62 INT6299 Regulation of Localization of Lhb 2 104 0.61 8.98 48.79
63 INT5025 Positive_regulation of Gene_expression of Cck 1 63 0.70 10.96 47.11
64 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
65 INT89 Positive_regulation of Gast 5 187 0.70 80.49 42.07
66 INT2364 Localization of Sct 9 134 0.80 26.21 41.47
67 INT50673 Positive_regulation of Gene_expression of CPOX 2 156 0.54 97.31 37.03
68 INT5620 Positive_regulation of Localization of Nppa 1 105 0.70 30.23 36.45
69 INT95734 Phosphorylation of Mapk8 3 108 0.82 49.92 33.52
70 INT7082 Gene_expression of CRH 2 180 0.78 64.66 31.74
71 INT117112 Negative_regulation of Mapk1 2 87 0.56 40.34 31.18
72 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
73 INT28 Regulation of Gast 1 106 0.62 26.37 29.85
74 INT57692 Positive_regulation of Gene_expression of Il1b 2 50 0.67 43.54 28.29
75 INT65537 Positive_regulation of Positive_regulation of Nfkb1 1 52 0.67 30.6 26.35
76 INT53949 Positive_regulation of Gene_expression of Cpox 4 82 0.65 38.12 25.93
77 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
78 INT122570 Negative_regulation of Akt1 1 173 0.59 91.44 25.53
79 INT61953 Transcription of Nos2 4 101 0.72 46.64 25.49
80 INT288 Positive_regulation of Sct 1 88 0.70 32.83 24.5
81 INT6441 Positive_regulation of CRH 1 98 0.69 57.22 24.12
82 INT58301 Positive_regulation of Mpo 1 87 0.70 80.19 23.99
83 INT51029 Negative_regulation of Il1b 1 34 0.57 29.34 23.62
84 INT76123 Gene_expression of Lep 7 193 0.78 94.17 22.76
85 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
86 INT99068 Gene_expression of Mapk8 2 62 0.78 33.57 21.25
87 INT28216 Gene_expression of HRAS 1 173 0.75 93.97 20.78
88 INT7561 Positive_regulation of gr 2 70 0.57 31.92 20.22
89 INT66755 Transcription of Tnf 2 45 0.72 37.1 19.11
90 INT81194 Binding of CPOX 1 40 0.29 23.7 18.95
91 INT109316 Negative_regulation of Mapk8 1 72 0.59 50.59 17.24
92 INT104493 Negative_regulation of Mapk8 1 56 0.53 27.76 16.86
93 INT61949 Regulation of Nos2 1 74 0.58 34.08 16.7
94 INT108588 Gene_expression of CASP3 2 126 0.78 84.49 16.2
95 INT69769 Positive_regulation of Pscs 1 61 0.56 39.32 15.93
96 INT124371 Negative_regulation of Gsk3b 1 170 0.55 87.92 15.51
97 INT61893 Gene_expression of Ghrl 7 125 0.75 71.49 15.14
98 INT2490 Regulation of Sct 2 44 0.62 9.45 13.11
99 INT14764 Negative_regulation of Localization of Nppa 1 28 0.59 11.29 12.82
100 INT48927 Regulation of Mapk3 1 25 0.60 14.06 12.82
101 INT84307 Binding of Cftr 2 31 0.47 26.19 12.8
102 INT58226 Negative_regulation of Gene_expression of Il1b 3 24 0.57 18.09 12.68
103 INT73641 Regulation of Lep 2 45 0.62 26.2 12.59
104 INT5452 Regulation of CRH 2 56 0.62 15.32 12.42
105 INT3173 Negative_regulation of Localization of Sct 2 28 0.55 6.46 12.11
106 INT60590 Positive_regulation of Gbf1 5 25 0.39 12.5 11.79
107 INT53038 Positive_regulation of Agtr1a 1 35 0.67 23.76 11.68
108 INT13743 Regulation of Gene_expression of Avp 1 30 0.62 6.9 11.66
109 INT14513 Localization of Ghrl 2 52 0.78 29.26 11.63
110 INT686 Negative_regulation of Sct 2 35 0.59 9.59 11.32
111 INT8065 Binding of AGT 1 54 0.48 20.54 10.85
112 INT53201 Negative_regulation of gr 4 35 0.50 17.76 10.62
113 INT50196 Transcription of Il1b 2 25 0.69 19.08 10.43
114 INT48921 Regulation of Mapk1 1 25 0.49 19.51 10.41
115 INT75137 Regulation of Akt1 1 74 0.48 37.89 9.7
116 INT107291 Positive_regulation of Ghrl 2 58 0.67 44.6 9.68
117 INT70850 Positive_regulation of Transcription of Nos2 2 30 0.70 18.95 9.68
118 INT82078 Negative_regulation of Lep 4 54 0.59 20.47 9.38
119 INT37896 Positive_regulation of Gene_expression of PTGS1 1 37 0.67 17.28 9.27
120 INT33220 Negative_regulation of ras 2 110 0.58 70.21 9.19
121 INT5939 Regulation of Gene_expression of Oxt 1 27 0.51 2.84 9.1
122 INT26751 Regulation of Nr3c1 1 13 0.61 6.58 8.65
123 INT82082 Localization of Lep 5 63 0.81 26.41 8.56
124 INT76427 Regulation of Negative_regulation of Cpox 1 17 0.31 6.75 7.93
125 INT53491 Negative_regulation of Jun 1 28 0.57 14.2 6.9
126 INT98310 Regulation of gr 3 21 0.39 15.04 6.68
127 INT93061 Binding of gr 1 31 0.48 10.93 6.45
128 INT16359 Positive_regulation of Gene_expression of AGT 1 30 0.49 28.27 6.14
129 INT52813 Regulation of Localization of CALCA 1 8 0.62 3.16 5.89
130 INT12564 Localization of Pthlh 1 23 0.81 4.37 5.82
131 INT86119 Regulation of Cftr 1 13 0.45 14.08 5.75
132 INT117855 Negative_regulation of Ghrl 2 29 0.57 17.52 5
133 INT3172 Regulation of Localization of Sct 5 9 0.57 1.08 4.99
134 INT61950 Regulation of Positive_regulation of Nos2 1 17 0.43 9.01 4.87
135 INT55114 Gene_expression of CRS 1 42 0.58 26.86 4.69
136 INT78995 Negative_regulation of Agtr2 1 26 0.42 13.05 4.56
137 INT89784 Regulation of Transcription of Nos2 1 14 0.42 8.39 4.24
138 INT7560 Transcription of gr 1 14 0.69 4.21 4.09
139 INT72936 Gene_expression of Pparg 5 39 0.77 19.01 4.02
140 INT62497 Binding of Il4 1 7 0.26 4.19 3.88
141 INT141285 Positive_regulation of Localization of Ghrl 1 11 0.63 9.38 3.86
142 INT132317 Positive_regulation of Gene_expression of Ghrl 3 20 0.49 21 3.57
143 INT135373 Regulation of Gsk3b 1 35 0.62 18.11 3.53
144 INT16966 Positive_regulation of CRS 5 23 0.60 22.5 3.49
145 INT3183 Negative_regulation of MRXS5 1 15 0.41 6.56 3.45
146 INT16969 Negative_regulation of CRS 1 28 0.37 14.77 3.35
147 INT58302 Regulation of Mpo 1 13 0.62 11.14 3.04
148 INT133085 Gene_expression of Mapk8ip1 1 7 0.66 6.13 2.98
149 INT22875 Regulation of CRS 1 16 0.39 14.33 2.69
150 INT95739 Negative_regulation of Phosphorylation of Mapk8 1 11 0.42 6.77 2.61
151 INT97398 Localization of gr 1 12 0.36 6.88 2.59
152 INT74306 Negative_regulation of Pik3cd 1 7 0.24 1.93 2.27
153 INT53202 Negative_regulation of Positive_regulation of gr 1 6 0.46 2.35 2.27
154 INT18360 Regulation of MRXS5 1 11 0.32 7.07 2.17
155 INT12565 Regulation of Localization of Pthlh 1 10 0.62 0.71 2.14
156 INT23748 Localization of Ltf 1 15 0.79 5.43 2.07
157 INT7562 Positive_regulation of Transcription of gr 1 8 0.48 2.47 1.97
158 INT60588 Negative_regulation of Positive_regulation of Gbf1 1 3 0.36 0.67 1.87
159 INT26750 Positive_regulation of Nr3c1 1 6 0.46 5.46 1.75
160 INT117438 Positive_regulation of Gene_expression of Pparg 1 11 0.69 8 1.63
161 INT139546 Gene_expression of URI1 1 3 0.75 3 1.49
162 INT117858 Positive_regulation of Pes1 2 4 0.19 0.09 1.48
163 INT159784 Gene_expression of Mapk9 1 8 0.61 6.28 1.37
164 INT143646 Negative_regulation of Mapk8ip1 2 5 0.03 5.46 1.28
165 INT117862 Negative_regulation of Pes1 1 2 0.15 0.28 1.27
166 INT112028 Regulation of Pik3cd 1 2 0.19 0.22 1.25
167 INT161750 Transcription of Ghrl 2 14 0.67 7.05 1.23
168 INT65275 Regulation of Fetub 1 3 0.23 3.08 1.13
169 INT51583 Gene_expression of Gbf1 1 5 0.24 2.3 1.11
170 INT140054 Negative_regulation of Mapk9 1 3 0.25 1.9 1.05
171 INT96320 Negative_regulation of Transcription of gr 1 3 0.41 1.38 1.05
172 INT117863 Localization of Ppdpf 2 1 0.02 0 1.01
173 INT94514 Localization of COX5A 1 3 0.78 0.54 0.9
174 INT161754 Transcription of Ppara 1 10 0.52 4.06 0.84
175 INT161751 Positive_regulation of Transcription of Ghrl 2 3 0.49 3.89 0.81
176 INT117864 Negative_regulation of Localization of Ppdpf 1 1 0.01 0 0.72
177 INT103886 Negative_regulation of Negative_regulation of Agtr2 1 5 0.31 2.16 0.71
178 INT117861 Positive_regulation of Localization of Ppdpf 1 1 0.01 0 0.71
179 INT117859 Localization of Pes1 1 1 0.13 0 0.7
180 INT117866 Positive_regulation of Ppdpf 1 1 0.01 0 0.7
181 INT166886 Negative_regulation of Gene_expression of Ghrl 1 3 0.41 4.11 0.66
182 INT151661 Regulation of Negative_regulation of gr 2 1 0.39 0.13 0.66
183 INT126543 Gene_expression of Nsfl1c 1 2 0.75 1.69 0.64
184 INT151663 Regulation of Gsk3a 1 3 0.16 1.03 0.54
185 INT158946 Negative_regulation of Pparg 1 3 0.43 1.53 0.51
186 INT167975 Negative_regulation of Gene_expression of Mapk9 1 2 0.02 1.18 0.47
187 INT167980 Regulation of Regulation of Mapk3 1 1 0.07 0.92 0.45
188 INT167981 Negative_regulation of Negative_regulation of Mapk8ip1 1 1 0.01 0.91 0.45
189 INT122364 Gene_expression of UCN 1 5 0.65 2.79 0.44
190 INT139547 Regulation of Itbq1 1 2 0.09 0.4 0.44
191 INT151662 Negative_regulation of Gsk3a 1 3 0.15 0.55 0.37
192 INT117865 Regulation of Localization of Ppdpf 1 1 0.01 0 0.32
193 INT117860 Regulation of Ppdpf 1 1 0.01 0 0.32
194 INT166885 Negative_regulation of Gene_expression of Pparg 1 5 0.41 2.6 0.26
195 INT117878 Positive_regulation of Regulation of Nos2 1 3 0.41 1.35 0.25
196 INT167972 Positive_regulation of Regulation of gr 1 1 0.03 0.77 0.21
197 INT151660 Regulation of Positive_regulation of gr 1 1 0.39 0.1 0.2
198 INT151659 Regulation of Positive_regulation of Nr3c1 1 1 0.03 0.1 0.2
199 INT161753 Regulation of Gene_expression of Pparg 1 2 0.35 1.28 0.19
200 INT161752 Regulation of Transcription of Ppara 1 1 0.03 0.94 0.19
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