J:J. Rheumatol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT130721 Binding of IL1B and IL1RN 6 1 0.05 5.29 2.85
2 INT51051 IL1B Positive_regulation of Localization of IL6 7 1 0.57 3.79 1.87
3 INT100274 IL1RN Negative_regulation of IL1B 5 4 0.53 1.79 1.65
4 INT130722 Binding of IL1B and Nfkb1 1 2 0.28 1.23 0.95
5 INT130725 Binding of IL1B and Il1rn 1 2 0.01 1.16 0.93
6 INT38057 Binding of Crp and Esr1 2 1 0.04 1.21 0.65
7 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 1 0.19 1.4 0.63
8 INT130726 Negative_regulation of Binding of IL1B and Il1rn 1 1 0.01 0.6 0.48
9 INT130723 Binding of IL1A and Il1rn 1 1 0.01 0.59 0.47
10 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 1 0.01 0.59 0.47
11 INT146699 Nfkb1 Regulation of Gene_expression of TNF 1 1 0.20 0.72 0.27
12 INT146697 REL Regulation of Gene_expression of TNF 1 1 0.29 0.72 0.26
13 INT146701 Nfkb1 Regulation of Gene_expression of TNF 1 1 0.02 0.72 0.26
14 INT66035 FOLR2 Negative_regulation of Il1a 1 1 0.00 0.56 0.18
15 INT66036 FOLR2 Negative_regulation of Tnf 1 1 0.00 0.56 0.18
16 INT66030 FOLR2 Negative_regulation of IL1B 1 1 0.00 0.56 0.18
17 INT66033 FOLR2 Negative_regulation of Tnf 1 1 0.00 0.56 0.18
18 INT153347 Binding of TLR4 and Cd14 1 1 0.10 0.17 0.17
19 INT42914 Tslp Regulation of thf 1 1 0.04 0.17 0.17
20 INT88238 HLA-B Regulation of Gene_expression of Gbp1 1 1 0.03 0.27 0.1
21 INT98925 Penk Negative_regulation of Gene_expression of IL1B 1 2 0.36 0.32 0
22 INT74217 Oprl1 Negative_regulation of Positive_regulation of Icam1 1 1 0.18 0.11 0
23 INT146700 TNF Regulation of Positive_regulation of Nfkb1 1 1 0.37 0.11 0
24 INT98924 Penk Negative_regulation of Gene_expression of TNF 1 2 0.02 0.32 0
25 INT90819 Binding of HLA-B and MICA 1 1 0.05 0 0
26 INT66034 FOLR2 Negative_regulation of Gene_expression of Il1a 1 1 0.00 0.18 0
27 INT92318 CALCA Positive_regulation of Localization of IL6 1 1 0.26 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
4 INT6483 Gene_expression of TNF 16 3152 0.78 2515.62 929.82
5 INT5202 Positive_regulation of Gene_expression of Fos 1 1163 0.70 319.28 684
6 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
7 INT5228 Positive_regulation of Fos 1 934 0.70 209.8 503.87
8 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
9 INT443 Localization of POMC 4 1020 0.81 284.52 443.17
10 INT9238 Gene_expression of IL6 17 1575 0.78 1135.66 424.22
11 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
12 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
13 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
14 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
15 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
16 INT5235 Negative_regulation of TNF 4 924 0.59 772.91 331.98
17 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
18 INT5059 Positive_regulation of TNF 7 1050 0.70 896.51 322.81
19 INT162 Regulation of Prl 2 794 0.62 165.01 322.24
20 INT9158 Gene_expression of Tnf 2 722 0.78 522.01 277.68
21 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
22 INT10832 Gene_expression of IL8 5 1050 0.78 698.72 270
23 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
24 INT5972 Gene_expression of IL1B 48 948 0.78 510.91 263.97
25 INT1893 Localization of Gh 1 1041 0.79 340.23 256.58
26 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
27 INT11377 Positive_regulation of Ngf 2 331 0.70 206.5 238
28 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
29 INT11009 Phosphorylation of Creb1 1 458 0.82 111.34 221.97
30 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
31 INT6293 Gene_expression of Oprm1 1 312 0.78 48.73 215.61
32 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
33 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
34 INT798 Positive_regulation of Gene_expression of Penk 1 394 0.70 78.53 203.07
35 INT528 Gene_expression of Prl 2 693 0.78 217.18 192.2
36 INT19472 Gene_expression of Il1 6 554 0.76 419.75 175.35
37 INT15516 Gene_expression of Crp 3 711 0.77 615.33 173.09
38 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
39 INT2640 Gene_expression of Pomc 3 424 0.78 120.72 155.37
40 INT15515 Positive_regulation of Crp 11 700 0.70 604.24 150.15
41 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
42 INT5116 Gene_expression of IL2 5 670 0.78 291.13 146.69
43 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
44 INT48895 Gene_expression of Il10 6 333 0.78 221.2 138.52
45 INT5497 Positive_regulation of Crh 2 299 0.70 125.54 131.14
46 INT1878 Binding of HLA-B 28 440 0.48 321.16 127.36
47 INT65054 Positive_regulation of Nfkb1 12 285 0.70 149.33 126.73
48 INT5008 Localization of Calca 9 204 0.81 80.35 125.16
49 INT6128 Positive_regulation of Localization of POMC 4 256 0.70 68.77 121.64
50 INT5010 Gene_expression of Calca 3 197 0.78 85.76 118.75
51 INT9235 Negative_regulation of Gene_expression of TNF 5 346 0.59 252.98 118.61
52 INT50674 Gene_expression of PTGS2 3 459 0.78 253.33 118.51
53 INT62124 Gene_expression of NOS1 2 444 0.78 218.08 114.85
54 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
55 INT1530 Regulation of Gh 2 382 0.61 115.96 112.47
56 INT11051 Positive_regulation of Gene_expression of IL6 4 415 0.69 319.21 109.3
57 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
58 INT12082 Localization of IL6 9 365 0.81 241.78 105.78
59 INT11381 Positive_regulation of IL1B 7 330 0.70 209.31 100.9
60 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
61 INT48406 Gene_expression of Icam1 9 277 0.78 238.28 81.71
62 INT749 Gene_expression of HLA-B 23 341 0.75 224.12 77.37
63 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
64 INT9236 Regulation of Gene_expression of TNF 4 204 0.62 162.66 72.99
65 INT11380 Negative_regulation of IL1B 21 215 0.59 125.62 72.35
66 INT6656 Gene_expression of YY1 1 135 0.75 24.73 72.16
67 INT5969 Gene_expression of Il1a 3 221 0.75 96.31 71.38
68 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
69 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
70 INT10837 Positive_regulation of Gene_expression of IL8 3 294 0.70 190.08 70.34
71 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
72 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
73 INT13286 Gene_expression of Ca2 1 317 0.67 71.58 65.01
74 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
75 INT17401 Gene_expression of IGF1 1 475 0.78 232.18 62.07
76 INT6477 Gene_expression of IL1RN 7 213 0.77 114.69 58.62
77 INT48901 Negative_regulation of IL6 2 186 0.57 136.33 57.87
78 INT9408 Positive_regulation of Crp 3 296 0.69 242.27 57.35
79 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
80 INT52800 Negative_regulation of Gene_expression of Tnf 1 142 0.59 92.27 55.47
81 INT9234 Negative_regulation of Gene_expression of IL6 5 171 0.59 101.61 53.15
82 INT97674 Positive_regulation of Localization of Calca 2 70 0.69 27.71 51.79
83 INT6473 Positive_regulation of Gene_expression of IL1B 9 204 0.70 117.23 50.86
84 INT9210 Regulation of IL6 2 166 0.62 125.61 49.95
85 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
86 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
87 INT16364 Gene_expression of HLA-DRA 1 234 0.78 118.81 45.01
88 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
89 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
90 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
91 INT3933 Positive_regulation of PLOD1 2 128 0.70 30.76 42.03
92 INT9233 Negative_regulation of Gene_expression of IL1B 21 114 0.59 56.99 41.82
93 INT29496 Gene_expression of MMP3 5 136 0.75 49.49 41.78
94 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
95 INT11939 Negative_regulation of Il6 2 138 0.59 87.46 41.24
96 INT28265 Positive_regulation of Calca 1 62 0.70 29.1 41.17
97 INT5793 Binding of CTS 1 110 0.48 63.91 40.62
98 INT52732 Negative_regulation of CRP 3 169 0.59 138.47 40.33
99 INT5973 Regulation of IL1B 4 109 0.62 66.6 39.88
100 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
101 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
102 INT63349 Gene_expression of PECAM1 2 199 0.75 166.03 36.76
103 INT12892 Negative_regulation of TIMP1 1 136 0.58 83.13 36.54
104 INT9239 Regulation of Gene_expression of IL6 6 106 0.61 75.24 36.53
105 INT12029 Gene_expression of Car1 1 143 0.67 29.69 36.39
106 INT51017 Positive_regulation of Icam1 2 113 0.70 81.16 35.55
107 INT59466 Gene_expression of ISYNA1 5 204 0.77 112.57 35.48
108 INT6484 Binding of IL1B 3 122 0.47 75.84 35.07
109 INT79060 Gene_expression of NOS2 4 116 0.78 69.25 34.84
110 INT6105 Positive_regulation of IL2 1 133 0.69 82.76 34.67
111 INT11013 Negative_regulation of Phosphorylation of Creb1 1 55 0.59 18.74 34.66
112 INT16960 Gene_expression of Crp 2 166 0.76 116.21 34.07
113 INT49214 Gene_expression of Cd4 2 269 0.78 154.22 34.05
114 INT11325 Gene_expression of HLA-E 2 209 0.76 98.05 33.72
115 INT93534 Gene_expression of Tnfsf11 6 185 0.77 119.26 33.66
116 INT65536 Negative_regulation of Positive_regulation of Nfkb1 1 77 0.59 38.86 33.33
117 INT10763 Localization of IL2 5 157 0.80 81.11 33.21
118 INT10248 Gene_expression of KRT20 4 436 0.78 231.96 32.88
119 INT81530 Gene_expression of Nfkb1 1 93 0.78 48.58 32.58
120 INT10915 Gene_expression of ITGAM 1 164 0.78 92.42 29.78
121 INT50230 Positive_regulation of Localization of IL6 1 105 0.70 69.21 29.52
122 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
123 INT22499 Regulation of Calca 1 42 0.62 17.32 28.02
124 INT22045 Gene_expression of IRF6 2 158 0.75 58.07 27.81
125 INT6624 Gene_expression of Pth 2 135 0.76 110.27 27.54
126 INT37296 Binding of Esr1 2 117 0.43 62.51 27.33
127 INT9647 Gene_expression of PROC 1 163 0.65 89.76 26.75
128 INT19856 Gene_expression of CD8A 6 240 0.75 147.86 26.39
129 INT9682 Positive_regulation of IGF1 1 238 0.70 120.03 26.36
130 INT2261 Gene_expression of Lhb 1 121 0.77 42.78 26.04
131 INT76095 Positive_regulation of ISYNA1 1 117 0.55 79.73 25.86
132 INT11014 Phosphorylation of CREB1 1 72 0.81 26.35 25.64
133 INT93717 Gene_expression of Mmp3 3 85 0.78 33.95 24.89
134 INT79061 Positive_regulation of NOS2 1 92 0.65 58.89 23.96
135 INT66758 Binding of Nfkb1 2 97 0.48 50.65 23.65
136 INT11746 Positive_regulation of Il1a 2 65 0.63 42.94 23.54
137 INT134651 Binding of TLR4 6 89 0.48 66.96 23.19
138 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
139 INT19330 Binding of HLA-A 2 99 0.48 76.26 22.85
140 INT19949 Regulation of Positive_regulation of Fos 1 36 0.60 6.11 22.05
141 INT48407 Positive_regulation of Gene_expression of Icam1 3 61 0.70 57.91 21.54
142 INT11346 Binding of Mtx1 1 39 0.41 24.88 21.21
143 INT5040 Regulation of Gal 2 42 0.60 12.72 21.18
144 INT1876 Positive_regulation of HLA-B 7 82 0.69 52.16 21.08
145 INT1792 Positive_regulation of CGA 2 123 0.70 64.73 20.79
146 INT69877 Positive_regulation of Positive_regulation of Nfkb1 1 53 0.68 31.44 20.7
147 INT51474 Binding of Il6 2 55 0.48 44.99 20.52
148 INT9237 Regulation of Gene_expression of IL1B 10 49 0.62 30.69 20.34
149 INT51055 Positive_regulation of TIMP1 1 103 0.69 50.07 19.86
150 INT18311 Positive_regulation of CD8A 2 145 0.69 113.48 19.44
151 INT49487 Gene_expression of Sele 1 65 0.76 68.11 19.41
152 INT756 Gene_expression of C3 1 138 0.75 100.6 19.2
153 INT51054 Negative_regulation of Localization of IL6 1 45 0.59 24.48 18.97
154 INT28951 Negative_regulation of IGF1 2 133 0.59 75.77 18.9
155 INT636 Binding of MRAP 2 54 0.48 40.36 18.77
156 INT10833 Regulation of Gene_expression of IL8 1 68 0.62 38.74 18.46
157 INT5967 Negative_regulation of Il1a 2 51 0.57 27.09 18.24
158 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
159 INT2216 Gene_expression of SELL 2 92 0.77 59.29 17.71
160 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
161 INT36054 Transcription of IL1B 3 53 0.72 32.64 17.31
162 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
163 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
164 INT38056 Localization of Crp 1 71 0.78 53.14 17.03
165 INT35998 Positive_regulation of Gene_expression of Calca 1 31 0.70 16.16 16.98
166 INT10187 Gene_expression of Il2ra 1 91 0.78 52.67 16.66
167 INT6480 Positive_regulation of IL1RN 2 59 0.69 33.7 16.66
168 INT17313 Positive_regulation of HSPG2 2 57 0.67 55.78 16.65
169 INT10000 Regulation of Gene_expression of IL2 1 56 0.45 15.33 16.2
170 INT2064 Positive_regulation of BTG3 1 29 0.49 25.58 15.37
171 INT75540 Positive_regulation of TH1L 1 62 0.67 43.45 15.02
172 INT74449 Positive_regulation of B4GALNT1 1 53 0.30 34.49 14.96
173 INT7674 Regulation of ENG 1 42 0.30 11.41 14.44
174 INT37722 Gene_expression of NCAM1 1 103 0.75 81.57 14.18
175 INT1873 Gene_expression of MRAP 5 51 0.76 31.75 13.92
176 INT91544 Gene_expression of CHI3L1 2 60 0.75 77.72 13.9
177 INT25076 Negative_regulation of Gene_expression of Il1 1 41 0.52 30.58 13.85
178 INT19399 Gene_expression of Rf 2 43 0.36 33.39 13.53
179 INT73594 Positive_regulation of Gene_expression of ISYNA1 1 61 0.55 31.35 13.45
180 INT11071 Positive_regulation of PPBP 2 43 0.68 26.85 13.43
181 INT10016 Negative_regulation of CD8A 2 81 0.42 56.68 13.15
182 INT2490 Regulation of Sct 1 44 0.62 9.45 13.11
183 INT4145 Gene_expression of FSHR 1 124 0.77 44.98 13.04
184 INT132178 Binding of CD80 3 41 0.47 15.55 12.98
185 INT63361 Gene_expression of CD44 1 126 0.77 71.58 12.96
186 INT10870 Regulation of IgG 1 67 0.59 43.27 12.74
187 INT74838 Positive_regulation of Sorbs1 1 18 0.34 6.93 12.63
188 INT60461 Positive_regulation of Gene_expression of Il1a 1 40 0.61 17.23 12.35
189 INT12084 Regulation of Localization of IL6 5 36 0.61 20.32 12.34
190 INT148207 Gene_expression of CTLA4 1 53 0.77 29.13 12.07
191 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
192 INT14867 Gene_expression of Igh-6 1 47 0.67 30.05 11.75
193 INT3602 Negative_regulation of Shbg 2 148 0.53 69.05 11.65
194 INT19527 Negative_regulation of Gene_expression of Il1a 1 26 0.51 15.4 11.58
195 INT5011 Negative_regulation of Gal 3 30 0.57 9.88 11.49
196 INT52625 Regulation of IL1RN 1 30 0.61 19.12 11.31
197 INT6474 Positive_regulation of Gene_expression of IL1RN 4 34 0.69 21.87 10.99
198 INT48912 Localization of NOS1 1 52 0.77 24.14 10.92
199 INT19944 Negative_regulation of IFNG 1 39 0.58 22.35 10.91
200 INT6515 Gene_expression of BGLAP 1 110 0.75 45.13 10.81
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