J:J. Rheumatol.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT130721	Binding of IL1B and IL1RN	6	1	0.05	5.29	2.85
2	INT51051	IL1B Positive_regulation of Localization of IL6	7	1	0.57	3.79	1.87
3	INT100274	IL1RN Negative_regulation of IL1B	5	4	0.53	1.79	1.65
4	INT130722	Binding of IL1B and Nfkb1	1	2	0.28	1.23	0.95
5	INT130725	Binding of IL1B and Il1rn	1	2	0.01	1.16	0.93
6	INT38057	Binding of Crp and Esr1	2	1	0.04	1.21	0.65
7	INT64956	IRF6 Positive_regulation of Gene_expression of IL6	4	1	0.19	1.4	0.63
8	INT130726	Negative_regulation of Binding of IL1B and Il1rn	1	1	0.01	0.6	0.48
9	INT130723	Binding of IL1A and Il1rn	1	1	0.01	0.59	0.47
10	INT130724	Negative_regulation of Binding of IL1A and Il1rn	1	1	0.01	0.59	0.47
11	INT146699	Nfkb1 Regulation of Gene_expression of TNF	1	1	0.20	0.72	0.27
12	INT146697	REL Regulation of Gene_expression of TNF	1	1	0.29	0.72	0.26
13	INT146701	Nfkb1 Regulation of Gene_expression of TNF	1	1	0.02	0.72	0.26
14	INT66035	FOLR2 Negative_regulation of Il1a	1	1	0.00	0.56	0.18
15	INT66036	FOLR2 Negative_regulation of Tnf	1	1	0.00	0.56	0.18
16	INT66030	FOLR2 Negative_regulation of IL1B	1	1	0.00	0.56	0.18
17	INT66033	FOLR2 Negative_regulation of Tnf	1	1	0.00	0.56	0.18
18	INT153347	Binding of TLR4 and Cd14	1	1	0.10	0.17	0.17
19	INT42914	Tslp Regulation of thf	1	1	0.04	0.17	0.17
20	INT88238	HLA-B Regulation of Gene_expression of Gbp1	1	1	0.03	0.27	0.1
21	INT98925	Penk Negative_regulation of Gene_expression of IL1B	1	2	0.36	0.32	0
22	INT74217	Oprl1 Negative_regulation of Positive_regulation of Icam1	1	1	0.18	0.11	0
23	INT146700	TNF Regulation of Positive_regulation of Nfkb1	1	1	0.37	0.11	0
24	INT98924	Penk Negative_regulation of Gene_expression of TNF	1	2	0.02	0.32	0
25	INT90819	Binding of HLA-B and MICA	1	1	0.05	0	0
26	INT66034	FOLR2 Negative_regulation of Gene_expression of Il1a	1	1	0.00	0.18	0
27	INT92318	CALCA Positive_regulation of Localization of IL6	1	1	0.26	0.26	0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT5200	Gene_expression of Fos	1	3083	0.78	894.43	1639.02
2	INT796	Gene_expression of Penk	1	1902	0.78	275.47	1057.59
3	INT158	Localization of Prl	1	2431	0.81	378.96	952.2
4	INT6483	Gene_expression of TNF	16	3152	0.78	2515.62	929.82
5	INT5202	Positive_regulation of Gene_expression of Fos	1	1163	0.70	319.28	684
6	INT728	Positive_regulation of Penk	2	1068	0.70	186.9	636.87
7	INT5228	Positive_regulation of Fos	1	934	0.70	209.8	503.87
8	INT155	Positive_regulation of Prl	2	1233	0.70	317.93	457.82
9	INT443	Localization of POMC	4	1020	0.81	284.52	443.17
10	INT9238	Gene_expression of IL6	17	1575	0.78	1135.66	424.22
11	INT467	Gene_expression of POMC	1	1048	0.78	332.8	394.16
12	INT1395	Negative_regulation of Penk	1	537	0.59	87.33	389.81
13	INT2540	Negative_regulation of Calca	1	538	0.59	172.11	384.38
14	INT6580	Negative_regulation of Ptgs1	3	929	0.59	381.53	376.26
15	INT720	Positive_regulation of POMC	2	807	0.70	237.37	353.83
16	INT5235	Negative_regulation of TNF	4	924	0.59	772.91	331.98
17	INT2649	Regulation of Calca	1	433	0.62	146.05	330.95
18	INT5059	Positive_regulation of TNF	7	1050	0.70	896.51	322.81
19	INT162	Regulation of Prl	2	794	0.62	165.01	322.24
20	INT9158	Gene_expression of Tnf	2	722	0.78	522.01	277.68
21	INT49750	Negative_regulation of CPOX	1	735	0.58	360.06	274.19
22	INT10832	Gene_expression of IL8	5	1050	0.78	698.72	270
23	INT9659	Gene_expression of Il6	2	991	0.78	715.11	265.57
24	INT5972	Gene_expression of IL1B	48	948	0.78	510.91	263.97
25	INT1893	Localization of Gh	1	1041	0.79	340.23	256.58
26	INT16868	Gene_expression of Il6	1	807	0.78	499.48	256.57
27	INT11377	Positive_regulation of Ngf	2	331	0.70	206.5	238
28	INT1562	Localization of Crh	1	499	0.81	126.74	236.68
29	INT11009	Phosphorylation of Creb1	1	458	0.82	111.34	221.97
30	INT626	Localization of CALCA	1	289	0.81	125.39	221.15
31	INT6293	Gene_expression of Oprm1	1	312	0.78	48.73	215.61
32	INT767	Localization of Gnrhr	1	565	0.80	106.68	214.57
33	INT6482	Positive_regulation of Gene_expression of TNF	2	659	0.70	569.88	210
34	INT798	Positive_regulation of Gene_expression of Penk	1	394	0.70	78.53	203.07
35	INT528	Gene_expression of Prl	2	693	0.78	217.18	192.2
36	INT19472	Gene_expression of Il1	6	554	0.76	419.75	175.35
37	INT15516	Gene_expression of Crp	3	711	0.77	615.33	173.09
38	INT739	Negative_regulation of POMC	1	358	0.59	102.28	166.77
39	INT2640	Gene_expression of Pomc	3	424	0.78	120.72	155.37
40	INT15515	Positive_regulation of Crp	11	700	0.70	604.24	150.15
41	INT13353	Positive_regulation of Tnf	1	332	0.70	248.75	148.1
42	INT5116	Gene_expression of IL2	5	670	0.78	291.13	146.69
43	INT9660	Regulation of TNF	1	363	0.62	312.94	139.99
44	INT48895	Gene_expression of Il10	6	333	0.78	221.2	138.52
45	INT5497	Positive_regulation of Crh	2	299	0.70	125.54	131.14
46	INT1878	Binding of HLA-B	28	440	0.48	321.16	127.36
47	INT65054	Positive_regulation of Nfkb1	12	285	0.70	149.33	126.73
48	INT5008	Localization of Calca	9	204	0.81	80.35	125.16
49	INT6128	Positive_regulation of Localization of POMC	4	256	0.70	68.77	121.64
50	INT5010	Gene_expression of Calca	3	197	0.78	85.76	118.75
51	INT9235	Negative_regulation of Gene_expression of TNF	5	346	0.59	252.98	118.61
52	INT50674	Gene_expression of PTGS2	3	459	0.78	253.33	118.51
53	INT62124	Gene_expression of NOS1	2	444	0.78	218.08	114.85
54	INT48593	Positive_regulation of NOS1	1	420	0.68	226.15	114.71
55	INT1530	Regulation of Gh	2	382	0.61	115.96	112.47
56	INT11051	Positive_regulation of Gene_expression of IL6	4	415	0.69	319.21	109.3
57	INT27096	Positive_regulation of Nfkb1	1	325	0.70	195.11	109.06
58	INT12082	Localization of IL6	9	365	0.81	241.78	105.78
59	INT11381	Positive_regulation of IL1B	7	330	0.70	209.31	100.9
60	INT11587	Gene_expression of CSF2	1	645	0.78	544.38	93.89
61	INT48406	Gene_expression of Icam1	9	277	0.78	238.28	81.71
62	INT749	Gene_expression of HLA-B	23	341	0.75	224.12	77.37
63	INT48244	Gene_expression of Il4	1	172	0.76	132.38	73.42
64	INT9236	Regulation of Gene_expression of TNF	4	204	0.62	162.66	72.99
65	INT11380	Negative_regulation of IL1B	21	215	0.59	125.62	72.35
66	INT6656	Gene_expression of YY1	1	135	0.75	24.73	72.16
67	INT5969	Gene_expression of Il1a	3	221	0.75	96.31	71.38
68	INT58400	Negative_regulation of Tnf	2	182	0.59	129.97	71
69	INT49995	Positive_regulation of Gene_expression of Tnf	1	187	0.70	125.07	70.54
70	INT10837	Positive_regulation of Gene_expression of IL8	3	294	0.70	190.08	70.34
71	INT6849	Localization of IL1B	1	229	0.81	112.56	69.63
72	INT5374	Gene_expression of Esr1	1	412	0.77	263.89	67.34
73	INT13286	Gene_expression of Ca2	1	317	0.67	71.58	65.01
74	INT9657	Positive_regulation of Gene_expression of Il6	1	237	0.70	180.45	63.6
75	INT17401	Gene_expression of IGF1	1	475	0.78	232.18	62.07
76	INT6477	Gene_expression of IL1RN	7	213	0.77	114.69	58.62
77	INT48901	Negative_regulation of IL6	2	186	0.57	136.33	57.87
78	INT9408	Positive_regulation of Crp	3	296	0.69	242.27	57.35
79	INT4509	Gene_expression of IGG	3	426	0.76	293.69	56.64
80	INT52800	Negative_regulation of Gene_expression of Tnf	1	142	0.59	92.27	55.47
81	INT9234	Negative_regulation of Gene_expression of IL6	5	171	0.59	101.61	53.15
82	INT97674	Positive_regulation of Localization of Calca	2	70	0.69	27.71	51.79
83	INT6473	Positive_regulation of Gene_expression of IL1B	9	204	0.70	117.23	50.86
84	INT9210	Regulation of IL6	2	166	0.62	125.61	49.95
85	INT22454	Regulation of Crp	1	213	0.62	160.67	49.24
86	INT66029	Negative_regulation of Tnf	1	100	0.59	84.28	48.16
87	INT16364	Gene_expression of HLA-DRA	1	234	0.78	118.81	45.01
88	INT2774	Binding of Crp	1	241	0.48	195.89	44.39
89	INT52531	Gene_expression of Nfkb1	1	153	0.75	82.84	42.9
90	INT13354	Transcription of TNF	1	108	0.72	85.81	42.32
91	INT3933	Positive_regulation of PLOD1	2	128	0.70	30.76	42.03
92	INT9233	Negative_regulation of Gene_expression of IL1B	21	114	0.59	56.99	41.82
93	INT29496	Gene_expression of MMP3	5	136	0.75	49.49	41.78
94	INT13556	Gene_expression of CD4	2	367	0.78	230.82	41.74
95	INT11939	Negative_regulation of Il6	2	138	0.59	87.46	41.24
96	INT28265	Positive_regulation of Calca	1	62	0.70	29.1	41.17
97	INT5793	Binding of CTS	1	110	0.48	63.91	40.62
98	INT52732	Negative_regulation of CRP	3	169	0.59	138.47	40.33
99	INT5973	Regulation of IL1B	4	109	0.62	66.6	39.88
100	INT9094	Gene_expression of COL7A1	1	277	0.77	143.42	38.73
101	INT55135	Positive_regulation of Gene_expression of PTGS2	1	137	0.70	80.32	38.46
102	INT63349	Gene_expression of PECAM1	2	199	0.75	166.03	36.76
103	INT12892	Negative_regulation of TIMP1	1	136	0.58	83.13	36.54
104	INT9239	Regulation of Gene_expression of IL6	6	106	0.61	75.24	36.53
105	INT12029	Gene_expression of Car1	1	143	0.67	29.69	36.39
106	INT51017	Positive_regulation of Icam1	2	113	0.70	81.16	35.55
107	INT59466	Gene_expression of ISYNA1	5	204	0.77	112.57	35.48
108	INT6484	Binding of IL1B	3	122	0.47	75.84	35.07
109	INT79060	Gene_expression of NOS2	4	116	0.78	69.25	34.84
110	INT6105	Positive_regulation of IL2	1	133	0.69	82.76	34.67
111	INT11013	Negative_regulation of Phosphorylation of Creb1	1	55	0.59	18.74	34.66
112	INT16960	Gene_expression of Crp	2	166	0.76	116.21	34.07
113	INT49214	Gene_expression of Cd4	2	269	0.78	154.22	34.05
114	INT11325	Gene_expression of HLA-E	2	209	0.76	98.05	33.72
115	INT93534	Gene_expression of Tnfsf11	6	185	0.77	119.26	33.66
116	INT65536	Negative_regulation of Positive_regulation of Nfkb1	1	77	0.59	38.86	33.33
117	INT10763	Localization of IL2	5	157	0.80	81.11	33.21
118	INT10248	Gene_expression of KRT20	4	436	0.78	231.96	32.88
119	INT81530	Gene_expression of Nfkb1	1	93	0.78	48.58	32.58
120	INT10915	Gene_expression of ITGAM	1	164	0.78	92.42	29.78
121	INT50230	Positive_regulation of Localization of IL6	1	105	0.70	69.21	29.52
122	INT2389	Regulation of PTGS1	1	86	0.61	31.23	28.95
123	INT22499	Regulation of Calca	1	42	0.62	17.32	28.02
124	INT22045	Gene_expression of IRF6	2	158	0.75	58.07	27.81
125	INT6624	Gene_expression of Pth	2	135	0.76	110.27	27.54
126	INT37296	Binding of Esr1	2	117	0.43	62.51	27.33
127	INT9647	Gene_expression of PROC	1	163	0.65	89.76	26.75
128	INT19856	Gene_expression of CD8A	6	240	0.75	147.86	26.39
129	INT9682	Positive_regulation of IGF1	1	238	0.70	120.03	26.36
130	INT2261	Gene_expression of Lhb	1	121	0.77	42.78	26.04
131	INT76095	Positive_regulation of ISYNA1	1	117	0.55	79.73	25.86
132	INT11014	Phosphorylation of CREB1	1	72	0.81	26.35	25.64
133	INT93717	Gene_expression of Mmp3	3	85	0.78	33.95	24.89
134	INT79061	Positive_regulation of NOS2	1	92	0.65	58.89	23.96
135	INT66758	Binding of Nfkb1	2	97	0.48	50.65	23.65
136	INT11746	Positive_regulation of Il1a	2	65	0.63	42.94	23.54
137	INT134651	Binding of TLR4	6	89	0.48	66.96	23.19
138	INT1221	Regulation of SGCG	1	65	0.60	24.21	22.94
139	INT19330	Binding of HLA-A	2	99	0.48	76.26	22.85
140	INT19949	Regulation of Positive_regulation of Fos	1	36	0.60	6.11	22.05
141	INT48407	Positive_regulation of Gene_expression of Icam1	3	61	0.70	57.91	21.54
142	INT11346	Binding of Mtx1	1	39	0.41	24.88	21.21
143	INT5040	Regulation of Gal	2	42	0.60	12.72	21.18
144	INT1876	Positive_regulation of HLA-B	7	82	0.69	52.16	21.08
145	INT1792	Positive_regulation of CGA	2	123	0.70	64.73	20.79
146	INT69877	Positive_regulation of Positive_regulation of Nfkb1	1	53	0.68	31.44	20.7
147	INT51474	Binding of Il6	2	55	0.48	44.99	20.52
148	INT9237	Regulation of Gene_expression of IL1B	10	49	0.62	30.69	20.34
149	INT51055	Positive_regulation of TIMP1	1	103	0.69	50.07	19.86
150	INT18311	Positive_regulation of CD8A	2	145	0.69	113.48	19.44
151	INT49487	Gene_expression of Sele	1	65	0.76	68.11	19.41
152	INT756	Gene_expression of C3	1	138	0.75	100.6	19.2
153	INT51054	Negative_regulation of Localization of IL6	1	45	0.59	24.48	18.97
154	INT28951	Negative_regulation of IGF1	2	133	0.59	75.77	18.9
155	INT636	Binding of MRAP	2	54	0.48	40.36	18.77
156	INT10833	Regulation of Gene_expression of IL8	1	68	0.62	38.74	18.46
157	INT5967	Negative_regulation of Il1a	2	51	0.57	27.09	18.24
158	INT61626	Transcription of IL6	1	73	0.72	42.04	17.86
159	INT2216	Gene_expression of SELL	2	92	0.77	59.29	17.71
160	INT4067	Negative_regulation of Esr1	1	97	0.50	43.45	17.52
161	INT36054	Transcription of IL1B	3	53	0.72	32.64	17.31
162	INT17237	Regulation of Esr1	1	74	0.43	49.09	17.25
163	INT3364	Binding of SGCG	1	87	0.47	31.93	17.24
164	INT38056	Localization of Crp	1	71	0.78	53.14	17.03
165	INT35998	Positive_regulation of Gene_expression of Calca	1	31	0.70	16.16	16.98
166	INT10187	Gene_expression of Il2ra	1	91	0.78	52.67	16.66
167	INT6480	Positive_regulation of IL1RN	2	59	0.69	33.7	16.66
168	INT17313	Positive_regulation of HSPG2	2	57	0.67	55.78	16.65
169	INT10000	Regulation of Gene_expression of IL2	1	56	0.45	15.33	16.2
170	INT2064	Positive_regulation of BTG3	1	29	0.49	25.58	15.37
171	INT75540	Positive_regulation of TH1L	1	62	0.67	43.45	15.02
172	INT74449	Positive_regulation of B4GALNT1	1	53	0.30	34.49	14.96
173	INT7674	Regulation of ENG	1	42	0.30	11.41	14.44
174	INT37722	Gene_expression of NCAM1	1	103	0.75	81.57	14.18
175	INT1873	Gene_expression of MRAP	5	51	0.76	31.75	13.92
176	INT91544	Gene_expression of CHI3L1	2	60	0.75	77.72	13.9
177	INT25076	Negative_regulation of Gene_expression of Il1	1	41	0.52	30.58	13.85
178	INT19399	Gene_expression of Rf	2	43	0.36	33.39	13.53
179	INT73594	Positive_regulation of Gene_expression of ISYNA1	1	61	0.55	31.35	13.45
180	INT11071	Positive_regulation of PPBP	2	43	0.68	26.85	13.43
181	INT10016	Negative_regulation of CD8A	2	81	0.42	56.68	13.15
182	INT2490	Regulation of Sct	1	44	0.62	9.45	13.11
183	INT4145	Gene_expression of FSHR	1	124	0.77	44.98	13.04
184	INT132178	Binding of CD80	3	41	0.47	15.55	12.98
185	INT63361	Gene_expression of CD44	1	126	0.77	71.58	12.96
186	INT10870	Regulation of IgG	1	67	0.59	43.27	12.74
187	INT74838	Positive_regulation of Sorbs1	1	18	0.34	6.93	12.63
188	INT60461	Positive_regulation of Gene_expression of Il1a	1	40	0.61	17.23	12.35
189	INT12084	Regulation of Localization of IL6	5	36	0.61	20.32	12.34
190	INT148207	Gene_expression of CTLA4	1	53	0.77	29.13	12.07
191	INT32203	Negative_regulation of Crp	1	48	0.58	32.77	11.89
192	INT14867	Gene_expression of Igh-6	1	47	0.67	30.05	11.75
193	INT3602	Negative_regulation of Shbg	2	148	0.53	69.05	11.65
194	INT19527	Negative_regulation of Gene_expression of Il1a	1	26	0.51	15.4	11.58
195	INT5011	Negative_regulation of Gal	3	30	0.57	9.88	11.49
196	INT52625	Regulation of IL1RN	1	30	0.61	19.12	11.31
197	INT6474	Positive_regulation of Gene_expression of IL1RN	4	34	0.69	21.87	10.99
198	INT48912	Localization of NOS1	1	52	0.77	24.14	10.92
199	INT19944	Negative_regulation of IFNG	1	39	0.58	22.35	10.91
200	INT6515	Gene_expression of BGLAP	1	110	0.75	45.13	10.81