J:J Carcinog

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 4 0.54 3.85 0.9
2 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 1 0.11 1.88 0.8
3 INT84040 EGF Positive_regulation of CPOX 2 1 0.07 1.91 0.8
4 INT177784 PDCD2 Positive_regulation of ASNS 1 1 0.04 0.76 0.46
5 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 1 0.11 0.77 0.46
6 INT177791 PDCD2 Positive_regulation of ATF4 1 1 0.06 0.76 0.46
7 INT177781 BUB1B Positive_regulation of ATF4 1 1 0.07 0.76 0.46
8 INT177780 BUB1B Positive_regulation of ASNS 1 1 0.05 0.76 0.46
9 INT177782 PDCD2 Positive_regulation of MTHFD2 1 1 0.06 0.76 0.46
10 INT177787 BUB1B Positive_regulation of MTHFD2 1 1 0.15 0.76 0.46
11 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 1 0.48 1.85 0.45
12 INT75057 Binding of POMC and Msx1 2 1 0.39 0.6 0.2
13 INT186098 EGF Positive_regulation of MAP2K5 1 1 0.01 0.19 0.18
14 INT189957 Binding of LDHA and Pttg1 1 1 0.05 0.35 0.08
15 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 1 0.20 0.38 0.04
16 INT242015 Binding of Mdm2 and Trp53 3 1 0.16 5.74 0
17 INT236720 Binding of Ctnnd2 and Tcf4 3 1 0.24 2.8 0
18 INT199863 Gopc Negative_regulation of Jun 1 1 0.03 1.07 0
19 INT177792 Binding of ATF4 and NFE2L2 1 1 0.06 0.25 0
20 INT199859 Gem Positive_regulation of Phosphorylation of Mapk8 1 1 0.10 0.67 0
21 INT199858 Gopc Negative_regulation of Phosphorylation of Jun 1 1 0.03 1.08 0
22 INT199365 Igf2 Positive_regulation of Phosphorylation of Macf1 1 1 0.13 1.84 0
23 INT199359 Igf2 Regulation of Macf1 1 2 0.11 3.11 0
24 INT186096 EGF Regulation of Positive_regulation of CASP3 1 1 0.01 0.28 0
25 INT199361 Regulation of Igf2 Regulation of Macf1 1 1 0.11 1.59 0
26 INT199367 DST Regulation of Igf2 1 1 0.03 1.03 0
27 INT177786 TFAM Regulation of Gene_expression of MT1F 1 1 0.00 0.17 0
28 INT308352 Binding of Ctnnd2 and Tcf7l2 1 1 0.15 0.74 0
29 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 1 0.18 0.44 0
30 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 1 0.04 1.51 0
31 INT177790 MTF1 Positive_regulation of NR2F1 1 1 0.10 0 0
32 INT199371 DST Regulation of Transcription of Igf2 1 1 0.05 1.47 0
33 INT177779 NR4A1 Positive_regulation of NR2F1 1 1 0.10 0 0
34 INT177788 NR4A1 Positive_regulation of MTF1 1 1 0.08 0 0
35 INT199861 Xiap Regulation of Gopc 1 1 0.07 0.46 0
36 INT199366 DST Positive_regulation of Macf1 1 1 0.01 1.14 0
37 INT177785 Negative_regulation of MTF1 Negative_regulation of MT1F 1 1 0.03 0.16 0
38 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 1 0.30 1.13 0
39 INT199363 Igf2 Regulation of Gopc 1 1 0.15 1.61 0
40 INT199370 DST Regulation of Gene_expression of Igf2 1 1 0.02 1.07 0
41 INT199369 DST Regulation of Igf1 1 1 0.02 0.8 0
42 INT199860 Gopc Negative_regulation of Positive_regulation of Mapk8 1 1 0.07 1.07 0
43 INT189956 TP53 Positive_regulation of Gene_expression of Pttg1 1 1 0.06 1.21 0
44 INT177789 MTF1 Positive_regulation of NR4A1 1 1 0.08 0 0
45 INT177783 Binding of HDAC1 and PCNA 1 1 0.09 0.5 0
46 INT199862 Mapk8 Negative_regulation of Jun 1 1 0.05 1.06 0
47 INT199362 Igf2 Positive_regulation of Macf1 1 1 0.11 1.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
2 INT49750 Negative_regulation of CPOX 5 735 0.58 360.06 274.19
3 INT68684 Gene_expression of VEGFA 6 2371 0.78 1742.52 259.2
4 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
5 INT50670 Gene_expression of CPOX 3 763 0.76 442.13 195.02
6 INT120811 Gene_expression of Gopc 3 1174 0.59 428.49 150.55
7 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
8 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
9 INT695 Binding of POMC 1 304 0.48 56.66 126.85
10 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
11 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
12 INT71789 Positive_regulation of MAPK1 4 396 0.70 234.44 89.27
13 INT68682 Positive_regulation of VEGFA 2 640 0.70 454.14 81.65
14 INT79494 Positive_regulation of Gene_expression of VEGFA 3 577 0.70 442.94 69.73
15 INT103924 Positive_regulation of Akt1 3 359 0.69 158.94 60.34
16 INT96914 Phosphorylation of Mapk14 1 168 0.82 108.46 53.32
17 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
18 INT71786 Phosphorylation of MAPK1 14 256 0.82 110.09 46.17
19 INT85943 Negative_regulation of Nos2 2 161 0.59 108.56 42.65
20 INT170054 Negative_regulation of Gopc 2 280 0.38 117.89 42.4
21 INT11560 Positive_regulation of CASP3 4 236 0.70 184.33 39.38
22 INT77307 Gene_expression of Bcl2 7 399 0.77 319.77 38
23 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
24 INT70437 Negative_regulation of Mdk 2 115 0.57 41.03 35.72
25 INT14559 Gene_expression of Igf1 3 254 0.78 112 34.17
26 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
27 INT10763 Localization of IL2 2 157 0.80 81.11 33.21
28 INT96913 Positive_regulation of Mapk8 3 179 0.69 130.44 32.2
29 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
30 INT99688 Negative_regulation of Gene_expression of VEGFA 2 274 0.58 201.8 31.1
31 INT65960 Gene_expression of BCL2 7 352 0.78 312.03 30.73
32 INT110020 Gene_expression of Mapk14 1 142 0.77 72.33 30.08
33 INT28361 Gene_expression of TP53 14 443 0.78 384.86 28.8
34 INT8097 Gene_expression of EGF 3 122 0.77 75.94 28.47
35 INT83708 Negative_regulation of MAPK1 4 156 0.57 84.93 27.85
36 INT62710 Gene_expression of HGF 1 160 0.78 88.27 26.14
37 INT11159 Gene_expression of EGFR 23 698 0.78 548.93 25.69
38 INT12124 Gene_expression of MAPK1 3 141 0.75 82.4 25.58
39 INT5199 Gene_expression of Fosl1 2 44 0.78 8.66 24.8
40 INT22708 Gene_expression of MUC1 1 297 0.78 232.71 24.19
41 INT64175 Negative_regulation of Gene_expression of CPOX 1 66 0.38 39.64 23.07
42 INT11157 Binding of EGF 1 88 0.48 53.73 21.25
43 INT28216 Gene_expression of HRAS 3 173 0.75 93.97 20.78
44 INT66281 Transcription of Nos2 1 81 0.71 39.49 20.37
45 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
46 INT23533 Gene_expression of CA2 3 110 0.75 30.81 19.4
47 INT712 Positive_regulation of LDHA 3 160 0.70 175.25 19.11
48 INT91462 Positive_regulation of Phosphorylation of MAPK1 2 99 0.67 40.28 18.99
49 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
50 INT56749 Gene_expression of PCNA 4 219 0.77 111.25 18.42
51 INT133647 Negative_regulation of HDAC9 1 149 0.57 106.84 17.9
52 INT151747 Positive_regulation of PSMD2 1 26 0.68 17.48 17.89
53 INT109316 Negative_regulation of Mapk8 4 72 0.59 50.59 17.24
54 INT65856 Positive_regulation of TP53 2 138 0.67 112.65 16.71
55 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
56 INT20622 Gene_expression of LDHA 3 107 0.76 77.97 16.3
57 INT108588 Gene_expression of CASP3 3 126 0.78 84.49 16.2
58 INT65659 Positive_regulation of STAT3 1 132 0.70 69.56 15.95
59 INT97245 Gene_expression of AKT1 2 217 0.77 119.63 15.59
60 INT75531 Regulation of MAPK1 2 70 0.61 34.39 15.42
61 INT94774 Regulation of CDKN2A 1 43 0.60 44.41 13.99
62 INT78472 Gene_expression of CDKN2A 7 223 0.78 173.76 13.61
63 INT78472 Gene_expression of CDKN2A 1 223 0.78 173.76 13.61
64 INT20066 Gene_expression of Mdk 1 38 0.76 21.41 13.4
65 INT86383 Negative_regulation of EGFR 27 258 0.59 173.94 13.32
66 INT11359 Gene_expression of PLAU 8 84 0.76 49.54 12.31
67 INT112003 Localization of ROS1 1 94 0.73 66.32 12.16
68 INT109315 Gene_expression of Mapk8 1 70 0.78 45.46 11.65
69 INT81640 Positive_regulation of Gene_expression of Bcl2 4 106 0.69 84.58 11.63
70 INT19795 Positive_regulation of EGFR 7 161 0.70 103.69 11.55
71 INT96915 Phosphorylation of Mapk8 1 73 0.81 40.69 11.44
72 INT95341 Gene_expression of NDOR1 1 17 0.75 4.27 10.98
73 INT74272 Localization of CPOX 1 39 0.63 25.12 10.53
74 INT9385 Localization of LDHA 3 74 0.81 31.67 10.5
75 INT60198 Binding of JUN 1 54 0.48 11.56 10.27
76 INT98130 Positive_regulation of CASP8 2 79 0.67 65.29 10.08
77 INT49660 Positive_regulation of EGR1 5 54 0.69 32.17 9.89
78 INT145695 Regulation of Mapk8 1 26 0.62 14.67 9.83
79 INT67101 Gene_expression of DST 2 47 0.54 25.92 9.59
80 INT24328 Gene_expression of Egf 1 97 0.75 59.65 9.42
81 INT73021 Gene_expression of EGR1 5 43 0.77 24.65 9.18
82 INT94196 Negative_regulation of Phosphorylation of MAPK1 5 60 0.59 31.64 9.16
83 INT104396 Positive_regulation of Positive_regulation of Akt1 1 44 0.55 14.78 8.69
84 INT123813 Positive_regulation of Parp1 1 74 0.70 65.36 8.56
85 INT177831 Gene_expression of HDAC1 1 24 0.65 21.37 8.37
86 INT36798 Gene_expression of Mki67 5 178 0.77 132 8.24
87 INT61363 Positive_regulation of TFAM 1 43 0.69 26.43 8.14
88 INT96912 Positive_regulation of Phosphorylation of Mapk8 1 29 0.69 18.33 8.14
89 INT39301 Gene_expression of Chd7 3 50 0.26 27.06 8.13
90 INT39170 Gene_expression of TSPO 1 76 0.78 24.11 8.05
91 INT6335 Binding of TSPO 1 39 0.44 10.88 7.66
92 INT170295 Positive_regulation of Ido1 1 40 0.67 28.89 7.61
93 INT113705 Gene_expression of Egfr 2 228 0.78 149.05 7.59
94 INT57748 Positive_regulation of Gene_expression of TP53 2 85 0.69 79.55 7.49
95 INT102572 Gene_expression of Ccnd1 2 79 0.69 56.37 7.34
96 INT96994 Phosphorylation of EGFR 23 99 0.82 52.75 7.33
97 INT75497 Regulation of JUN 1 28 0.61 11.04 7.09
98 INT38644 Positive_regulation of DST 1 30 0.53 12.48 6.59
99 INT73022 Positive_regulation of Gene_expression of EGR1 2 21 0.69 10.61 6.5
100 INT10131 Gene_expression of Serpinf1 3 53 0.76 35.57 6.42
101 INT64052 Positive_regulation of FGFR1 2 26 0.52 28.47 6.36
102 INT11154 Binding of EGFR 1 149 0.48 96.23 6.29
103 INT14258 Regulation of TSPO 1 32 0.60 10.16 6.24
104 INT114882 Positive_regulation of Gene_expression of Akt1 1 45 0.69 21.29 6.06
105 INT130111 Regulation of Positive_regulation of MAPK1 1 14 0.36 11.01 5.9
106 INT17892 Gene_expression of Myc 2 57 0.75 36.37 5.82
107 INT36921 Regulation of Mdk 1 14 0.26 6.49 5.8
108 INT123726 Positive_regulation of Notch1 1 23 0.70 7.2 5.65
109 INT125467 Positive_regulation of Gene_expression of CDKN2A 1 35 0.63 39.07 5.56
110 INT22839 Gene_expression of F2 3 31 0.74 15.53 5.56
111 INT125066 Negative_regulation of HDAC4 3 56 0.49 41.55 5.42
112 INT89794 Positive_regulation of CDKN2A 1 58 0.67 50.18 5.38
113 INT70613 Negative_regulation of Gene_expression of BCL2 1 48 0.59 38.91 5.22
114 INT37227 Regulation of EGF 1 19 0.45 11.16 5.17
115 INT135291 Positive_regulation of Positive_regulation of Mapk8 1 24 0.64 19.37 5.16
116 INT11158 Positive_regulation of Gene_expression of EGFR 2 165 0.70 131.26 4.93
117 INT57376 Transcription of EGR1 2 20 0.69 12.94 4.84
118 INT106524 Phosphorylation of Jun 2 23 0.80 15.35 4.78
119 INT15474 Gene_expression of PLAUR 1 36 0.75 22.32 4.63
120 INT62684 Negative_regulation of TP53 2 66 0.58 66.09 4.62
121 INT49805 Positive_regulation of MUC1 1 56 0.70 44.5 4.56
122 INT73309 Regulation of Negative_regulation of PTGS2 1 14 0.44 9.55 4.5
123 INT14557 Negative_regulation of Igf1 2 96 0.59 54.83 4.45
124 INT57749 Negative_regulation of Gene_expression of TP53 3 39 0.56 36.79 4.45
125 INT80175 Positive_regulation of Gene_expression of HRAS 1 24 0.67 14.69 3.97
126 INT71602 Negative_regulation of Trp53 2 84 0.59 67.77 3.68
127 INT102076 Regulation of DST 1 15 0.22 10 3.5
128 INT163832 Negative_regulation of Gene_expression of EGFR 14 50 0.59 39.71 3.45
129 INT137634 Localization of Aifm1 6 17 0.80 11.8 3.45
130 INT109403 Regulation of Gene_expression of BCL2 3 31 0.60 31.22 3.4
131 INT79270 Gene_expression of MKI67 4 113 0.77 63.52 3.38
132 INT145520 Positive_regulation of Dss1 3 16 0.39 14.04 3.38
133 INT78471 Regulation of Gene_expression of CDKN2A 2 13 0.45 12.52 3.28
134 INT78471 Regulation of Gene_expression of CDKN2A 1 13 0.45 12.52 3.28
135 INT94164 Phosphorylation of RB1 1 83 0.80 48.84 3.21
136 INT81642 Regulation of Gene_expression of Bcl2 2 20 0.44 16.93 3.19
137 INT20006 Gene_expression of MT1F 4 27 0.68 19.55 3.18
138 INT116235 Negative_regulation of Transcription of Nos2 1 23 0.58 7.91 3.14
139 INT117348 Regulation of EGFR 3 75 0.61 47.73 3.09
140 INT116143 Positive_regulation of Casp9 1 32 0.67 30.34 3.04
141 INT123815 Gene_expression of Parp1 3 42 0.67 27.82 3.02
142 INT8103 Binding of TP53 1 46 0.44 40.2 2.96
143 INT7904 Positive_regulation of Gene_expression of Fosl1 2 5 0.61 1.39 2.96
144 INT188047 Positive_regulation of Wnt2 1 51 0.58 31.41 2.94
145 INT98554 Positive_regulation of Casp8 1 20 0.67 21.32 2.9
146 INT134795 Positive_regulation of Scrib 1 30 0.22 36.91 2.81
147 INT78248 Negative_regulation of Cdkn2a 3 17 0.59 15.15 2.8
148 INT130705 Gene_expression of TFAM 1 50 0.77 38.85 2.79
149 INT22212 Gene_expression of CYP1A1 3 34 0.76 10.11 2.77
150 INT145328 Negative_regulation of Scrib 3 25 0.16 26.79 2.66
151 INT16463 Gene_expression of FTH1 1 15 0.65 6.28 2.66
152 INT103282 Positive_regulation of ATF4 1 12 0.66 7.28 2.65
153 INT15543 Gene_expression of CASP8 4 32 0.75 25.6 2.61
154 INT92141 Negative_regulation of CDKN2A 2 53 0.57 44.23 2.48
155 INT92141 Negative_regulation of CDKN2A 1 53 0.57 44.23 2.48
156 INT96876 Gene_expression of AHR 3 20 0.77 10.43 2.39
157 INT11357 Negative_regulation of Gene_expression of PLAU 2 10 0.56 5.3 2.38
158 INT57970 Positive_regulation of Rb1 1 17 0.67 7.03 2.36
159 INT186116 Regulation of Gene_expression of MAPK1 2 9 0.44 5.85 2.32
160 INT73266 Gene_expression of RB1 2 50 0.70 29.09 2.31
161 INT50558 Negative_regulation of PCNA 3 31 0.57 13.97 2.3
162 INT61418 Positive_regulation of ITGAL 1 24 0.14 12.86 2.3
163 INT100886 Gene_expression of GCLC 2 16 0.76 5.63 2.29
164 INT63505 Negative_regulation of F2 1 18 0.57 7.4 2.2
165 INT101866 Positive_regulation of Gene_expression of AKT1 2 49 0.52 17.47 2.14
166 INT82226 Negative_regulation of Gene_expression of EGF 2 11 0.58 6.36 2.13
167 INT108335 Phosphorylation of EGF 2 17 0.80 7.3 2.09
168 INT94772 Gene_expression of Cdkn2a 1 14 0.75 8.25 2.04
169 INT100897 Positive_regulation of Gene_expression of GCLC 1 9 0.68 1.84 1.99
170 INT177841 Gene_expression of CCNA2 1 2 0.50 0.64 1.97
171 INT13907 Gene_expression of SCLC1 3 16 0.59 16.58 1.89
172 INT65545 Localization of EGFR 2 35 0.79 20.8 1.88
173 INT120563 Positive_regulation of Gene_expression of Egfr 2 56 0.70 46.19 1.82
174 INT131818 Binding of Parp1 1 14 0.46 8.74 1.76
175 INT115721 Positive_regulation of Gene_expression of PLAU 3 11 0.67 7.66 1.55
176 INT118292 Negative_regulation of Phosphorylation of EGFR 9 27 0.59 13.62 1.54
177 INT64233 Regulation of Trp53 2 35 0.62 27.11 1.53
178 INT130704 Gene_expression of ATF4 4 9 0.78 5.29 1.45
179 INT98635 Negative_regulation of Gene_expression of EGR1 1 5 0.58 2.2 1.42
180 INT189948 Gene_expression of Pttg1 85 106 0.76 104.68 1.41
181 INT172953 Binding of Trp53 1 33 0.37 20.76 1.41
182 INT93357 Regulation of Gene_expression of Trp53 1 15 0.62 13.4 1.41
183 INT78470 Negative_regulation of Gene_expression of CDKN2A 1 14 0.59 14.44 1.38
184 INT191678 Gene_expression of Xiap 2 60 0.71 57.25 1.37
185 INT96993 Positive_regulation of Phosphorylation of EGFR 3 15 0.59 5.44 1.37
186 INT71782 Gene_expression of MAP2K1 1 7 0.68 3.17 1.37
187 INT172452 Gene_expression of Myc 6 121 0.78 69.56 1.36
188 INT90491 Binding of Igf1 1 25 0.44 9.75 1.36
189 INT116265 Binding of Myc 1 9 0.36 4.28 1.36
190 INT40771 Positive_regulation of Iars 2 6 0.36 2.1 1.33
191 INT169907 Gene_expression of Rb1 1 25 0.60 21.95 1.32
192 INT127725 Negative_regulation of Positive_regulation of EGFR 2 6 0.57 2.69 1.3
193 INT177840 Negative_regulation of PLAU 2 3 0.41 3.37 1.27
194 INT124816 Negative_regulation of PDCD2 2 2 0.42 1.35 1.25
195 INT31397 Gene_expression of Iars 1 7 0.51 4.16 1.24
196 INT89765 Positive_regulation of NR4A1 1 12 0.69 8.13 1.23
197 INT175520 Gene_expression of Igf2 27 43 0.78 48.93 1.21
198 INT166171 Negative_regulation of Gene_expression of HRAS 1 5 0.07 3.98 1.11
199 INT68339 Gene_expression of HDAC2 1 3 0.51 1.71 1.1
200 INT118293 Regulation of Phosphorylation of EGFR 1 2 0.61 1.01 1.1
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