J:J Clin Pharmacol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT25026 PLOD1 Regulation of FSHR 4 1 0.19 0.38 1.15
2 INT19535 Binding of ADRA1D and ALB 3 1 0.42 0.8 1.15
3 INT35157 GH1 Regulation of GHRH 3 1 0.17 0.5 0.99
4 INT35160 GH1 Regulation of PRL 2 1 0.37 0 0.89
5 INT35159 FSHR Regulation of PRL 2 1 0.34 0 0.6
6 INT35154 PLOD1 Regulation of PRL 2 1 0.17 0 0.6
7 INT50883 Binding of AGTR2 and ALB 1 2 0.37 0.19 0.56
8 INT47101 Adra1a Regulation of Localization of Gnrhr 1 1 0.02 0.24 0.44
9 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 1 0.00 0.68 0.43
10 INT60063 IL1B Regulation of NPEPPS 1 1 0.00 0.29 0.42
11 INT35162 GH1 Regulation of FSHR 1 1 0.17 0 0.21
12 INT35151 PLOD1 Regulation of PGR 1 1 0.09 0 0.21
13 INT35149 PLOD1 Regulation of GHRH 1 1 0.02 0 0.21
14 INT35161 FSHR Regulation of LHB 1 1 0.18 0 0.21
15 INT35152 GH1 Regulation of PGR 1 1 0.08 0 0.21
16 INT35153 FSHR Regulation of GHRH 1 1 0.04 0 0.21
17 INT35156 FSHR Regulation of PGR 1 1 0.18 0 0.21
18 INT35150 PLOD1 Regulation of LHB 1 1 0.09 0 0.21
19 INT35158 GH1 Regulation of LHB 1 1 0.08 0 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
2 INT6580 Negative_regulation of Ptgs1 10 929 0.59 381.53 376.26
3 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
4 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
5 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
6 INT16868 Gene_expression of Il6 4 807 0.78 499.48 256.57
7 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
8 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
9 INT2391 Negative_regulation of PTGS1 3 501 0.59 207.62 205.6
10 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
11 INT49441 Negative_regulation of Cpox 2 494 0.59 303.22 177.46
12 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
13 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
14 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
15 INT915 Positive_regulation of PRL 1 342 0.70 141.96 104.31
16 INT214 Localization of AVP 1 370 0.81 208.51 91.09
17 INT148 Positive_regulation of Gnrhr 3 182 0.70 47.44 79.64
18 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
19 INT546 Binding of ALB 4 311 0.48 85.98 60.14
20 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
21 INT18883 Negative_regulation of RYBP 2 53 0.56 21.14 57.52
22 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
23 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
24 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
25 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
26 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
27 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
28 INT2604 Positive_regulation of Got1 3 223 0.70 154.78 49.51
29 INT7093 Negative_regulation of CYP2B6 3 146 0.58 37.3 48.39
30 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
31 INT50957 Negative_regulation of Il6 1 134 0.59 79.08 42.67
32 INT685 Regulation of AVP 2 124 0.62 34.9 39.91
33 INT11246 Binding of Grin1 1 65 0.48 14.53 36.93
34 INT59466 Gene_expression of ISYNA1 1 204 0.77 112.57 35.48
35 INT326 Gene_expression of Gnrhr 1 105 0.76 35.87 34.93
36 INT8905 Gene_expression of EDN1 1 215 0.78 157.1 34.19
37 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
38 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
39 INT1116 Regulation of Ren 1 103 0.62 27.66 33.26
40 INT234 Binding of Alb 3 151 0.48 52.34 32.97
41 INT10248 Gene_expression of KRT20 1 436 0.78 231.96 32.88
42 INT10797 Binding of CYP2D6 2 86 0.48 15.09 31.16
43 INT10285 Binding of ADRA1D 3 102 0.47 25.82 31.11
44 INT1179 Negative_regulation of Ace 5 157 0.59 67.03 30.46
45 INT1473 Localization of Gcg 1 95 0.80 17.35 30.31
46 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
47 INT651 Positive_regulation of PTGS1 2 93 0.69 37.27 29.18
48 INT16814 Negative_regulation of COX5A 1 74 0.57 33.72 28.63
49 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
50 INT97 Negative_regulation of Adrb1 2 102 0.59 32.44 26.9
51 INT74688 Regulation of Nos1 1 55 0.62 22.16 25.3
52 INT48235 Negative_regulation of NPEPPS 1 72 0.46 44.54 25.03
53 INT21503 Binding of Ptgs1 1 45 0.48 15.6 22.29
54 INT16396 Negative_regulation of CEBPZ 1 76 0.48 30.03 21.6
55 INT8662 Positive_regulation of EDN1 1 144 0.70 125.34 19.59
56 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
57 INT4420 Positive_regulation of GOT1 3 103 0.64 88.4 18.38
58 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
59 INT66857 Regulation of CCL2 1 39 0.53 28.55 18.35
60 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
61 INT3400 Positive_regulation of pr 1 57 0.68 36.9 16.24
62 INT3793 Regulation of CEBPZ 2 59 0.61 20.91 15.83
63 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
64 INT2630 Positive_regulation of Shbg 1 134 0.70 65.26 15.19
65 INT505 Positive_regulation of GPT 2 89 0.67 69.38 14.94
66 INT95 Positive_regulation of Adrb1 3 34 0.62 11.95 14.41
67 INT73594 Positive_regulation of Gene_expression of ISYNA1 1 61 0.55 31.35 13.45
68 INT711 Positive_regulation of PIK3C2A 1 83 0.70 76.87 13.18
69 INT21979 Negative_regulation of EDN1 1 52 0.58 24.65 12.55
70 INT11897 Gene_expression of Atp7b 1 25 0.13 7.85 12.5
71 INT70050 Negative_regulation of IL10 1 56 0.58 37.45 12.39
72 INT9832 Gene_expression of Shbg 2 96 0.75 56.71 12.19
73 INT3602 Negative_regulation of Shbg 2 148 0.53 69.05 11.65
74 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
75 INT3851 Gene_expression of Got1 2 58 0.65 29.15 10.52
76 INT6431 Positive_regulation of Ass1 1 36 0.24 8.08 10.43
77 INT39712 Binding of pad 1 82 0.48 110.92 10.33
78 INT59 Regulation of Adrb1 1 25 0.42 8.32 9.78
79 INT68372 Regulation of CYP2C9 1 28 0.62 5.64 9.53
80 INT59465 Negative_regulation of ISYNA1 2 41 0.49 21.9 9.46
81 INT23178 Gene_expression of H1 1 38 0.68 13.37 9.09
82 INT93490 Gene_expression of GPM6A 2 14 0.69 3.14 9.08
83 INT82839 Negative_regulation of ABCB1 2 61 0.59 16.09 8.83
84 INT7105 Gene_expression of pad 1 54 0.77 63.68 8.8
85 INT22798 Regulation of Shbg 1 64 0.60 26.71 8.76
86 INT61264 Regulation of Jun 1 36 0.61 18.42 8.71
87 INT28521 Gene_expression of HBG2 1 56 0.77 16.62 8.64
88 INT4046 Positive_regulation of HBG2 4 42 0.69 13.66 8.51
89 INT14368 Regulation of Gene_expression of Gnrhr 1 13 0.61 3.23 8.45
90 INT6133 Negative_regulation of Serpinc1 1 56 0.58 42.8 8.35
91 INT61599 Positive_regulation of CYP2C9 1 43 0.69 11.1 8.33
92 INT34009 Binding of Tbxa2r 1 33 0.36 17.98 8.01
93 INT12334 Positive_regulation of CYP3A 2 34 0.70 6.77 7.85
94 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
95 INT20348 Negative_regulation of Tbxa2r 2 47 0.59 19.88 7.68
96 INT10344 Localization of Jun 2 23 0.73 6.36 7.46
97 INT81378 Negative_regulation of Dpp4 2 18 0.59 7.87 7.42
98 INT47994 Negative_regulation of Lipg 1 45 0.50 27.19 7.24
99 INT49751 Negative_regulation of Positive_regulation of PTGS1 2 12 0.45 4.73 7.23
100 INT78404 Gene_expression of COX5A 1 24 0.75 9.73 7.07
101 INT612 Positive_regulation of Orm1 1 15 0.68 5.24 6.73
102 INT22205 Gene_expression of CCT6A 2 7 0.29 0.86 6.63
103 INT120895 Binding of CCL2 1 22 0.37 15.86 6.55
104 INT15775 Positive_regulation of Ren1 2 50 0.69 22.38 6.19
105 INT17370 Negative_regulation of Negative_regulation of Ptgs1 2 16 0.22 6.5 6.12
106 INT11896 Negative_regulation of Atp7b 2 15 0.11 6.01 6.09
107 INT3894 Negative_regulation of Localization of Gcg 1 18 0.52 2.7 5.77
108 INT9895 Binding of GHR 1 18 0.36 4.8 5.65
109 INT26112 Positive_regulation of Hrh2 1 10 0.69 4.28 5.54
110 INT77281 Negative_regulation of HIVEP1 1 132 0.49 102.78 5.36
111 INT28145 Binding of PAPPA 1 26 0.48 7.4 4.96
112 INT12412 Binding of MPG 2 21 0.47 3.92 4.94
113 INT60066 Positive_regulation of NPEPPS 1 17 0.22 11.99 4.83
114 INT81761 Negative_regulation of Prep 1 12 0.55 8.48 4.73
115 INT20196 Negative_regulation of Gene_expression of Atp7b 1 8 0.07 2.49 4.63
116 INT78995 Negative_regulation of Agtr2 1 26 0.42 13.05 4.56
117 INT73309 Regulation of Negative_regulation of PTGS2 1 14 0.44 9.55 4.5
118 INT39000 Regulation of pr 1 24 0.44 12.51 4.36
119 INT60067 Localization of NPEPPS 5 9 0.26 3.36 4.15
120 INT144 Positive_regulation of H1 1 10 0.64 2.77 4.13
121 INT38066 Binding of MSC 1 14 0.41 5.28 4.12
122 INT37907 Positive_regulation of Capns1 2 9 0.41 3.55 4.1
123 INT465 Binding of Adrb1 1 14 0.35 3.04 4.07
124 INT27964 Negative_regulation of CBR1 1 12 0.58 5.48 3.74
125 INT38065 Localization of Sfat 2 3 0.03 1.26 3.71
126 INT76672 Regulation of GPM6A 1 3 0.15 0.24 3.6
127 INT28802 Binding of F2 1 15 0.47 8.8 3.47
128 INT55875 Negative_regulation of GPM6A 1 4 0.31 0.06 3.31
129 INT21156 Binding of PLXNA3 1 21 0.36 7.95 3.3
130 INT31340 Positive_regulation of Gene_expression of Got1 1 20 0.46 10.5 3.17
131 INT2837 Regulation of PAEP 1 17 0.53 7.84 3.17
132 INT6063 Positive_regulation of Bche 2 17 0.66 6.07 3.08
133 INT26996 Positive_regulation of Gene_expression of Crp 1 21 0.68 21.55 2.75
134 INT19621 Positive_regulation of CD86 1 23 0.69 14 2.58
135 INT25166 Regulation of Tbxa2r 1 12 0.43 5.94 2.47
136 INT7313 Negative_regulation of CDNF 1 7 0.05 2.53 2.34
137 INT28486 Positive_regulation of Phdlc1 1 18 0.40 14.4 2.17
138 INT97134 Negative_regulation of CD80 1 8 0.57 5.09 2.11
139 INT38906 Transcription of Hrh2 1 6 0.62 3.11 2.03
140 INT149263 Regulation of Negative_regulation of CYP3A4 1 4 0.44 1 2.03
141 INT10976 Negative_regulation of ENPP3 1 13 0.42 5.11 1.92
142 INT93912 Positive_regulation of CD80 1 11 0.56 7.01 1.88
143 INT16202 Negative_regulation of Positive_regulation of Shbg 1 8 0.58 5.24 1.86
144 INT55606 Binding of Ace 1 14 0.37 10.73 1.82
145 INT19617 Negative_regulation of CD86 1 12 0.42 3.68 1.77
146 INT36581 Binding of Orm1 1 6 0.48 0.47 1.73
147 INT32688 Positive_regulation of Gene_expression of Shbg 1 14 0.45 7.01 1.6
148 INT19109 Positive_regulation of CYP3A5 1 7 0.67 1.48 1.51
149 INT112832 Negative_regulation of Gene_expression of COX5A 1 4 0.41 2.68 1.51
150 INT60065 Positive_regulation of Localization of NPEPPS 1 3 0.22 1.07 1.41
151 INT60064 Negative_regulation of Localization of NPEPPS 2 3 0.05 0.68 1.27
152 INT38067 Transcription of MSC 1 1 0.55 0.55 1.25
153 INT102880 Regulation of CCT6A 1 1 0.06 0.05 1.18
154 INT31326 Binding of TREH 3 7 0.17 2.29 1.14
155 INT45090 Negative_regulation of IRGM 1 3 0.51 1.06 1.14
156 INT4609 Gene_expression of Klkb1 1 5 0.47 0.81 1.03
157 INT81762 Negative_regulation of PREP 2 6 0.42 1.88 0.8
158 INT9928 Negative_regulation of Orm1 1 3 0.25 1.21 0.73
159 INT64247 Regulation of Phdlc1 1 2 0.03 2.21 0.66
160 INT11907 Regulation of LTBR 1 2 0.41 1.7 0.61
161 INT104446 Binding of Atp7b 1 2 0.09 0.77 0.53
162 INT22333 Regulation of Negative_regulation of Ace 1 3 0.45 0.72 0.52
163 INT147456 Negative_regulation of Positive_regulation of CD80 1 2 0.41 1.32 0.5
164 INT115330 Localization of HM13 2 3 0.45 0.76 0.38
165 INT50884 Binding of MBNL1 2 3 0.23 0.32 0.37
166 INT39333 Negative_regulation of Positive_regulation of Orm1 1 1 0.09 0.4 0.36
167 INT10858 Negative_regulation of Apol7b 2 3 0.02 5.28 0.33
168 INT115328 Negative_regulation of HM13 1 3 0.28 1.1 0.27
169 INT3979 Positive_regulation of Positive_regulation of PIK3C2A 1 2 0.45 1.49 0.27
170 INT38388 Regulation of TPR 1 3 0.23 0.75 0.19
171 INT115327 Positive_regulation of HM13 1 2 0.26 0.47 0.16
172 INT115329 Gene_expression of HM13 1 1 0.38 0.67 0.16
173 INT107758 Gene_expression of GPR161 1 2 0.36 0.4 0.15
174 INT74687 Negative_regulation of STAB2 2 1 0.00 0.29 0.15
175 INT44373 Positive_regulation of Positive_regulation of HBG2 1 1 0.46 0.29 0.14
176 INT74686 Negative_regulation of Calcr 1 1 0.05 0.14 0.06
177 INT11690 Positive_regulation of Soat1 1 1 0.01 0.14 0
178 INT29975 Regulation of Mlvi3 1 1 0.01 0.62 0
179 INT29976 Regulation of Mlvi2 1 1 0.00 0.62 0
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