J:J Exp Clin Cancer Res

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT173059 Binding of KDR and VEGFA 43 2 0.43 29.63 1.1
2 INT30905 SST Negative_regulation of Localization of GCG 2 2 0.12 1.56 1.04
3 INT75283 SST Negative_regulation of Localization of INS 2 2 0.47 1.45 0.96
4 INT303656 SST Negative_regulation of Localization of GAST 1 2 0.12 1.45 0.82
5 INT303652 Binding of SST and SSTR2 1 1 0.26 0.46 0.57
6 INT303654 Binding of SST and SSTR5 1 1 0.22 0.46 0.57
7 INT303653 Binding of DRD2 and SST 1 1 0.18 0.45 0.54
8 INT292814 Binding of VEGFA and Kdr 8 3 0.18 3.63 0.48
9 INT303651 Binding of SSTR2 and SSTR5 1 1 0.24 0.23 0.45
10 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 2 0.16 2.19 0.41
11 INT303650 Binding of IGF1 and SSTR1 1 2 0.12 2.17 0.4
12 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 1 0.00 1.44 0.33
13 INT355038 NRP1 Negative_regulation of CKAP4 1 1 0.02 1.23 0.29
14 INT262809 Il10 Positive_regulation of Regulation of Slc11a1 1 1 0.17 1.12 0.27
15 INT262810 Slc11a1 Positive_regulation of Gene_expression of Il10 1 1 0.20 0.97 0.27
16 INT237927 BCL2 Positive_regulation of BAX 2 1 0.24 2.22 0.26
17 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 1 0.21 1.17 0.22
18 INT318211 MUC5AC Positive_regulation of Muc4 1 1 0.17 1.12 0.17
19 INT318188 MUC5AC Positive_regulation of MUC1 1 1 0.16 1.12 0.17
20 INT303659 SSTR2 Negative_regulation of Gene_expression of SST 1 1 0.30 0.94 0.16
21 INT303657 Gene_expression of SSTR2 Negative_regulation of Gene_expression of SST 1 1 0.30 0.94 0.16
22 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 1 0.01 0.97 0.14
23 INT318209 Sis Negative_regulation of VEGFA 1 1 0.00 1.09 0.14
24 INT347639 Binding of Atp9a and Hdac4 1 1 0.01 0.97 0.14
25 INT318185 MUC5AC Positive_regulation of Gene_expression of MMP3 1 1 0.09 0.86 0.13
26 INT318192 MUC5AC Negative_regulation of Gene_expression of VEGFA 1 1 0.20 0.98 0.1
27 INT318210 MUC5AC Negative_regulation of Phosphorylation of Flt1 1 1 0.07 0.98 0.09
28 INT344254 Binding of PARP1 and CASP3 1 1 0.06 0.94 0.06
29 INT324938 Binding of VEGFA and AMIGO3 1 1 0.02 0.69 0.05
30 INT318186 MUC5AC Positive_regulation of Gene_expression of VEGFA 1 1 0.22 1.01 0.04
31 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 1 0.08 0.4 0.03
32 INT318191 INCENP Negative_regulation of Gene_expression of VEGFA 1 1 0.00 1.05 0.03
33 INT318190 Negative_regulation of MUC5AC Negative_regulation of Gene_expression of VEGFA 1 1 0.23 1.06 0.03
34 INT318187 Binding of INCENP and MUC5AC 1 1 0.00 1.03 0.03
35 INT327981 CASP9 Positive_regulation of CASP3 2 2 0.29 1.34 0
36 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 1 0.15 1.14 0
37 INT329676 CBX7 Regulation of Localization of CDKN2A 1 2 0.51 2.4 0
38 INT327969 Binding of PNLIP and TNFRSF11A 1 1 0.09 0.89 0
39 INT351734 SSD Positive_regulation of ROS1 1 1 0.27 0.3 0
40 INT245158 AD5 Regulation of PKD1 1 1 0.00 0.44 0
41 INT327978 PNLIP Regulation of Regulation of CASP9 1 1 0.19 0.57 0
42 INT327971 PNLIP Positive_regulation of Gene_expression of BAX 1 3 0.43 1.95 0
43 INT351732 SSD Regulation of CALR 1 3 0.01 2.95 0
44 INT260025 PROM1 Positive_regulation of Gene_expression of NES 1 1 0.56 0.74 0
45 INT327980 PNLIP Regulation of TNFRSF11A 1 1 0.15 0.89 0
46 INT327972 Negative_regulation of BCL2 Positive_regulation of BAX 1 1 0.22 0.82 0
47 INT351733 CALR Positive_regulation of ROS1 1 1 0.03 0.3 0
48 INT327982 PNLIP Regulation of Gene_expression of CASP3 1 1 0.13 0.58 0
49 INT327970 GOPC Regulation of Gene_expression of BAD 1 1 0.08 0.6 0
50 INT327977 TNFRSF11A Regulation of BCL2 1 1 0.05 0.67 0
51 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 1 0.02 0.72 0
52 INT327973 PNLIP Negative_regulation of NFKBIB 1 1 0.07 0.9 0
53 INT329677 CDKN2A Regulation of CBX7 1 2 0.31 2.23 0
54 INT327975 GOPC Regulation of Gene_expression of BAX 1 1 0.15 0.6 0
55 INT327976 PNLIP Negative_regulation of Gene_expression of BCL2 1 1 0.29 0.53 0
56 INT327979 Positive_regulation of CASP9 Positive_regulation of Gene_expression of CASP3 1 1 0.07 0.78 0
57 INT327974 GOPC Regulation of Gene_expression of BCL2 1 1 0.13 0.6 0
58 INT329679 CBX7 Regulation of CDKN2A 1 4 0.31 4.18 0
59 INT351731 SSD Positive_regulation of Positive_regulation of ROS1 1 1 0.18 0.71 0
60 INT260024 PROM1 Positive_regulation of NES 1 1 0.56 0.73 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
2 INT68684 Gene_expression of VEGFA 26 2371 0.78 1742.52 259.2
3 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
4 INT49441 Negative_regulation of Cpox 5 494 0.59 303.22 177.46
5 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
6 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
7 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
8 INT812 Localization of INS 1 1026 0.81 515.6 145.31
9 INT60694 Gene_expression of Il10 7 567 0.78 369.48 143.69
10 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
11 INT65600 Positive_regulation of Casp3 4 376 0.70 198.44 128.03
12 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 5 1138 0.72 311.58 119.18
13 INT69440 Gene_expression of ROS1 10 752 0.78 477.64 103.83
14 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
15 INT397 Localization of SST 6 232 0.81 58.05 101.19
16 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
17 INT68682 Positive_regulation of VEGFA 3 640 0.70 454.14 81.65
18 INT79494 Positive_regulation of Gene_expression of VEGFA 3 577 0.70 442.94 69.73
19 INT8347 Gene_expression of SST 18 181 0.78 104.59 65.45
20 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
21 INT17564 Gene_expression of Gpt 3 322 0.75 208.51 60.36
22 INT546 Binding of ALB 1 311 0.48 85.98 60.14
23 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
24 INT63975 Positive_regulation of Il10 2 175 0.68 134.13 54.69
25 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
26 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
27 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
28 INT5118 Regulation of SST 3 97 0.62 34.35 51.74
29 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
30 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
31 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
32 INT26500 Gene_expression of MMP2 10 201 0.78 110.57 46.9
33 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
34 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
35 INT80124 Negative_regulation of VEGFA 6 450 0.58 311.19 44.53
36 INT60695 Positive_regulation of Gene_expression of Il10 2 154 0.70 120.28 43.07
37 INT29496 Gene_expression of MMP3 4 136 0.75 49.49 41.78
38 INT69437 Positive_regulation of ROS1 18 328 0.58 222.83 40.56
39 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
40 INT11560 Positive_regulation of CASP3 7 236 0.70 184.33 39.38
41 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
42 INT68975 Gene_expression of Mmp9 11 111 0.78 79.57 38.55
43 INT77307 Gene_expression of Bcl2 2 399 0.77 319.77 38
44 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
45 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
46 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
47 INT74563 Positive_regulation of Gene_expression of ROS1 5 258 0.61 168.18 34.08
48 INT49214 Gene_expression of Cd4 2 269 0.78 154.22 34.05
49 INT10248 Gene_expression of KRT20 1 436 0.78 231.96 32.88
50 INT691 Binding of SST 5 67 0.48 24.66 32.67
51 INT14497 Gene_expression of GRP 1 82 0.78 17.67 32.27
52 INT48693 Regulation of VEGFA 9 268 0.62 191.88 31.52
53 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
54 INT65960 Gene_expression of BCL2 9 352 0.78 312.03 30.73
55 INT68973 Positive_regulation of Mmp9 1 89 0.52 58.56 30.04
56 INT7412 Positive_regulation of SST 4 71 0.70 24.44 29.48
57 INT28361 Gene_expression of TP53 18 443 0.78 384.86 28.8
58 INT4861 Localization of GRP 1 84 0.80 8.26 28.03
59 INT55737 Positive_regulation of MMP2 1 101 0.68 59.11 27.71
60 INT5206 Gene_expression of AR 1 316 0.78 113.83 27.29
61 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
62 INT12124 Gene_expression of MAPK1 2 141 0.75 82.4 25.58
63 INT17625 Localization of GCG 3 210 0.80 55.69 24.97
64 INT64185 Gene_expression of TNFRSF11A 1 131 0.76 75.15 24.73
65 INT22708 Gene_expression of MUC1 1 297 0.78 232.71 24.19
66 INT90300 Gene_expression of Abcb1a 12 56 0.78 11.05 22.89
67 INT693 Negative_regulation of Localization of SST 1 46 0.59 8.57 21.75
68 INT48692 Binding of VEGFA 3 345 0.48 210.3 21.31
69 INT73593 Gene_expression of BAX 9 173 0.76 147.81 20.94
70 INT28216 Gene_expression of HRAS 1 173 0.75 93.97 20.78
71 INT7336 Positive_regulation of VIP 1 60 0.70 24.2 19.62
72 INT89396 Phosphorylation of AKT1 8 225 0.82 111.66 19.61
73 INT86187 Positive_regulation of AKT1 3 199 0.69 122.13 19.44
74 INT76924 Positive_regulation of Slc17a5 1 71 0.70 41.21 19.31
75 INT28951 Negative_regulation of IGF1 2 133 0.59 75.77 18.9
76 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
77 INT28642 Gene_expression of CXCR2 1 60 0.78 38.69 18.11
78 INT133647 Negative_regulation of HDAC9 8 149 0.57 106.84 17.9
79 INT7414 Regulation of Localization of SST 1 31 0.60 4.85 17.46
80 INT68681 Transcription of VEGFA 1 132 0.71 80.47 17.03
81 INT94467 Positive_regulation of Hand1 2 71 0.58 59 16.96
82 INT65856 Positive_regulation of TP53 2 138 0.67 112.65 16.71
83 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
84 INT108588 Gene_expression of CASP3 7 126 0.78 84.49 16.2
85 INT2243 Localization of GAST 1 67 0.81 34.54 16.19
86 INT26314 Positive_regulation of MMP3 1 48 0.67 22.14 16.17
87 INT80972 Gene_expression of Tp53 1 104 0.78 102.74 16.02
88 INT14152 Gene_expression of Slc17a5 3 46 0.61 20.01 15.9
89 INT97245 Gene_expression of AKT1 4 217 0.77 119.63 15.59
90 INT26501 Positive_regulation of Gene_expression of MMP2 1 51 0.67 39 15.16
91 INT49219 Gene_expression of Hrh1 1 28 0.75 13.77 14.99
92 INT7776 Gene_expression of Abcb1b 19 63 0.75 21.35 14.92
93 INT94774 Regulation of CDKN2A 8 43 0.60 44.41 13.99
94 INT55740 Gene_expression of Timp1 1 53 0.75 28.63 13.85
95 INT69435 Negative_regulation of ROS1 1 74 0.51 50.38 13.71
96 INT78472 Gene_expression of CDKN2A 45 223 0.78 173.76 13.61
97 INT86383 Negative_regulation of EGFR 1 258 0.59 173.94 13.32
98 INT80222 Negative_regulation of Bcl2 4 82 0.58 69.16 13.18
99 INT89395 Negative_regulation of AKT1 1 127 0.58 70.27 12.54
100 INT8224 Gene_expression of CHGA 3 73 0.75 53.63 12.31
101 INT69436 Negative_regulation of Gene_expression of ROS1 1 81 0.38 46.58 12.22
102 INT81626 Positive_regulation of Positive_regulation of Casp3 1 34 0.69 16.75 12.18
103 INT39587 Gene_expression of CP 2 42 0.65 31.48 11.87
104 INT69029 Gene_expression of PTPRC 1 127 0.75 74.26 11.57
105 INT68976 Positive_regulation of Gene_expression of Mmp9 1 34 0.42 28.21 11.28
106 INT25963 Gene_expression of DES 1 122 0.75 98.81 11.25
107 INT63773 Gene_expression of DRD2 1 25 0.78 10.41 10.8
108 INT9385 Localization of LDHA 3 74 0.81 31.67 10.5
109 INT94784 Binding of ROS1 2 113 0.40 71.57 10.26
110 INT98130 Positive_regulation of CASP8 1 79 0.67 65.29 10.08
111 INT62269 Gene_expression of Cdkn1a 1 60 0.73 35.78 9.84
112 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
113 INT4494 Regulation of GCG 1 41 0.45 18.38 9.68
114 INT26492 Negative_regulation of Localization of GCG 2 73 0.58 22.2 9.48
115 INT26502 Negative_regulation of Gene_expression of MMP2 3 39 0.58 21.45 9.42
116 INT8225 Localization of CHGA 2 26 0.78 13.52 9.4
117 INT73596 Positive_regulation of Gene_expression of BAX 1 43 0.67 40.97 9.22
118 INT94196 Negative_regulation of Phosphorylation of MAPK1 1 60 0.59 31.64 9.16
119 INT9899 Gene_expression of Vwf 4 91 0.74 45.06 9.13
120 INT80037 Gene_expression of BAK1 1 58 0.75 39.49 9.08
121 INT113845 Protein_catabolism of PARP1 3 54 0.88 43.86 8.77
122 INT61264 Regulation of Jun 1 36 0.61 18.42 8.71
123 INT6810 Gene_expression of ENO2 4 70 0.78 54.8 8.35
124 INT15529 Gene_expression of GCG 2 51 0.75 18.55 8.35
125 INT39170 Gene_expression of TSPO 1 76 0.78 24.11 8.05
126 INT6884 Negative_regulation of pr 1 20 0.42 13.18 7.97
127 INT53487 Gene_expression of TSC1 2 81 0.58 77.71 7.94
128 INT73595 Positive_regulation of BAX 1 61 0.61 56.97 7.82
129 INT126583 Positive_regulation of PARP1 4 50 0.68 41.44 7.78
130 INT111607 Gene_expression of CDH1 3 103 0.75 90.45 7.77
131 INT21685 Gene_expression of ras 1 115 0.66 85.6 7.76
132 INT167052 Gene_expression of Cr2 2 43 0.56 25.7 7.76
133 INT77306 Negative_regulation of Gene_expression of Bcl2 1 46 0.58 38.05 7.71
134 INT8669 Positive_regulation of Afp 1 66 0.70 58.21 7.67
135 INT72219 Gene_expression of METTL3 2 45 0.24 9.58 7.61
136 INT113705 Gene_expression of Egfr 3 228 0.78 149.05 7.59
137 INT57748 Positive_regulation of Gene_expression of TP53 6 85 0.69 79.55 7.49
138 INT102572 Gene_expression of Ccnd1 2 79 0.69 56.37 7.34
139 INT134624 Gene_expression of Flt1 3 77 0.66 48.86 7.27
140 INT82610 Positive_regulation of SRC 1 53 0.67 26.89 7.27
141 INT43727 Negative_regulation of Gene_expression of MMP3 1 16 0.40 4.81 7.18
142 INT79062 Gene_expression of B4GALNT1 1 42 0.14 18.89 6.98
143 INT69439 Regulation of ROS1 1 46 0.45 31.22 6.94
144 INT102749 Positive_regulation of Positive_regulation of CASP3 1 32 0.67 26.07 6.93
145 INT2037 Negative_regulation of EGF 2 30 0.59 15.05 6.81
146 INT22024 Negative_regulation of HBG1 1 45 0.58 26 6.8
147 INT245173 Gene_expression of MDK 55 81 0.49 51.08 6.78
148 INT19146 Negative_regulation of Apoa2 1 19 0.36 5.34 6.73
149 INT84685 Regulation of BCL2 3 67 0.60 72.96 6.65
150 INT108585 Positive_regulation of Gene_expression of CASP3 2 35 0.70 28.37 6.45
151 INT7205 Positive_regulation of HBG1 3 65 0.69 40.35 6.37
152 INT192225 Gene_expression of HDAC9 2 35 0.58 32.82 6.36
153 INT38672 Binding of KRT20 1 69 0.39 48.01 6.31
154 INT93359 Positive_regulation of Trp53 1 90 0.70 69.77 6.24
155 INT88245 Gene_expression of Slc11a1 6 42 0.53 18.86 6.2
156 INT24042 Gene_expression of MUC5AC 17 98 0.77 74.99 6.18
157 INT2137 Localization of Cea 1 27 0.70 19.22 6.14
158 INT24724 Positive_regulation of Gene_expression of SST 1 11 0.67 7.51 6.12
159 INT111545 Phosphorylation of VEGFA 5 50 0.76 22.19 5.88
160 INT86111 Positive_regulation of Positive_regulation of VEGFA 2 38 0.69 33.81 5.78
161 INT62270 Positive_regulation of Gene_expression of Cdkn1a 1 30 0.47 18.73 5.69
162 INT55733 Negative_regulation of VTN 1 47 0.58 47.22 5.68
163 INT80033 Binding of FAS 2 37 0.48 41.19 5.67
164 INT3395 Negative_regulation of VIP 1 15 0.59 4.23 5.62
165 INT125467 Positive_regulation of Gene_expression of CDKN2A 6 35 0.63 39.07 5.56
166 INT89794 Positive_regulation of CDKN2A 4 58 0.67 50.18 5.38
167 INT213741 Gene_expression of Kdr 15 60 0.75 44.24 5.35
168 INT95120 Positive_regulation of CASP9 10 76 0.67 67.55 5.33
169 INT18681 Gene_expression of Thy1 1 80 0.71 38.8 5.23
170 INT3811 Negative_regulation of PAEP 1 36 0.50 23.7 5.18
171 INT73262 Negative_regulation of BCL2 5 67 0.57 61.01 5.07
172 INT110202 Positive_regulation of Gene_expression of Abcb1a 2 13 0.67 2.08 5.01
173 INT14681 Negative_regulation of GCG 1 31 0.57 13.55 4.98
174 INT142435 Gene_expression of NES 40 86 0.78 47.53 4.92
175 INT116464 Negative_regulation of Birc5 1 53 0.59 45.4 4.91
176 INT105336 Regulation of AKT1 1 52 0.56 32.53 4.89
177 INT67195 Negative_regulation of Gene_expression of SST 1 7 0.42 6.98 4.88
178 INT18898 Positive_regulation of CHGA 3 38 0.67 28.99 4.86
179 INT129856 Positive_regulation of TNFRSF11A 1 26 0.68 16.21 4.75
180 INT174189 Gene_expression of E2F2 1 19 0.49 12.58 4.71
181 INT62684 Negative_regulation of TP53 1 66 0.58 66.09 4.62
182 INT57749 Negative_regulation of Gene_expression of TP53 2 39 0.56 36.79 4.45
183 INT113107 Phosphorylation of Hist1h3f 1 21 0.51 8.01 4.45
184 INT141000 Negative_regulation of GSK 3 24 0.57 9.46 4.4
185 INT103155 Gene_expression of KDR 3 78 0.66 50.53 4.38
186 INT80983 Regulation of Abcb1b 1 16 0.60 1.95 4.32
187 INT745 Gene_expression of Afp 5 65 0.78 52.89 4.24
188 INT109450 Positive_regulation of Phosphorylation of AKT1 1 62 0.64 25.18 4.21
189 INT84686 Regulation of BAX 2 26 0.49 28.54 4.13
190 INT138872 Gene_expression of SPINK5 4 21 0.58 30.11 4.12
191 INT171252 Gene_expression of BMI1 4 21 0.70 26.98 4.11
192 INT170455 Gene_expression of Atp8a1 1 66 0.75 24.63 3.94
193 INT140542 Gene_expression of SSTR2 13 18 0.65 13.58 3.94
194 INT37380 Negative_regulation of Sis 1 31 0.55 19.89 3.92
195 INT14930 Regulation of Gene_expression of SST 5 12 0.45 6.86 3.89
196 INT117828 Regulation of Gene_expression of Abcb1b 3 7 0.60 1.8 3.76
197 INT10992 Gene_expression of PARP1 2 32 0.76 22.22 3.74
198 INT135016 Positive_regulation of Gene_expression of Slc17a5 1 7 0.55 4.33 3.74
199 INT88805 Protein_catabolism of CASP3 3 24 0.86 18.38 3.7
200 INT97126 Regulation of CASP3 1 9 0.40 8.15 3.6
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