J:J Med Case Reports

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT326303 Binding of CRP and FKBP4 1 1 0.15 1.22 0.41
2 INT353836 Binding of CEACAM7 and ICA1 1 1 0.08 0.32 0.39
3 INT321601 Binding of C3 and PRTN3 1 1 0.00 0.99 0.27
4 INT321602 Binding of C4A and PRTN3 1 1 0.00 0.99 0.27
5 INT348637 Binding of TLE4 and OLFM1 1 1 0.01 1.67 0.24
6 INT320492 KRT7 Positive_regulation of Pip 1 1 0.00 1.02 0.2
7 INT210029 PROC Negative_regulation of PRTN3 1 1 0.00 1.06 0.18
8 INT252646 Binding of C6orf25 and SYT16 1 1 0.00 0.51 0.17
9 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 1 0.00 0.78 0.17
10 INT244116 ELAVL3 Negative_regulation of MUC1 1 1 0.09 3.41 0.15
11 INT303600 IGF1 Regulation of Gene_expression of GH1 1 1 0.39 0.83 0.14
12 INT223482 CRP Positive_regulation of GOPC 1 1 0.08 0.8 0.1
13 INT137398 Binding of CD99 and Vim 2 1 0.02 2.36 0.09
14 INT350106 Binding of SLC4A3 and SLC4A1 1 2 0.13 2.78 0.09
15 INT259716 Loxl1 Regulation of Loxl1 1 1 0.00 1.84 0.08
16 INT212080 Eno2 Regulation of Localization of SYP 1 1 0.03 0.51 0.07
17 INT212071 Eno2 Regulation of Localization of Afp 1 1 0.01 0.52 0.07
18 INT212079 SYP Regulation of Localization of Afp 1 1 0.10 0.52 0.07
19 INT212078 Eno2 Regulation of Localization of EPHB6 1 1 0.03 0.52 0.07
20 INT212063 CHGA Regulation of Localization of SYP 1 1 0.49 0.51 0.07
21 INT212077 CHGA Regulation of Localization of Afp 1 1 0.10 0.52 0.07
22 INT212070 ENO2 Regulation of Localization of AFP 1 1 0.49 0.52 0.07
23 INT212064 ENO2 Regulation of Localization of SYP 1 1 0.49 0.51 0.07
24 INT212068 CHGA Regulation of Localization of EPHB6 1 1 0.49 0.52 0.07
25 INT212076 ENO2 Regulation of Localization of Afp 1 1 0.10 0.52 0.07
26 INT212069 SYP Regulation of Localization of EPHB6 1 1 0.49 0.52 0.07
27 INT212067 CHGA Regulation of Localization of AFP 1 1 0.49 0.52 0.07
28 INT212081 Eno2 Regulation of Localization of AFP 1 1 0.03 0.52 0.07
29 INT212062 SYP Regulation of Localization of AFP 1 1 0.49 0.52 0.07
30 INT332588 Binding of RAPH1 and MND1 1 2 0.01 3.88 0.07
31 INT212066 ENO2 Regulation of Localization of EPHB6 1 1 0.49 0.52 0.07
32 INT251645 Binding of SERPING1 and CD79A 1 1 0.10 1.31 0.06
33 INT224922 Binding of FAP and TARM1 1 1 0.06 1.4 0.06
34 INT342887 Binding of IFNG and IFNGR1 1 1 0.02 0.65 0.05
35 INT342886 Binding of C3 and CD40 1 1 0.02 0.66 0.05
36 INT219875 Binding of KRT7 and Krt20 1 1 0.01 1.32 0.04
37 INT219857 Binding of Krt20 and Nbr1 1 1 0.00 1.31 0.04
38 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 1 0.00 2.21 0.03
39 INT224921 Binding of TTR and TARM1 1 1 0.06 1.06 0
40 INT296670 Binding of Bcl2 and Vim 1 1 0.00 1.31 0
41 INT304776 Binding of KMS and KTWS 1 1 0.01 2.24 0
42 INT248765 Binding of RUNX1 and CSF2 1 1 0.02 1.36 0
43 INT296684 Binding of CD99 and Bcl2 1 1 0.01 1.68 0
44 INT305632 Binding of BCL6 and MME 1 1 0.00 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 7 1020 0.81 284.52 443.17
3 INT9238 Gene_expression of IL6 8 1575 0.78 1135.66 424.22
4 INT467 Gene_expression of POMC 13 1048 0.78 332.8 394.16
5 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
6 INT5235 Negative_regulation of TNF 4 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 3 1050 0.70 896.51 322.81
8 INT477 Localization of Avp 2 813 0.81 131.58 300.4
9 INT10832 Gene_expression of IL8 4 1050 0.78 698.72 270
10 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
11 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
12 INT16868 Gene_expression of Il6 3 807 0.78 499.48 256.57
13 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
14 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
15 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
16 INT10194 Positive_regulation of IL6 11 702 0.70 600.62 183.38
17 INT15516 Gene_expression of Crp 7 711 0.77 615.33 173.09
18 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
19 INT739 Negative_regulation of POMC 3 358 0.59 102.28 166.77
20 INT15515 Positive_regulation of Crp 6 700 0.70 604.24 150.15
21 INT2451 Positive_regulation of Avp 2 355 0.70 102.66 147.69
22 INT9852 Positive_regulation of Gpt 15 563 0.70 364.64 146.82
23 INT812 Localization of INS 1 1026 0.81 515.6 145.31
24 INT425 Localization of PRL 11 455 0.81 189.64 144.8
25 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
26 INT695 Binding of POMC 1 304 0.48 56.66 126.85
27 INT252 Localization of GH1 4 529 0.80 227.4 122.05
28 INT17612 Gene_expression of CRP 12 676 0.78 580.61 119.03
29 INT12339 Localization of IL8 4 437 0.81 251.87 117.39
30 INT1793 Localization of CGA 2 379 0.81 67.38 114.69
31 INT11051 Positive_regulation of Gene_expression of IL6 7 415 0.69 319.21 109.3
32 INT60526 Gene_expression of IL10 5 449 0.78 292.71 107.84
33 INT915 Positive_regulation of PRL 3 342 0.70 141.96 104.31
34 INT18009 Positive_regulation of CRP 21 518 0.70 553.03 103.74
35 INT397 Localization of SST 2 232 0.81 58.05 101.19
36 INT4860 Positive_regulation of CALCA 1 148 0.00 73.35 97.61
37 INT11587 Gene_expression of CSF2 31 645 0.78 544.38 93.89
38 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
39 INT86024 Gene_expression of PPARA 3 736 0.78 497.93 91.14
40 INT214 Localization of AVP 4 370 0.81 208.51 91.09
41 INT914 Positive_regulation of GH1 3 292 0.69 100.7 84.91
42 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
43 INT2893 Localization of Oxt 1 219 0.80 28.96 79.43
44 INT920 Localization of PLOD1 4 223 0.81 42.25 78.7
45 INT4358 Positive_regulation of Localization of Avp 2 195 0.70 30.79 77.58
46 INT749 Gene_expression of HLA-B 4 341 0.75 224.12 77.37
47 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
48 INT1724 Negative_regulation of ACE 3 437 0.59 315.64 74.48
49 INT10837 Positive_regulation of Gene_expression of IL8 2 294 0.70 190.08 70.34
50 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
51 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
52 INT4960 Positive_regulation of CSF2 8 285 0.70 256.73 65.73
53 INT3375 Gene_expression of IGHE 2 535 0.77 387.47 65.46
54 INT8347 Gene_expression of SST 2 181 0.78 104.59 65.45
55 INT15514 Negative_regulation of Crp 10 275 0.59 194.6 64.86
56 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
57 INT17401 Gene_expression of IGF1 21 475 0.78 232.18 62.07
58 INT18981 Gene_expression of ABAT 1 78 0.68 38.35 61.36
59 INT17564 Gene_expression of Gpt 5 322 0.75 208.51 60.36
60 INT1759 Gene_expression of TIMP1 2 267 0.77 133.87 59.29
61 INT48901 Negative_regulation of IL6 4 186 0.57 136.33 57.87
62 INT73048 Gene_expression of MMP9 1 268 0.77 159.75 57.81
63 INT9408 Positive_regulation of Crp 6 296 0.69 242.27 57.35
64 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
65 INT1579 Gene_expression of PRL 4 279 0.78 119.2 55.41
66 INT78899 Gene_expression of CCL5 1 155 0.77 84.02 55.09
67 INT82650 Gene_expression of Bcl2 2 312 0.78 211.71 55.03
68 INT49993 Positive_regulation of Gene_expression of Il6 2 149 0.70 88.07 53.78
69 INT9234 Negative_regulation of Gene_expression of IL6 3 171 0.59 101.61 53.15
70 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
71 INT249 Localization of GHRH 4 215 0.80 78.02 51.87
72 INT921 Regulation of GH1 1 172 0.60 52.88 51.04
73 INT2604 Positive_regulation of Got1 2 223 0.70 154.78 49.51
74 INT22454 Regulation of Crp 3 213 0.62 160.67 49.24
75 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
76 INT671 Positive_regulation of Cea 3 221 0.69 164.5 47.79
77 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
78 INT531 Gene_expression of GH1 14 376 0.75 193.45 46.24
79 INT42980 Gene_expression of GAD1 2 139 0.69 94.77 45.11
80 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
81 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
82 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
83 INT4216 Gene_expression of CD40LG 10 328 0.78 256.02 44.23
84 INT73502 Positive_regulation of IL10 6 154 0.69 124.87 43.5
85 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
86 INT157666 Positive_regulation of GOPC 2 335 0.60 120.19 42.75
87 INT50957 Negative_regulation of Il6 3 134 0.59 79.08 42.67
88 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
89 INT3933 Positive_regulation of PLOD1 3 128 0.70 30.76 42.03
90 INT61619 Gene_expression of IL12A 1 194 0.77 146.07 41.97
91 INT13556 Gene_expression of CD4 4 367 0.78 230.82 41.74
92 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
93 INT69437 Positive_regulation of ROS1 2 328 0.58 222.83 40.56
94 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
95 INT52732 Negative_regulation of CRP 3 169 0.59 138.47 40.33
96 INT3987 Positive_regulation of IGHE 4 316 0.70 283.2 40.16
97 INT3758 Gene_expression of ALB 4 326 0.78 184.65 38.75
98 INT9094 Gene_expression of COL7A1 4 277 0.77 143.42 38.73
99 INT14009 Gene_expression of Sst 1 66 0.77 19.6 37.3
100 INT63349 Gene_expression of PECAM1 2 199 0.75 166.03 36.76
101 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
102 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
103 INT59466 Gene_expression of ISYNA1 1 204 0.77 112.57 35.48
104 INT326 Gene_expression of Gnrhr 1 105 0.76 35.87 34.93
105 INT1705 Gene_expression of pCA 3 126 0.65 88.65 34.81
106 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
107 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
108 INT53475 Gene_expression of MRI1 2 116 0.59 77.68 33.98
109 INT10248 Gene_expression of KRT20 7 436 0.78 231.96 32.88
110 INT985 Negative_regulation of GH1 10 213 0.57 89.53 32.39
111 INT56290 Negative_regulation of Gene_expression of Il6 3 79 0.59 47.98 31.07
112 INT65960 Gene_expression of BCL2 1 352 0.78 312.03 30.73
113 INT11650 Negative_regulation of Gpt 2 122 0.59 69.15 30.36
114 INT72923 Positive_regulation of MCRS1 4 72 0.50 99.19 30.36
115 INT11554 Negative_regulation of CSF2 2 129 0.59 108.55 29.44
116 INT3841 Gene_expression of FCGR3B 1 117 0.75 58.99 28.87
117 INT28361 Gene_expression of TP53 3 443 0.78 384.86 28.8
118 INT15610 Localization of GOPC 1 223 0.65 68.26 28.7
119 INT703 Positive_regulation of Pth 3 177 0.70 127.09 27.26
120 INT14690 Localization of CSF2 1 124 0.80 85.17 27.26
121 INT13995 Gene_expression of gr 1 96 0.74 48.21 26.54
122 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
123 INT17739 Gene_expression of S100B 8 226 0.78 132.7 26.4
124 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
125 INT9682 Positive_regulation of IGF1 7 238 0.70 120.03 26.36
126 INT130176 Positive_regulation of Gene_expression of CRP 6 125 0.66 137.06 25.9
127 INT76095 Positive_regulation of ISYNA1 2 117 0.55 79.73 25.86
128 INT3777 Positive_regulation of NARFL 8 256 0.56 302.43 25.74
129 INT11159 Gene_expression of EGFR 11 698 0.78 548.93 25.69
130 INT70048 Positive_regulation of Gene_expression of IL10 1 90 0.55 71.34 25.66
131 INT48235 Negative_regulation of NPEPPS 1 72 0.46 44.54 25.03
132 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
133 INT2614 Gene_expression of CGA 3 187 0.78 105.89 24.77
134 INT58192 Positive_regulation of MRI1 1 86 0.61 53.81 24.68
135 INT22708 Gene_expression of MUC1 2 297 0.78 232.71 24.19
136 INT17275 Gene_expression of HIVEP1 1 267 0.75 232.07 24.06
137 INT58288 Positive_regulation of Gene_expression of Crp 2 83 0.61 82.23 23.7
138 INT8775 Binding of IGHE 2 167 0.48 102.61 23.54
139 INT5055 Positive_regulation of IFNG 1 89 0.69 64.03 23.05
140 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
141 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
142 INT6868 Gene_expression of GFAP 5 136 0.78 84.65 22.7
143 INT91891 Gene_expression of Kit 1 268 0.78 158.89 22.67
144 INT16996 Gene_expression of PRTN3 2 113 0.75 85.61 22.57
145 INT823 Negative_regulation of ESR1 3 144 0.58 63.72 22.52
146 INT2386 Gene_expression of Pgr 4 112 0.78 45.46 22.19
147 INT103842 Gene_expression of Cftr 4 53 0.78 59.59 21.82
148 INT5328 Positive_regulation of CD4 3 191 0.69 133.43 21.31
149 INT4535 Localization of PROC 1 106 0.73 76.24 21.1
150 INT1792 Positive_regulation of CGA 7 123 0.70 64.73 20.79
151 INT1703 Regulation of pCA 1 52 0.52 23.65 20.6
152 INT125312 Positive_regulation of COPD 1 134 0.59 162.55 20.27
153 INT7470 Positive_regulation of Gene_expression of Avp 1 37 0.70 19.55 19.96
154 INT51055 Positive_regulation of TIMP1 1 103 0.69 50.07 19.86
155 INT12265 Positive_regulation of IgG 2 168 0.63 104.89 19.76
156 INT8662 Positive_regulation of EDN1 2 144 0.70 125.34 19.59
157 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
158 INT184895 Gene_expression of MCRS1 3 46 0.42 56.03 19.44
159 INT756 Gene_expression of C3 5 138 0.75 100.6 19.2
160 INT5398 Positive_regulation of ALPP 14 178 0.70 110.52 19.18
161 INT9552 Positive_regulation of TNNI3 2 209 0.70 128.67 19.15
162 INT712 Positive_regulation of LDHA 9 160 0.70 175.25 19.11
163 INT75742 Binding of RLS 8 86 0.42 95.27 19.04
164 INT28951 Negative_regulation of IGF1 8 133 0.59 75.77 18.9
165 INT18672 Gene_expression of Ncam1 4 54 0.78 36.64 18.79
166 INT18010 Positive_regulation of CD40LG 2 122 0.70 100.8 18.46
167 INT4420 Positive_regulation of GOT1 4 103 0.64 88.4 18.38
168 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
169 INT1642 Negative_regulation of Localization of PLOD1 1 40 0.58 10.67 17.95
170 INT20631 Positive_regulation of CHKB 2 166 0.69 109.86 17.92
171 INT80755 Gene_expression of CD40 1 88 0.75 53.68 17.86
172 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
173 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
174 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
175 INT1578 Negative_regulation of Localization of PRL 1 52 0.59 20.62 17.18
176 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
177 INT26972 Negative_regulation of Tenc1 1 57 0.57 56.71 16.87
178 INT13510 Gene_expression of ERBB2 2 530 0.78 405.68 16.79
179 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
180 INT28950 Positive_regulation of Gene_expression of IGF1 2 99 0.69 46.9 16.47
181 INT5841 Gene_expression of Vim 3 181 0.72 138.54 16.33
182 INT20622 Gene_expression of LDHA 4 107 0.76 77.97 16.3
183 INT10214 Gene_expression of VIM 10 153 0.78 115.88 16.29
184 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
185 INT2243 Localization of GAST 2 67 0.81 34.54 16.19
186 INT8571 Gene_expression of B3GAT1 2 54 0.75 36.85 15.98
187 INT103245 Positive_regulation of Gene_expression of MMP9 1 64 0.68 36.86 15.7
188 INT912 Localization of FSHR 1 91 0.79 23.61 15.58
189 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
190 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
191 INT5333 Gene_expression of NPEPPS 1 45 0.65 26.34 15.25
192 INT71634 Gene_expression of SLC6A3 2 45 0.78 13.48 15.23
193 INT34590 Gene_expression of ALPP 6 199 0.75 89.85 15.1
194 INT505 Positive_regulation of GPT 2 89 0.67 69.38 14.94
195 INT10709 Negative_regulation of CD4 1 106 0.59 95.6 14.89
196 INT1888 Protein_catabolism of F13A1 2 97 0.99 63.48 14.82
197 INT25493 Gene_expression of TFPI 2 74 0.76 39.44 14.78
198 INT11340 Positive_regulation of SLC17A5 7 120 0.67 113.52 14.5
199 INT1982 Regulation of NARFL 1 119 0.49 116.2 14.35
200 INT54924 Gene_expression of RLS 5 67 0.62 83.2 14.25
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