J:J Orthop Surg

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT198970 GAPDH Negative_regulation of ADAMTS3 1 1 0.47 0 0.35
2 INT198971 GAPDH Negative_regulation of ADAMTS5 1 1 0.47 0 0.35
3 INT198969 GAPDH Negative_regulation of TIMP1 1 1 0.47 0 0.35
4 INT274531 Il6 Regulation of Localization of Lpl 1 1 0.04 1.49 0.33
5 INT274530 Il6 Regulation of Lpl 1 1 0.07 1.48 0.32
6 INT242094 Binding of ACLY and Pts 1 2 0.01 0 0.22
7 INT326460 NR1I2 Regulation of Cyp4f18 1 1 0.01 0.72 0.18
8 INT234113 COL18A1 Negative_regulation of Phosphorylation of VEGFA 1 1 0.26 0.17 0.16
9 INT234112 Binding of VEGFA and COL18A1 1 1 0.21 0.16 0.15
10 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 1 0.00 0.52 0.14
11 INT309780 Binding of PTH and PTH1R 3 2 0.12 0.3 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
2 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
3 INT16868 Gene_expression of Il6 16 807 0.78 499.48 256.57
4 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
5 INT11313 Positive_regulation of Il6 4 526 0.70 331.27 201.59
6 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
7 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
8 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
9 INT62124 Gene_expression of NOS1 3 444 0.78 218.08 114.85
10 INT18009 Positive_regulation of CRP 4 518 0.70 553.03 103.74
11 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
12 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
13 INT403 Localization of Trh 1 241 0.81 28.55 81.45
14 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
15 INT1377 Positive_regulation of Trh 4 172 0.70 40.55 69.83
16 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
17 INT19511 Localization of Il6 4 212 0.81 118.17 67.67
18 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
19 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
20 INT10706 Regulation of Il6 4 150 0.62 93.23 62.34
21 INT17401 Gene_expression of IGF1 3 475 0.78 232.18 62.07
22 INT14740 Gene_expression of TGFB1 7 272 0.78 168.48 60.18
23 INT546 Binding of ALB 1 311 0.48 85.98 60.14
24 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
25 INT117713 Phosphorylation of Akt1 1 275 0.82 95.82 54.34
26 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
27 INT2323 Gene_expression of Trh 1 146 0.78 29.92 49.5
28 INT157666 Positive_regulation of GOPC 2 335 0.60 120.19 42.75
29 INT50957 Negative_regulation of Il6 1 134 0.59 79.08 42.67
30 INT9094 Gene_expression of COL7A1 2 277 0.77 143.42 38.73
31 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
32 INT60710 Gene_expression of Col7a1 1 217 0.78 113.2 35.2
33 INT17381 Gene_expression of Tbxa2r 1 146 0.78 65.01 34.15
34 INT53475 Gene_expression of MRI1 1 116 0.59 77.68 33.98
35 INT56290 Negative_regulation of Gene_expression of Il6 2 79 0.59 47.98 31.07
36 INT72375 Phosphorylation of Mapk3 1 87 0.80 43.66 30.27
37 INT64113 Positive_regulation of Gene_expression of NOS1 2 110 0.60 71.03 29.72
38 INT129956 Gene_expression of MMP13 1 145 0.72 60.48 26.98
39 INT58192 Positive_regulation of MRI1 2 86 0.61 53.81 24.68
40 INT14733 Positive_regulation of Gene_expression of TGFB1 2 71 0.69 49.89 22.2
41 INT2386 Gene_expression of Pgr 1 112 0.78 45.46 22.19
42 INT8580 Gene_expression of ELANE 1 132 0.75 62.98 21.79
43 INT4535 Localization of PROC 1 106 0.73 76.24 21.1
44 INT51474 Binding of Il6 1 55 0.48 44.99 20.52
45 INT49487 Gene_expression of Sele 1 65 0.76 68.11 19.41
46 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
47 INT78024 Gene_expression of ACLY 16 73 0.75 59.15 18.54
48 INT12081 Localization of TGFB1 1 64 0.81 35.4 17.47
49 INT12081 Localization of TGFB1 3 64 0.81 35.4 17.47
50 INT68681 Transcription of VEGFA 1 132 0.71 80.47 17.03
51 INT13510 Gene_expression of ERBB2 1 530 0.78 405.68 16.79
52 INT5841 Gene_expression of Vim 2 181 0.72 138.54 16.33
53 INT899 Gene_expression of F13A1 4 122 0.70 78.02 16.26
54 INT170855 Negative_regulation of GOPC 4 188 0.38 70.92 15.41
55 INT24670 Gene_expression of FGF2 1 121 0.78 85.64 15.12
56 INT49532 Regulation of Gene_expression of Il6 2 43 0.61 25.8 14.99
57 INT180497 Binding of MRI1 1 45 0.42 28.35 14.77
58 INT60197 Gene_expression of JUN 1 90 0.78 42.32 14.61
59 INT8794 Negative_regulation of Ppt1 1 35 0.57 6.44 14.52
60 INT63361 Gene_expression of CD44 1 126 0.77 71.58 12.96
61 INT125477 Gene_expression of HHIP 12 91 0.78 31.18 12.57
62 INT158124 Gene_expression of COL5A2 3 136 0.69 72.3 12.44
63 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
64 INT28952 Negative_regulation of Gene_expression of IGF1 1 75 0.58 41.11 12.32
65 INT48335 Negative_regulation of NOSTRIN 1 38 0.56 16.22 12.05
66 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
67 INT50933 Transcription of Il6 4 38 0.72 24.31 11.58
68 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
69 INT2792 Gene_expression of Mb 1 91 0.76 41.56 10.25
70 INT35612 Gene_expression of REG3A 1 37 0.78 33.33 10.13
71 INT11679 Negative_regulation of F13A1 1 55 0.54 33.69 9.43
72 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
73 INT173587 Protein_catabolism of COL5A2 1 59 0.32 32.73 8.96
74 INT17701 Gene_expression of PTHLH 3 103 0.78 64.23 8.85
75 INT34777 Localization of IGF1 2 82 0.80 42.68 8.62
76 INT4991 Positive_regulation of Vim 1 74 0.69 69.84 8.33
77 INT19829 Negative_regulation of Gene_expression of Tbxa2r 1 32 0.56 12.78 8.3
78 INT3765 Positive_regulation of Actvty1 1 8 0.06 23.53 7.37
79 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
80 INT173639 Positive_regulation of INCENP 2 40 0.14 20.97 6.7
81 INT65480 Gene_expression of Pts 1 15 0.66 7.53 6.46
82 INT233812 Gene_expression of PTH1R 21 32 0.77 18.15 6.15
83 INT55655 Gene_expression of DCN 1 17 0.75 7.98 5.98
84 INT111545 Phosphorylation of VEGFA 1 50 0.76 22.19 5.88
85 INT174851 Positive_regulation of COL5A2 13 46 0.54 12.73 5.48
86 INT97905 Positive_regulation of FGF2 1 33 0.70 26.74 5.17
87 INT17489 Regulation of F13A1 1 28 0.45 15.79 4.93
88 INT140350 Binding of C2 1 17 0.36 3.97 4.69
89 INT125478 Localization of HHIP 2 32 0.80 3.43 4.68
90 INT165058 Negative_regulation of MID1 1 14 0.37 10.82 4.67
91 INT4683 Negative_regulation of PDXK 1 17 0.55 12.81 4.39
92 INT89103 Regulation of Gene_expression of TGFB1 1 15 0.56 8.11 4.37
93 INT52133 Regulation of Localization of Il6 1 7 0.61 5.35 4.37
94 INT48518 Gene_expression of ANPEP 1 51 0.78 22.88 4.18
95 INT38066 Binding of MSC 1 14 0.41 5.28 4.12
96 INT50295 Regulation of Mtpn 1 13 0.26 7.54 3.77
97 INT125479 Positive_regulation of HHIP 1 38 0.44 12.39 3.75
98 INT38561 Regulation of SEMG1 1 19 0.51 3.75 3.66
99 INT12083 Regulation of TGFB1 1 22 0.53 15.4 3.6
100 INT56300 Negative_regulation of Gene_expression of TGFB1 1 13 0.41 4.87 3.5
101 INT236824 Negative_regulation of Gene_expression of PTH1R 9 10 0.58 9.3 3.42
102 INT122051 Negative_regulation of ROM1 1 17 0.48 9.11 3.38
103 INT122051 Negative_regulation of ROM1 4 17 0.48 9.11 3.38
104 INT97737 Negative_regulation of Phosphorylation of Mapk3 1 9 0.57 5.64 3.3
105 INT81453 Positive_regulation of Gene_expression of JUN 1 18 0.50 9.39 3.23
106 INT111547 Negative_regulation of Phosphorylation of VEGFA 1 13 0.42 5.08 3.22
107 INT77670 Positive_regulation of ACLY 2 24 0.49 21.68 3.12
108 INT94947 Positive_regulation of Transcription of Il6 1 9 0.67 6.91 3.04
109 INT96423 Gene_expression of Bmp2 23 61 0.78 25.07 3.01
110 INT88810 Positive_regulation of Gene_expression of FGF2 1 17 0.50 12.62 2.98
111 INT37363 Localization of PTHLH 1 14 0.68 13.23 2.92
112 INT133144 Localization of Mtpn 1 18 0.24 7.88 2.77
113 INT4686 Gene_expression of Cys1 1 32 0.66 36.24 2.49
114 INT173592 Binding of COL5A2 1 32 0.33 9.14 2.48
115 INT204019 Negative_regulation of C2 1 10 0.26 6.23 2.44
116 INT102639 Positive_regulation of VDR 1 31 0.69 18.05 2.38
117 INT59784 Binding of DES 1 22 0.47 19.48 2.27
118 INT158123 Negative_regulation of Gene_expression of COL5A2 1 19 0.46 15.27 2.23
119 INT5844 Positive_regulation of Gene_expression of Vim 1 14 0.25 9.64 2.18
120 INT125480 Regulation of HHIP 1 17 0.38 6.16 2.16
121 INT170469 Gene_expression of THY1 10 66 0.65 11.9 2.15
122 INT70987 Binding of RAC1 1 14 0.37 12.14 2.13
123 INT12086 Regulation of Localization of TGFB1 1 4 0.43 1.65 2.09
124 INT30531 Gene_expression of C2 3 15 0.66 5.5 1.99
125 INT85337 Negative_regulation of Slc9a3r2 1 5 0.34 2.32 1.8
126 INT105920 Binding of SLC9A3R2 2 5 0.36 1.99 1.75
127 INT120088 Gene_expression of Bmp4 3 37 0.73 13.89 1.73
128 INT62071 Positive_regulation of Gene_expression of PTHLH 1 13 0.70 19.32 1.73
129 INT44637 Positive_regulation of Slc9a3r2 4 18 0.55 7.27 1.72
130 INT73927 Gene_expression of FBL 4 10 0.48 3.55 1.72
131 INT234116 Positive_regulation of MID1 3 9 0.03 3.78 1.61
132 INT92311 Regulation of SIL1 1 7 0.44 6.2 1.61
133 INT30039 Negative_regulation of HAL 1 7 0.42 4.32 1.61
134 INT81982 Gene_expression of Bmpr2 2 36 0.60 14.58 1.55
135 INT9642 Gene_expression of Actvty1 2 7 0.06 3.03 1.41
136 INT12085 Positive_regulation of Localization of TGFB1 2 7 0.42 4.9 1.4
137 INT60860 Gene_expression of Slmap 2 32 0.66 8.55 1.34
138 INT199004 Gene_expression of ARMC9 1 43 0.58 17.72 1.32
139 INT52212 Gene_expression of Bmp6 1 6 0.64 2.38 1.27
140 INT188396 Positive_regulation of Positive_regulation of GOPC 1 13 0.42 1.78 1.21
141 INT118196 Gene_expression of ROM1 1 18 0.66 4.81 1.19
142 INT4576 Localization of Aoc2-ps1 2 4 0.33 1.75 1.18
143 INT190075 Regulation of Transcription of Il6 1 2 0.45 2.17 1.18
144 INT110075 Binding of FTH1 1 10 0.36 1.12 1.13
145 INT96424 Transcription of Bmp2 4 6 0.69 6.34 1.11
146 INT182285 Positive_regulation of Positive_regulation of COL5A2 3 2 0.13 0.37 1.07
147 INT233816 Negative_regulation of PTH1R 3 2 0.58 4.08 1.07
148 INT165387 Regulation of ROM1 1 6 0.37 0.87 1.06
149 INT74166 Positive_regulation of C2 2 10 0.55 2.83 1.05
150 INT19849 Positive_regulation of Smc1b 2 8 0.50 4.09 1.01
151 INT32760 Regulation of Gene_expression of PTHLH 1 4 0.51 6.32 1
152 INT164229 Gene_expression of LECT1 2 8 0.67 3.08 0.96
153 INT150879 Gene_expression of PTCRA 9 12 0.77 2.1 0.94
154 INT128717 Regulation of Tgfb1 2 6 0.61 1.94 0.94
155 INT269485 Positive_regulation of Gene_expression of HHIP 2 9 0.41 1.08 0.92
156 INT88000 Gene_expression of LAP 2 15 0.55 6.94 0.91
157 INT309781 Positive_regulation of Gene_expression of PTH1R 1 2 0.46 1.88 0.87
158 INT62072 Negative_regulation of Gene_expression of PTHLH 1 3 0.43 4.45 0.85
159 INT96188 Binding of Cd34 1 11 0.31 10.4 0.82
160 INT210247 Positive_regulation of Bmp4 3 6 0.65 4.36 0.8
161 INT111199 Gene_expression of Acly 8 11 0.16 5.65 0.78
162 INT139845 Negative_regulation of Cyp4f18 1 4 0.28 0.95 0.78
163 INT86149 Localization of Smad1 2 2 0.56 1.29 0.76
164 INT67988 Positive_regulation of ROM1 3 7 0.41 1.9 0.7
165 INT244300 Localization of PTH1R 1 2 0.74 2.03 0.67
166 INT4367 Regulation of LAP 1 4 0.40 2.89 0.65
167 INT142005 Gene_expression of COL18A1 1 6 0.75 4.53 0.62
168 INT9102 Negative_regulation of SLC9A3R2 1 2 0.31 1.62 0.55
169 INT242093 Negative_regulation of Positive_regulation of COL5A2 2 1 0.08 0 0.53
170 INT227703 Gene_expression of F11 3 5 0.75 1.07 0.5
171 INT146917 Localization of Slmap 1 4 0.80 1.56 0.42
172 INT196026 Positive_regulation of Gene_expression of Bmp2 2 14 0.69 3.19 0.35
173 INT277252 Gene_expression of PPIAP10 1 2 0.75 1.31 0.35
174 INT274529 Localization of Lpl 1 2 0.46 2.31 0.32
175 INT171995 Binding of PTH1R 1 8 0.35 1.16 0.31
176 INT278734 Phosphorylation of Smad1 3 5 0.34 1.48 0.3
177 INT159213 Gene_expression of BMP4 1 8 0.74 2.1 0.28
178 INT159212 Positive_regulation of Gene_expression of BMP4 1 2 0.66 0.91 0.28
179 INT309782 Regulation of PTH1R 1 1 0.45 0.88 0.28
180 INT185009 Negative_regulation of BMP4 1 2 0.56 1.04 0.25
181 INT145305 Positive_regulation of Bmp2 4 12 0.69 8.65 0.24
182 INT227702 Negative_regulation of PTCRA 3 4 0.43 1.21 0.22
183 INT142121 Positive_regulation of Gene_expression of Bmp4 1 3 0.47 7 0.21
184 INT198977 Negative_regulation of Gene_expression of LECT1 1 1 0.42 0.48 0.21
185 INT198975 Gene_expression of ADAMTS3 1 1 0.58 0 0.21
186 INT231466 Binding of COL18A1 1 2 0.25 1.19 0.18
187 INT269670 Gene_expression of CFL1 2 5 0.58 0.74 0.16
188 INT118459 Regulation of Bmp7 1 3 0.43 0.25 0.15
189 INT282160 Regulation of Binding of RAC1 1 1 0.18 0.45 0.13
190 INT347937 Regulation of Binding of C2 1 1 0.03 0.31 0.12
191 INT170472 Negative_regulation of Gene_expression of THY1 1 4 0.41 0.26 0.1
192 INT34927 Negative_regulation of Smc1b 1 2 0.25 0.49 0.09
193 INT329390 Negative_regulation of Gene_expression of Acly 2 1 0.10 0.83 0.09
194 INT304488 Binding of KLHDC2 1 1 0.04 0 0.08
195 INT88001 Binding of LAP 2 6 0.45 7.85 0.07
196 INT329391 Positive_regulation of Gene_expression of Acly 3 1 0.12 0.68 0.06
197 INT200458 Positive_regulation of Tha1 1 3 0.15 0.78 0.03
198 INT202693 Gene_expression of LCS1 1 3 0.32 0.99 0
199 INT112009 Positive_regulation of Slmap 1 3 0.58 0.23 0
200 INT234117 Positive_regulation of Binding of MRI1 1 2 0.44 0.19 0
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