J:Journal of Medicinal Chemistry

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT72418 Binding of Cnr1 and Cnr2 3 2 0.42 0.07 0.79
2 INT144107 Binding of SLC6A2 and SLC6A4 1 1 0.00 0.18 0.62
3 INT308831 Binding of RFC1 and IGKV2D-29 1 2 0.02 0 0.06
4 INT354622 CTSB Regulation of PRDX5 1 1 0.00 0.38 0
5 INT318683 ARPP21 Negative_regulation of SET 1 1 0.00 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT64202 Positive_regulation of Trpv1 4 643 0.70 249.66 397.42
2 INT5979 Gene_expression of Oprd1 9 428 0.78 75.64 320.32
3 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
4 INT2909 Positive_regulation of Abat 1 334 0.70 62.1 256.43
5 INT4893 Gene_expression of Tacr1 2 366 0.78 129.67 213.92
6 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
7 INT2391 Negative_regulation of PTGS1 6 501 0.59 207.62 205.6
8 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
9 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
10 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
11 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
12 INT86024 Gene_expression of PPARA 6 736 0.78 497.93 91.14
13 INT18032 Positive_regulation of Oprk1 2 108 0.70 30.78 89.7
14 INT73340 Negative_regulation of Faah 11 134 0.59 38.67 85.03
15 INT15613 Negative_regulation of Ptgs2 15 160 0.59 71.08 65.08
16 INT67614 Positive_regulation of PPARA 9 438 0.68 293.28 63.61
17 INT546 Binding of ALB 2 311 0.48 85.98 60.14
18 INT62960 Gene_expression of P2rx2 3 149 0.77 58.31 59.16
19 INT20964 Gene_expression of OPRK1 3 96 0.78 23.54 58.18
20 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
21 INT10304 Binding of OPRK1 13 89 0.48 9.28 49.42
22 INT63383 Binding of Cnr1 7 77 0.48 22.28 44.61
23 INT85943 Negative_regulation of Nos2 3 161 0.59 108.56 42.65
24 INT64440 Gene_expression of Pnoc 3 66 0.78 13.61 41.76
25 INT65245 Gene_expression of Nos3 2 121 0.78 98.14 41.56
26 INT6943 Positive_regulation of Gabrd 2 71 0.70 17.36 35.25
27 INT103094 Binding of PPARA 9 308 0.47 177.26 34.75
28 INT49519 Gene_expression of P2rx7 1 84 0.76 36.88 34.69
29 INT74563 Positive_regulation of Gene_expression of ROS1 2 258 0.61 168.18 34.08
30 INT50308 Binding of Cnr1 3 61 0.48 14.41 33.52
31 INT1613 Binding of Nts 1 58 0.48 10.55 28.18
32 INT5206 Gene_expression of AR 3 316 0.78 113.83 27.29
33 INT81496 Gene_expression of CNR2 1 68 0.75 30.04 24.92
34 INT51801 Gene_expression of Gabrd 2 64 0.72 19.17 22.61
35 INT73625 Gene_expression of PPARG 1 108 0.78 104.85 21.42
36 INT101517 Negative_regulation of PPARA 2 168 0.57 112.24 21.41
37 INT85952 Positive_regulation of AR 1 168 0.67 64.36 20.66
38 INT96511 Negative_regulation of Positive_regulation of Trpv1 1 35 0.59 10.95 19.79
39 INT66004 Binding of Cnr2 5 35 0.48 12.82 18.63
40 INT32515 Negative_regulation of B4GALNT1 1 82 0.43 28.1 17.46
41 INT68640 Regulation of Pnoc 2 18 0.54 7.6 17.27
42 INT15202 Regulation of Tacr1 1 26 0.60 9.65 16.48
43 INT131871 Negative_regulation of Mgll 3 23 0.58 5.1 16.03
44 INT91285 Negative_regulation of P2rx2 1 29 0.57 12.74 15.48
45 INT92839 Regulation of P2rx2 1 36 0.45 13.19 15.38
46 INT74449 Positive_regulation of B4GALNT1 1 53 0.30 34.49 14.96
47 INT94650 Gene_expression of Grm5 1 32 0.77 11.26 14.82
48 INT103096 Regulation of PPARA 2 113 0.60 62.47 14.57
49 INT100139 Positive_regulation of Gene_expression of PPARA 1 160 0.63 97.78 14.53
50 INT51158 Positive_regulation of Tacr1 1 33 0.70 15.22 13.91
51 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
52 INT83601 Binding of CNR2 2 30 0.47 7.79 12.37
53 INT91413 Negative_regulation of PTGES 4 35 0.58 17.94 12.03
54 INT93122 Gene_expression of P2ry1 1 32 0.75 11.82 11.42
55 INT12444 Binding of Gabrd 2 26 0.48 4.7 11.23
56 INT73338 Gene_expression of Faah 1 21 0.77 6.72 10.73
57 INT113317 Regulation of Cnr2 2 17 0.52 10.27 10.68
58 INT82854 Gene_expression of MRGPRX1 1 61 0.75 10.14 10.65
59 INT82854 Gene_expression of MRGPRX1 2 61 0.75 10.14 10.65
60 INT173159 Localization of PPARA 3 96 0.74 64.55 10.26
61 INT122584 Negative_regulation of Gene_expression of PPARA 1 56 0.58 37.61 9.76
62 INT35366 Binding of AR 5 87 0.47 30.52 8.9
63 INT124702 Positive_regulation of Trpv4 3 21 0.69 7.14 8.2
64 INT78371 Gene_expression of IGKV2D-29 5 29 0.75 6.95 7.66
65 INT3309 Binding of CP 1 25 0.47 17.87 6.62
66 INT50387 Negative_regulation of AR 1 67 0.45 26.31 6.61
67 INT169697 Negative_regulation of Ephx2 2 35 0.59 38.21 5.92
68 INT32793 Negative_regulation of Slc6a2 2 12 0.44 1.8 5.78
69 INT86023 Transcription of PPARA 2 60 0.66 25.8 5.7
70 INT55917 Binding of Sigmar1 3 26 0.45 12.65 5.58
71 INT59891 Positive_regulation of GSTK1 1 46 0.67 17.66 5.33
72 INT50105 Localization of CTSB 1 29 0.78 10.98 5.21
73 INT99091 Regulation of AR 1 70 0.45 31.68 5.05
74 INT86219 Negative_regulation of GSTK1 1 25 0.41 8.99 4.97
75 INT122078 Gene_expression of Crygb 1 7 0.76 1.25 4.34
76 INT89925 Gene_expression of NR1I2 1 22 0.75 9.63 4.21
77 INT216851 Binding of IGKV2D-29 5 8 0.36 1.56 3.93
78 INT26233 Binding of GSR 2 45 0.46 18.22 3.74
79 INT22009 Negative_regulation of Ctsa 1 12 0.58 3.14 3.59
80 INT87281 Localization of ADCY1 1 7 0.64 1.84 3.42
81 INT115790 Negative_regulation of P2rx6 1 8 0.47 4.13 3.19
82 INT110521 Regulation of Crygb 1 5 0.28 1.42 2.92
83 INT110980 Gene_expression of CTSB 1 17 0.45 8.02 2.69
84 INT123713 Binding of Grm5 1 7 0.31 2.96 2.38
85 INT96199 Negative_regulation of PGP 1 15 0.59 1.07 2.35
86 INT156301 Regulation of Trpv4 1 11 0.60 2.81 2.35
87 INT115401 Negative_regulation of P2ry1 1 6 0.42 1.27 2.25
88 INT101516 Positive_regulation of PPARD 1 8 0.49 4.75 2.19
89 INT85201 Binding of Npffr1 1 4 0.38 0.72 2.05
90 INT154922 Gene_expression of Icos 1 11 0.65 4.64 1.96
91 INT173333 Negative_regulation of MRGPRX1 1 5 0.20 0.9 1.9
92 INT173180 Positive_regulation of Binding of PPARA 1 14 0.49 3.66 1.88
93 INT68649 Gene_expression of IL24 2 9 0.72 6.7 1.7
94 INT84722 Regulation of Gene_expression of AR 1 20 0.61 7.73 1.69
95 INT124337 Gene_expression of Tacr2 1 4 0.66 0.57 1.68
96 INT78202 Binding of GSTK1 1 17 0.31 5.44 1.66
97 INT13176 Positive_regulation of Binding of Gabrd 2 3 0.38 0.73 1.55
98 INT101859 Gene_expression of MCF2 1 34 0.49 19.45 1.51
99 INT173198 Regulation of Binding of PPARA 1 17 0.43 9.58 1.47
100 INT87625 Positive_regulation of IGKV2D-29 1 8 0.67 1.97 1.47
101 INT20937 Regulation of MGP 2 4 0.43 0.62 1.37
102 INT141642 Positive_regulation of Ctsa 1 5 0.49 2.87 1.27
103 INT231592 Binding of ADRA2B 1 5 0.18 0.13 1.23
104 INT132453 Binding of TF 1 31 0.36 12.98 1.22
105 INT163874 Binding of Slc6a2 3 4 0.28 1.21 1.21
106 INT91304 Binding of Npffr2 1 3 0.32 0.44 1.13
107 INT118947 Positive_regulation of FABP4 3 6 0.67 3.44 1.07
108 INT204156 Gene_expression of HAMP 1 7 0.75 8.1 0.94
109 INT107714 Localization of PPARG 1 4 0.73 0.88 0.91
110 INT252442 Binding of RFC1 1 3 0.05 0.3 0.84
111 INT180534 Gene_expression of SARS 2 40 0.59 35.47 0.81
112 INT144908 Gene_expression of SEA 1 15 0.52 3.81 0.79
113 INT162663 Negative_regulation of SLC6A2 3 4 0.05 0.41 0.78
114 INT149014 Negative_regulation of Tph1 1 5 0.58 1.43 0.74
115 INT278104 Negative_regulation of IGKV2D-29 1 2 0.11 0.18 0.74
116 INT263519 Negative_regulation of Positive_regulation of FABP4 2 1 0.08 0 0.55
117 INT144098 Localization of Pparg 2 2 0.59 0.73 0.52
118 INT68529 Negative_regulation of ADRA2B 1 3 0.14 0.79 0.47
119 INT166287 Negative_regulation of Binding of Mgll 2 1 0.37 0.18 0.47
120 INT166288 Binding of Mgll 2 1 0.32 0.18 0.47
121 INT156100 Gene_expression of AKR1B1 1 4 0.65 3.64 0.41
122 INT308840 Regulation of Gene_expression of IGKV2D-29 1 1 0.06 0.39 0.4
123 INT154869 Gene_expression of Hrh4 1 2 0.26 1.33 0.38
124 INT163873 Positive_regulation of Binding of Slc6a2 1 1 0.37 0.38 0.38
125 INT154868 Binding of Hrh4 1 2 0.35 1.01 0.36
126 INT226427 Gene_expression of FABP4 2 9 0.44 4.07 0.34
127 INT157059 Negative_regulation of Gene_expression of IL24 1 1 0.31 0.1 0.34
128 INT130583 Regulation of Binding of Cnr1 1 2 0.41 0.17 0.26
129 INT169755 Regulation of Binding of CNR2 1 1 0.44 0 0.26
130 INT260854 Negative_regulation of Binding of Gabrd 1 1 0.10 0.06 0.22
131 INT87627 Positive_regulation of Gene_expression of IGKV2D-29 1 1 0.49 0.59 0.19
132 INT76752 Negative_regulation of TOP2B 1 8 0.42 6.2 0.14
133 INT166776 Localization of HMGN4 1 2 0.32 1.14 0.12
134 INT263518 Regulation of Gene_expression of FABP4 1 1 0.05 0 0.12
135 INT263517 Regulation of FABP4 1 1 0.26 0 0.12
136 INT308839 Gene_expression of KRT31 1 2 0.58 7.38 0.11
137 INT308841 Positive_regulation of Gene_expression of SEA 1 1 0.04 0 0.09
138 INT154870 Binding of Hrh4 1 1 0.16 0 0.04
139 INT287857 Binding of Cand1 1 2 0.47 0.13 0.03
140 INT354644 Gene_expression of CUBN 1 1 0.65 0.32 0
141 INT354643 Positive_regulation of HMGN4 1 1 0.05 0.07 0
142 INT354641 Negative_regulation of Positive_regulation of HMGN4 1 1 0.04 0.07 0
143 INT354645 Binding of HMGN4 3 1 0.03 0.35 0
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