J:Jpn. J. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT104710 Em Positive_regulation of Rbm39 1 1 0.02 0.07 1.76
2 INT104709 Msh3 Positive_regulation of Rbm39 1 1 0.01 0.07 1.76
3 INT32839 Binding of Trh and Penk 2 1 0.42 0 1.63
4 INT6976 Helt Regulation of Gene_expression of St8sia1 1 1 0.00 0.07 1.45
5 INT38453 Binding of Pomc and Penk 1 1 0.17 0 1.33
6 INT42554 Oprl1 Regulation of Npr1 2 1 0.06 0 1.22
7 INT33142 Pck1 Positive_regulation of Npr1 4 1 0.01 0.5 1.02
8 INT42555 Oprl1 Negative_regulation of Npr1 1 1 0.02 0 0.99
9 INT41617 Sp5 Positive_regulation of Mlf1 1 1 0.02 0.25 0.94
10 INT6975 Zeb1 Positive_regulation of St8sia1 1 1 0.03 0.17 0.91
11 INT32840 Regulation of Binding of Trh and Penk 1 1 0.26 0 0.91
12 INT93709 Positive_regulation of Oprd1 Regulation of Calm3 1 1 0.01 0 0.74
13 INT18447 Binding of Ache and Chat 2 2 0.33 0.33 0.73
14 INT93708 Oprd1 Regulation of Calm3 1 1 0.01 0 0.73
15 INT93710 Oprm1 Positive_regulation of Gene_expression of Calm3 1 1 0.25 0 0.73
16 INT45335 Mlst8 Positive_regulation of Localization of Abat 1 1 0.36 0 0.65
17 INT45334 Mlst8 Regulation of Localization of Abat 1 1 0.21 0 0.65
18 INT802 Aap Regulation of Grhpr 1 1 0.01 0 0.6
19 INT803 Aap Regulation of Cyb5 1 1 0.05 0 0.6
20 INT804 Aap Negative_regulation of MBD2 1 1 0.01 0 0.57
21 INT66129 Binding of Tia1 and Olfr927-ps1 1 1 0.16 0.16 0.56
22 INT64384 Agt Negative_regulation of Son 1 1 0.26 0 0.39
23 INT33581 Thop1 Positive_regulation of Cpe 1 1 0.01 0 0.33
24 INT33584 Enpep Positive_regulation of Cpe 1 1 0.03 0 0.27
25 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 1 0.03 0 0.27
26 INT33582 Thop1 Regulation of Positive_regulation of Cpe 1 1 0.01 0 0.26
27 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 1 0.01 0 0.26
28 INT60417 Chrm1 Regulation of Localization of Acot1 1 1 0.13 0 0.19
29 INT38074 Gm2232 Negative_regulation of Maoa 1 1 0.10 0 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 5 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 25 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 5 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
6 INT1912 Gene_expression of Calca 3 1152 0.78 453.25 739.84
7 INT3439 Localization of Abat 5 1017 0.78 112.39 727.06
8 INT5202 Positive_regulation of Gene_expression of Fos 1 1163 0.70 319.28 684
9 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
10 INT2543 Positive_regulation of Calca 2 787 0.70 331.13 592.08
11 INT5228 Positive_regulation of Fos 5 934 0.70 209.8 503.87
12 INT155 Positive_regulation of Prl 7 1233 0.70 317.93 457.82
13 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
14 INT4758 Positive_regulation of Localization of Calca 12 557 0.70 138.55 411.04
15 INT5895 Gene_expression of Oprm1 2 525 0.78 120.67 407.29
16 INT1395 Negative_regulation of Penk 4 537 0.59 87.33 389.81
17 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
18 INT2540 Negative_regulation of Calca 6 538 0.59 172.11 384.38
19 INT18357 Gene_expression of TRPV1 4 825 0.78 307.11 382.81
20 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
21 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
22 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
23 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
24 INT2649 Regulation of Calca 4 433 0.62 146.05 330.95
25 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
26 INT162 Regulation of Prl 3 794 0.62 165.01 322.24
27 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
28 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
29 INT477 Localization of Avp 8 813 0.81 131.58 300.4
30 INT161 Regulation of Localization of Prl 2 615 0.62 65.37 298.66
31 INT1352 Localization of Acot1 9 728 0.80 73.01 296.01
32 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
33 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
34 INT16868 Gene_expression of Il6 3 807 0.78 499.48 256.57
35 INT2909 Positive_regulation of Abat 3 334 0.70 62.1 256.43
36 INT5501 Regulation of Oprd1 3 283 0.62 55.1 249.9
37 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
38 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
39 INT1665 Positive_regulation of Pag1 4 270 0.68 186.63 229.87
40 INT4759 Negative_regulation of Localization of Calca 3 294 0.59 82.62 226.45
41 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
42 INT1212 Binding of Oprl1 3 312 0.48 28.6 225.15
43 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
44 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
45 INT6293 Gene_expression of Oprm1 1 312 0.78 48.73 215.61
46 INT4893 Gene_expression of Tacr1 1 366 0.78 129.67 213.92
47 INT2211 Negative_regulation of Abat 3 267 0.59 66.51 200.98
48 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
49 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
50 INT3440 Negative_regulation of Localization of Abat 1 221 0.57 33.94 180.36
51 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
52 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
53 INT1114 Localization of Ins1 9 748 0.80 192.95 165.48
54 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
55 INT51921 Gene_expression of Cpox 2 501 0.73 229.81 157.81
56 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
57 INT1303 Negative_regulation of Npr1 4 278 0.55 35.1 156.78
58 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
59 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
60 INT5050 Regulation of Localization of Calca 1 149 0.62 41.25 148.57
61 INT7628 Gene_expression of Ltp 1 273 0.77 70.21 147.87
62 INT2451 Positive_regulation of Avp 5 355 0.70 102.66 147.69
63 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
64 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
65 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
66 INT5061 Negative_regulation of Mme 2 306 0.59 51.97 136.9
67 INT64161 Positive_regulation of Prkca 2 213 0.70 85.06 129.91
68 INT1614 Gene_expression of Oprl1 1 164 0.78 31.43 127.74
69 INT4259 Positive_regulation of Npr1 3 262 0.70 49.37 123.11
70 INT6128 Positive_regulation of Localization of POMC 1 256 0.70 68.77 121.64
71 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
72 INT90 Localization of Gast 1 400 0.81 137.67 113
73 INT4936 Localization of Tacr1 1 125 0.80 35.7 107.7
74 INT114 Binding of Oprl1 1 139 0.48 23 103.35
75 INT5587 Regulation of Fos 1 191 0.62 40.81 99.7
76 INT293 Protein_catabolism of Penk 2 161 1.00 11.71 98.45
77 INT4860 Positive_regulation of CALCA 1 148 0.00 73.35 97.61
78 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
79 INT1281 Negative_regulation of Maoa 3 203 0.59 22.47 91.66
80 INT77435 Positive_regulation of Nos2 4 343 0.70 208.49 91.43
81 INT18032 Positive_regulation of Oprk1 1 108 0.70 30.78 89.7
82 INT64158 Negative_regulation of Prkca 1 121 0.59 29.8 88.66
83 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
84 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
85 INT3766 Positive_regulation of Localization of Acot1 2 192 0.69 21.8 85.35
86 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
87 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
88 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
89 INT4358 Positive_regulation of Localization of Avp 5 195 0.70 30.79 77.58
90 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
91 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
92 INT7028 Localization of Pdyn 1 90 0.81 8.89 73.54
93 INT1080 Negative_regulation of Ache 2 343 0.59 108.51 72.4
94 INT8962 Gene_expression of Cpe 2 110 0.71 39.67 71.67
95 INT2055 Regulation of Gnrh1 2 185 0.62 23.65 71.26
96 INT5993 Positive_regulation of Nts 1 122 0.70 26.82 70.45
97 INT1376 Binding of Trh 1 121 0.48 20 69.86
98 INT53964 Negative_regulation of Prkaca 2 131 0.58 38.76 69.52
99 INT14624 Gene_expression of Pax3 1 100 0.38 33.22 69.47
100 INT13276 Regulation of Ltp 1 107 0.53 30.78 69.13
101 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
102 INT1988 Positive_regulation of Localization of Ins1 6 254 0.69 59.25 68.37
103 INT1603 Negative_regulation of Rtcd1 2 131 0.51 29.99 66.66
104 INT6176 Positive_regulation of Htr1a 2 117 0.67 28.23 66.17
105 INT9304 Negative_regulation of Pag1 1 70 0.39 51.97 64.23
106 INT2212 Binding of Abat 3 89 0.48 18.36 63.99
107 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
108 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
109 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
110 INT2761 Regulation of Gabrg1 1 119 0.61 18.8 60.52
111 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
112 INT7491 Localization of Pdyn 1 80 0.81 3.94 58.77
113 INT20964 Gene_expression of OPRK1 4 96 0.78 23.54 58.18
114 INT6669 Negative_regulation of Positive_regulation of Fos 1 98 0.59 23.5 56.82
115 INT20266 Positive_regulation of Bdkrb1 2 60 0.69 63.64 56.59
116 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
117 INT1486 Negative_regulation of Cpe 5 85 0.59 28.78 54.08
118 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
119 INT49993 Positive_regulation of Gene_expression of Il6 2 149 0.70 88.07 53.78
120 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
121 INT1487 Regulation of Cpe 3 68 0.62 10.24 52.91
122 INT5623 Positive_regulation of Nppa 1 174 0.70 69.96 52.33
123 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
124 INT5704 Binding of Slc3a1 1 78 0.43 8.52 51.78
125 INT8490 Negative_regulation of CALCA 2 87 0.59 29.73 51.34
126 INT5957 Positive_regulation of Cpe 2 65 0.69 21.07 51.22
127 INT10304 Binding of OPRK1 2 89 0.48 9.28 49.42
128 INT7059 Regulation of Adra2a 2 89 0.62 18.24 48.43
129 INT1977 Negative_regulation of Positive_regulation of Prl 1 98 0.59 17.06 47.88
130 INT654 Localization of REN 2 250 0.81 75.12 47.86
131 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
132 INT4776 Localization of TAC1 2 82 0.78 16.89 45.21
133 INT2275 Negative_regulation of Localization of Ins1 3 183 0.59 51.02 44.94
134 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
135 INT5214 Localization of Cpe 2 49 0.73 13.3 44.36
136 INT1474 Regulation of Localization of Ins1 4 132 0.61 25.96 43.07
137 INT89 Positive_regulation of Gast 1 187 0.70 80.49 42.07
138 INT5539 Negative_regulation of Mme 6 75 0.59 28.91 41.84
139 INT7824 Regulation of Cck 2 39 0.62 5.31 39.28
140 INT103261 Positive_regulation of Nav1 1 68 0.70 24.25 39.27
141 INT2531 Positive_regulation of Cebpz 1 166 0.00 43.08 38.86
142 INT115 Negative_regulation of Maoa 1 65 0.59 16.27 38.66
143 INT3188 Regulation of Localization of Acot1 2 84 0.59 8.94 38.56
144 INT4925 Binding of Tacr1 2 57 0.48 17.39 38.38
145 INT385 Gene_expression of Agt 1 182 0.78 63.62 37.91
146 INT14009 Gene_expression of Sst 2 66 0.77 19.6 37.3
147 INT390 Positive_regulation of Agt 2 170 0.70 61.47 36.08
148 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
149 INT49 Negative_regulation of Ren 1 129 0.59 37.48 35.62
150 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
151 INT7608 Positive_regulation of Adra2a 1 66 0.70 17.81 35.15
152 INT946 Negative_regulation of Nts 1 60 0.57 4.61 34.44
153 INT103262 Localization of Nav1 2 53 0.81 19.23 34.44
154 INT34465 Regulation of Oprd1 1 34 0.45 7.14 34.29
155 INT17381 Gene_expression of Tbxa2r 1 146 0.78 65.01 34.15
156 INT5489 Localization of CA2 1 172 0.80 39.46 33.56
157 INT8784 Negative_regulation of Positive_regulation of Calca 1 40 0.59 14.67 33.49
158 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
159 INT9796 Gene_expression of Cck 1 63 0.78 11.44 32.09
160 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
161 INT56290 Negative_regulation of Gene_expression of Il6 2 79 0.59 47.98 31.07
162 INT64164 Regulation of Prkca 1 34 0.62 10.44 30.99
163 INT1179 Negative_regulation of Ace 2 157 0.59 67.03 30.46
164 INT1079 Positive_regulation of Ache 1 104 0.70 23.52 30.28
165 INT6196 Regulation of Nppa 3 83 0.62 30.31 30.18
166 INT894 Binding of Avp 1 84 0.48 29.16 29.63
167 INT15296 Regulation of Rbm39 1 45 0.29 10.66 29.27
168 INT67 Negative_regulation of Ddc 1 66 0.59 15.34 28.96
169 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
170 INT6765 Localization of Oprl1 2 49 0.81 5.11 28.87
171 INT1166 Negative_regulation of Dbh 3 56 0.59 12.54 28.26
172 INT52722 Localization of RETNLB 2 54 0.38 48.63 27.98
173 INT66381 Regulation of Prkaca 1 40 0.62 13.38 27.96
174 INT5771 Binding of Oprd1 1 37 0.48 2.6 27.54
175 INT7717 Positive_regulation of Adra2a 1 62 0.70 17.68 27.32
176 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
177 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
178 INT29107 Regulation of Oprk1 1 31 0.45 6.16 26.61
179 INT7832 Localization of Cck 4 39 0.81 6.81 26.54
180 INT605 Regulation of Acot1 1 61 0.62 10.7 26.34
181 INT8205 Negative_regulation of Nppa 3 77 0.59 26.43 25.72
182 INT1728 Negative_regulation of Cndp2 2 36 0.57 3.76 25.39
183 INT5622 Gene_expression of Nppa 1 101 0.78 49.46 25.31
184 INT19986 Negative_regulation of Cck 2 31 0.59 4.32 24.99
185 INT81496 Gene_expression of CNR2 1 68 0.75 30.04 24.92
186 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
187 INT6385 Regulation of Man2a2 1 48 0.61 7.8 24.68
188 INT288 Positive_regulation of Sct 2 88 0.70 32.83 24.5
189 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
190 INT66026 Gene_expression of Cxcl1 3 74 0.78 31.87 23.37
191 INT8699 Gene_expression of Nka1 1 45 0.67 6.41 22.56
192 INT104707 Gene_expression of Em 2 16 0.65 3.95 22.19
193 INT8048 Gene_expression of Nts 2 45 0.74 8.9 21.84
194 INT56769 Gene_expression of Ntrk1 1 36 0.77 15.79 20.75
195 INT90849 Gene_expression of F2rl1 2 55 0.78 31.31 20.65
196 INT12951 Negative_regulation of Cat 1 126 0.57 64.39 20.61
197 INT7017 Regulation of Npr1 1 45 0.52 3.38 20.05
198 INT7487 Gene_expression of Htr1a 1 36 0.75 11.08 20.05
199 INT41494 Negative_regulation of Gene_expression of Tacr1 1 25 0.58 11.73 19.91
200 INT7994 Gene_expression of Lta 1 113 0.67 69.81 19.59
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