J:Malar J

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 9 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 7 0.40 9.26 3.27
3 INT189490 Binding of Ccr3 and Ccl5 1 7 0.33 8.54 2.6
4 INT83425 Binding of CD40LG and IGHG3 11 2 0.21 4.56 2.09
5 INT198653 TNF Positive_regulation of MIF 1 3 0.15 3.81 1.55
6 INT195668 Binding of F2 and THBD 7 4 0.08 5.67 0.98
7 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 1 0.03 1.32 0.37
8 INT189493 Tnf Positive_regulation of Localization of Darc 1 1 0.00 0.53 0.37
9 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 1 0.19 0.64 0.36
10 INT198647 TNF Positive_regulation of HIF1A 1 2 0.03 2.97 0.34
11 INT189492 Ifng Positive_regulation of Localization of Darc 1 1 0.00 0.53 0.34
12 INT189489 Il1b Positive_regulation of Localization of Darc 1 1 0.00 0.53 0.34
13 INT198642 GPI Positive_regulation of TNF 1 1 0.03 0.98 0.33
14 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 1 0.16 0.66 0.32
15 INT198640 TNF Positive_regulation of ISYNA1 1 1 0.04 1.07 0.29
16 INT198648 VCAM1 Positive_regulation of CADM1 1 2 0.00 1.1 0.25
17 INT198644 TNF Positive_regulation of CADM1 1 2 0.02 1.07 0.24
18 INT198643 CD36 Positive_regulation of CADM1 1 2 0.01 1.07 0.24
19 INT198649 Binding of HIF1A and MIF 1 1 0.01 1.53 0.18
20 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 1 0.03 1.44 0.15
21 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 1 0.00 1.37 0.13
22 INT202543 Binding of IGHE and IL10 1 1 0.03 0.79 0.12
23 INT288616 EPO Positive_regulation of Nos3 1 1 0.08 0.69 0.11
24 INT202544 Binding of IFNA1 and IL4 1 1 0.00 0.49 0.11
25 INT226044 Lta Positive_regulation of Ecm1 1 1 0.02 0.44 0.08
26 INT202541 IL4 Regulation of IGHE 1 1 0.02 0.49 0.08
27 INT202545 Binding of IGHE and IL4 1 1 0.03 0.49 0.08
28 INT74033 Binding of IGHG3 and Ighg1 2 1 0.08 0.87 0.06
29 INT202542 IGHE Positive_regulation of Localization of IL4 1 1 0.06 0.44 0.05
30 INT226043 Epo Positive_regulation of Ecm1 1 1 0.04 1.35 0.05
31 INT202547 IGHE Positive_regulation of Localization of IL13 1 1 0.04 0.44 0.05
32 INT202566 Re Positive_regulation of Localization of IL4 1 1 0.00 0.44 0.05
33 INT307157 Berr1 Regulation of Mgst1 1 2 0.00 1.51 0.05
34 INT231771 Binding of HMOX1 and TNF 2 1 0.14 1.41 0.04
35 INT202546 Binding of FCER1A and IGHE 1 1 0.02 0.49 0.04
36 INT198639 S100A12 Positive_regulation of TNF 1 1 0.15 1.49 0.04
37 INT198646 S100A12 Positive_regulation of IL1B 1 1 0.01 1.49 0.04
38 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 1 0.15 1.5 0.04
39 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 1 0.01 1.5 0.04
40 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 1 0.00 0.9 0.03
41 INT288617 Binding of CSF2RB and Epor 1 1 0.19 0.73 0
42 INT307155 Char1 Regulation of Ppig 1 1 0.00 0.92 0
43 INT226045 Binding of Casp1 and Lta 1 1 0.04 0.73 0
44 INT188836 Binding of LHCGR and C4b 1 1 0.39 0.76 0
45 INT307160 Regulation of Binding of Cyp2a5 and Ppig 1 1 0.05 1.22 0
46 INT307159 Cyp2a5 Regulation of Ppig 1 1 0.03 0.91 0
47 INT226042 Binding of Casp1 and Casp3 1 1 0.02 0.73 0
48 INT255203 Binding of INCENP and Ie 1 1 0.00 0.77 0
49 INT307158 Binding of Cyp2a5 and Ppig 1 1 0.04 1.22 0
50 INT208139 Binding of PITX1 and URI1 1 1 0.01 0.62 0
51 INT186415 IL1RN Regulation of Gene_expression of IL1B 1 1 0.25 0.67 0
52 INT174720 Ddit3 Regulation of Gtf3a 1 1 0.01 0.35 0
53 INT307156 Esr1 Positive_regulation of Hspa5 1 1 0.04 0.79 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 25 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 11 1050 0.70 896.51 322.81
5 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
6 INT6852 Localization of TNF 5 883 0.81 705.95 270.84
7 INT5972 Gene_expression of IL1B 7 948 0.78 510.91 263.97
8 INT6481 Binding of TNF 3 624 0.48 510.2 214.82
9 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
10 INT50670 Gene_expression of CPOX 6 763 0.76 442.13 195.02
11 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
12 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
13 INT867 Gene_expression of IFNA1 7 930 0.78 594.85 168.03
14 INT66280 Gene_expression of Nos2 12 534 0.78 330.78 157.07
15 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
16 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
17 INT65600 Positive_regulation of Casp3 11 376 0.70 198.44 128.03
18 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
19 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
20 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
21 INT20374 Gene_expression of Il4 2 515 0.76 306.15 114.12
22 INT60526 Gene_expression of IL10 10 449 0.78 292.71 107.84
23 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
24 INT18009 Positive_regulation of CRP 4 518 0.70 553.03 103.74
25 INT11381 Positive_regulation of IL1B 2 330 0.70 209.31 100.9
26 INT1760 Gene_expression of PTGER2 1 524 0.57 226.94 96.4
27 INT11587 Gene_expression of CSF2 2 645 0.78 544.38 93.89
28 INT77435 Positive_regulation of Nos2 2 343 0.70 208.49 91.43
29 INT48408 Gene_expression of ICAM1 2 494 0.78 340.08 88.6
30 INT82448 Gene_expression of S100a8 1 246 0.77 236.72 84.02
31 INT56291 Gene_expression of Ros1 2 503 0.63 274.12 81.5
32 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
33 INT5056 Gene_expression of IFNG 3 216 0.78 137.52 74.57
34 INT56298 Gene_expression of IL4 3 306 0.78 182.18 72.92
35 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
36 INT11380 Negative_regulation of IL1B 2 215 0.59 125.62 72.35
37 INT7534 Gene_expression of Ifng 4 193 0.78 111.02 68.6
38 INT9484 Gene_expression of Jun 2 175 0.78 34.89 68.54
39 INT102546 Gene_expression of Ccl2 1 197 0.78 192.8 67.41
40 INT5374 Gene_expression of Esr1 2 412 0.77 263.89 67.34
41 INT9489 Gene_expression of SFTPA1 1 112 0.66 55.38 66.45
42 INT4960 Positive_regulation of CSF2 2 285 0.70 256.73 65.73
43 INT3375 Gene_expression of IGHE 46 535 0.77 387.47 65.46
44 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
45 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
46 INT67981 Positive_regulation of CCL2 4 165 0.70 136.84 61.85
47 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
48 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
49 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
50 INT50672 Positive_regulation of CPOX 2 205 0.44 125.93 60.06
51 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
52 INT31116 Gene_expression of Casp3 2 192 0.78 78.21 57.43
53 INT4509 Gene_expression of IGG 10 426 0.76 293.69 56.64
54 INT20375 Gene_expression of Hand1 2 213 0.60 148.51 54.53
55 INT62543 Gene_expression of Icam1 1 231 0.78 187.58 52.71
56 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
57 INT72182 Gene_expression of Mcpt1 3 167 0.75 123.7 52.15
58 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
59 INT6796 Positive_regulation of Jun 1 165 0.70 37.18 49.64
60 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
61 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
62 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
63 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
64 INT4216 Gene_expression of CD40LG 3 328 0.78 256.02 44.23
65 INT73502 Positive_regulation of IL10 6 154 0.69 124.87 43.5
66 INT4004 Gene_expression of IGHG3 15 321 0.71 221.03 42.33
67 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
68 INT65245 Gene_expression of Nos3 1 121 0.78 98.14 41.56
69 INT97596 Localization of S100a8 1 94 0.78 90.69 40.41
70 INT3987 Positive_regulation of IGHE 16 316 0.70 283.2 40.16
71 INT77434 Positive_regulation of Gene_expression of Nos2 7 151 0.69 96.76 38.94
72 INT50673 Positive_regulation of Gene_expression of CPOX 1 156 0.54 97.31 37.03
73 INT9082 Positive_regulation of ESR1 5 238 0.69 148.51 36.69
74 INT62827 Positive_regulation of ICAM1 3 184 0.70 180.95 36.28
75 INT59466 Gene_expression of ISYNA1 1 204 0.77 112.57 35.48
76 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
77 INT6484 Binding of IL1B 3 122 0.47 75.84 35.07
78 INT20380 Gene_expression of Il5 1 172 0.78 104.75 34.78
79 INT104392 Gene_expression of Cxcl10 4 113 0.75 106.86 34.12
80 INT53475 Gene_expression of MRI1 2 116 0.59 77.68 33.98
81 INT84825 Gene_expression of CD36 1 121 0.78 43.73 33.23
82 INT6302 Binding of IFNA1 2 196 0.48 133.85 32.73
83 INT73982 Gene_expression of Hmox1 8 141 0.78 119.43 32.17
84 INT92837 Negative_regulation of Gene_expression of Nos2 1 116 0.59 59.67 31.82
85 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
86 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
87 INT11554 Negative_regulation of CSF2 1 129 0.59 108.55 29.44
88 INT65597 Negative_regulation of Casp3 4 69 0.59 39.19 29.32
89 INT15174 Gene_expression of Itgam 1 238 0.73 104.92 29.26
90 INT6364 Gene_expression of Edn1 1 123 0.78 73.76 28.43
91 INT133876 Positive_regulation of Gene_expression of Ros1 1 141 0.32 75.55 27.45
92 INT1765 Positive_regulation of Gene_expression of PTGER2 1 140 0.51 68.68 27
93 INT13995 Gene_expression of gr 3 96 0.74 48.21 26.54
94 INT69036 Gene_expression of IL18 1 99 0.77 77.92 25.95
95 INT130176 Positive_regulation of Gene_expression of CRP 2 125 0.66 137.06 25.9
96 INT76095 Positive_regulation of ISYNA1 9 117 0.55 79.73 25.86
97 INT70048 Positive_regulation of Gene_expression of IL10 2 90 0.55 71.34 25.66
98 INT130186 Gene_expression of Ccl5 32 101 0.74 79.96 25.01
99 INT73670 Gene_expression of Vcam1 1 128 0.78 123.79 24.96
100 INT141612 Gene_expression of Ccr1 19 92 0.77 72.09 24.14
101 INT55583 Localization of IFNA1 1 135 0.78 85.07 24.13
102 INT89854 Regulation of Nos2 2 49 0.61 42.58 24.1
103 INT4809 Gene_expression of PTGDS 1 103 0.76 52.94 24.01
104 INT86534 Positive_regulation of MAPK14 1 81 0.62 57.81 23.62
105 INT8775 Binding of IGHE 7 167 0.48 102.61 23.54
106 INT5055 Positive_regulation of IFNG 3 89 0.69 64.03 23.05
107 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
108 INT16721 Negative_regulation of Cat 1 56 0.59 44.44 22.84
109 INT16996 Gene_expression of PRTN3 1 113 0.75 85.61 22.57
110 INT823 Negative_regulation of ESR1 12 144 0.58 63.72 22.52
111 INT48081 Localization of Il1b 1 46 0.80 21.59 22.4
112 INT23257 Regulation of CRP 1 127 0.62 100.05 21.87
113 INT5096 Positive_regulation of Gtf3a 4 79 0.60 42.26 20.62
114 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
115 INT1756 Negative_regulation of DNAH8 1 105 0.59 42.73 20.24
116 INT12265 Positive_regulation of IgG 2 168 0.63 104.89 19.76
117 INT53574 Regulation of Tnf 1 45 0.62 40.68 19.71
118 INT78694 Positive_regulation of Gene_expression of Casp3 1 46 0.66 18.64 19.62
119 INT7994 Gene_expression of Lta 5 113 0.67 69.81 19.59
120 INT76924 Positive_regulation of Slc17a5 1 71 0.70 41.21 19.31
121 INT712 Positive_regulation of LDHA 1 160 0.70 175.25 19.11
122 INT19509 Localization of Ifng 2 55 0.78 28.25 18.67
123 INT56301 Positive_regulation of IL4 2 68 0.56 54.51 18.65
124 INT5137 Binding of pCA 1 45 0.47 16.91 18.47
125 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
126 INT167679 Gene_expression of Ccr5 22 74 0.75 59.03 18.16
127 INT80223 Positive_regulation of Hmox1 5 128 0.68 77.71 17.64
128 INT35487 Localization of PTGER2 1 103 0.46 51.24 17.45
129 INT36054 Transcription of IL1B 10 53 0.72 32.64 17.31
130 INT24209 Negative_regulation of Ifng 1 37 0.57 16.52 17.15
131 INT94467 Positive_regulation of Hand1 1 71 0.58 59 16.96
132 INT24225 Gene_expression of Alms1 1 93 0.62 52.75 16.93
133 INT9220 Gene_expression of Ighg1 6 125 0.77 85.74 15.92
134 INT14152 Gene_expression of Slc17a5 1 46 0.61 20.01 15.9
135 INT170754 Localization of IFN1@ 1 121 0.78 66.78 15.6
136 INT92354 Localization of ESR1 4 77 0.75 33.04 15.51
137 INT85964 Gene_expression of Pecam1 1 109 0.78 69.73 15.21
138 INT505 Positive_regulation of GPT 1 89 0.67 69.38 14.94
139 INT165773 Gene_expression of Darc 5 37 0.75 22.28 14.84
140 INT25493 Gene_expression of TFPI 1 74 0.76 39.44 14.78
141 INT70265 Regulation of MRI1 1 42 0.39 30.95 14.18
142 INT80228 Positive_regulation of Gene_expression of Hmox1 1 68 0.70 62.88 14.01
143 INT18012 Gene_expression of EPO 29 169 0.78 108.36 13.75
144 INT17565 Regulation of Gpt 1 85 0.60 43.64 13.68
145 INT5207 Negative_regulation of Alms1 1 70 0.41 41.56 13.68
146 INT1125 Positive_regulation of IGHG3 4 130 0.69 112.07 13.18
147 INT116528 Gene_expression of HMOX1 4 106 0.78 86.13 12.8
148 INT2385 Gene_expression of MIF 4 57 0.68 40.74 12.78
149 INT10870 Regulation of IgG 2 67 0.59 43.27 12.74
150 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
151 INT89294 Gene_expression of Ccr3 19 53 0.68 43.9 12.62
152 INT10433 Positive_regulation of Junb 1 35 0.70 6.55 12.42
153 INT70050 Negative_regulation of IL10 2 56 0.58 37.45 12.39
154 INT94464 Negative_regulation of Hand1 1 44 0.41 31.5 12.39
155 INT90673 Gene_expression of LOX 10 66 0.65 69.71 12.18
156 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
157 INT87844 Binding of IL1RN 1 40 0.41 24.37 11.92
158 INT24816 Binding of CD40LG 2 68 0.47 45.48 11.56
159 INT52625 Regulation of IL1RN 2 30 0.61 19.12 11.31
160 INT1762 Negative_regulation of PTGER2 1 64 0.43 28.21 11.27
161 INT96271 Positive_regulation of Gene_expression of Mcpt1 2 30 0.53 21.34 11.06
162 INT56448 Regulation of ICAM1 1 52 0.60 55.1 10.96
163 INT111223 Positive_regulation of HMOX1 8 47 0.70 39.14 10.92
164 INT19944 Negative_regulation of IFNG 1 39 0.58 22.35 10.91
165 INT168409 Positive_regulation of Ccl5 16 47 0.64 45.84 10.83
166 INT4498 Gene_expression of F2 1 83 0.65 57.4 10.8
167 INT51265 Phosphorylation of TNF 1 32 0.81 25.33 10.75
168 INT701 Localization of IGHE 2 87 0.80 40.5 10.62
169 INT53201 Negative_regulation of gr 1 35 0.50 17.76 10.62
170 INT16449 Binding of IGHG3 6 67 0.48 39.55 10.59
171 INT74272 Localization of CPOX 1 39 0.63 25.12 10.53
172 INT78695 Regulation of Casp3 1 24 0.44 9.43 10.48
173 INT100379 Positive_regulation of HIF1A 2 69 0.69 57.31 10.4
174 INT110110 Gene_expression of ACCS 1 85 0.58 75.88 10.2
175 INT7995 Positive_regulation of Lta 2 28 0.66 14.98 9.8
176 INT35164 Negative_regulation of IGHE 1 96 0.58 76.3 9.74
177 INT80549 Binding of ICAM1 3 53 0.47 42.76 9.72
178 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
179 INT3988 Positive_regulation of Gene_expression of IGHE 9 98 0.68 91.46 9.61
180 INT3366 Localization of PLEK 2 44 0.78 15.83 9.55
181 INT105103 Regulation of Gene_expression of Casp3 1 11 0.39 3.15 9.22
182 INT64346 Positive_regulation of S100B 1 95 0.70 63.11 9.17
183 INT63338 Regulation of Gene_expression of ICAM1 1 42 0.62 28.26 9.06
184 INT23147 Negative_regulation of MRI1 1 26 0.38 14.33 8.96
185 INT17101 Positive_regulation of Gene_expression of Edn1 1 24 0.69 24.9 8.86
186 INT36449 Negative_regulation of G6PD 8 74 0.59 54.15 8.85
187 INT104394 Positive_regulation of Gene_expression of Cxcl10 2 28 0.65 25.64 8.79
188 INT38345 Positive_regulation of Nfyb 1 13 0.60 2.61 8.77
189 INT79693 Regulation of Il4 1 30 0.51 21.96 8.6
190 INT20205 Binding of IgG 2 108 0.46 66.68 8.57
191 INT102658 Negative_regulation of Gene_expression of CSF2 1 42 0.50 38.63 8.32
192 INT77249 Positive_regulation of Gene_expression of gr 2 24 0.67 16.09 8.17
193 INT15687 Regulation of ESR1 11 91 0.60 40.42 7.95
194 INT166881 Positive_regulation of Ccr1 5 31 0.69 18.14 7.9
195 INT2971 Regulation of IGHE 3 42 0.61 28.81 7.87
196 INT78226 Gene_expression of Mbp 2 43 0.75 22.14 7.79
197 INT24978 Binding of SFTPA1 1 22 0.47 15.09 7.76
198 INT5409 Negative_regulation of G6pd 16 33 0.57 29.21 7.64
199 INT102351 Regulation of Pecam1 1 7 0.61 22.45 7.58
200 INT91667 Localization of IL12A 1 39 0.74 25.51 7.36
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