J:Marine Drugs

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT305408 Binding of KCNMA1 and ST8SIA2 1 2 0.01 0.09 1.24
2 INT305406 Binding of CAV3 and ST8SIA2 1 1 0.16 0 0.86
3 INT112869 Aap Positive_regulation of Gpt 2 1 0.26 0.75 0.6
4 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 3 0.10 0.06 0.39
5 INT305407 Binding of ST8SIA2 and ANTXR1 1 1 0.00 0.09 0.38
6 INT306694 Nav1 Positive_regulation of Gene_expression of Scn7a 1 1 0.01 0.07 0.38
7 INT305405 Binding of KCNMA1 and ANTXR1 1 1 0.00 0.09 0.38
8 INT306692 Prkaca Regulation of Positive_regulation of Nav1 1 3 0.13 0.06 0.35
9 INT309298 Binding of NA and ST8SIA2 1 1 0.00 0 0.28
10 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 1 0.01 0.54 0.14
11 INT243525 Binding of NTF3 and SOX10 1 1 0.01 0.54 0.14
12 INT275462 Negative_regulation of JUN Positive_regulation of Gene_expression of MMP9 1 1 0.04 0.27 0.12
13 INT243557 Binding of PSPH and SPECC1 1 1 0.01 1.19 0.12
14 INT336425 MGAT1 Positive_regulation of Gene_expression of COL5A2 1 1 0.00 0.4 0.08
15 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 1 0.07 0.65 0.07
16 INT275463 ZNF69 Negative_regulation of MMP2 1 1 0.01 0 0.05
17 INT275464 ZNF69 Negative_regulation of Gene_expression of MMP2 1 1 0.01 0 0.05
18 INT275503 Ccl4 Positive_regulation of Gpt 1 1 0.20 0 0.04
19 INT275502 Ccl4 Positive_regulation of Slc17a5 1 1 0.09 0 0.04
20 INT336469 Binding of CTS and SAFB 1 3 0.09 0 0
21 INT326809 Binding of Ankrd36 and SLC25A22 1 1 0.10 0.13 0
22 INT275501 Aap Positive_regulation of Positive_regulation of Gpt 1 1 0.12 0.23 0
23 INT326808 Binding of Ankrd36 and SLC25A18 1 1 0.12 0.13 0
24 INT336468 Binding of CTS and ADAP1 1 6 0.02 0.42 0
25 INT326793 FGFR1 Positive_regulation of Gene_expression of ST8SIA2 1 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT46460 Gene_expression of NAV1 20 288 0.78 135.51 305.75
2 INT94450 Gene_expression of Nav1 7 359 0.78 131.85 275.46
3 INT68684 Gene_expression of VEGFA 5 2371 0.78 1742.52 259.2
4 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
5 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
6 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
7 INT64161 Positive_regulation of Prkca 9 213 0.70 85.06 129.91
8 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
9 INT48593 Positive_regulation of NOS1 2 420 0.68 226.15 114.71
10 INT69440 Gene_expression of ROS1 2 752 0.78 477.64 103.83
11 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
12 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
13 INT64158 Negative_regulation of Prkca 2 121 0.59 29.8 88.66
14 INT15898 Positive_regulation of Prkaca 11 199 0.70 50.89 87.54
15 INT3657 Gene_expression of Ins1 2 514 0.78 321.69 75.76
16 INT14049 Positive_regulation of GRIN1 3 102 0.70 48.31 71.06
17 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
18 INT53964 Negative_regulation of Prkaca 3 131 0.58 38.76 69.52
19 INT4960 Positive_regulation of CSF2 1 285 0.70 256.73 65.73
20 INT1536 Negative_regulation of NA 6 244 0.55 52.67 59.79
21 INT6623 Gene_expression of NA 8 231 0.78 45.78 59.36
22 INT1759 Gene_expression of TIMP1 3 267 0.77 133.87 59.29
23 INT73048 Gene_expression of MMP9 8 268 0.77 159.75 57.81
24 INT48232 Gene_expression of MMP1 4 245 0.78 96.31 57.72
25 INT129303 Positive_regulation of NAV1 1 54 0.70 36.92 57.45
26 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
27 INT19488 Localization of ABAT 1 56 0.69 21.51 50.56
28 INT9556 Negative_regulation of NAV1 3 47 0.59 28.49 49.33
29 INT111051 Negative_regulation of Nav1 2 64 0.59 25.51 47.27
30 INT26500 Gene_expression of MMP2 9 201 0.78 110.57 46.9
31 INT6979 Positive_regulation of CA2 6 206 0.67 50.79 44.97
32 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
33 INT66383 Phosphorylation of Prkaca 1 143 0.80 30.85 43.38
34 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
35 INT57442 Phosphorylation of Prkca 2 98 0.70 31.58 41.04
36 INT5793 Binding of CTS 6 110 0.48 63.91 40.62
37 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
38 INT11560 Positive_regulation of CASP3 3 236 0.70 184.33 39.38
39 INT11560 Positive_regulation of CASP3 2 236 0.70 184.33 39.38
40 INT103261 Positive_regulation of Nav1 29 68 0.70 24.25 39.27
41 INT16323 Gene_expression of pr 1 62 0.66 36.14 38.26
42 INT116321 Regulation of Nav1 3 38 0.62 26.62 37.97
43 INT4449 Positive_regulation of NA 5 179 0.55 40.26 37.82
44 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
45 INT80690 Positive_regulation of MAPK8 2 223 0.68 125.63 36.75
46 INT12892 Negative_regulation of TIMP1 1 136 0.58 83.13 36.54
47 INT101992 Localization of VEGFA 3 413 0.81 258.23 36.15
48 INT23330 Binding of Chrna7 1 79 0.48 10.06 35.5
49 INT111052 Positive_regulation of Gene_expression of Nav1 1 44 0.70 18.98 35.28
50 INT47710 Negative_regulation of GRIN1 1 71 0.57 25.57 34.24
51 INT5489 Localization of CA2 2 172 0.80 39.46 33.56
52 INT9694 Positive_regulation of Csf2 1 102 0.68 70.09 33.07
53 INT6302 Binding of IFNA1 1 196 0.48 133.85 32.73
54 INT48693 Regulation of VEGFA 4 268 0.62 191.88 31.52
55 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
56 INT99688 Negative_regulation of Gene_expression of VEGFA 4 274 0.58 201.8 31.1
57 INT64164 Regulation of Prkca 1 34 0.62 10.44 30.99
58 INT11650 Negative_regulation of Gpt 3 122 0.59 69.15 30.36
59 INT145594 Gene_expression of Mtx1 6 64 0.57 35.33 30.35
60 INT28361 Gene_expression of TP53 2 443 0.78 384.86 28.8
61 INT66381 Regulation of Prkaca 1 40 0.62 13.38 27.96
62 INT55737 Positive_regulation of MMP2 4 101 0.68 59.11 27.71
63 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
64 INT2609 Localization of ELANE 1 111 0.81 50.22 26.63
65 INT123419 Binding of NAV1 3 37 0.48 7.09 26.43
66 INT73047 Positive_regulation of MMP9 1 133 0.68 73.22 26.42
67 INT116226 Regulation of NAV1 3 20 0.51 14.32 25.61
68 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
69 INT48235 Negative_regulation of NPEPPS 2 72 0.46 44.54 25.03
70 INT86295 Gene_expression of Mmp2 1 114 0.76 73.68 24.25
71 INT34487 Localization of MMP2 1 56 0.81 31.41 23.61
72 INT4465 Gene_expression of CEL 1 116 0.77 98.35 23.58
73 INT91891 Gene_expression of Kit 1 268 0.78 158.89 22.67
74 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
75 INT34488 Negative_regulation of MMP2 11 85 0.59 41.98 21.72
76 INT43226 Gene_expression of Hivep3 5 75 0.71 30.53 21.14
77 INT53575 Regulation of Gene_expression of Tnf 1 46 0.62 34.35 20.63
78 INT50814 Positive_regulation of Mmp2 1 72 0.68 51.37 20.42
79 INT66281 Transcription of Nos2 1 81 0.71 39.49 20.37
80 INT116282 Gene_expression of Mmp13 1 83 0.75 45.4 20.18
81 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
82 INT28151 Positive_regulation of CTs 2 55 0.61 35.09 20.14
83 INT76336 Negative_regulation of PDE5A 1 192 0.59 112.02 20.09
84 INT51055 Positive_regulation of TIMP1 2 103 0.69 50.07 19.86
85 INT53574 Regulation of Tnf 1 45 0.62 40.68 19.71
86 INT23533 Gene_expression of CA2 1 110 0.75 30.81 19.4
87 INT19763 Gene_expression of CTs 8 69 0.78 32.92 18.87
88 INT4420 Positive_regulation of GOT1 1 103 0.64 88.4 18.38
89 INT28215 Gene_expression of CDKN1A 2 196 0.76 113.9 18.3
90 INT6782 Gene_expression of SCN5A 3 156 0.78 33.13 17.88
91 INT6791 Binding of NA 5 55 0.46 5.36 17.59
92 INT3206 Positive_regulation of Got1 2 39 0.69 19.36 17.02
93 INT1020 Negative_regulation of BCHE 1 109 0.59 44.86 16.4
94 INT108588 Gene_expression of CASP3 10 126 0.78 84.49 16.2
95 INT114507 Negative_regulation of Gene_expression of NAV1 2 17 0.43 7.24 15.93
96 INT52591 Gene_expression of KCNMA1 1 78 0.76 13.95 15.55
97 INT112207 Binding of Nav1 1 27 0.47 7.1 15.43
98 INT5536 Regulation of NA 1 74 0.59 16.61 15.36
99 INT26501 Positive_regulation of Gene_expression of MMP2 3 51 0.67 39 15.16
100 INT34590 Gene_expression of ALPP 2 199 0.75 89.85 15.1
101 INT3545 Positive_regulation of Mtx1 1 27 0.42 11.97 14.83
102 INT1888 Protein_catabolism of F13A1 1 97 0.99 63.48 14.82
103 INT6163 Negative_regulation of INA 1 39 0.43 2.9 14.8
104 INT60197 Gene_expression of JUN 2 90 0.78 42.32 14.61
105 INT34952 Regulation of ABAT 1 28 0.61 6.05 14.39
106 INT99586 Binding of IRF6 2 60 0.36 27.87 13.2
107 INT711 Positive_regulation of PIK3C2A 2 83 0.70 76.87 13.18
108 INT4145 Gene_expression of FSHR 2 124 0.77 44.98 13.04
109 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
110 INT11793 Negative_regulation of CA2 2 78 0.57 19.63 12.35
111 INT116433 Gene_expression of CYBB 1 93 0.70 50.44 11.91
112 INT93715 Negative_regulation of MMP9 15 69 0.55 36.05 11.73
113 INT48009 Gene_expression of Pde6b 7 38 0.68 15.03 11.41
114 INT73959 Positive_regulation of NOSTRIN 1 49 0.61 31.1 11.27
115 INT13240 Gene_expression of TF 1 94 0.76 57.81 10.99
116 INT11479 Positive_regulation of KCNMA1 2 30 0.68 10.07 10.82
117 INT62895 Gene_expression of NOSTRIN 1 51 0.75 28.8 10.68
118 INT22132 Positive_regulation of CAT 1 41 0.67 18.64 10.67
119 INT9385 Localization of LDHA 1 74 0.81 31.67 10.5
120 INT1934 Positive_regulation of Cys1 8 68 0.68 60.56 10.47
121 INT952 Negative_regulation of GHRH 1 57 0.56 25.3 10.34
122 INT89282 Regulation of MMP9 2 39 0.60 25.45 10.34
123 INT43009 Gene_expression of Scn7a 4 45 0.68 7.85 10.29
124 INT4297 Negative_regulation of CFP 1 21 0.42 12.7 10.29
125 INT19132 Gene_expression of CYP27A1 4 83 0.75 34.31 10.17
126 INT115046 Gene_expression of Crem 1 68 0.77 27.24 10.01
127 INT107606 Negative_regulation of MMP1 2 38 0.42 11.94 10.01
128 INT102865 Positive_regulation of Positive_regulation of Prkca 1 25 0.69 8.34 9.9
129 INT126031 Negative_regulation of Gene_expression of MMP9 4 40 0.57 22.71 9.79
130 INT23535 Positive_regulation of Localization of CA2 2 41 0.41 13.52 9.43
131 INT26502 Negative_regulation of Gene_expression of MMP2 4 39 0.58 21.45 9.42
132 INT48233 Negative_regulation of Gene_expression of MMP1 2 34 0.58 12.94 9.08
133 INT71478 Positive_regulation of Positive_regulation of Prkaca 1 21 0.37 5.14 8.85
134 INT13010 Gene_expression of TYR 1 38 0.65 14.81 8.84
135 INT2241 Negative_regulation of CEL 3 56 0.58 29.32 8.83
136 INT113845 Protein_catabolism of PARP1 1 54 0.88 43.86 8.77
137 INT11146 Negative_regulation of CTS 1 26 0.51 10.33 8.77
138 INT34372 Gene_expression of Cfp 9 102 0.67 37.66 8.72
139 INT939 Gene_expression of PAEP 1 86 0.77 31.02 8.59
140 INT22383 Binding of IL2 1 59 0.48 39.06 8.56
141 INT148703 Gene_expression of NOVA2 1 73 0.65 18.05 8.3
142 INT4021 Positive_regulation of PLA2G1B 1 35 0.70 23.27 8.2
143 INT134106 Positive_regulation of SPECC1 3 14 0.68 9.44 8.09
144 INT5481 Binding of TYR 1 26 0.47 1.3 7.95
145 INT160440 Positive_regulation of Crem 2 48 0.69 20.38 7.66
146 INT4022 Negative_regulation of PLA2G1B 2 30 0.59 10.41 7.58
147 INT84162 Negative_regulation of KCNMA1 2 26 0.58 5.05 7.58
148 INT17029 Regulation of Scn7a 3 23 0.45 3.89 7.02
149 INT36960 Gene_expression of vs 1 33 0.43 20.77 6.97
150 INT21579 Negative_regulation of Gene_expression of TIMP1 1 25 0.57 12.41 6.94
151 INT102749 Positive_regulation of Positive_regulation of CASP3 1 32 0.67 26.07 6.93
152 INT55091 Positive_regulation of Mgst1 1 35 0.69 10.77 6.88
153 INT16389 Gene_expression of Plg 2 80 0.67 36.88 6.74
154 INT12924 Negative_regulation of Gene_expression of NA 1 25 0.30 6.59 6.71
155 INT25609 Localization of Il1f5 2 17 0.80 10.66 6.71
156 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
157 INT53572 Negative_regulation of Localization of Il1 1 18 0.40 12.78 6.7
158 INT22781 Binding of COL7A1 1 76 0.48 41.59 6.66
159 INT68653 Negative_regulation of JUN 1 34 0.58 14.27 6.56
160 INT108585 Positive_regulation of Gene_expression of CASP3 4 35 0.70 28.37 6.45
161 INT71002 Gene_expression of ALOX15 1 21 0.78 21.16 6.37
162 INT168383 Positive_regulation of Mmp13 2 27 0.67 17.9 6.27
163 INT111049 Negative_regulation of Positive_regulation of Nav1 6 5 0.43 4.39 6.25
164 INT95607 Regulation of MMP1 2 19 0.60 7.86 6.18
165 INT34370 Positive_regulation of Cfp 8 26 0.46 15.21 6.12
166 INT108628 Regulation of MMP2 2 27 0.60 14.85 6.06
167 INT134544 Negative_regulation of Positive_regulation of CASP3 1 23 0.57 18.48 5.95
168 INT111545 Phosphorylation of VEGFA 1 50 0.76 22.19 5.88
169 INT12616 Positive_regulation of REG1A 1 23 0.69 6.57 5.81
170 INT1242 Negative_regulation of Slc17a5 2 14 0.42 4.06 5.78
171 INT34592 Positive_regulation of Gene_expression of ALPP 1 51 0.67 20.62 5.68
172 INT3731 Negative_regulation of Neu1 1 17 0.39 8.35 5.67
173 INT7126 Negative_regulation of PLA2G2A 5 26 0.58 12.97 5.64
174 INT71477 Negative_regulation of Positive_regulation of Prkaca 2 10 0.37 1.69 5.57
175 INT5490 Binding of CA2 1 52 0.36 9.73 5.53
176 INT164587 Gene_expression of MCL1 1 94 0.75 124.05 5.39
177 INT77281 Negative_regulation of HIVEP1 1 132 0.49 102.78 5.36
178 INT23598 Binding of SCN5A 1 32 0.40 16 5.35
179 INT4342 Localization of ALPP 1 27 0.69 15.19 5.32
180 INT89304 Binding of ST8SIA2 11 12 0.35 0.93 5.23
181 INT24080 Negative_regulation of Mtor 1 64 0.37 41.56 5.19
182 INT10100 Binding of ELANE 1 22 0.47 15.32 5.19
183 INT7130 Localization of PLA2G2A 5 32 0.80 20.4 5.05
184 INT111594 Positive_regulation of Gene_expression of NOSTRIN 1 20 0.32 8.69 5
185 INT245574 Regulation of SPECC1 1 5 0.44 6.03 5
186 INT17582 Negative_regulation of Localization of ELANE 1 17 0.53 6.11 4.89
187 INT21582 Regulation of Gene_expression of TIMP1 2 20 0.61 12.39 4.77
188 INT1539 Positive_regulation of MSMB 1 22 0.69 9.42 4.62
189 INT115074 Positive_regulation of GRIA1 2 10 0.67 2.66 4.48
190 INT11565 Gene_expression of Tf 3 24 0.68 5.89 4.36
191 INT152616 Gene_expression of SPECC1 3 8 0.66 8.43 4.32
192 INT6967 Regulation of KCNMA1 3 28 0.61 3.37 4.3
193 INT156097 Negative_regulation of Localization of VEGFA 1 70 0.58 34.96 4.17
194 INT99608 Transcription of MMP9 3 18 0.65 9.67 4.11
195 INT48008 Negative_regulation of Pde6b 2 9 0.15 6.12 4.11
196 INT16478 Positive_regulation of Plg 4 29 0.45 18.07 4.07
197 INT210975 Regulation of Cfp 2 10 0.24 5.3 3.93
198 INT14091 Binding of Vsig2 3 8 0.42 3.21 3.91
199 INT7437 Gene_expression of CFP 1 21 0.65 4.93 3.89
200 INT133312 Binding of MMP9 1 25 0.42 16.79 3.83
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