J:Mediators of Inflammation

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
2 INT155484 Binding of CD86 and CTLA4 15 2 0.52 8.85 6.09
3 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 1 0.59 9.37 4.48
4 INT189488 Binding of Ccr1 and Ccl5 8 1 0.40 9.26 3.27
5 INT130721 Binding of IL1B and IL1RN 6 1 0.05 5.29 2.85
6 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 4 0.09 4.04 2.69
7 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 4 0.32 3.42 1.97
8 INT183781 Binding of IL6 and INS 6 1 0.22 8.97 1.87
9 INT215096 Binding of Hmgb1 and Tlr2 9 1 0.38 11.61 1.61
10 INT222185 Binding of Ccr1 and Ccl3 4 1 0.23 2.7 1.47
11 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 2 0.03 2.83 1.46
12 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 1 0.12 3 1.24
13 INT260833 Binding of NRP2 and Flt1 1 3 0.00 3.61 1.22
14 INT194861 Binding of IL1B and IL1R1 2 2 0.01 1.55 1.2
15 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 1 0.00 1.57 1.05
16 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 2 0.08 2.96 1.04
17 INT278962 LEP Positive_regulation of CPOX 1 1 0.05 1.33 1
18 INT278946 IL6 Regulation of Gene_expression of IL8 1 4 0.20 1.9 1
19 INT296179 Pla2g2a Positive_regulation of Apcs 1 4 0.17 7.13 0.96
20 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 2 0.34 1.68 0.96
21 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 1 0.06 2.45 0.93
22 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 2 0.07 1.38 0.91
23 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 1 0.14 3.53 0.9
24 INT276964 Binding of Tlr1 and Tlr2 11 4 0.24 4.22 0.89
25 INT209881 Binding of TNFRSF11B and TNFSF11 8 1 0.36 8.92 0.86
26 INT260842 Binding of NRP2 and Kdr 1 2 0.00 2.28 0.85
27 INT182636 Binding of TNFSF11 and TNFRSF11A 16 2 0.29 17.5 0.84
28 INT189671 DAG1 Positive_regulation of PRKCA 3 1 0.12 0.71 0.82
29 INT286346 IRF6 Positive_regulation of IL8 3 1 0.03 0.88 0.8
30 INT276988 Binding of Tlr6 and Tlr2 11 4 0.26 4.89 0.79
31 INT302831 Binding of Creb1 and Mapkapk5 1 2 0.07 1.3 0.79
32 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 1 0.32 1.93 0.78
33 INT183698 Binding of Cxcr2 and Cxcl1 3 1 0.33 3.26 0.76
34 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 2 0.76 1.73 0.75
35 INT278958 LEP Positive_regulation of IL1B 1 2 0.33 1.91 0.74
36 INT142847 IRF6 Positive_regulation of IL6 5 1 0.07 1.09 0.73
37 INT296097 Acsm3 Negative_regulation of SOD1 1 1 0.01 1.3 0.72
38 INT260832 Binding of NRP2 and Nrp1 1 2 0.00 2.32 0.7
39 INT222811 Binding of Hand2 and TH1L 4 1 0.03 8.26 0.69
40 INT278956 LEP Regulation of Gene_expression of IL8 1 2 0.30 1.11 0.69
41 INT278968 LEP Regulation of Gene_expression of IL6 1 2 0.29 1.11 0.69
42 INT278951 LEP Regulation of Gene_expression of PTGER2 1 2 0.07 1.11 0.69
43 INT230336 IL4 Regulation of IL5 2 1 0.04 0.82 0.67
44 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 1 0.23 1.82 0.67
45 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 1 0.27 0.73 0.67
46 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 2 0.04 1.38 0.67
47 INT285562 Binding of Il27ra and Il27 1 2 0.10 2.19 0.67
48 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 1 0.28 0.74 0.67
49 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 1 0.29 2.12 0.66
50 INT316690 Binding of Myd88 and Il1 2 1 0.06 1.75 0.66
51 INT306020 Binding of LBP and Tlr4 1 1 0.13 0.34 0.66
52 INT221847 Binding of Calca and Ntrk1 1 1 0.03 0.9 0.65
53 INT255690 Binding of VEGFA and Flt1 8 1 0.34 3.44 0.61
54 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 1 0.05 1.33 0.61
55 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 5 0.40 5.85 0.6
56 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 1 0.03 1 0.57
57 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 1 0.01 1.17 0.57
58 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 1 0.31 1.92 0.56
59 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 1 0.01 1.48 0.56
60 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 1 0.01 1.5 0.56
61 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 1 0.36 1.5 0.56
62 INT302832 Tnfsf10 Positive_regulation of Akt1 1 1 0.04 1.63 0.56
63 INT297311 Casp1 Positive_regulation of Il18 1 1 0.09 1.02 0.55
64 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 1 0.05 1.02 0.54
65 INT194595 Binding of TNFSF10 and TNFRSF10B 4 1 0.15 9.3 0.53
66 INT310532 IL6 Regulation of Regulation of TNF 1 1 0.34 0.73 0.52
67 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 1 0.19 0.73 0.52
68 INT302838 TNF Positive_regulation of Sox18 1 1 0.00 0.71 0.5
69 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 2 0.00 1.59 0.5
70 INT179507 Tlr4 Positive_regulation of Tlr2 2 1 0.17 1.07 0.49
71 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 1 0.01 0.98 0.49
72 INT306019 Binding of Tlr4 and LY96 1 3 0.06 0.91 0.49
73 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 1 0.04 1.03 0.49
74 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 1 0.15 1.91 0.49
75 INT302823 Stat3 Regulation of Gene_expression of Il7 1 1 0.04 1.03 0.49
76 INT300956 Il4 Negative_regulation of IL8 1 1 0.02 0.37 0.48
77 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 1 0.06 1.67 0.48
78 INT300960 Il4 Negative_regulation of IL1B 1 1 0.03 0.37 0.48
79 INT300957 Binding of IL13 and Il4 1 1 0.01 0.58 0.48
80 INT300959 Il4 Negative_regulation of TNF 1 1 0.03 0.37 0.48
81 INT300955 Il4 Negative_regulation of Il6 1 1 0.03 0.37 0.48
82 INT302839 MIR15A Negative_regulation of Bcl2 1 1 0.15 1.41 0.47
83 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 1 0.06 1.67 0.47
84 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 1 0.06 1.67 0.47
85 INT231340 INCENP Regulation of Gene_expression of IL6 1 1 0.01 1.09 0.47
86 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 1 0.01 1.21 0.47
87 INT265646 Binding of Mapk1 and Mapk14 1 1 0.01 1.53 0.46
88 INT355672 Il6 Negative_regulation of Transcription of TNF 1 1 0.05 0.98 0.46
89 INT296795 Binding of Tlr9 and Tlr3 2 1 0.22 1.29 0.45
90 INT222923 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of Mpo 1 1 0.04 0.59 0.45
91 INT222924 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il12a 1 1 0.01 0.59 0.45
92 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 1 0.01 1.05 0.44
93 INT355571 MIF Positive_regulation of IL8 1 1 0.04 1.05 0.44
94 INT222922 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il1 1 1 0.01 0.56 0.44
95 INT228732 Il13 Regulation of Gene_expression of Il5 1 1 0.15 0.44 0.44
96 INT355568 MIF Positive_regulation of IL6 1 1 0.05 1.05 0.44
97 INT320695 TNF Positive_regulation of Localization of Il1 1 1 0.05 1.38 0.44
98 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 1 0.01 1.92 0.43
99 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 1 0.25 0.47 0.43
100 INT265647 Binding of Ephb1 and Mapk1 1 1 0.00 1.48 0.43
101 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 1 0.15 0.47 0.43
102 INT302829 Mapkapk5 Positive_regulation of Trp53 1 1 0.07 0.81 0.43
103 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 1 0.01 0.94 0.41
104 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 1 0.01 0.99 0.41
105 INT240618 Binding of INS and ADIPOQ 3 1 0.17 2.54 0.4
106 INT329801 Binding of CAMP and IFNA1 1 1 0.03 1.48 0.4
107 INT298584 IL1B Regulation of Gene_expression of TNFRSF11B 1 3 0.22 0.7 0.4
108 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 1 0.11 0.64 0.4
109 INT324802 Binding of Cd24a and Siglecg 1 2 0.03 1.34 0.4
110 INT329799 Binding of CD14 and LY96 2 1 0.04 1.02 0.39
111 INT302825 Binding of Creb1 and Xpnpep1 1 1 0.00 0.64 0.39
112 INT278944 ZEB1 Negative_regulation of IL1B 1 1 0.00 1.09 0.39
113 INT228739 Il4 Positive_regulation of Gene_expression of Ccl17 1 1 0.14 0.66 0.39
114 INT228761 Tnf Positive_regulation of Gene_expression of Ccl17 1 1 0.20 0.66 0.39
115 INT285560 Il23a Positive_regulation of Il17a 1 1 0.09 1.45 0.39
116 INT302836 Negative_regulation of Mapk8 Negative_regulation of TNF Positive_regulation of Mir155 1 1 0.00 0.48 0.39
117 INT194596 Binding of HLA-DRB4 and TNFSF10 3 1 0.08 6 0.38
118 INT285571 Binding of IL8 and Il17a 1 1 0.04 1.03 0.38
119 INT302815 TNF Positive_regulation of TNF Positive_regulation of Mir155 1 1 0.00 0.47 0.38
120 INT302840 Positive_regulation of TNF Positive_regulation of Mir155 1 1 0.01 0.47 0.38
121 INT302821 Mdk Negative_regulation of Il1 1 1 0.02 0.91 0.38
122 INT278960 ZEB1 Negative_regulation of MMP3 1 1 0.00 1.05 0.38
123 INT302843 TNF Positive_regulation of Mir155 1 1 0.01 0.47 0.38
124 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 1 0.28 0.67 0.38
125 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 1 0.00 1.05 0.38
126 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 1 0.19 2.36 0.37
127 INT303994 Il6 Positive_regulation of JAK2 1 1 0.03 0.41 0.37
128 INT324821 Tlr4 Positive_regulation of Gene_expression of Maob 1 1 0.07 0.44 0.37
129 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 1 0.11 0.66 0.37
130 INT297314 Binding of Bsg and Sele 1 1 0.11 1.37 0.37
131 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 1 0.02 0.44 0.37
132 INT303982 Il6 Positive_regulation of STAT3 1 1 0.03 0.41 0.37
133 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 1 0.12 0.65 0.37
134 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 1 0.21 0.51 0.37
135 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 1 0.02 0.44 0.37
136 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 1 0.21 0.51 0.37
137 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 1 0.09 0.44 0.37
138 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 1 0.05 0.65 0.37
139 INT324827 Hmgb1 Positive_regulation of Bad 1 1 0.02 0.43 0.36
140 INT329170 DCPS Positive_regulation of Gene_expression of IFN1@ 1 1 0.04 1.55 0.36
141 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 1 0.16 0.62 0.36
142 INT270789 CRP Negative_regulation of Gene_expression of TNF 1 1 0.34 0.87 0.36
143 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 1 0.42 0.63 0.36
144 INT324808 Tlr4 Positive_regulation of Bad 1 1 0.02 0.43 0.36
145 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 1 0.07 1.11 0.36
146 INT298588 IL1B Regulation of Gene_expression of CSF1 1 3 0.35 0.59 0.36
147 INT285568 Binding of TNF and Tnfsf10 1 1 0.12 1.39 0.36
148 INT285557 Eae2 Positive_regulation of Cia1 1 1 0.02 1.85 0.36
149 INT174699 Binding of Tlr2 and Tlr3 3 1 0.14 0.66 0.35
150 INT285465 IL7 Positive_regulation of TNF 1 1 0.04 0.67 0.35
151 INT285570 Binding of IL8 and Cdkn1c 1 1 0.11 0.76 0.34
152 INT320694 C5 Regulation of Gene_expression of Il2 1 1 0.03 2.15 0.34
153 INT320692 C5 Regulation of Gene_expression of Il12a 1 1 0.03 2.15 0.34
154 INT320693 C5 Regulation of Gene_expression of Il6 1 1 0.04 2.15 0.34
155 INT320696 C5 Regulation of Gene_expression of TNF 1 1 0.34 2.15 0.34
156 INT320691 C5 Regulation of Gene_expression of Il1 1 1 0.06 2.15 0.34
157 INT89381 INS Positive_regulation of AKT1 6 1 0.43 3.06 0.33
158 INT324690 Binding of Traf6 and Ticam1 2 2 0.07 0.23 0.33
159 INT230855 KNG1 Regulation of NOS1 2 1 0.03 0.94 0.33
160 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 1 0.02 0.62 0.33
161 INT285558 Binding of Il11ra1 and Il27 1 1 0.05 1.1 0.33
162 INT285566 F8 Negative_regulation of IL2 1 1 0.00 0.62 0.33
163 INT302830 Mapk14 Regulation of Mapkapk5 1 1 0.12 0.53 0.33
164 INT285563 Zeb1 Negative_regulation of IL2 1 1 0.01 0.62 0.33
165 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 2 0.15 0.24 0.33
166 INT228759 Rae1 Negative_regulation of Il5 1 3 0.09 1.32 0.33
167 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 1 0.01 0.35 0.33
168 INT230852 ACE Regulation of KNG1 2 1 0.03 0.72 0.32
169 INT302842 Binding of S1PR1 and S1pr1 1 2 0.24 0.92 0.32
170 INT278942 LEP Regulation of IL6 1 1 0.29 0.61 0.31
171 INT285567 Binding of IL1B and Cdc42 1 1 0.03 0.77 0.31
172 INT278939 LEP Regulation of IL8 1 1 0.13 0.61 0.31
173 INT285564 Binding of IL1B and Ripk2 1 1 0.04 0.76 0.31
174 INT278969 LEP Regulation of PTGER2 1 1 0.03 0.6 0.31
175 INT313740 Negative_regulation of NOS1 Positive_regulation of Gene_expression of Ccl2 1 1 0.02 0.38 0.3
176 INT324832 Tlr4 Positive_regulation of IFNA1 1 1 0.05 0.46 0.3
177 INT329173 Binding of PDC and RARRES2 1 1 0.07 1.02 0.3
178 INT324830 Hspd1 Positive_regulation of IFNA1 1 1 0.04 0.46 0.3
179 INT278961 IL6 Regulation of Gene_expression of LEP 1 1 0.29 0.89 0.3
180 INT303983 Lep Positive_regulation of CXCL10 1 1 0.06 0.31 0.29
181 INT260841 Il6 Positive_regulation of Localization of NRP2 1 1 0.00 0.7 0.29
182 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 1 0.04 0.31 0.29
183 INT303995 Lep Positive_regulation of PSME1 1 1 0.09 0.32 0.29
184 INT260831 Pgf Positive_regulation of TNF 1 1 0.60 0.75 0.29
185 INT228734 Rae1 Negative_regulation of Il4 1 3 0.08 0.68 0.29
186 INT215274 Tlr4 Positive_regulation of Ros1 2 1 0.02 1.48 0.28
187 INT303949 LEPR Positive_regulation of SOAT1 1 1 0.01 0.22 0.28
188 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 2 0.06 0.85 0.28
189 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 1 0.03 0.86 0.28
190 INT230337 IL1B Regulation of IL5 1 1 0.04 0.57 0.28
191 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 1 0.01 0.73 0.28
192 INT324825 Binding of Chuk and Myd88 1 1 0.03 0.86 0.28
193 INT324810 Binding of Chuk and Irak1 1 1 0.02 0.85 0.28
194 INT230342 IL6 Regulation of IL4 1 1 0.02 0.57 0.28
195 INT230333 IL6 Regulation of IL13 1 1 0.03 0.57 0.28
196 INT230339 IL6 Regulation of IL5 1 1 0.03 0.57 0.28
197 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 1 0.00 0.9 0.28
198 INT230341 IL9 Regulation of IL5 1 1 0.06 0.57 0.28
199 INT230334 IL1B Regulation of IL9 1 1 0.02 0.57 0.28
200 INT230343 IL1B Regulation of IL13 1 1 0.02 0.57 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 115 3152 0.78 2515.62 929.82
2 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
3 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
4 INT9238 Gene_expression of IL6 100 1575 0.78 1135.66 424.22
5 INT9238 Gene_expression of IL6 5 1575 0.78 1135.66 424.22
6 INT5235 Negative_regulation of TNF 11 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 33 1050 0.70 896.51 322.81
8 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
9 INT9158 Gene_expression of Tnf 25 722 0.78 522.01 277.68
10 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
11 INT6852 Localization of TNF 26 883 0.81 705.95 270.84
12 INT10832 Gene_expression of IL8 57 1050 0.78 698.72 270
13 INT9659 Gene_expression of Il6 40 991 0.78 715.11 265.57
14 INT9659 Gene_expression of Il6 3 991 0.78 715.11 265.57
15 INT5972 Gene_expression of IL1B 49 948 0.78 510.91 263.97
16 INT68684 Gene_expression of VEGFA 6 2371 0.78 1742.52 259.2
17 INT16868 Gene_expression of Il6 15 807 0.78 499.48 256.57
18 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
19 INT95787 Positive_regulation of Mapk1 6 568 0.70 226.51 220.94
20 INT6481 Binding of TNF 6 624 0.48 510.2 214.82
21 INT6482 Positive_regulation of Gene_expression of TNF 12 659 0.70 569.88 210
22 INT48955 Gene_expression of Nos2 3 753 0.78 403.87 208.08
23 INT11313 Positive_regulation of Il6 6 526 0.70 331.27 201.59
24 INT50670 Gene_expression of CPOX 8 763 0.76 442.13 195.02
25 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
26 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
27 INT94952 Positive_regulation of Mapk14 3 305 0.70 197.83 186.61
28 INT24326 Gene_expression of Ngf 3 346 0.78 218.67 184.71
29 INT10194 Positive_regulation of IL6 31 702 0.70 600.62 183.38
30 INT19472 Gene_expression of Il1 17 554 0.76 419.75 175.35
31 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
32 INT15516 Gene_expression of Crp 7 711 0.77 615.33 173.09
33 INT867 Gene_expression of IFNA1 27 930 0.78 594.85 168.03
34 INT55879 Gene_expression of CCL2 15 421 0.78 240.74 166.02
35 INT1114 Localization of Ins1 6 748 0.80 192.95 165.48
36 INT66280 Gene_expression of Nos2 3 534 0.78 330.78 157.07
37 INT15515 Positive_regulation of Crp 5 700 0.70 604.24 150.15
38 INT13353 Positive_regulation of Tnf 11 332 0.70 248.75 148.1
39 INT9852 Positive_regulation of Gpt 4 563 0.70 364.64 146.82
40 INT5116 Gene_expression of IL2 18 670 0.78 291.13 146.69
41 INT812 Localization of INS 9 1026 0.81 515.6 145.31
42 INT60694 Gene_expression of Il10 9 567 0.78 369.48 143.69
43 INT9660 Regulation of TNF 10 363 0.62 312.94 139.99
44 INT48895 Gene_expression of Il10 2 333 0.78 221.2 138.52
45 INT48953 Positive_regulation of Nos2 5 486 0.70 239.85 131.87
46 INT115386 Gene_expression of Ppara 3 779 0.77 549.99 128.36
47 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
48 INT7533 Gene_expression of Tlr4 48 720 0.78 343.22 121.57
49 INT14151 Gene_expression of Casp3 8 311 0.78 140.26 120.68
50 INT8243 Positive_regulation of Il6 11 451 0.70 358.24 119.28
51 INT17612 Gene_expression of CRP 73 676 0.78 580.61 119.03
52 INT5010 Gene_expression of Calca 3 197 0.78 85.76 118.75
53 INT9235 Negative_regulation of Gene_expression of TNF 10 346 0.59 252.98 118.61
54 INT50674 Gene_expression of PTGS2 5 459 0.78 253.33 118.51
55 INT12339 Localization of IL8 2 437 0.81 251.87 117.39
56 INT92669 Gene_expression of Bdnf 1 309 0.78 178.26 116.68
57 INT62124 Gene_expression of NOS1 2 444 0.78 218.08 114.85
58 INT48593 Positive_regulation of NOS1 6 420 0.68 226.15 114.71
59 INT20374 Gene_expression of Il4 21 515 0.76 306.15 114.12
60 INT118381 Gene_expression of Il17a 26 405 0.76 306.97 112.06
61 INT11051 Positive_regulation of Gene_expression of IL6 20 415 0.69 319.21 109.3
62 INT27096 Positive_regulation of Nfkb1 3 325 0.70 195.11 109.06
63 INT60526 Gene_expression of IL10 17 449 0.78 292.71 107.84
64 INT3038 Gene_expression of INS 36 1583 0.78 1174.16 107.01
65 INT12082 Localization of IL6 7 365 0.81 241.78 105.78
66 INT69440 Gene_expression of ROS1 27 752 0.78 477.64 103.83
67 INT18009 Positive_regulation of CRP 10 518 0.70 553.03 103.74
68 INT10838 Positive_regulation of IL8 11 381 0.70 295.51 101.62
69 INT82878 Gene_expression of Ccl2 14 201 0.78 164.95 101.35
70 INT11381 Positive_regulation of IL1B 15 330 0.70 209.31 100.9
71 INT65500 Gene_expression of App 1 605 0.78 429.94 98.31
72 INT1760 Gene_expression of PTGER2 38 524 0.57 226.94 96.4
73 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
74 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
75 INT86024 Gene_expression of PPARA 1 736 0.78 497.93 91.14
76 INT48767 Negative_regulation of NOS1 4 312 0.59 154.25 90.32
77 INT71789 Positive_regulation of MAPK1 1 396 0.70 234.44 89.27
78 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
79 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
80 INT54571 Positive_regulation of NFKB1 4 263 0.70 138.99 87.32
81 INT1472 Positive_regulation of Ins1 2 349 0.69 146.2 86.36
82 INT21793 Positive_regulation of Ngf 2 154 0.70 94.78 85.27
83 INT82448 Gene_expression of S100a8 5 246 0.77 236.72 84.02
84 INT92434 Phosphorylation of Mapk1 2 287 0.82 91.65 83.46
85 INT84546 Positive_regulation of Ppara 3 481 0.70 334.21 83.45
86 INT48406 Gene_expression of Icam1 14 277 0.78 238.28 81.71
87 INT68682 Positive_regulation of VEGFA 5 640 0.70 454.14 81.65
88 INT56291 Gene_expression of Ros1 11 503 0.63 274.12 81.5
89 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
90 INT2431 Positive_regulation of Mpo 6 275 0.70 211.99 78.47
91 INT60691 Gene_expression of Il12a 12 331 0.78 208.03 75.96
92 INT3657 Gene_expression of Ins1 8 514 0.78 321.69 75.76
93 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
94 INT5056 Gene_expression of IFNG 4 216 0.78 137.52 74.57
95 INT1724 Negative_regulation of ACE 5 437 0.59 315.64 74.48
96 INT9236 Regulation of Gene_expression of TNF 9 204 0.62 162.66 72.99
97 INT56298 Gene_expression of IL4 13 306 0.78 182.18 72.92
98 INT39565 Gene_expression of Ptger2 11 424 0.75 229.28 72.68
99 INT11380 Negative_regulation of IL1B 5 215 0.59 125.62 72.35
100 INT12720 Positive_regulation of Il1 6 246 0.70 195.97 72.05
101 INT5969 Gene_expression of Il1a 1 221 0.75 96.31 71.38
102 INT57380 Phosphorylation of Creb1 2 213 0.82 66.8 71.26
103 INT58400 Negative_regulation of Tnf 5 182 0.59 129.97 71
104 INT49995 Positive_regulation of Gene_expression of Tnf 10 187 0.70 125.07 70.54
105 INT10837 Positive_regulation of Gene_expression of IL8 9 294 0.70 190.08 70.34
106 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
107 INT170332 Gene_expression of IFN1@ 2 477 0.75 275.21 69.65
108 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
109 INT14624 Gene_expression of Pax3 2 100 0.38 33.22 69.47
110 INT7534 Gene_expression of Ifng 2 193 0.78 111.02 68.6
111 INT1988 Positive_regulation of Localization of Ins1 3 254 0.69 59.25 68.37
112 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
113 INT6489 Positive_regulation of Gene_expression of Tnf 2 140 0.70 92.31 67.85
114 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
115 INT102546 Gene_expression of Ccl2 8 197 0.78 192.8 67.41
116 INT5374 Gene_expression of Esr1 3 412 0.77 263.89 67.34
117 INT6486 Positive_regulation of Tnf 2 168 0.70 123.47 66.05
118 INT11807 Gene_expression of Il2 2 266 0.78 112 64.97
119 INT15514 Negative_regulation of Crp 2 275 0.59 194.6 64.86
120 INT11937 Localization of Il6 15 228 0.81 139.83 64.39
121 INT9657 Positive_regulation of Gene_expression of Il6 5 237 0.70 180.45 63.6
122 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
123 INT9664 Binding of LBP 2 127 0.48 94.9 63.42
124 INT1951 Positive_regulation of Tlr4 21 345 0.70 176.99 62.42
125 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
126 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
127 INT50971 Gene_expression of Ntrk1 2 180 0.75 73.52 62.28
128 INT17401 Gene_expression of IGF1 2 475 0.78 232.18 62.07
129 INT67981 Positive_regulation of CCL2 7 165 0.70 136.84 61.85
130 INT11318 Gene_expression of Gtf3a 3 274 0.52 183.82 60.89
131 INT5058 Positive_regulation of IFNA1 13 356 0.70 245.75 60.52
132 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
133 INT103924 Positive_regulation of Akt1 2 359 0.69 158.94 60.34
134 INT14740 Gene_expression of TGFB1 2 272 0.78 168.48 60.18
135 INT50672 Positive_regulation of CPOX 2 205 0.44 125.93 60.06
136 INT55344 Gene_expression of Ros1 1 396 0.54 217.64 59.98
137 INT1759 Gene_expression of TIMP1 2 267 0.77 133.87 59.29
138 INT48901 Negative_regulation of IL6 6 186 0.57 136.33 57.87
139 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
140 INT48232 Gene_expression of MMP1 1 245 0.78 96.31 57.72
141 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
142 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
143 INT48891 Positive_regulation of Il10 3 143 0.70 101.42 56.72
144 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
145 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
146 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
147 INT52800 Negative_regulation of Gene_expression of Tnf 7 142 0.59 92.27 55.47
148 INT251 Regulation of INS 3 398 0.62 232.47 55.04
149 INT82650 Gene_expression of Bcl2 5 312 0.78 211.71 55.03
150 INT63975 Positive_regulation of Il10 2 175 0.68 134.13 54.69
151 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
152 INT117223 Gene_expression of TLR4 19 348 0.78 206.18 54.42
153 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
154 INT49993 Positive_regulation of Gene_expression of Il6 6 149 0.70 88.07 53.78
155 INT48952 Negative_regulation of Nos2 6 204 0.59 101.73 53.15
156 INT9234 Negative_regulation of Gene_expression of IL6 6 171 0.59 101.61 53.15
157 INT9234 Negative_regulation of Gene_expression of IL6 3 171 0.59 101.61 53.15
158 INT62543 Gene_expression of Icam1 8 231 0.78 187.58 52.71
159 INT22112 Positive_regulation of Localization of TNF 3 164 0.70 115.66 52.18
160 INT72182 Gene_expression of Mcpt1 3 167 0.75 123.7 52.15
161 INT22546 Positive_regulation of Gene_expression of Casp3 1 97 0.70 47.89 51.92
162 INT83199 Gene_expression of Nos3 3 193 0.78 100.72 51.57
163 INT20382 Gene_expression of Hand2 6 211 0.66 142.26 51.05
164 INT19775 Localization of Il1 7 183 0.78 145.5 50.91
165 INT6473 Positive_regulation of Gene_expression of IL1B 11 204 0.70 117.23 50.86
166 INT1199 Positive_regulation of INS 11 579 0.70 399.64 50.43
167 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
168 INT9210 Regulation of IL6 5 166 0.62 125.61 49.95
169 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
170 INT51163 Gene_expression of Gal 1 119 0.78 67.48 49.23
171 INT55671 Gene_expression of Ik 5 151 0.27 80.1 48.49
172 INT17881 Gene_expression of LEP 64 278 0.78 221.61 48.31
173 INT66029 Negative_regulation of Tnf 2 100 0.59 84.28 48.16
174 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
175 INT48718 Positive_regulation of PRKCA 3 109 0.69 36.16 46.49
176 INT20345 Gene_expression of Dbi 1 136 0.78 56.41 46.2
177 INT110023 Negative_regulation of Mapk14 1 127 0.59 84.27 45.42
178 INT145266 Gene_expression of IL17A 11 154 0.75 109.83 45.33
179 INT81498 Positive_regulation of Gene_expression of CCL2 11 107 0.70 53.89 45.22
180 INT6979 Positive_regulation of CA2 3 206 0.67 50.79 44.97
181 INT2275 Negative_regulation of Localization of Ins1 2 183 0.59 51.02 44.94
182 INT18522 Positive_regulation of Gene_expression of IFNA1 10 248 0.67 160.85 44.87
183 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
184 INT27493 Negative_regulation of Casp3 1 114 0.56 56.89 44.63
185 INT80124 Negative_regulation of VEGFA 4 450 0.58 311.19 44.53
186 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
187 INT25610 Positive_regulation of Gene_expression of Il1 2 136 0.67 104.43 43.86
188 INT83953 Gene_expression of Cxcl2 8 140 0.75 113.07 43.65
189 INT73502 Positive_regulation of IL10 4 154 0.69 124.87 43.5
190 INT100939 Gene_expression of Il13 14 176 0.73 125.1 43.38
191 INT25383 Gene_expression of Csf2 4 222 0.76 152.93 43.32
192 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
193 INT60695 Positive_regulation of Gene_expression of Il10 3 154 0.70 120.28 43.07
194 INT1474 Regulation of Localization of Ins1 1 132 0.61 25.96 43.07
195 INT49105 Gene_expression of Vcam1 1 157 0.78 157.27 43.01
196 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
197 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
198 INT50957 Negative_regulation of Il6 2 134 0.59 79.08 42.67
199 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
200 INT13354 Transcription of TNF 3 108 0.72 85.81 42.32
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