J:Metab. Clin. Exp.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT26468 Ghrh Positive_regulation of Localization of Gh 21 3 0.37 3.26 9.21
2 INT10844 Ghrh Regulation of Gh 13 1 0.13 4.77 4.71
3 INT16221 Ghrh Positive_regulation of Gh 8 1 0.21 1.89 4.08
4 INT26812 SST Regulation of Localization of OXT 1 2 0.40 0.57 1.37
5 INT18324 Sst Negative_regulation of Localization of Ins1 2 1 0.46 1.09 1.24
6 INT25026 PLOD1 Regulation of FSHR 4 2 0.19 0.38 1.15
7 INT18325 Grem2 Positive_regulation of Ins1 1 1 0.02 0.9 0.88
8 INT35159 FSHR Regulation of PRL 2 1 0.34 0 0.6
9 INT35154 PLOD1 Regulation of PRL 2 1 0.17 0 0.6
10 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 1 0.04 1.66 0.55
11 INT54584 GNRH1 Positive_regulation of FSHR 3 1 0.48 2.02 0.54
12 INT71550 GTPBP4 Regulation of Localization of INS 1 1 0.00 0.16 0.28
13 INT36292 GCG Positive_regulation of MIA3 1 1 0.01 1.06 0.26
14 INT97188 Gh Positive_regulation of Localization of Igf1 1 1 0.02 0.54 0.25
15 INT39738 PRL Regulation of Localization of GH1 1 1 0.37 0.6 0.24
16 INT29099 Binding of ADRB2 and PPAP2A 1 1 0.03 0.77 0.22
17 INT75355 Negative_regulation of GCG Regulation of Gh 1 1 0.01 1.26 0.18
18 INT75356 GCG Regulation of Gh 1 1 0.01 1.25 0.18
19 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 1 0.01 0.14 0.17
20 INT15523 INS Negative_regulation of FFAR1 1 1 0.02 0.35 0.16
21 INT15524 GCG Negative_regulation of FFAR1 1 1 0.07 0.35 0.16
22 INT71548 ADRA2C Negative_regulation of Localization of INS 1 1 0.04 0.13 0.16
23 INT15525 MIA3 Negative_regulation of FFAR1 1 1 0.01 0.35 0.16
24 INT109959 INS Positive_regulation of FBF1 1 1 0.27 0.24 0.09
25 INT66590 Gnrhr Regulation of Ldlr 1 1 0.02 0.4 0.06

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 5 2431 0.81 378.96 952.2
3 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
4 INT443 Localization of POMC 4 1020 0.81 284.52 443.17
5 INT467 Gene_expression of POMC 4 1048 0.78 332.8 394.16
6 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
7 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
8 INT720 Positive_regulation of POMC 4 807 0.70 237.37 353.83
9 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
10 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
11 INT9158 Gene_expression of Tnf 3 722 0.78 522.01 277.68
12 INT2365 Positive_regulation of Cck 1 354 0.70 87.8 277.41
13 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
14 INT1893 Localization of Gh 27 1041 0.79 340.23 256.58
15 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
16 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
17 INT738 Regulation of POMC 3 459 0.62 111.19 243.74
18 INT767 Localization of Gnrhr 2 565 0.80 106.68 214.57
19 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
20 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
21 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
22 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
23 INT1114 Localization of Ins1 16 748 0.80 192.95 165.48
24 INT3448 Positive_regulation of Gh 17 521 0.69 180.03 161.18
25 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
26 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
27 INT812 Localization of INS 13 1026 0.81 515.6 145.31
28 INT425 Localization of PRL 9 455 0.81 189.64 144.8
29 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
30 INT252 Localization of GH1 23 529 0.80 227.4 122.05
31 INT6128 Positive_regulation of Localization of POMC 1 256 0.70 68.77 121.64
32 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
33 INT1530 Regulation of Gh 6 382 0.61 115.96 112.47
34 INT3038 Gene_expression of INS 10 1583 0.78 1174.16 107.01
35 INT9012 Localization of Vip 3 283 0.81 31.71 106.16
36 INT915 Positive_regulation of PRL 2 342 0.70 141.96 104.31
37 INT5865 Positive_regulation of Localization of Gh 9 282 0.69 84.86 93.5
38 INT214 Localization of AVP 4 370 0.81 208.51 91.09
39 INT914 Positive_regulation of GH1 10 292 0.69 100.7 84.91
40 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
41 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
42 INT1309 Positive_regulation of Localization of Gnrhr 2 152 0.69 24.25 81.56
43 INT403 Localization of Trh 3 241 0.81 28.55 81.45
44 INT1498 Gene_expression of Gh 7 521 0.75 220.84 81.16
45 INT7528 Regulation of OPRM1 2 100 0.62 20.63 80.57
46 INT3214 Localization of Ins1 2 527 0.80 196.9 79.26
47 INT2155 Negative_regulation of Sst 3 111 0.59 16.58 77.74
48 INT1497 Negative_regulation of Gh 11 415 0.59 192.95 74.71
49 INT1988 Positive_regulation of Localization of Ins1 2 254 0.69 59.25 68.37
50 INT253 Regulation of PRL 9 184 0.62 47.27 65.79
51 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
52 INT5095 Localization of Ghrh 5 185 0.81 28.09 62.08
53 INT17401 Gene_expression of IGF1 2 475 0.78 232.18 62.07
54 INT67981 Positive_regulation of CCL2 1 165 0.70 136.84 61.85
55 INT3161 Regulation of Localization of Gh 8 163 0.61 35.43 59.45
56 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
57 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
58 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
59 INT251 Regulation of INS 5 398 0.62 232.47 55.04
60 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
61 INT3213 Gene_expression of Ins1 2 511 0.76 357.59 53.32
62 INT249 Localization of GHRH 7 215 0.80 78.02 51.87
63 INT921 Regulation of GH1 15 172 0.60 52.88 51.04
64 INT1199 Positive_regulation of INS 4 579 0.70 399.64 50.43
65 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
66 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
67 INT17881 Gene_expression of LEP 2 278 0.78 221.61 48.31
68 INT1197 Negative_regulation of Localization of POMC 2 109 0.59 28.29 48.02
69 INT683 Positive_regulation of AVP 2 173 0.70 74.55 46.41
70 INT531 Gene_expression of GH1 4 376 0.75 193.45 46.24
71 INT1322 Positive_regulation of Localization of INS 5 293 0.70 120.86 45.98
72 INT2275 Negative_regulation of Localization of Ins1 13 183 0.59 51.02 44.94
73 INT2774 Binding of Crp 4 241 0.48 195.89 44.39
74 INT8824 Regulation of Vip 1 95 0.62 15.7 43.63
75 INT1894 Negative_regulation of Localization of Gh 10 168 0.58 64.12 43.56
76 INT1474 Regulation of Localization of Ins1 2 132 0.61 25.96 43.07
77 INT49105 Gene_expression of Vcam1 2 157 0.78 157.27 43.01
78 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
79 INT957 Positive_regulation of GHRH 3 136 0.70 36.84 40.52
80 INT918 Positive_regulation of Localization of PRL 3 90 0.70 23.97 40.3
81 INT3252 Negative_regulation of INS 4 428 0.59 271.65 39.52
82 INT916 Regulation of Localization of PRL 2 92 0.62 22.98 38.13
83 INT3253 Negative_regulation of Localization of INS 6 205 0.59 130.39 36.61
84 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
85 INT255 Regulation of Localization of GH1 15 89 0.62 18.71 35.3
86 INT8747 Positive_regulation of Ins1 3 221 0.69 154.28 35.15
87 INT2274 Regulation of Localization of INS 3 101 0.62 41.55 34.79
88 INT7675 Gene_expression of ENG 1 146 0.77 45.35 34.6
89 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
90 INT248 Positive_regulation of Localization of GH1 5 137 0.69 49.25 32.92
91 INT5868 Positive_regulation of GNRH1 2 122 0.69 20.96 32.8
92 INT985 Negative_regulation of GH1 2 213 0.57 89.53 32.39
93 INT3117 Regulation of Oxt 2 103 0.61 17.93 32.28
94 INT7975 Regulation of PLOD1 1 97 0.62 20.9 30.51
95 INT1473 Localization of Gcg 5 95 0.80 17.35 30.31
96 INT5100 Positive_regulation of Ghrh 2 100 0.64 24.2 30.21
97 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
98 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
99 INT6624 Gene_expression of Pth 2 135 0.76 110.27 27.54
100 INT7894 Negative_regulation of Vip 2 59 0.59 11.76 27.36
101 INT3217 Regulation of Ins1 2 154 0.62 87.11 27.29
102 INT9682 Positive_regulation of IGF1 7 238 0.70 120.03 26.36
103 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
104 INT49141 Gene_expression of Selp 1 157 0.78 85.22 24.78
105 INT6726 Positive_regulation of Edn1 4 118 0.70 65.96 24.07
106 INT250 Regulation of GHRH 3 65 0.61 17.46 23.19
107 INT18323 Negative_regulation of Localization of Ins1 1 122 0.58 45.74 23.04
108 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
109 INT18322 Negative_regulation of Ins1 7 132 0.58 88.49 22.59
110 INT16303 Negative_regulation of Localization of GH1 2 89 0.59 37.31 22.15
111 INT1644 Regulation of FSHR 1 77 0.55 15.62 21.49
112 INT6127 Regulation of Localization of AVP 2 60 0.62 15.12 20.84
113 INT51474 Binding of Il6 1 55 0.48 44.99 20.52
114 INT49103 Positive_regulation of Vcam1 2 71 0.69 59.52 19.85
115 INT2165 Localization of Cga 1 41 0.80 4.02 19.53
116 INT7364 Regulation of Ghrh 1 49 0.58 8.05 19.05
117 INT14306 Positive_regulation of Gal 1 36 0.70 21.66 18.51
118 INT13454 Positive_regulation of Positive_regulation of Gh 2 49 0.68 14.53 18.49
119 INT18010 Positive_regulation of CD40LG 2 122 0.70 100.8 18.46
120 INT11525 Negative_regulation of Localization of Vip 2 42 0.49 6.91 18.04
121 INT14419 Negative_regulation of Localization of Trh 2 40 0.59 2.04 17.42
122 INT12875 Regulation of Adra2a 3 26 0.45 7.51 17.35
123 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
124 INT6129 Positive_regulation of Localization of AVP 3 63 0.70 30.44 16.64
125 INT117500 Gene_expression of Adipoq 2 90 0.74 67.79 16.58
126 INT984 Positive_regulation of Localization of GHRH 2 58 0.70 12.66 16.51
127 INT28950 Positive_regulation of Gene_expression of IGF1 1 99 0.69 46.9 16.47
128 INT50932 Positive_regulation of Positive_regulation of Il6 1 36 0.69 24.9 16.12
129 INT6110 Negative_regulation of Gene_expression of Ins1 1 83 0.56 60.59 16.07
130 INT26538 Positive_regulation of FSHR 2 103 0.69 30.95 15.33
131 INT7475 Positive_regulation of Hdl1 1 138 0.67 175.81 15.05
132 INT663 Negative_regulation of Adrb3 1 55 0.59 15.95 14.68
133 INT8088 Regulation of Localization of Cga 1 28 0.60 2.37 13.91
134 INT9649 Positive_regulation of LPA 1 105 0.69 74.75 13.89
135 INT5806 Regulation of Edn1 1 63 0.62 23.46 13.88
136 INT22000 Positive_regulation of Sst 1 25 0.70 14.82 13.6
137 INT6575 Positive_regulation of Localization of Gcg 3 33 0.69 3.48 13.31
138 INT17539 Positive_regulation of Igf1 1 68 0.69 28.47 13.02
139 INT9678 Positive_regulation of Positive_regulation of GH1 2 32 0.68 8.14 12.97
140 INT8210 Positive_regulation of Gene_expression of INS 1 188 0.68 146.57 12.83
141 INT3040 Gene_expression of MIA3 2 81 0.24 53.61 12.62
142 INT28952 Negative_regulation of Gene_expression of IGF1 2 75 0.58 41.11 12.32
143 INT39587 Gene_expression of CP 1 42 0.65 31.48 11.87
144 INT49142 Gene_expression of SELP 2 94 0.75 54.61 11.64
145 INT24816 Binding of CD40LG 1 68 0.47 45.48 11.56
146 INT254 Regulation of Localization of GHRH 4 30 0.60 5.17 11.46
147 INT141 Binding of Th 1 21 0.48 3.53 11.04
148 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
149 INT4494 Regulation of GCG 4 41 0.45 18.38 9.68
150 INT15722 Positive_regulation of PPAP2A 1 25 0.43 4.83 9.65
151 INT3703 Negative_regulation of Grhpr 1 38 0.50 11.43 9.2
152 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
153 INT11510 Negative_regulation of Positive_regulation of Gh 4 28 0.52 12.71 9.16
154 INT684 Binding of AVP 1 38 0.48 13.9 8.85
155 INT34777 Localization of IGF1 1 82 0.80 42.68 8.62
156 INT3658 Regulation of Gcg 1 28 0.53 12.89 8.58
157 INT14582 Negative_regulation of Negative_regulation of Sst 1 9 0.56 0.52 8.38
158 INT15529 Gene_expression of GCG 1 51 0.75 18.55 8.35
159 INT26815 Regulation of OXT 1 15 0.46 5.38 8.31
160 INT12292 Negative_regulation of Positive_regulation of GH1 1 22 0.58 5.02 8.28
161 INT36173 Positive_regulation of Gs 2 17 0.43 7.48 8.19
162 INT3401 Positive_regulation of Hp 1 22 0.69 16.33 7.97
163 INT5164 Negative_regulation of Ldlr 1 83 0.58 55.01 7.87
164 INT34741 Positive_regulation of Gene_expression of GH1 2 58 0.67 35.06 7.8
165 INT81399 Regulation of Vcam1 1 24 0.46 23.53 7.68
166 INT2587 Regulation of Localization of Gcg 2 22 0.60 1.73 7.59
167 INT298 Negative_regulation of ADRB3 1 23 0.59 6.82 7.56
168 INT26707 Binding of PPAP2A 1 21 0.35 6.01 7.43
169 INT3659 Negative_regulation of Gcg 1 26 0.51 10.08 7.39
170 INT7883 Binding of ADRB2 1 18 0.47 5.49 7.37
171 INT10863 Positive_regulation of Ldlr 1 45 0.68 31.06 7.05
172 INT110599 Gene_expression of Bglap 1 49 0.74 41.23 6.97
173 INT19302 Localization of OXT 3 31 0.79 3.39 6.92
174 INT256 Localization of ADRA1D 1 11 0.78 2.91 6.85
175 INT21138 Binding of ADRA2A 1 16 0.48 5.57 6.8
176 INT120895 Binding of CCL2 2 22 0.37 15.86 6.55
177 INT3041 Positive_regulation of MIA3 2 34 0.56 21.11 6.49
178 INT7205 Positive_regulation of HBG1 1 65 0.69 40.35 6.37
179 INT14560 Regulation of Igf1 1 41 0.59 19.59 6.3
180 INT12054 Negative_regulation of MIA3 4 32 0.45 23.2 6.18
181 INT15528 Positive_regulation of GCG 1 38 0.63 20.47 6.14
182 INT10843 Regulation of Regulation of Gh 1 14 0.22 5.56 5.93
183 INT12042 Regulation of MIA3 4 28 0.23 17.33 5.79
184 INT13857 Binding of Sst 1 11 0.24 2.48 5.76
185 INT146594 Negative_regulation of Gene_expression of LEP 1 25 0.42 18.88 5.71
186 INT17425 Regulation of Gene_expression of Ins1 2 23 0.45 18.99 5.61
187 INT8866 Positive_regulation of TAT 1 30 0.67 18.06 5.57
188 INT13735 Negative_regulation of Regulation of GH1 2 14 0.42 4.35 5.39
189 INT21067 Regulation of Regulation of PRL 1 11 0.60 2 5.31
190 INT49801 Positive_regulation of SELP 1 21 0.48 21.34 5.25
191 INT9178 Regulation of Localization of Ghrh 1 13 0.45 2.28 5.08
192 INT117499 Negative_regulation of Adipoq 1 28 0.56 24.15 5.07
193 INT22022 Regulation of PPY 1 8 0.26 5.52 5.02
194 INT14681 Negative_regulation of GCG 1 31 0.57 13.55 4.98
195 INT3215 Regulation of Gene_expression of Ins1 1 32 0.52 19.83 4.85
196 INT49130 Positive_regulation of IGFBP3 1 49 0.63 27.55 4.78
197 INT4378 Regulation of Gene_expression of GH1 1 26 0.47 10.2 4.61
198 INT19967 Gene_expression of C9orf3 1 18 0.75 26.51 4.6
199 INT16220 Negative_regulation of Regulation of Gh 2 13 0.42 3.59 4.33
200 INT24441 Positive_regulation of FBF1 3 13 0.39 6.52 4.29
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