J:Methods Find Exp Clin Pharmacol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT167530 Phax Regulation of Gene_expression of Trpv1 1 2 0.16 0.86 2.05
2 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 1 0.06 0.49 1.39
3 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 1 0.26 0.49 1.38
4 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 1 0.07 0.07 1.25
5 INT76150 Das Negative_regulation of Gpi1 1 1 0.03 0 0.99
6 INT53377 Binding of Edn1 and Edn3 1 5 0.39 0 0.81
7 INT51933 MSMB Negative_regulation of Positive_regulation of Gpt 1 1 0.18 0.33 0.74
8 INT102316 Ugt1a6a Positive_regulation of Cyb5 1 1 0.16 0.08 0.64
9 INT84771 Positive_regulation of Binding of App and Pag1 1 1 0.17 0.9 0.62
10 INT84770 Binding of App and Pag1 1 1 0.13 0.89 0.57

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
2 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
3 INT58061 Gene_expression of Trpv1 5 1117 0.78 451.54 637.59
4 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
5 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
6 INT50058 Negative_regulation of Cpox 3 907 0.58 426.28 428.29
7 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
8 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
9 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
10 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
11 INT4941 Positive_regulation of Oprd1 2 345 0.70 74.26 304.41
12 INT3579 Localization of Oxt 1 555 0.81 43.35 292.44
13 INT3948 Regulation of Cck 1 291 0.62 58.07 255.88
14 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
15 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
16 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
17 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
18 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
19 INT6042 Binding of Oprm1 4 248 0.48 31.77 154.34
20 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
21 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
22 INT5116 Gene_expression of IL2 2 670 0.78 291.13 146.69
23 INT812 Localization of INS 4 1026 0.81 515.6 145.31
24 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
25 INT695 Binding of POMC 1 304 0.48 56.66 126.85
26 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
27 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
28 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
29 INT3038 Gene_expression of INS 20 1583 0.78 1174.16 107.01
30 INT940 Negative_regulation of Ptgs1 3 219 0.59 104.34 95.97
31 INT38731 Localization of Trpv1 1 138 0.81 52.73 90.49
32 INT6214 Negative_regulation of Adarb1 1 123 0.50 26.39 89.57
33 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
34 INT5056 Gene_expression of IFNG 2 216 0.78 137.52 74.57
35 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
36 INT6894 Gene_expression of CNR1 1 168 0.78 74.07 62.84
37 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
38 INT3920 Localization of Ldha 2 241 0.81 83.08 58.72
39 INT20266 Positive_regulation of Bdkrb1 1 60 0.69 63.64 56.59
40 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
41 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
42 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
43 INT76620 Gene_expression of Cnr2 1 93 0.78 34.7 50.14
44 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
45 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
46 INT7059 Regulation of Adra2a 1 89 0.62 18.24 48.43
47 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
48 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
49 INT4887 Gene_expression of Tac4 1 70 0.77 11.66 40.97
50 INT2531 Positive_regulation of Cebpz 1 166 0.00 43.08 38.86
51 INT58062 Negative_regulation of Gene_expression of Trpv1 2 66 0.59 22.34 38.02
52 INT64558 Negative_regulation of Nos1 1 88 0.58 26.76 36.78
53 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
54 INT8747 Positive_regulation of Ins1 1 221 0.69 154.28 35.15
55 INT1163 Negative_regulation of Rbm39 1 64 0.29 16.8 34.74
56 INT8905 Gene_expression of EDN1 1 215 0.78 157.1 34.19
57 INT234 Binding of Alb 2 151 0.48 52.34 32.97
58 INT2330 Regulation of CB 1 78 0.10 20.46 32.6
59 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
60 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
61 INT1158 Regulation of Agt 3 106 0.61 29.4 30.29
62 INT11796 Positive_regulation of Helt 3 52 0.31 11.7 29.22
63 INT47712 Positive_regulation of App 1 135 0.69 101.38 28.94
64 INT6765 Localization of Oprl1 1 49 0.81 5.11 28.87
65 INT2532 Negative_regulation of Cebpz 1 98 0.00 53.06 28.57
66 INT6364 Gene_expression of Edn1 3 123 0.78 73.76 28.43
67 INT3286 Positive_regulation of Gpt 1 90 0.69 45.08 28.34
68 INT20044 Negative_regulation of Gpi1 1 50 0.59 29.96 26
69 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
70 INT4890 Gene_expression of Ppt1 1 51 0.77 8.93 21.83
71 INT65502 Regulation of App 1 77 0.62 52.05 19.44
72 INT1278 Negative_regulation of Ldha 1 93 0.59 37.66 19.36
73 INT16110 Positive_regulation of ZC3H12D 1 30 0.46 6.27 18.72
74 INT1060 Negative_regulation of Pla2g1b 1 50 0.57 22.91 18.12
75 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
76 INT3926 Regulation of Bdkrb1 1 22 0.61 16.72 16.1
77 INT2480 Negative_regulation of Got1 1 43 0.51 14.47 16.09
78 INT13400 Negative_regulation of Enpep 1 30 0.50 4.23 15.86
79 INT3392 Negative_regulation of Sst 1 23 0.59 8.21 15.82
80 INT20966 Positive_regulation of Arc 1 30 0.70 24.38 15.62
81 INT11795 Negative_regulation of Helt 4 33 0.28 6.51 14.76
82 INT36262 Positive_regulation of Tbce 1 35 0.49 28.79 14.33
83 INT18012 Gene_expression of EPO 1 169 0.78 108.36 13.75
84 INT12191 Negative_regulation of Localization of Ldha 2 35 0.59 13.71 12.35
85 INT86698 Gene_expression of Cav1 2 38 0.78 16.37 11.75
86 INT52775 Positive_regulation of Phax 2 15 0.42 6.87 11.45
87 INT13338 Regulation of Sigmar1 1 22 0.57 2.91 11.35
88 INT14420 Regulation of Nka1 1 12 0.45 3.82 11.33
89 INT3851 Gene_expression of Got1 2 58 0.65 29.15 10.52
90 INT94859 Negative_regulation of Pde5a 2 67 0.43 33.66 10.28
91 INT84769 Positive_regulation of St8sia1 3 10 0.41 7.56 9.86
92 INT39532 Negative_regulation of Hrh2 1 7 0.43 7.5 9.4
93 INT1118 Gene_expression of C6orf25 1 73 0.77 47.24 9.1
94 INT23178 Gene_expression of H1 1 38 0.68 13.37 9.09
95 INT17101 Positive_regulation of Gene_expression of Edn1 1 24 0.69 24.9 8.86
96 INT92822 Negative_regulation of Gene_expression of Crp 1 36 0.49 29.5 8.83
97 INT12095 Negative_regulation of Edn1 1 26 0.59 12.01 8.79
98 INT3287 Gene_expression of Gpt 2 50 0.75 23.69 8.57
99 INT84672 Negative_regulation of Positive_regulation of Nos1 1 12 0.48 3.76 8.27
100 INT1448 Binding of Adra1a 1 23 0.48 1.41 8.01
101 INT17867 Positive_regulation of Cyp1a2 1 39 0.69 2.58 7.57
102 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
103 INT118782 Protein_catabolism of Pax3 6 7 0.94 0.46 6.95
104 INT50705 Localization of Phax 1 9 0.44 4.65 6.53
105 INT15339 Regulation of Phax 1 8 0.45 4.34 6.49
106 INT57562 Gene_expression of GLA 2 52 0.77 24.62 6.14
107 INT3645 Positive_regulation of Grhpr 1 17 0.42 3.64 6.06
108 INT5156 Regulation of ZC3H12D 2 7 0.27 2.64 5.53
109 INT62336 Positive_regulation of Hdc 2 38 0.70 14.45 5.51
110 INT71841 Negative_regulation of Thop1 1 7 0.48 0.41 5.08
111 INT49319 Regulation of Hrh2 1 5 0.45 2.31 5.04
112 INT17803 Regulation of Edn1 1 14 0.54 4.75 4.71
113 INT51819 Negative_regulation of MSMB 1 8 0.49 4.5 4
114 INT76149 Gene_expression of Das 1 18 0.37 6.55 3.92
115 INT16787 Negative_regulation of ZC3H12D 1 8 0.42 2.22 3.82
116 INT31528 Regulation of TYR 1 6 0.44 0.83 3.63
117 INT2886 Gene_expression of SCT 1 13 0.78 4.55 3.57
118 INT20586 Regulation of Gfra1 1 20 0.51 9.43 3.41
119 INT8475 Positive_regulation of COLQ 6 14 0.45 1.36 3.37
120 INT53374 Binding of Edn1 2 17 0.43 11.66 2.98
121 INT12812 Regulation of Hrh3 1 10 0.51 1.07 2.95
122 INT19985 Negative_regulation of Negative_regulation of Rbm39 1 4 0.16 0.99 2.79
123 INT80395 Negative_regulation of Vom1r68 1 7 0.23 1.11 2.76
124 INT56382 Negative_regulation of Cpa1 2 5 0.34 2.06 2.73
125 INT69259 Gene_expression of Pst 1 7 0.54 4.11 2.69
126 INT163359 Gene_expression of RFC1 1 9 0.65 3.34 2.64
127 INT9440 Binding of MSMB 1 4 0.38 3.66 2.61
128 INT52871 Regulation of Hdc 2 6 0.60 3.26 2.51
129 INT18843 Binding of H1 2 10 0.47 5.44 2.4
130 INT61434 Regulation of Nf1 2 3 0.26 1.39 2.4
131 INT28833 Localization of Bdkrb1 1 3 0.81 2.17 2.28
132 INT30061 Negative_regulation of Hdc 1 8 0.59 2.14 2.27
133 INT18570 Gene_expression of HERPUD1 1 3 0.57 0.45 2.15
134 INT1265 Positive_regulation of Cyb5 1 4 0.43 0.79 2.11
135 INT33394 Negative_regulation of esterase 1 10 0.57 1.57 2.06
136 INT61650 Protein_catabolism of Tac1 1 3 0.52 0.88 1.98
137 INT67089 Positive_regulation of Ugt1a6a 1 4 0.27 0.34 1.9
138 INT120873 Gene_expression of Fhl1 2 3 0.08 0.45 1.9
139 INT23622 Negative_regulation of Klk1c12 1 3 0.57 0.79 1.84
140 INT51127 Regulation of Nsa2 1 2 0.23 0.51 1.84
141 INT164254 Gene_expression of Dnaja3 2 1 0.57 1.1 1.83
142 INT63716 Transcription of Hdc 4 10 0.69 7.57 1.82
143 INT61939 Negative_regulation of Positive_regulation of Tbce 1 5 0.06 4.82 1.82
144 INT4786 Gene_expression of GHRL 1 7 0.78 7.94 1.76
145 INT134316 Positive_regulation of RT1-Hb-ps1 1 6 0.32 8.44 1.76
146 INT88184 Gene_expression of ENDO1 4 5 0.16 0.54 1.69
147 INT35008 Regulation of ES-J995 2 5 0.45 1.7 1.68
148 INT64559 Positive_regulation of Negative_regulation of Nos1 1 2 0.41 1.58 1.68
149 INT44545 Gene_expression of Dclk2 1 5 0.65 0.77 1.41
150 INT61076 Gene_expression of RHD 1 9 0.65 3.52 1.39
151 INT14954 Gene_expression of COLQ 3 7 0.52 2.59 1.39
152 INT134315 Gene_expression of RT1-Hb-ps1 1 3 0.35 3.35 1.34
153 INT96132 Gene_expression of F10 1 10 0.58 6.99 1.24
154 INT61435 Negative_regulation of Binding of Pou2f1 1 1 0.42 0 1.24
155 INT61431 Binding of Pou2f1 1 1 0.37 0 1.23
156 INT118781 Protein_catabolism of Thop1 1 1 0.15 0.05 1.2
157 INT118779 Positive_regulation of Protein_catabolism of Pax3 1 1 0.47 0.05 1.2
158 INT118780 Positive_regulation of Protein_catabolism of Thop1 1 1 0.08 0.05 1.2
159 INT61430 Negative_regulation of Pou2f1 1 1 0.58 0 1.19
160 INT140288 Localization of Pon1 1 4 0.78 6.15 1.15
161 INT61433 Positive_regulation of Regulation of Pou2f1 1 1 0.49 0 1.09
162 INT61432 Regulation of Pou2f1 1 1 0.61 0 1.08
163 INT63719 Positive_regulation of Transcription of Hdc 1 3 0.52 3.91 1.01
164 INT164259 Gene_expression of H19 1 8 0.75 27.5 0.97
165 INT44972 Negative_regulation of Gfra1 2 16 0.58 10.17 0.93
166 INT56599 Positive_regulation of ES-J995 1 4 0.68 0.85 0.93
167 INT118783 Negative_regulation of Protein_catabolism of Pax3 1 1 0.35 0.09 0.89
168 INT57560 Positive_regulation of GLA 1 14 0.54 5.01 0.83
169 INT22709 Negative_regulation of COLQ 2 3 0.28 0 0.83
170 INT94833 Gene_expression of FGF1 1 4 0.53 2.01 0.81
171 INT30006 Regulation of Hal 1 3 0.27 0.26 0.74
172 INT164258 Positive_regulation of Gene_expression of GLA 1 6 0.47 0.55 0.65
173 INT102315 Positive_regulation of Positive_regulation of Ugt1a6a 1 1 0.27 0.09 0.63
174 INT115260 Negative_regulation of Clcf1 1 2 0.06 1.84 0.58
175 INT164260 Positive_regulation of Gene_expression of H19 1 2 0.67 4.29 0.43
176 INT156763 Gene_expression of TMEM37 1 5 0.39 1.48 0.36
177 INT72495 Negative_regulation of Regulation of ASA esterase 1 1 0.35 0.65 0.35
178 INT19783 Localization of Wdtc1 1 2 0.13 1.89 0.33
179 INT36751 Gene_expression of ZMYND10 1 7 0.75 3.92 0.32
180 INT155822 Localization of ADH1A 1 3 0.78 3.74 0.32
181 INT53375 Binding of Edn3 2 1 0.36 0 0.32
182 INT134317 Positive_regulation of Positive_regulation of RT1-Hb-ps1 1 1 0.32 0.57 0.3
183 INT168052 Gene_expression of Akr1c1 1 1 0.40 0 0.28
184 INT19785 Negative_regulation of Positive_regulation of COLQ 1 1 0.38 0 0.28
185 INT84768 Positive_regulation of Positive_regulation of St8sia1 1 1 0.38 0.62 0.27
186 INT165737 Localization of RHD 1 1 0.01 0.08 0.26
187 INT165738 Localization of TRAPPC1 1 1 0.04 0.08 0.26
188 INT165736 Gene_expression of TRAPPC1 1 1 0.03 0.08 0.25
189 INT154825 Gene_expression of HBXIP 1 1 0.09 0.2 0.25
190 INT156762 Gene_expression of CLC 1 1 0.29 0.09 0.23
191 INT63721 Regulation of Transcription of Hdc 2 3 0.45 1.72 0.19
192 INT53376 Positive_regulation of Regulation of Edn3 1 1 0.48 0 0.19
193 INT53372 Positive_regulation of Regulation of Edn1 1 1 0.50 0 0.19
194 INT53373 Regulation of Edn3 1 2 0.45 1.38 0.18
195 INT64846 Localization of MAA 1 2 0.61 0.14 0.1
196 INT63717 Negative_regulation of Transcription of Hdc 1 1 0.43 0.89 0.1
197 INT64845 Binding of MAA 1 2 0.48 0 0.09
198 INT63720 Protein_catabolism of Hdc 1 1 0.57 0.8 0.08
199 INT63718 Positive_regulation of Protein_catabolism of Hdc 1 1 0.41 0.83 0.08
200 INT58888 Negative_regulation of Localization of Bdkrb1 1 1 0.43 0.5 0
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