J:Mod Rheumatol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT115367 Binding of IL6 and IL6R 12 1 0.07 8.16 2.36
2 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
3 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 1 0.17 1.5 1.05
4 INT266742 GOPC Regulation of Positive_regulation of ACR 1 3 0.02 0.36 1.05
5 INT228498 Il10 Negative_regulation of Hand1 1 1 0.03 1.4 0.99
6 INT228496 Il4 Negative_regulation of Hand1 1 1 0.02 1.4 0.99
7 INT228495 Il13 Negative_regulation of Hand1 1 1 0.01 1.4 0.98
8 INT228499 Binding of FAS and Fasl 1 2 0.15 2.75 0.73
9 INT228494 Binding of Ncoa5 and Rela 1 1 0.00 1.58 0.72
10 INT172097 Binding of HLA-E and Trav6-3 10 1 0.02 3.71 0.71
11 INT228497 Il4 Regulation of Ncoa5 1 1 0.01 1.24 0.57
12 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 1 0.31 1.77 0.48
13 INT287819 Binding of CD80 and Cd28 1 1 0.25 0.7 0.4
14 INT287818 Negative_regulation of Binding of CD80 and Cd28 1 1 0.29 0.7 0.4
15 INT228500 Fadd Positive_regulation of FAS 1 1 0.14 1.12 0.28
16 INT228501 Binding of AAVS1 and Fgfr1 1 1 0.01 0.57 0.07
17 INT288003 Binding of COL2A1 and PADI1 1 1 0.09 0.11 0.06
18 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 1 0.03 0.15 0.03
19 INT288002 Binding of COL2A1 and GOPC 1 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 7 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
5 INT6852 Localization of TNF 3 883 0.81 705.95 270.84
6 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
7 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
8 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
9 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
10 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
11 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
12 INT15516 Gene_expression of Crp 4 711 0.77 615.33 173.09
13 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
14 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
15 INT9852 Positive_regulation of Gpt 3 563 0.70 364.64 146.82
16 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
17 INT9660 Regulation of TNF 6 363 0.62 312.94 139.99
18 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
19 INT20374 Gene_expression of Il4 9 515 0.76 306.15 114.12
20 INT118381 Gene_expression of Il17a 2 405 0.76 306.97 112.06
21 INT18009 Positive_regulation of CRP 7 518 0.70 553.03 103.74
22 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
23 INT82448 Gene_expression of S100a8 2 246 0.77 236.72 84.02
24 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
25 INT60691 Gene_expression of Il12a 3 331 0.78 208.03 75.96
26 INT5374 Gene_expression of Esr1 7 412 0.77 263.89 67.34
27 INT15514 Negative_regulation of Crp 4 275 0.59 194.6 64.86
28 INT48901 Negative_regulation of IL6 3 186 0.57 136.33 57.87
29 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
30 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
31 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
32 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
33 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
34 INT117598 Regulation of ACR 8 118 0.26 41.25 48.01
35 INT3361 Positive_regulation of Esr1 3 273 0.69 208.53 44.81
36 INT80124 Negative_regulation of VEGFA 6 450 0.58 311.19 44.53
37 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
38 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
39 INT97596 Localization of S100a8 2 94 0.78 90.69 40.41
40 INT163134 Gene_expression of ACR 9 78 0.65 30.39 38.48
41 INT104551 Gene_expression of Il18 2 156 0.76 115.51 36.95
42 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
43 INT49214 Gene_expression of Cd4 2 269 0.78 154.22 34.05
44 INT132161 Gene_expression of MTX1 3 48 0.58 26.55 32.32
45 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
46 INT17886 Negative_regulation of Il1 3 95 0.57 70.91 31.25
47 INT56290 Negative_regulation of Gene_expression of Il6 1 79 0.59 47.98 31.07
48 INT54302 Positive_regulation of Gene_expression of Il4 5 126 0.68 86.18 30.75
49 INT34729 Positive_regulation of IFN1@ 1 233 0.67 128.04 30.38
50 INT145594 Gene_expression of Mtx1 11 64 0.57 35.33 30.35
51 INT90792 Localization of Il10 1 144 0.80 87.88 30.03
52 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
53 INT15610 Localization of GOPC 2 223 0.65 68.26 28.7
54 INT48202 Gene_expression of Tgfb1 1 146 0.78 89.93 27.76
55 INT21900 Gene_expression of Mthfd1 7 150 0.75 69.47 27.03
56 INT59449 Negative_regulation of Timp1 2 76 0.42 54.86 26.99
57 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
58 INT93626 Gene_expression of Fasl 3 118 0.75 115.24 25.11
59 INT11659 Gene_expression of COL2A1 15 164 0.78 78.49 22.58
60 INT170313 Gene_expression of Mmp1a 1 50 0.65 38.53 21.36
61 INT11346 Binding of Mtx1 5 39 0.41 24.88 21.21
62 INT20379 Localization of Il4 2 85 0.73 51.22 20.55
63 INT105021 Binding of GOPC 1 187 0.40 60.39 20.38
64 INT49985 Transcription of Il6 1 62 0.72 40.13 20.29
65 INT12265 Positive_regulation of IgG 1 168 0.63 104.89 19.76
66 INT70614 Gene_expression of FAS 1 118 0.75 112.33 19.01
67 INT4420 Positive_regulation of GOT1 4 103 0.64 88.4 18.38
68 INT73252 Positive_regulation of Mthfd1 3 124 0.59 59.48 18.35
69 INT33542 Gene_expression of Il1rn 1 41 0.76 32.47 18.08
70 INT70145 Gene_expression of Trav6-3 1 136 0.76 69.6 18.05
71 INT4067 Negative_regulation of Esr1 5 97 0.50 43.45 17.52
72 INT17237 Regulation of Esr1 2 74 0.43 49.09 17.25
73 INT38056 Localization of Crp 1 71 0.78 53.14 17.03
74 INT93948 Negative_regulation of Gene_expression of Il12a 1 48 0.55 27.77 16.87
75 INT10187 Gene_expression of Il2ra 1 91 0.78 52.67 16.66
76 INT103757 Negative_regulation of Il12a 1 37 0.55 21.62 16.38
77 INT9220 Gene_expression of Ighg1 12 125 0.77 85.74 15.92
78 INT10323 Gene_expression of Fam166a 1 48 0.00 11.76 15.68
79 INT170754 Localization of IFN1@ 2 121 0.78 66.78 15.6
80 INT92354 Localization of ESR1 1 77 0.75 33.04 15.51
81 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
82 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
83 INT81627 Gene_expression of Fas 1 120 0.78 115.51 15.36
84 INT142464 Gene_expression of Socs3 1 58 0.77 52.04 15.34
85 INT106745 Localization of CRP 3 65 0.81 66.44 15.21
86 INT3545 Positive_regulation of Mtx1 3 27 0.42 11.97 14.83
87 INT11340 Positive_regulation of SLC17A5 3 120 0.67 113.52 14.5
88 INT20665 Gene_expression of ACE 1 87 0.78 51.71 14.19
89 INT25076 Negative_regulation of Gene_expression of Il1 1 41 0.52 30.58 13.85
90 INT34904 Negative_regulation of Gtf3a 1 48 0.15 38.88 13.73
91 INT173505 Localization of Hand2 1 63 0.57 45.32 13.66
92 INT152729 Negative_regulation of Gene_expression of S100a8 1 33 0.42 32.25 13.64
93 INT20378 Localization of Hand1 1 53 0.71 41.96 13.31
94 INT141014 Positive_regulation of Gene_expression of Il18 2 46 0.68 47.63 13.3
95 INT26545 Gene_expression of Hras1 13 173 0.78 79.54 13.21
96 INT87235 Negative_regulation of Il4 1 54 0.48 31.51 13.15
97 INT2385 Gene_expression of MIF 2 57 0.68 40.74 12.78
98 INT195226 Positive_regulation of ACR 9 23 0.26 7.85 12.62
99 INT20102 Gene_expression of Serpine1 1 102 0.78 65.99 12.61
100 INT94464 Negative_regulation of Hand1 1 44 0.41 31.5 12.39
101 INT72949 Binding of Mif 1 31 0.46 23.12 11.65
102 INT86291 Negative_regulation of Mmp2 1 33 0.57 20.38 10.76
103 INT133172 Gene_expression of Il12b 3 98 0.75 52.16 10.68
104 INT103554 Positive_regulation of MTX1 2 19 0.45 11.23 10
105 INT140338 Negative_regulation of Gene_expression of Il17a 1 34 0.46 23.82 9.87
106 INT120509 Gene_expression of Cat 1 65 0.77 50.9 9.75
107 INT137400 Regulation of Mtx1 6 16 0.52 9.19 9.45
108 INT47301 Gene_expression of Ctsl 1 27 0.76 7.72 9.32
109 INT155944 Gene_expression of Foxp3 2 66 0.66 24.37 9.12
110 INT156874 Positive_regulation of Gene_expression of S100a8 1 26 0.49 32.8 8.99
111 INT22285 Negative_regulation of Mtx1 2 16 0.49 7.84 8.98
112 INT92822 Negative_regulation of Gene_expression of Crp 2 36 0.49 29.5 8.83
113 INT117553 Regulation of MIF 1 10 0.56 12.76 8.67
114 INT178174 Gene_expression of Tnfsf10 2 78 0.76 56.83 8.64
115 INT15723 Gene_expression of Fn1 1 47 0.78 37.59 8.51
116 INT142462 Positive_regulation of Gene_expression of Socs3 1 23 0.68 23.27 8.27
117 INT725 Negative_regulation of IgG 1 62 0.41 37.21 8.16
118 INT24232 Localization of Mtx1 2 24 0.65 8.06 7.99
119 INT177759 Negative_regulation of IFN1@ 1 51 0.57 31.81 7.76
120 INT182320 Binding of MTX1 2 14 0.18 8.5 7.65
121 INT75841 Binding of Trav6-3 1 66 0.47 29.14 7.63
122 INT103289 Binding of Il10 2 15 0.35 13.67 7.42
123 INT153794 Gene_expression of Ctsk 1 51 0.77 24.99 7.28
124 INT16389 Gene_expression of Plg 3 80 0.67 36.88 6.74
125 INT228469 Negative_regulation of Il17a 1 19 0.54 18.76 6.43
126 INT22901 Negative_regulation of Gene_expression of Esr1 2 30 0.42 20.92 6.29
127 INT136555 Negative_regulation of Tnfsf11 1 31 0.55 22.23 6.23
128 INT121370 Positive_regulation of MIF 1 22 0.70 17.79 6.08
129 INT104547 Negative_regulation of Il18 1 24 0.59 17.89 6.01
130 INT115947 Regulation of Il17a 1 17 0.37 14.26 5.97
131 INT80033 Binding of FAS 1 37 0.48 41.19 5.67
132 INT135319 Positive_regulation of Positive_regulation of CRP 1 20 0.50 26.45 5.61
133 INT22943 Positive_regulation of Positive_regulation of Gpt 1 23 0.47 16.09 5.55
134 INT96234 Localization of Il13 3 11 0.62 10.94 5.48
135 INT266746 Binding of ACR 1 8 0.23 3.44 5.26
136 INT120511 Positive_regulation of Gene_expression of Cat 1 26 0.69 19.82 5.2
137 INT68244 Positive_regulation of Ighg1 13 60 0.61 48.86 5.01
138 INT59320 Transcription of Il2 1 32 0.69 6.39 4.95
139 INT121372 Positive_regulation of Gene_expression of MIF 1 17 0.60 14.78 4.73
140 INT104549 Localization of Il18 1 16 0.78 13.01 4.64
141 INT26546 Positive_regulation of Gene_expression of Hras1 3 35 0.70 16.59 4.54
142 INT81628 Positive_regulation of Gene_expression of Fas 1 32 0.67 38.13 4.23
143 INT117205 Transcription of Esr1 1 23 0.65 9.4 4.14
144 INT47298 Localization of Ctsl 1 13 0.79 3.77 4.08
145 INT9223 Localization of Ighg1 2 22 0.78 11.03 3.67
146 INT90406 Gene_expression of IL6R 1 27 0.38 15.74 3.64
147 INT174816 Binding of IL6R 2 14 0.09 11.26 3.63
148 INT228465 Positive_regulation of Timp2 1 4 0.64 6.29 3.54
149 INT192951 Negative_regulation of AES 1 15 0.38 6.38 3.5
150 INT53021 Positive_regulation of COL2A1 2 29 0.55 27.75 3.47
151 INT170606 Regulation of Gene_expression of GOPC 1 31 0.37 6.08 3.31
152 INT227515 Regulation of Gene_expression of Mtx1 2 5 0.38 4.34 3.24
153 INT239495 Negative_regulation of Gene_expression of Mtx1 3 3 0.36 1.55 3.24
154 INT188406 Binding of Fasl 1 19 0.44 24.67 3.17
155 INT209561 Negative_regulation of Ncoa5 6 2 0.05 6.88 3.14
156 INT99911 Localization of MTX1 1 5 0.45 3.81 3.07
157 INT211192 Localization of ACR 2 8 0.73 3.04 3.03
158 INT170324 Negative_regulation of Gene_expression of Mmp1a 1 8 0.13 6.28 2.94
159 INT266745 Regulation of Gene_expression of ACR 5 6 0.10 1.53 2.87
160 INT188590 Positive_regulation of Gene_expression of Mthfd1 3 23 0.49 16.56 2.84
161 INT163290 Binding of MIF 2 9 0.31 7.57 2.8
162 INT157188 Positive_regulation of Gene_expression of Il13 1 3 0.05 4.94 2.79
163 INT96693 Binding of COL2A1 1 45 0.46 37.11 2.61
164 INT169987 Transcription of GOPC 1 45 0.60 21.88 2.61
165 INT82966 Transcription of Crp 1 14 0.70 9.91 2.61
166 INT104476 Protein_catabolism of Timp1 1 6 0.41 5.75 2.61
167 INT194586 Negative_regulation of ACR 2 8 0.26 2.04 2.41
168 INT50994 Binding of Il27ra 1 5 0.11 1.77 2.15
169 INT146660 Negative_regulation of Ctsk 1 9 0.43 6.01 2.07
170 INT27878 Gene_expression of FCGR1B 1 22 0.26 20.62 2.04
171 INT209559 Regulation of Ncoa5 3 1 0.03 4.37 2
172 INT71115 Positive_regulation of Gene_expression of Serpine1 1 20 0.70 15.32 1.97
173 INT90219 Gene_expression of Lgals1 1 6 0.20 3.47 1.94
174 INT209564 Positive_regulation of Ncoa5 1 6 0.05 4.72 1.89
175 INT173939 Negative_regulation of IL6R 2 9 0.11 5.92 1.83
176 INT209567 Gene_expression of Ncoa5 2 4 0.05 4.81 1.78
177 INT10207 Gene_expression of PADI4 1 22 0.75 23.49 1.74
178 INT204763 Transcription of S100a8 1 8 0.69 6.22 1.69
179 INT107641 Negative_regulation of Ighg1 1 19 0.39 11.44 1.54
180 INT164410 Negative_regulation of Col2a1 1 4 0.39 3.75 1.53
181 INT90218 Localization of Lgals1 1 3 0.18 1.77 1.51
182 INT156108 Regulation of TSS 2 5 0.23 0.59 1.45
183 INT232486 Positive_regulation of Gene_expression of Mtx1 1 3 0.42 0.96 1.41
184 INT94126 Positive_regulation of Cd28 1 9 0.50 4.23 1.33
185 INT36330 Positive_regulation of Positive_regulation of GOT1 2 4 0.32 4.42 1.26
186 INT35103 Positive_regulation of Positive_regulation of SLC17A5 1 5 0.12 7.51 1.25
187 INT47305 Positive_regulation of Gene_expression of Ctsl 1 5 0.59 2.06 1.12
188 INT139064 Binding of Cd80 1 3 0.35 1.64 1.07
189 INT184020 Localization of Socs3 1 3 0.75 4.05 1.06
190 INT27587 Positive_regulation of STAR 1 7 0.46 6.37 0.99
191 INT124975 Gene_expression of Tnfrsf22 1 2 0.41 3.57 0.97
192 INT180183 Regulation of Positive_regulation of GOPC 1 4 0.26 1.47 0.96
193 INT209423 Negative_regulation of Gene_expression of Ctsk 1 4 0.41 2.4 0.96
194 INT139176 Gene_expression of Fadd 1 5 0.51 5.26 0.92
195 INT70817 Negative_regulation of Transcription of Il2 1 5 0.40 0.25 0.87
196 INT209562 Negative_regulation of Gene_expression of Ncoa5 1 2 0.03 1.75 0.79
197 INT228474 Regulation of Gene_expression of Tnfsf10 1 3 0.44 3.81 0.75
198 INT154421 Regulation of Cdan1 2 2 0.07 0.68 0.75
199 INT102311 Regulation of IL6R 1 4 0.12 2.37 0.74
200 INT228470 Phosphorylation of Il1rap 1 1 0.11 1.34 0.7
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