J:Mol. Cell. Endocrinol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 2 0.73 0.87 14.34
2 INT73775 Binding of GH1 and GHR 4 1 0.35 0.68 0.8
3 INT73776 Regulation of Binding of GH1 and GHR 2 1 0.26 0.16 0.75
4 INT85736 Positive_regulation of Il1b Positive_regulation of Tpgs2 1 1 0.02 0.2 0.48
5 INT85735 Il1b Positive_regulation of Tpgs2 1 1 0.02 0.2 0.47
6 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 2 0.21 0.6 0.44
7 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 2 0.42 0.59 0.44
8 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 2 0.15 0.28 0.38
9 INT6121 Gmcl1 Regulation of Gene_expression of Penk 1 1 0.03 0 0.36
10 INT21301 Gnrh1 Negative_regulation of LH 2 1 0.28 0 0.3
11 INT74433 Binding of INS and Cpe 2 1 0.03 0 0.25
12 INT36171 Ptger2 Positive_regulation of Localization of Gnrh1 1 2 0.10 0 0.25
13 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 1 0.02 0.28 0.22
14 INT51034 Slc30a2 Positive_regulation of Enpep 1 1 0.01 0 0.19
15 INT21300 Gnrh1 Negative_regulation of Localization of LH 1 1 0.28 0 0.17
16 INT21302 Gnrh1 Positive_regulation of Positive_regulation of Fshr 1 1 0.25 0 0.15
17 INT34101 NA Positive_regulation of Localization of Gnrh1 2 1 0.03 0 0.12
18 INT21310 Binding of Gnrh1 and Positive_regulation of Localization of CGA 1 1 0.00 0 0.09
19 INT6120 Gmcl1 Positive_regulation of Pigm 1 1 0.01 0 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 4 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 18 2431 0.81 378.96 952.2
5 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
6 INT155 Positive_regulation of Prl 4 1233 0.70 317.93 457.82
7 INT1045 Localization of LH 4 1211 0.81 87.04 456.25
8 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
9 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
10 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
11 INT157 Positive_regulation of Localization of Prl 15 790 0.70 104.54 374.78
12 INT439 Localization of Gnrh1 13 976 0.81 100.96 363.25
13 INT876 Localization of Gh1 11 843 0.80 67.75 340.82
14 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
15 INT161 Regulation of Localization of Prl 3 615 0.62 65.37 298.66
16 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
17 INT5597 Gene_expression of Pdyn 5 433 0.78 62.97 235.47
18 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
19 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
20 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
21 INT159 Negative_regulation of Localization of Prl 11 416 0.59 55.34 171.8
22 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
23 INT5127 Localization of Lhb 2 488 0.80 50.48 162.66
24 INT1044 Negative_regulation of Localization of LH 1 358 0.59 25.95 151.31
25 INT880 Positive_regulation of Localization of Gh1 8 304 0.70 14.79 150.23
26 INT2451 Positive_regulation of Avp 4 355 0.70 102.66 147.69
27 INT2379 Positive_regulation of Localization of LH 1 349 0.70 27.86 144.53
28 INT2780 Regulation of Gene_expression of Penk 2 265 0.62 32.45 143.88
29 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
30 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
31 INT7395 Localization of GNRH1 2 399 0.81 62.88 117.68
32 INT4207 Regulation of Avp 5 267 0.62 63.72 115.33
33 INT1793 Localization of CGA 3 379 0.81 67.38 114.69
34 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
35 INT874 Positive_regulation of Gh1 2 244 0.70 27.17 97.98
36 INT4822 Localization of Ca2 2 417 0.80 99.57 96.45
37 INT2122 Negative_regulation of Localization of Gnrh1 4 226 0.59 26.92 92.04
38 INT5594 Regulation of Pdyn 1 137 0.62 27.04 86.63
39 INT4289 Positive_regulation of Localization of Gnrh1 5 202 0.70 12.3 84.01
40 INT4631 Positive_regulation of Sst 1 127 0.70 17.37 83.29
41 INT1309 Positive_regulation of Localization of Gnrhr 3 152 0.69 24.25 81.56
42 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
43 INT2155 Negative_regulation of Sst 1 111 0.59 16.58 77.74
44 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
45 INT881 Negative_regulation of Localization of Gh1 2 164 0.58 15.1 75.28
46 INT5593 Positive_regulation of Gene_expression of Pdyn 1 114 0.70 29.1 74.46
47 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
48 INT8962 Gene_expression of Cpe 4 110 0.71 39.67 71.67
49 INT5128 Positive_regulation of Lhb 2 232 0.69 44.23 71.26
50 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
51 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
52 INT6824 Regulation of Gene_expression of Pdyn 2 114 0.62 9.48 66.73
53 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
54 INT1794 Regulation of Localization of CGA 1 136 0.57 13.39 59.07
55 INT5710 Negative_regulation of Localization of Lhb 1 146 0.57 20.51 58.33
56 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
57 INT5598 Negative_regulation of Pdyn 2 95 0.59 14.4 55.43
58 INT1579 Gene_expression of PRL 3 279 0.78 119.2 55.41
59 INT6116 Regulation of Gene_expression of Oprd1 1 69 0.62 16.43 54
60 INT1977 Negative_regulation of Positive_regulation of Prl 2 98 0.59 17.06 47.88
61 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
62 INT48718 Positive_regulation of PRKCA 1 109 0.69 36.16 46.49
63 INT531 Gene_expression of GH1 2 376 0.75 193.45 46.24
64 INT619 Positive_regulation of Positive_regulation of Prl 2 116 0.70 22.69 45.06
65 INT5214 Localization of Cpe 1 49 0.73 13.3 44.36
66 INT5130 Regulation of GNRH1 1 139 0.62 31.95 42.08
67 INT4449 Positive_regulation of NA 2 179 0.55 40.26 37.82
68 INT65055 Negative_regulation of Nfkb1 2 83 0.58 44.85 34.94
69 INT67613 Positive_regulation of PPARG 1 94 0.70 69.15 34.38
70 INT2699 Binding of Cpe 1 40 0.48 7.07 33.64
71 INT5868 Positive_regulation of GNRH1 7 122 0.69 20.96 32.8
72 INT7396 Regulation of Localization of GNRH1 1 81 0.62 6.57 31.31
73 INT11361 Gene_expression of SERPINE1 9 183 0.78 136.45 27.97
74 INT7565 Transcription of Pomc 1 69 0.72 14.46 27.41
75 INT22764 Localization of Ptger2 1 81 0.64 24.38 26.77
76 INT5232 Negative_regulation of Enpep 2 56 0.57 3.25 26.7
77 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
78 INT2261 Gene_expression of Lhb 3 121 0.77 42.78 26.04
79 INT6115 Positive_regulation of Pigm 1 82 0.64 16.96 25.73
80 INT5948 Regulation of Il1b 1 44 0.60 22.8 25.4
81 INT18400 Localization of Glp1r 1 97 0.80 11.96 24.32
82 INT10349 Negative_regulation of Il1b 2 48 0.58 25.53 24.24
83 INT11303 Gene_expression of Avp 1 116 0.78 39.23 23.88
84 INT250 Regulation of GHRH 1 65 0.61 17.46 23.19
85 INT4612 Positive_regulation of Localization of CGA 3 64 0.64 8.51 22.39
86 INT11893 Positive_regulation of Ptger2 2 96 0.69 31.49 21.92
87 INT1512 Binding of Prl 6 73 0.48 26.22 20.63
88 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
89 INT5967 Negative_regulation of Il1a 1 51 0.57 27.09 18.24
90 INT30312 Binding of Pdyn 1 30 0.37 4.2 18.23
91 INT18660 Binding of Gnrhr 1 45 0.41 10.6 16.85
92 INT6110 Negative_regulation of Gene_expression of Ins1 1 83 0.56 60.59 16.07
93 INT11636 Positive_regulation of SERPINE1 1 85 0.69 68.73 14.8
94 INT8089 Binding of Gnrh1 1 47 0.48 10.04 13.99
95 INT17938 Binding of Cpe 1 28 0.48 11.17 13.62
96 INT12321 Binding of Nr3c2 2 19 0.46 5.44 13.46
97 INT14572 Binding of INS 3 205 0.48 175.43 13.38
98 INT27242 Gene_expression of PGR 1 153 0.75 98.77 12.79
99 INT11208 Gene_expression of Cpe 2 23 0.78 2.42 11.09
100 INT952 Negative_regulation of GHRH 2 57 0.56 25.3 10.34
101 INT20425 Localization of Cpe 1 23 0.81 5.18 9.14
102 INT3467 Positive_regulation of Ptger1 1 28 0.54 10.59 8.93
103 INT13739 Positive_regulation of Positive_regulation of Avp 1 18 0.70 4.78 8.2
104 INT2257 Localization of Gip 1 31 0.74 11.08 7.92
105 INT28358 Gene_expression of Nanog 1 25 0.70 3.52 7.85
106 INT50195 Positive_regulation of Positive_regulation of Il1b 1 12 0.67 7.41 7.64
107 INT3659 Negative_regulation of Gcg 1 26 0.51 10.08 7.39
108 INT9785 Negative_regulation of Positive_regulation of Gnrh1 1 18 0.43 1.88 7.35
109 INT6933 Gene_expression of ANTXRL 1 15 0.10 4.77 6.84
110 INT62691 Transcription of Cpe 2 11 0.40 3.5 6.66
111 INT24460 Localization of Drd2 1 12 0.73 2.96 6.46
112 INT9683 Binding of GH1 2 57 0.47 21.14 5.99
113 INT45275 Gene_expression of CSH1 2 39 0.62 9.39 5.85
114 INT1649 Localization of CSH1 2 15 0.46 3.65 5.75
115 INT4034 Negative_regulation of Gip 2 16 0.53 6.46 5.65
116 INT11360 Localization of SERPINE1 3 41 0.80 33.98 5.61
117 INT19900 Binding of GHRH 1 22 0.37 5.75 5
118 INT1634 Gene_expression of Gcg 1 25 0.75 14.98 4.42
119 INT11354 Regulation of Gene_expression of SERPINE1 2 11 0.61 8.66 4.42
120 INT57642 Gene_expression of PCSK1 7 26 0.76 5.09 4.28
121 INT11635 Positive_regulation of Gene_expression of SERPINE1 2 35 0.68 24.57 4.26
122 INT110348 Negative_regulation of Dpp4 1 28 0.46 22.39 4.12
123 INT1640 Regulation of Localization of CSH1 1 3 0.19 0 4.12
124 INT108086 Negative_regulation of AKR1C3 2 17 0.58 7.7 3.99
125 INT84852 Transcription of Nfkb1 1 12 0.67 4.28 3.84
126 INT20915 Positive_regulation of Gabrp 1 6 0.64 1.01 3.49
127 INT7224 Positive_regulation of Gene_expression of Lhb 1 18 0.45 10.22 3.4
128 INT29333 Positive_regulation of Enpep 1 8 0.70 3.22 3.25
129 INT20146 Localization of Tfpi 1 5 0.81 1.21 3.11
130 INT4186 Negative_regulation of Localization of Gip 1 7 0.53 2.11 2.98
131 INT132760 Gene_expression of Pgr 1 47 0.66 28.17 2.85
132 INT78146 Gene_expression of AKR1C3 3 24 0.77 5.71 2.77
133 INT10350 Negative_regulation of Regulation of Il1b 1 3 0.41 0.58 2.69
134 INT1643 Regulation of CSH1 1 10 0.26 2.45 2.53
135 INT10070 Negative_regulation of Fshb 3 13 0.42 3.48 2.5
136 INT22019 Regulation of GHR 2 9 0.62 2.56 2.39
137 INT6117 Gene_expression of Gmcl1 1 4 0.49 2.39 2.33
138 INT31796 Gene_expression of Enpep 2 5 0.65 0.42 2.32
139 INT9386 Transcription of Cpe 1 7 0.72 0.53 2.31
140 INT72109 Negative_regulation of Localization of Glp1r 1 8 0.59 0.8 2.3
141 INT132769 Negative_regulation of PRS 1 7 0.37 4.82 2.25
142 INT12622 Localization of LGALS1 2 9 0.78 0.55 2.19
143 INT1511 Negative_regulation of Binding of Prl 2 7 0.59 1.64 2.19
144 INT62512 Gene_expression of PRS 1 10 0.64 6.03 2.09
145 INT51316 Regulation of NR3C1 1 7 0.51 4.23 2.09
146 INT10071 Gene_expression of Chrne 2 5 0.06 0.6 2.06
147 INT59737 Negative_regulation of Glp1r 2 15 0.43 6.94 2.01
148 INT47062 Gene_expression of ANTXR1 1 10 0.66 4.63 1.93
149 INT85178 Gene_expression of OAS2 1 10 0.21 4.17 1.93
150 INT93886 Positive_regulation of Gene_expression of PGR 1 19 0.52 15.78 1.89
151 INT48722 Negative_regulation of Gene_expression of SERPINE1 1 12 0.43 7.66 1.85
152 INT62692 Localization of Nanog 1 3 0.73 0.82 1.85
153 INT81415 Gene_expression of Gabrp 1 2 0.30 1.49 1.84
154 INT36168 Regulation of Positive_regulation of Ptger2 1 5 0.45 0.19 1.76
155 INT92402 Negative_regulation of Transcription of Nfkb1 1 4 0.42 1.75 1.76
156 INT48720 Transcription of SERPINE1 2 11 0.68 4.76 1.67
157 INT89467 Gene_expression of Lhcgr 3 9 0.36 1.59 1.62
158 INT51984 Localization of Pcsk2 2 3 0.66 0.37 1.62
159 INT113279 Gene_expression of HSD17B2 2 3 0.24 3.65 1.59
160 INT132761 Negative_regulation of Pgr 1 6 0.50 3.07 1.58
161 INT28300 Gene_expression of GHR 1 10 0.78 4.29 1.5
162 INT10069 Negative_regulation of Lhb 1 2 0.49 0 1.36
163 INT47102 Regulation of Binding of GHRH 1 2 0.28 0 1.34
164 INT12621 Positive_regulation of Localization of LGALS1 2 2 0.08 0.07 1.17
165 INT32786 Localization of Enpep 1 4 0.68 0 1.16
166 INT10625 Regulation of Positive_regulation of Avp 1 4 0.44 1.06 1.04
167 INT31314 Positive_regulation of Negative_regulation of Enpep 1 3 0.35 0.18 1.02
168 INT132770 Positive_regulation of Gene_expression of HSD17B2 2 1 0.02 2.28 1.01
169 INT91035 Positive_regulation of HSD17B2 1 7 0.66 5.2 0.98
170 INT85733 Positive_regulation of Tpgs2 2 1 0.21 0.4 0.95
171 INT42258 Binding of Ubr4 3 1 0.40 0 0.9
172 INT99342 Positive_regulation of Gene_expression of Gabrp 1 2 0.23 0.76 0.87
173 INT73784 Regulation of Binding of GH1 1 2 0.26 0.82 0.86
174 INT48717 Positive_regulation of Localization of SERPINE1 2 6 0.66 2.64 0.83
175 INT1513 Regulation of Binding of Prl 1 4 0.45 0 0.81
176 INT51231 Regulation of Gene_expression of ANTXRL 1 1 0.01 0.1 0.81
177 INT47937 Positive_regulation of Gene_expression of ANTXR1 1 3 0.49 0.86 0.8
178 INT27546 Positive_regulation of Furin 1 4 0.40 0.49 0.75
179 INT27545 Gene_expression of Furin 1 6 0.63 0.75 0.74
180 INT4397 Transcription of CSH1 5 7 0.57 0.65 0.72
181 INT73783 Regulation of Gene_expression of GHR 1 1 0.45 0 0.7
182 INT70362 Transcription of GH1 3 9 0.56 2.01 0.69
183 INT132759 Positive_regulation of Gene_expression of Pgr 1 9 0.38 5.12 0.64
184 INT132768 Negative_regulation of Gene_expression of PRS 1 1 0.03 1.18 0.61
185 INT118585 Binding of PNN 1 6 0.25 2.47 0.56
186 INT47933 Positive_regulation of Localization of Drd2 1 1 0.10 0.23 0.56
187 INT47934 Negative_regulation of Localization of Drd2 1 1 0.10 0.22 0.56
188 INT132762 Gene_expression of Hsd17b2 1 1 0.06 1.21 0.55
189 INT132763 Positive_regulation of Gene_expression of Hsd17b2 1 1 0.04 1.21 0.55
190 INT29235 Negative_regulation of Localization of Tfpi 1 1 0.26 0 0.49
191 INT85734 Positive_regulation of Positive_regulation of Tpgs2 1 1 0.21 0.2 0.48
192 INT85732 Negative_regulation of Tpgs2 1 1 0.25 0.18 0.46
193 INT47935 Binding of Pitx3 1 1 0.06 0.18 0.44
194 INT53084 Gene_expression of PCSK2 8 13 0.78 3.98 0.43
195 INT70561 Regulation of ESRRB 1 4 0.27 1.03 0.42
196 INT89465 Positive_regulation of Gene_expression of Lhcgr 2 4 0.24 1.03 0.41
197 INT157431 Binding of Sf1 1 1 0.05 0.99 0.39
198 INT48721 Negative_regulation of Localization of SERPINE1 1 3 0.43 2.4 0.38
199 INT51232 Positive_regulation of Localization of CSH1 1 3 0.31 0.32 0.37
200 INT21304 Positive_regulation of Fshr 1 2 0.40 0.2 0.35
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