J:Mol. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 1 0.02 0.36 1.5
2 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 1 0.50 0.2 1.09
3 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 1 0.75 0.2 1.08
4 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 1 0.54 0.2 1.08
5 INT151807 Binding of NFATC1 and OPRM1 1 1 0.19 0 0.79
6 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 1 0.20 0 0.76
7 INT153879 Gast Positive_regulation of Positive_regulation of TRPV1 1 1 0.09 0.35 0.76
8 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 1 0.26 0 0.74
9 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 1 0.32 0 0.74
10 INT151806 TRAF3IP2 Positive_regulation of Positive_regulation of OPRM1 1 1 0.06 0 0.74
11 INT150338 Binding of F2 and F2R 1 4 0.11 0.4 0.67
12 INT153797 NUBPL Negative_regulation of PPARD 1 1 0.02 0.69 0.64
13 INT153796 NUBPL Negative_regulation of YWHAQ 1 1 0.02 0.69 0.64
14 INT148541 ST3GAL4 Positive_regulation of Positive_regulation of Trpv1 1 1 0.08 0.96 0.56
15 INT148542 ST3GAL4 Regulation of Gene_expression of Trpv1 1 1 0.05 0.97 0.51
16 INT146306 Binding of Chrna9 and Myo5c 1 1 0.01 0.27 0.48
17 INT146276 Binding of P2RX4 and P2RX7 1 3 0.38 0.38 0.43
18 INT159349 Zfp956 Negative_regulation of Nos1 1 2 0.03 0.61 0.43
19 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 1 0.05 0.19 0.36
20 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 1 0.03 0.07 0.36
21 INT163906 CCL2 Positive_regulation of CCR2 1 1 0.18 0.2 0.35
22 INT167551 Binding of MECP2 and SP3 1 1 0.01 0.06 0.35
23 INT163908 CCL2 Positive_regulation of Ccr2 1 1 0.05 0.2 0.35
24 INT169049 Positive_regulation of Binding of Creb1 and Sult4a1 1 1 0.47 0.11 0.24
25 INT169048 Positive_regulation of Binding of Atf2 and Sult4a1 1 1 0.38 0.11 0.24
26 INT169054 Binding of Atf2 and Sult4a1 1 1 0.37 0.11 0.24
27 INT169051 Binding of Creb1 and Sult4a1 1 1 0.32 0.11 0.24
28 INT169053 Oprm1 Regulation of Sult4a1 1 1 0.10 0.05 0.23
29 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 1 0.27 0.34 0.22
30 INT159348 Binding of Nos1 and Nos2 1 1 0.23 0.29 0.22
31 INT159350 Zfp956 Negative_regulation of Nos2 1 1 0.03 0.3 0.21
32 INT146841 Tnf Positive_regulation of Trib3 1 1 0.03 0.77 0.16
33 INT146845 Tnf Positive_regulation of Positive_regulation of Trib3 1 1 0.03 0.77 0.16
34 INT146846 Tnf Negative_regulation of Plin1 1 1 0.59 0.66 0.13
35 INT146840 Tnf Regulation of Pnpla2 1 1 0.25 0.4 0.08
36 INT146842 Tnf Regulation of Lipe 1 1 0.19 0.4 0.08
37 INT169052 Atf2 Regulation of Sult4a1 1 1 0.21 0.17 0
38 INT169050 Nfe2l2 Regulation of Sult4a1 1 1 0.01 0.17 0
39 INT169056 Nfe2l2 Regulation of SULT1A2 1 1 0.00 0.17 0
40 INT169055 Atf2 Regulation of SULT1A2 1 1 0.00 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 12 3083 0.78 894.43 1639.02
2 INT58061 Gene_expression of Trpv1 14 1117 0.78 451.54 637.59
3 INT5895 Gene_expression of Oprm1 27 525 0.78 120.67 407.29
4 INT64202 Positive_regulation of Trpv1 12 643 0.70 249.66 397.42
5 INT76660 Gene_expression of Trpv1 5 691 0.78 329.46 386.42
6 INT18357 Gene_expression of TRPV1 6 825 0.78 307.11 382.81
7 INT5979 Gene_expression of Oprd1 11 428 0.78 75.64 320.32
8 INT5540 Positive_regulation of Oprm1 35 344 0.70 76.77 319.71
9 INT4941 Positive_regulation of Oprd1 14 345 0.70 74.26 304.41
10 INT11624 Gene_expression of OPRM1 13 445 0.78 72.36 294.36
11 INT5379 Gene_expression of Fos 4 656 0.78 255.5 292.54
12 INT9158 Gene_expression of Tnf 2 722 0.78 522.01 277.68
13 INT9381 Positive_regulation of TRPV1 17 523 0.70 187.4 276.05
14 INT5591 Regulation of Gene_expression of Fos 5 425 0.62 129.06 265.78
15 INT87687 Positive_regulation of Trpv1 2 409 0.70 210.24 257.59
16 INT5501 Regulation of Oprd1 4 283 0.62 55.1 249.9
17 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
18 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
19 INT2651 Positive_regulation of Pomc 2 403 0.70 95.72 206.24
20 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
21 INT94952 Positive_regulation of Mapk14 3 305 0.70 197.83 186.61
22 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
23 INT4937 Negative_regulation of Oprd1 9 224 0.59 44.51 171.11
24 INT4768 Positive_regulation of OPRM1 11 212 0.70 31.09 164.28
25 INT4740 Gene_expression of Th 12 298 0.78 61.27 154.03
26 INT5497 Positive_regulation of Crh 2 299 0.70 125.54 131.14
27 INT5380 Positive_regulation of Gene_expression of Fos 2 243 0.70 105.65 131.05
28 INT65054 Positive_regulation of Nfkb1 3 285 0.70 149.33 126.73
29 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
30 INT49651 Gene_expression of Creb1 6 276 0.78 114.77 111.96
31 INT27096 Positive_regulation of Nfkb1 4 325 0.70 195.11 109.06
32 INT94953 Negative_regulation of Mapk14 2 156 0.59 104.77 91.51
33 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
34 INT1639 Negative_regulation of OPRM1 15 107 0.59 13.86 90.37
35 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
36 INT71789 Positive_regulation of MAPK1 9 396 0.70 234.44 89.27
37 INT96917 Positive_regulation of Mapk14 2 261 0.70 173.29 88.79
38 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
39 INT10534 Positive_regulation of Trib3 6 209 0.60 78.75 81.48
40 INT12476 Negative_regulation of TRPV1 5 124 0.59 47.95 77.98
41 INT98621 Regulation of Trpv1 4 121 0.62 79.24 75.23
42 INT6656 Gene_expression of YY1 10 135 0.75 24.73 72.16
43 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
44 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
45 INT87686 Positive_regulation of Gene_expression of Trpv1 1 101 0.70 72.41 69.15
46 INT6926 Regulation of Pag1 2 72 0.39 55.79 65.09
47 INT24989 Positive_regulation of Cfp 2 125 0.61 29.55 64.9
48 INT9304 Negative_regulation of Pag1 1 70 0.39 51.97 64.23
49 INT102020 Gene_expression of Creb1 1 190 0.78 57.31 59.77
50 INT49170 Negative_regulation of Nos1 4 116 0.59 60.66 58.87
51 INT8732 Positive_regulation of Gene_expression of Oprm1 2 76 0.70 22.59 58.83
52 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
53 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
54 INT10668 Positive_regulation of Gene_expression of Oprd1 3 61 0.69 15.21 52.12
55 INT5957 Positive_regulation of Cpe 1 65 0.69 21.07 51.22
56 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
57 INT109430 Positive_regulation of Trpa1 3 119 0.70 44 49.14
58 INT62521 Phosphorylation of Oprm1 4 44 0.82 2.66 47.45
59 INT1564 Localization of OPRM1 2 41 0.80 8.03 44.67
60 INT85943 Negative_regulation of Nos2 3 161 0.59 108.56 42.65
61 INT114751 Gene_expression of Mapk1 1 137 0.76 60.14 39.98
62 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
63 INT80690 Positive_regulation of MAPK8 1 223 0.68 125.63 36.75
64 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
65 INT6105 Positive_regulation of IL2 1 133 0.69 82.76 34.67
66 INT16714 Regulation of Creb1 1 64 0.62 22.23 33.56
67 INT65536 Negative_regulation of Positive_regulation of Nfkb1 1 77 0.59 38.86 33.33
68 INT64171 Regulation of CPOX 2 109 0.36 55.36 32.96
69 INT81530 Gene_expression of Nfkb1 1 93 0.78 48.58 32.58
70 INT8531 Transcription of PDYN 2 56 0.72 19.51 30.99
71 INT5505 Regulation of Localization of Pomc 1 54 0.61 6.96 30.77
72 INT69483 Transcription of OPRM1 7 45 0.72 7.31 30.22
73 INT110020 Gene_expression of Mapk14 1 142 0.77 72.33 30.08
74 INT16769 Positive_regulation of Positive_regulation of Oprm1 5 31 0.57 8.29 29.66
75 INT127499 Positive_regulation of TRPA1 5 72 0.70 21.7 26.86
76 INT5378 Regulation of Gene_expression of Fos 1 47 0.60 14.47 26.41
77 INT50490 Regulation of PTGS2 2 80 0.48 39.51 25.85
78 INT12124 Gene_expression of MAPK1 1 141 0.75 82.4 25.58
79 INT124144 Negative_regulation of Mors1 1 21 0.41 2.87 24.71
80 INT9377 Positive_regulation of Positive_regulation of TRPV1 5 43 0.70 15.81 24.47
81 INT64076 Positive_regulation of Kcnma1 3 47 0.40 11.52 24.19
82 INT71781 Phosphorylation of MAPK3 1 62 0.80 27.73 23.73
83 INT127500 Gene_expression of TRPA1 2 79 0.78 24.58 23.3
84 INT102021 Positive_regulation of Gene_expression of Creb1 1 66 0.70 24.04 23.28
85 INT88327 Gene_expression of P2rx7 1 109 0.77 48.86 22.41
86 INT101517 Negative_regulation of PPARA 1 168 0.57 112.24 21.41
87 INT69877 Positive_regulation of Positive_regulation of Nfkb1 1 53 0.68 31.44 20.7
88 INT17848 Binding of PTGS2 3 70 0.46 32.1 20.6
89 INT1756 Negative_regulation of DNAH8 2 105 0.59 42.73 20.24
90 INT49835 Negative_regulation of Positive_regulation of Oprm1 1 21 0.42 4.11 20.11
91 INT86187 Positive_regulation of AKT1 1 199 0.69 122.13 19.44
92 INT77902 Negative_regulation of Positive_regulation of TRPV1 2 30 0.59 9.36 19.2
93 INT71787 Positive_regulation of MAPK3 4 37 0.67 17.5 17.88
94 INT6791 Binding of NA 1 55 0.46 5.36 17.59
95 INT7644 Positive_regulation of Gene_expression of PDYN 1 27 0.69 10.19 17.47
96 INT33915 Regulation of Positive_regulation of Oprm1 2 22 0.60 2.44 16.43
97 INT151434 Positive_regulation of Ccr2 2 26 0.68 18.34 16.34
98 INT97245 Gene_expression of AKT1 1 217 0.77 119.63 15.59
99 INT75531 Regulation of MAPK1 3 70 0.61 34.39 15.42
100 INT127046 Gene_expression of P2RX7 4 65 0.78 34.28 14.76
101 INT80688 Positive_regulation of Positive_regulation of MAPK1 1 72 0.69 39.35 14.11
102 INT104954 Negative_regulation of Positive_regulation of Mapk14 1 29 0.58 17.71 13.31
103 INT144646 Positive_regulation of Rela 4 53 0.67 27.78 13.2
104 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
105 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
106 INT119396 Regulation of Positive_regulation of Mapk1 1 22 0.61 7.88 12.25
107 INT12232 Regulation of Gene_expression of PDYN 1 21 0.60 9.91 12.18
108 INT102731 Regulation of ABCB1 1 29 0.62 5.36 11.67
109 INT80251 Binding of Nos1 1 21 0.30 8.24 11.31
110 INT75525 Negative_regulation of Positive_regulation of MAPK1 5 40 0.59 25.15 11.15
111 INT81531 Positive_regulation of Gene_expression of Nfkb1 1 27 0.69 13.9 11.04
112 INT4498 Gene_expression of F2 2 83 0.65 57.4 10.8
113 INT118390 Positive_regulation of Nfe2l2 1 82 0.70 20.41 10.61
114 INT112037 Negative_regulation of Positive_regulation of Trpv1 1 19 0.59 8.9 10.55
115 INT98329 Gene_expression of P2RX4 3 23 0.75 13.13 10.25
116 INT145875 Gene_expression of Grm2 2 28 0.58 6.81 10.19
117 INT58986 Gene_expression of Clu 1 17 0.77 8.35 9.61
118 INT7572 Regulation of Crhr1 1 8 0.45 5.6 8.93
119 INT82839 Negative_regulation of ABCB1 1 61 0.59 16.09 8.83
120 INT113845 Protein_catabolism of PARP1 2 54 0.88 43.86 8.77
121 INT47769 Phosphorylation of Fos 3 20 0.61 3.03 8.68
122 INT90020 Gene_expression of SUCLG1 7 8 0.75 1.61 8.34
123 INT108202 Positive_regulation of PIK3CG 1 47 0.67 25.83 8.25
124 INT71785 Gene_expression of MAPK3 1 22 0.75 11.35 8.21
125 INT69460 Positive_regulation of Grm2 1 12 0.49 6.54 8.18
126 INT126583 Positive_regulation of PARP1 2 50 0.68 41.44 7.78
127 INT74326 Gene_expression of Crhr1 2 25 0.66 9.7 7.48
128 INT92755 Regulation of MRGPRX1 2 26 0.27 3.63 7.37
129 INT80161 Positive_regulation of Crhr1 1 13 0.67 9.66 7.33
130 INT138802 Gene_expression of CFTR 3 36 0.70 18.8 7.02
131 INT110605 Gene_expression of KCNK2 1 24 0.78 5.71 6.85
132 INT31333 Gene_expression of Esr2 2 19 0.69 8.78 6.83
133 INT18460 Positive_regulation of Transcription of PDYN 1 11 0.67 2.14 6.61
134 INT94649 Gene_expression of Grm1 1 19 0.77 5.11 6.58
135 INT107737 Positive_regulation of Pld2 1 11 0.67 0.33 6.45
136 INT42832 Negative_regulation of Positive_regulation of OPRM1 1 6 0.36 0.96 6.35
137 INT115849 Localization of Prkcc 3 5 0.77 0.65 6.26
138 INT60161 Gene_expression of EPHA3 2 43 0.75 3.66 6.25
139 INT71758 Gene_expression of P2RX1 1 40 0.75 9.01 6.14
140 INT127237 Phosphorylation of Prkcc 2 7 0.81 0 5.96
141 INT18832 Positive_regulation of CASP4 2 11 0.44 7.12 5.68
142 INT1849 Binding of SUPT7L 1 14 0.47 0.95 5.44
143 INT147869 Positive_regulation of Gene_expression of TRPA1 2 5 0.70 5.33 5.21
144 INT56122 Positive_regulation of Abcc3 1 7 0.47 2.25 4.9
145 INT148540 Positive_regulation of Phospho1 1 3 0.36 1.28 4.89
146 INT87611 Gene_expression of Mrgprc 2 6 0.64 1.92 4.84
147 INT147870 Binding of TRPA1 1 11 0.48 3.12 4.77
148 INT7568 Negative_regulation of Crhr1 1 8 0.43 4.63 4.77
149 INT70539 Negative_regulation of Cxcl1 1 13 0.57 7.15 4.58
150 INT79682 Gene_expression of Grm7 1 6 0.75 4.74 4.5
151 INT145876 Regulation of Gene_expression of Grm2 1 3 0.00 2.4 4.46
152 INT16569 Negative_regulation of HTR3A 1 14 0.57 6.91 4.42
153 INT158377 Positive_regulation of Positive_regulation of Rela 4 6 0.49 3.08 4.11
154 INT148168 Positive_regulation of Localization of Prkcc 3 4 0.48 0.15 4.03
155 INT23088 Phosphorylation of Tnf 1 15 0.79 9.85 3.82
156 INT18515 Gene_expression of Lipg 1 18 0.66 9.3 3.72
157 INT167410 Positive_regulation of MAP1LC3C 5 1 0.02 2.97 3.66
158 INT100893 Positive_regulation of ABCC3 2 8 0.64 4.66 3.65
159 INT84891 Gene_expression of PPARD 2 10 0.78 6.8 3.64
160 INT145873 Positive_regulation of Gene_expression of Grm2 1 3 0.26 3.44 3.45
161 INT110608 Negative_regulation of KCNK2 3 10 0.59 0.91 3.26
162 INT133557 Transcription of Rela 2 6 0.52 3.86 3.2
163 INT17562 Negative_regulation of Lipg 1 32 0.51 16.91 3.17
164 INT84890 Negative_regulation of PPARD 3 7 0.59 3.27 3.1
165 INT136891 Negative_regulation of TRPA1 1 7 0.43 2.45 3.06
166 INT89392 Negative_regulation of Positive_regulation of AKT1 1 23 0.50 15.69 3.02
167 INT103607 Binding of Sp1 1 7 0.42 1.26 2.92
168 INT110609 Binding of KCNK2 3 3 0.48 0.25 2.88
169 INT169046 Gene_expression of Sult4a1 5 12 0.71 1.49 2.83
170 INT22831 Negative_regulation of Positive_regulation of IL2 1 7 0.55 1.7 2.62
171 INT167556 Binding of MECP2 1 7 0.27 4.57 2.6
172 INT118114 Negative_regulation of ABCG2 2 5 0.57 2.52 2.47
173 INT150339 Gene_expression of F2R 2 10 0.73 3.59 2.46
174 INT120271 Gene_expression of Grm4 1 3 0.01 1.71 2.46
175 INT148166 Positive_regulation of Phosphorylation of Prkcc 1 2 0.68 0 2.44
176 INT141367 Negative_regulation of Transcription of IL2 1 9 0.32 2.07 2.43
177 INT148539 Gene_expression of Phospho1 1 6 0.35 3.02 2.34
178 INT101516 Positive_regulation of PPARD 1 8 0.49 4.75 2.19
179 INT137972 Binding of P2RX7 2 12 0.36 8.01 2.18
180 INT154937 Positive_regulation of MAP1LC3A 2 4 0.60 4.42 2.1
181 INT103608 Negative_regulation of Binding of Sp1 1 4 0.35 0.69 2.1
182 INT41557 Gene_expression of Sp1 1 5 0.68 1.17 2.04
183 INT166710 Positive_regulation of Gene_expression of CFTR 1 9 0.46 3.72 2.03
184 INT153800 Positive_regulation of Protein_catabolism of PARP1 1 18 0.49 16.16 1.89
185 INT68857 Positive_regulation of Rxfp2 1 5 0.34 1.51 1.86
186 INT158374 Negative_regulation of Aadac 1 13 0.07 7.19 1.76
187 INT153918 Binding of Esr2 1 3 0.33 2.56 1.7
188 INT143807 Negative_regulation of Abcc2 3 4 0.58 0.93 1.65
189 INT88746 Positive_regulation of Transcription of IL2 1 7 0.51 2.14 1.6
190 INT167416 Regulation of Gene_expression of MAP1LC3C 2 1 0.02 1.14 1.56
191 INT167415 Gene_expression of MAP1LC3C 2 1 0.04 1.13 1.55
192 INT104185 Negative_regulation of ABCC2 1 7 0.57 0.64 1.5
193 INT167413 Positive_regulation of Positive_regulation of MAP1LC3C 2 1 0.02 1.15 1.5
194 INT84889 Positive_regulation of Gene_expression of PPARD 1 4 0.70 2.94 1.49
195 INT110444 Positive_regulation of Atf2 1 7 0.50 2 1.48
196 INT107735 Positive_regulation of Positive_regulation of Pld2 1 3 0.48 0 1.47
197 INT165690 Localization of Abcc2 2 4 0.79 1.31 1.38
198 INT127768 Gene_expression of Sec22b 1 5 0.13 1.93 1.33
199 INT94692 Positive_regulation of Gene_expression of Sp1 1 3 0.17 0.39 1.28
200 INT167825 Regulation of Mrgpre 1 3 0.27 2.88 1.27
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