J:Mol Neurobiol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT259184 Binding of Gria2 and Gria1 2 1 0.26 0.28 0.54
2 INT273945 Crh Positive_regulation of Gene_expression of Crem 1 1 0.20 0.52 0.43
3 INT273939 Positive_regulation of Crem Negative_regulation of Transcription of Crh 1 1 0.18 0.99 0.39
4 INT273956 Binding of Crem and Negative_regulation of Transcription of Crh 1 1 0.18 0.99 0.39
5 INT207211 Binding of Creb1 and Crem 2 2 0.30 1.35 0.36
6 INT273955 Creb1 Positive_regulation of Transcription of Crh 1 1 0.14 0.96 0.33
7 INT273953 Crem Regulation of Transcription of Crh 1 1 0.26 0.99 0.27
8 INT273935 Crem Regulation of Gene_expression of Egr2 1 1 0.05 0.16 0.26
9 INT346745 Binding of Cacng2 and Grip2 1 3 0.01 0 0.25
10 INT346765 Binding of RBM10 and Grip2 1 3 0.00 0 0.25
11 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 1 0.00 0.87 0.25
12 INT312550 DAK Positive_regulation of Rxra 1 2 0.00 1.48 0.18
13 INT301782 Binding of Dmd and Utrn 1 1 0.24 0.15 0.18
14 INT312519 DAK Positive_regulation of PPARA 1 2 0.00 1.46 0.18
15 INT346748 Binding of Shisa9 and Grip2 1 1 0.00 0 0.17
16 INT346766 Negative_regulation of Binding of RBM10 and Grip2 1 1 0.00 0 0.17
17 INT301784 Binding of Dmd and Sntb1 1 2 0.05 0.36 0.16
18 INT301783 Binding of Dtna and Sntb1 1 1 0.01 0.05 0.12
19 INT301788 Binding of Dmd and Dtna 1 1 0.09 0.05 0.12
20 INT301789 Binding of Sntb1 and Utrn 1 1 0.03 0.05 0.12
21 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 1 0.01 0.6 0.08
22 INT265256 Binding of Gria2 and Cdh2 2 1 0.02 0.17 0.07
23 INT273947 Binding of Gabra1 and Mrvi1 1 1 0.00 0.94 0.07
24 INT273936 Binding of Crem and Mrvi1 1 1 0.00 0.94 0.07
25 INT273937 Binding of Crem and Gabra1 1 1 0.30 0.94 0.07
26 INT346752 Binding of Dlg1 and Gria1 1 1 0.02 0 0.06
27 INT346754 Binding of Dlg4 and Gria2 1 1 0.02 0 0.06
28 INT273944 Negative_regulation of Creb1 Positive_regulation of Positive_regulation of Crem 1 1 0.26 0.62 0.05
29 INT301786 Negative_regulation of Binding of Dmd and Sntb1 1 1 0.06 0.31 0.04
30 INT273946 Phosphorylation of Creb1 Positive_regulation of Gene_expression of Crem 1 1 0.29 0 0
31 INT346742 Binding of Cacng2 and Dlg4 1 1 0.03 0 0
32 INT273938 Creb1 Positive_regulation of Transcription of Mirg 1 1 0.01 0.06 0
33 INT273948 Binding of Creb1 and Pmp2 1 1 0.04 0 0
34 INT346753 Binding of Grip2 and Nptx1 1 1 0.00 0.1 0
35 INT273952 Creb1 Positive_regulation of Pmp2 1 1 0.09 0.06 0
36 INT346756 Binding of Cdh2 and Grip2 1 1 0.00 0.1 0
37 INT273949 Binding of Crem and Smarca4 1 2 0.01 0 0
38 INT273950 Binding of Crem and Cst8 1 2 0.10 0 0
39 INT346746 Binding of Cacng2 and Gria2 1 1 0.21 0.18 0
40 INT346755 Atf6 Positive_regulation of Hsp90b1 1 1 0.00 0 0
41 INT273943 Creb1 Positive_regulation of Transcription of Crem 1 1 0.44 0.07 0
42 INT346747 Binding of Dlg4 and Shisa9 1 1 0.01 0 0
43 INT301787 Dtna Regulation of Prkx 1 1 0.00 0.1 0
44 INT346743 Atf6 Positive_regulation of Hspa5 1 1 0.00 0 0
45 INT346744 Binding of Dlg4 and Tinagl1 1 1 0.03 0 0
46 INT273941 Binding of Atf1 and Crem 1 1 0.15 0 0
47 INT273957 Binding of Creb1 and Pmp2 Positive_regulation of Gene_expression of Crem 1 1 0.06 0 0
48 INT346764 Binding of RBM10 and Gria2 1 1 0.01 0.18 0
49 INT273951 Phosphorylation of Creb1 Positive_regulation of Pmp2 1 1 0.06 0.06 0
50 INT273942 Creb1 Positive_regulation of Gene_expression of Crem 1 1 0.29 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
2 INT95787 Positive_regulation of Mapk1 3 568 0.70 226.51 220.94
3 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
4 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
5 INT7628 Gene_expression of Ltp 2 273 0.77 70.21 147.87
6 INT14843 Gene_expression of Gabrg1 2 301 0.77 62.63 139.16
7 INT64161 Positive_regulation of Prkca 1 213 0.70 85.06 129.91
8 INT92669 Gene_expression of Bdnf 1 309 0.78 178.26 116.68
9 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
10 INT49171 Gene_expression of Nos1 4 241 0.78 140.7 104.76
11 INT3537 Positive_regulation of Car2 2 413 0.56 103.51 94.35
12 INT11587 Gene_expression of CSF2 2 645 0.78 544.38 93.89
13 INT9516 Negative_regulation of Gabrg1 2 149 0.53 27.83 91.02
14 INT96917 Positive_regulation of Mapk14 1 261 0.70 173.29 88.79
15 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
16 INT56291 Gene_expression of Ros1 2 503 0.63 274.12 81.5
17 INT13036 Positive_regulation of Positive_regulation of Ltp 1 105 0.51 23.71 77.66
18 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
19 INT57380 Phosphorylation of Creb1 4 213 0.82 66.8 71.26
20 INT5374 Gene_expression of Esr1 5 412 0.77 263.89 67.34
21 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
22 INT103924 Positive_regulation of Akt1 6 359 0.69 158.94 60.34
23 INT102020 Gene_expression of Creb1 6 190 0.78 57.31 59.77
24 INT79093 Positive_regulation of Nos1 1 101 0.70 46.89 59.61
25 INT49170 Negative_regulation of Nos1 2 116 0.59 60.66 58.87
26 INT82055 Positive_regulation of Creb1 5 176 0.70 60.2 58.39
27 INT8071 Positive_regulation of Gria1 1 102 0.70 26.61 53.37
28 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
29 INT30170 Gene_expression of Car2 2 330 0.66 77.26 46.76
30 INT3361 Positive_regulation of Esr1 7 273 0.69 208.53 44.81
31 INT25610 Positive_regulation of Gene_expression of Il1 1 136 0.67 104.43 43.86
32 INT57442 Phosphorylation of Prkca 1 98 0.70 31.58 41.04
33 INT30817 Gene_expression of Th 1 142 0.76 33.56 38.12
34 INT14009 Gene_expression of Sst 1 66 0.77 19.6 37.3
35 INT96913 Positive_regulation of Mapk8 1 179 0.69 130.44 32.2
36 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
37 INT124860 Gene_expression of Bace1 1 330 0.78 157.11 31.65
38 INT49110 Regulation of Grip2 5 46 0.61 13.57 30.87
39 INT57379 Positive_regulation of Phosphorylation of Creb1 1 79 0.69 28.24 30.25
40 INT7664 Negative_regulation of Grip2 2 68 0.49 10.11 29.93
41 INT6660 Positive_regulation of Jun 1 148 0.69 67.58 29.73
42 INT11554 Negative_regulation of CSF2 1 129 0.59 108.55 29.44
43 INT56525 Gene_expression of Gria2 16 74 0.75 23.15 28.6
44 INT133876 Positive_regulation of Gene_expression of Ros1 2 141 0.32 75.55 27.45
45 INT37296 Binding of Esr1 2 117 0.43 62.51 27.33
46 INT32826 Positive_regulation of Gene_expression of Ltp 1 52 0.45 10.34 26.8
47 INT56524 Gene_expression of Grip2 14 67 0.74 14.77 26.23
48 INT48832 Positive_regulation of Grip2 1 48 0.69 12.13 25.99
49 INT122570 Negative_regulation of Akt1 4 173 0.59 91.44 25.53
50 INT7584 Gene_expression of Crh 5 112 0.78 39.15 25.33
51 INT57874 Gene_expression of Egr1 1 113 0.78 68.46 24.95
52 INT44954 Gene_expression of APP 3 191 0.78 105.86 23.9
53 INT102021 Positive_regulation of Gene_expression of Creb1 1 66 0.70 24.04 23.28
54 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
55 INT170444 Binding of Gopc 1 172 0.39 45.05 20.71
56 INT113399 Positive_regulation of Pla2g4a 3 36 0.67 33.83 18.78
57 INT62577 Negative_regulation of Creb1 3 55 0.59 19.68 18.1
58 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
59 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
60 INT109316 Negative_regulation of Mapk8 1 72 0.59 50.59 17.24
61 INT48690 Localization of Grip2 3 33 0.61 6.13 16.81
62 INT102023 Regulation of Creb1 2 51 0.62 16.29 16.71
63 INT49263 Binding of Grip2 7 31 0.41 9.86 16.38
64 INT111073 Gene_expression of Psen1 2 167 0.76 78.65 15.83
65 INT124371 Negative_regulation of Gsk3b 6 170 0.55 87.92 15.51
66 INT18513 Binding of GRIN1 2 32 0.47 9.44 15.08
67 INT114510 Positive_regulation of Gria2 1 36 0.57 14.91 14.85
68 INT64112 Regulation of Gene_expression of Nos1 2 22 0.62 21.45 14.76
69 INT124372 Gene_expression of Gsk3b 3 164 0.75 95.64 14.35
70 INT28314 Negative_regulation of Gene_expression of Gabrg1 1 29 0.44 12.56 13.8
71 INT49538 Binding of Gria1 3 22 0.47 2.66 13.35
72 INT2038 Localization of Esr1 10 104 0.79 40.12 13.27
73 INT80222 Negative_regulation of Bcl2 1 82 0.58 69.16 13.18
74 INT119400 Phosphorylation of Car2 1 19 0.52 8.47 11.63
75 INT57069 Regulation of Gria2 2 28 0.44 10.11 11.06
76 INT62576 Transcription of Creb1 1 34 0.69 16.97 10.6
77 INT17421 Negative_regulation of Alox5 1 41 0.57 15.23 10.05
78 INT115046 Gene_expression of Crem 60 68 0.77 27.24 10.01
79 INT179696 Negative_regulation of DAK 1 5 0.02 16.79 9.42
80 INT41569 Regulation of APP 2 32 0.62 17.15 9.4
81 INT135372 Positive_regulation of Gsk3b 5 72 0.70 50.03 9.28
82 INT26487 Positive_regulation of Npr1 1 17 0.70 10.01 8.78
83 INT85651 Positive_regulation of ACACA 1 17 0.67 4.73 8.63
84 INT78766 Negative_regulation of Gria2 3 20 0.52 6.27 8.12
85 INT71381 Localization of Nos1 5 33 0.79 11.46 8.05
86 INT22056 Positive_regulation of CYBB 2 88 0.68 32.13 7.95
87 INT160440 Positive_regulation of Crem 37 48 0.69 20.38 7.66
88 INT126200 Negative_regulation of Bace1 1 73 0.58 50.19 7.44
89 INT84932 Negative_regulation of APP 2 29 0.57 28.45 7.2
90 INT273933 Positive_regulation of Gene_expression of Crem 37 1 0.69 17.95 6.69
91 INT88786 Binding of Dlg4 2 11 0.46 2.73 6.58
92 INT92971 Binding of Creb1 3 31 0.47 11.3 6.22
93 INT64111 Negative_regulation of Gene_expression of Nos1 1 22 0.57 8.96 6.02
94 INT43997 Positive_regulation of Gene_expression of Esr1 1 57 0.51 36.66 5.51
95 INT57068 Regulation of Gene_expression of Gria2 2 12 0.36 3.76 5.44
96 INT95696 Gene_expression of Dmd 34 130 0.68 26.02 5.34
97 INT85946 Localization of Gria2 1 10 0.61 1.23 5.09
98 INT102019 Regulation of Gene_expression of Creb1 1 14 0.61 5.27 5.08
99 INT26042 Binding of Gria2 8 20 0.40 4.88 5.04
100 INT91225 Positive_regulation of Pla2g2a 1 22 0.57 14.77 5.01
101 INT57441 Positive_regulation of Phosphorylation of Prkca 1 9 0.40 2.72 4.89
102 INT131152 Gene_expression of Cr1l 1 17 0.75 10.83 4.88
103 INT26167 Positive_regulation of Hrasls 2 18 0.23 8.67 4.87
104 INT97894 Positive_regulation of Gene_expression of Crh 2 27 0.70 11.82 4.82
105 INT114511 Positive_regulation of Gene_expression of Gria2 2 14 0.41 3.9 4.71
106 INT72703 Gene_expression of Ide 1 79 0.70 45.04 4.47
107 INT111066 Regulation of Bace1 1 40 0.61 31.47 4.28
108 INT19449 Binding of FANCB 2 22 0.47 7.4 4.27
109 INT76467 Regulation of Gene_expression of Car2 2 41 0.37 12.88 4.21
110 INT74365 Positive_regulation of Alox5 1 19 0.47 11.03 4.04
111 INT134008 Transcription of Crh 3 8 0.59 6.12 3.95
112 INT217102 Gene_expression of Egr2 1 50 0.78 10.91 3.89
113 INT105975 Gene_expression of ACACA 1 16 0.75 5.73 3.86
114 INT179542 Positive_regulation of C3 1 27 0.52 19.39 3.83
115 INT143082 Positive_regulation of Gene_expression of ACACA 1 5 0.67 5.36 3.83
116 INT14281 Gene_expression of Hspa5 1 44 0.63 34.19 3.31
117 INT217389 Negative_regulation of Gene_expression of Bace1 1 43 0.59 18.57 3.27
118 INT103739 Negative_regulation of Gene_expression of Crh 1 19 0.59 10.19 3.17
119 INT126172 Negative_regulation of Pla2g4a 2 7 0.39 9.01 2.89
120 INT65049 Positive_regulation of Gene_expression of Grip2 1 7 0.60 1.72 2.71
121 INT59454 Regulation of Gene_expression of CSF2 2 22 0.52 19.67 2.69
122 INT207165 Gene_expression of DAK 1 18 0.08 9.41 2.69
123 INT51869 Negative_regulation of Dmd 9 24 0.52 10.4 2.18
124 INT169318 Positive_regulation of Rxra 1 15 0.42 4.35 2.12
125 INT117197 Gene_expression of Zmat3 1 19 0.05 8.3 2.05
126 INT204018 Localization of Gsk3b 1 27 0.71 13.67 1.87
127 INT111070 Negative_regulation of Gene_expression of Psen1 1 17 0.42 9.47 1.77
128 INT115045 Regulation of Crem 11 3 0.61 3.88 1.7
129 INT222089 Positive_regulation of Localization of Esr1 3 19 0.49 8.73 1.58
130 INT56526 Gene_expression of Gria4 1 4 0.75 0.15 1.54
131 INT221773 Negative_regulation of Crem 6 5 0.58 5.93 1.51
132 INT28647 Binding of CTD 1 13 0.31 14.2 1.5
133 INT179693 Positive_regulation of DAK 2 14 0.04 6.02 1.4
134 INT268619 Phosphorylation of Pla2g4a 1 5 0.69 2.14 1.36
135 INT40771 Positive_regulation of Iars 1 6 0.36 2.1 1.33
136 INT202817 Gene_expression of Dag1 8 16 0.75 7.82 1.3
137 INT200266 Gene_expression of Ahrr 1 4 0.01 0.73 1.29
138 INT128752 Negative_regulation of Localization of Esr1 1 11 0.43 4.8 1.23
139 INT216103 Positive_regulation of Dmd 4 15 0.46 5.92 1.21
140 INT113398 Transcription of Pla2g2a 1 3 0.19 1.64 1.14
141 INT208536 Positive_regulation of Positive_regulation of Gsk3b 1 6 0.30 4.83 1.11
142 INT36451 Gene_expression of G6PD 1 26 0.75 7.2 1.09
143 INT211095 Negative_regulation of Dag1 3 14 0.57 7.18 1.07
144 INT231162 Localization of Dmd 7 6 0.71 2.27 1.07
145 INT115047 Regulation of Gene_expression of Crem 1 2 0.39 0.32 0.99
146 INT100171 Gene_expression of Utrn 6 17 0.75 3.93 0.98
147 INT116314 Gene_expression of Myod1 2 38 0.70 16.6 0.89
148 INT77928 Binding of Pla2g4a 1 3 0.10 2.5 0.84
149 INT192494 Binding of Crem 5 3 0.37 2.26 0.79
150 INT37113 Positive_regulation of Sult1a1 1 3 0.44 0.81 0.75
151 INT239494 Regulation of Localization of Esr1 1 4 0.19 1.15 0.72
152 INT232841 Gene_expression of Scap 1 11 0.02 8.68 0.7
153 INT286615 Phosphorylation of Ide 1 7 0.31 5.22 0.7
154 INT216104 Positive_regulation of Gene_expression of Dmd 3 23 0.46 4.52 0.68
155 INT283119 Regulation of Dag1 1 4 0.44 1.98 0.65
156 INT283110 Localization of Dag1 1 5 0.73 3.14 0.61
157 INT132484 Localization of Hrasls 1 3 0.17 1.5 0.6
158 INT312549 Binding of DAK 1 2 0.01 1.72 0.59
159 INT272575 Binding of Cacng2 5 3 0.36 0.54 0.58
160 INT200164 Binding of Dmd 6 5 0.42 2.35 0.56
161 INT210539 Binding of Ide 1 11 0.29 6.09 0.52
162 INT100172 Positive_regulation of Utrn 2 6 0.67 5.35 0.51
163 INT100167 Positive_regulation of Gene_expression of Utrn 1 3 0.67 1.31 0.5
164 INT37013 Negative_regulation of Sult1a1 1 3 0.57 0.35 0.48
165 INT273919 Positive_regulation of Positive_regulation of Crem 2 1 0.46 0.56 0.48
166 INT191968 Negative_regulation of Gene_expression of Ide 1 9 0.39 7.14 0.47
167 INT216108 Negative_regulation of Gene_expression of Dmd 3 12 0.45 1.32 0.46
168 INT207194 Regulation of Regulation of Creb1 1 2 0.45 1.09 0.46
169 INT312528 Binding of Spib 2 1 0.00 1.46 0.46
170 INT154748 Positive_regulation of Gene_expression of Hspa5 1 11 0.44 7.66 0.44
171 INT216105 Regulation of Gene_expression of Dmd 2 7 0.36 2.55 0.41
172 INT124256 Positive_regulation of Binding of Creb1 2 2 0.40 1.27 0.39
173 INT283120 Regulation of Gene_expression of Dag1 1 4 0.52 1.32 0.38
174 INT144582 Gene_expression of Shisa9 3 3 0.22 0.22 0.36
175 INT273912 Negative_regulation of Positive_regulation of Crem 1 1 0.43 0.95 0.36
176 INT192845 Negative_regulation of Positive_regulation of Esr1 1 2 0.35 1.15 0.31
177 INT287027 Gene_expression of Dtna 4 2 0.20 0.87 0.31
178 INT301723 Localization of Utrn 1 2 0.43 0.45 0.3
179 INT301730 Regulation of Negative_regulation of Dmd 1 1 0.40 0.28 0.3
180 INT287028 Positive_regulation of Dtna 1 3 0.11 1.16 0.29
181 INT264831 Regulation of Atf1 1 2 0.09 0.9 0.28
182 INT273918 Negative_regulation of Gene_expression of Crem 1 1 0.43 0.65 0.28
183 INT301726 Negative_regulation of Positive_regulation of Sult1a1 1 1 0.04 0.35 0.27
184 INT273924 Gene_expression of Jund 1 2 0.39 0.5 0.26
185 INT312524 Positive_regulation of Transcription of Pla2g2a 1 1 0.05 0.62 0.26
186 INT301753 Regulation of POMT1 1 5 0.44 2.41 0.25
187 INT307146 Gene_expression of G6pdx 1 2 0.24 1.7 0.24
188 INT119543 Gene_expression of Ttr 1 10 0.74 5.14 0.22
189 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 1 0.16 0.68 0.22
190 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 1 0.14 0.68 0.21
191 INT100168 Binding of Utrn 2 3 0.36 0.81 0.2
192 INT172021 Localization of Hspa5 1 2 0.18 0.93 0.2
193 INT312527 Negative_regulation of G6pdx 1 1 0.11 0.45 0.2
194 INT231152 Regulation of Dmd 2 9 0.47 3.64 0.19
195 INT273914 Regulation of Positive_regulation of Crem 2 1 0.39 0.42 0.19
196 INT273454 Gene_expression of Fat1 1 21 0.76 6.6 0.18
197 INT170513 Gene_expression of Cacng2 1 3 0.65 0.06 0.18
198 INT244270 Localization of GOLPH3 1 2 0.68 0.29 0.17
199 INT287026 Localization of Dtna 1 2 0.20 0.49 0.17
200 INT346726 Binding of Shisa9 2 1 0.14 0 0.17
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