J:NIDA Res. Monogr.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT24388 CRH Positive_regulation of Localization of POMC 8 1 0.51 5.67 3.35
2 INT31513 Crh Regulation of POMC 3 1 0.29 5.06 2.78
3 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 1 0.44 0 2.35
4 INT30954 Crh Negative_regulation of LH 5 1 0.46 1.4 2.06
5 INT29715 Crh Negative_regulation of Localization of LH 5 2 0.43 0 1.78
6 INT2457 Agt Positive_regulation of Localization of Avp 5 2 0.59 0.2 1.09
7 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 1 0.00 0.27 1
8 INT31494 Pomc Regulation of Crh 2 1 0.12 0.13 0.97
9 INT31495 Pomc Regulation of Localization of Gnrh1 2 1 0.04 0 0.86
10 INT5451 CRH Regulation of POMC 2 1 0.28 0.39 0.85
11 INT29323 Trmt2a Negative_regulation of Binding of Srms 1 1 0.00 0 0.84
12 INT29324 Trmt2a Negative_regulation of Binding of Pomc 1 1 0.00 0 0.71
13 INT32548 Pomc Positive_regulation of Regulation of Nts 1 1 0.14 0 0.41
14 INT32549 Grpr Positive_regulation of Regulation of Nts 1 1 0.03 0 0.41
15 INT32550 POMC Positive_regulation of Regulation of Nts 1 1 0.02 0 0.41
16 INT24187 Gnrh1 Negative_regulation of Penk 1 1 0.08 0 0.32
17 INT35216 Binding of KNG1 and Thop1 1 1 0.01 0 0.32
18 INT24185 Sst Negative_regulation of Penk 1 1 0.05 0 0.32
19 INT24186 Nts Negative_regulation of Penk 1 1 0.05 0 0.32
20 INT31507 FEM1B Positive_regulation of Localization of POMC 1 1 0.51 0 0.29
21 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 1 0.54 0 0.28
22 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 1 0.54 0 0.28
23 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 1 0.05 0 0.1
24 INT32547 Gsk3b Negative_regulation of Localization of LH 1 1 0.04 0 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 5 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 1 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 11 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
5 INT1045 Localization of LH 5 1211 0.81 87.04 456.25
6 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
7 INT1395 Negative_regulation of Penk 5 537 0.59 87.33 389.81
8 INT439 Localization of Gnrh1 5 976 0.81 100.96 363.25
9 INT5660 Binding of Oprd1 3 477 0.48 71.86 342.06
10 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
11 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
12 INT9131 Positive_regulation of Prkcg 2 431 0.70 130.8 302.41
13 INT477 Localization of Avp 5 813 0.81 131.58 300.4
14 INT1396 Binding of Penk 2 355 0.48 22.79 269.65
15 INT1562 Localization of Crh 2 499 0.81 126.74 236.68
16 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
17 INT6665 Gene_expression of FOS 2 520 0.77 165.31 217.66
18 INT9132 Negative_regulation of Prkcg 1 279 0.59 88.05 203.47
19 INT798 Positive_regulation of Gene_expression of Penk 1 394 0.70 78.53 203.07
20 INT1429 Gene_expression of PDYN 5 308 0.78 61.33 175.65
21 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
22 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
23 INT1303 Negative_regulation of Npr1 4 278 0.55 35.1 156.78
24 INT2640 Gene_expression of Pomc 2 424 0.78 120.72 155.37
25 INT1044 Negative_regulation of Localization of LH 3 358 0.59 25.95 151.31
26 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
27 INT2379 Positive_regulation of Localization of LH 1 349 0.70 27.86 144.53
28 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
29 INT5595 Positive_regulation of Pdyn 2 223 0.70 48.37 130.14
30 INT695 Binding of POMC 5 304 0.48 56.66 126.85
31 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
32 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
33 INT12569 Localization of Oprd1 2 94 0.81 23.81 104.56
34 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
35 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
36 INT293 Protein_catabolism of Penk 3 161 1.00 11.71 98.45
37 INT7944 Positive_regulation of Fos 1 193 0.70 60.69 98.31
38 INT2122 Negative_regulation of Localization of Gnrh1 4 226 0.59 26.92 92.04
39 INT6437 Binding of YY1 1 154 0.47 26.3 90.46
40 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
41 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
42 INT12536 Localization of Prkcg 6 101 0.80 36.37 73.81
43 INT7886 Regulation of Localization of Avp 2 146 0.62 14.53 72.99
44 INT5852 Gene_expression of Penk 2 167 0.78 44.44 71.13
45 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
46 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
47 INT462 Regulation of Pomc 3 157 0.62 41.67 67.27
48 INT1425 Gene_expression of Rbm39 2 143 0.58 51.32 65.44
49 INT480 Negative_regulation of Localization of Avp 3 151 0.59 27.64 63.72
50 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
51 INT12175 Positive_regulation of PDYN 1 86 0.69 18.27 62.04
52 INT1437 Negative_regulation of Pomc 2 132 0.59 35.22 60.97
53 INT5016 Negative_regulation of Crh 2 129 0.59 36.74 59.28
54 INT1510 Binding of PDYN 3 94 0.48 4.68 56.44
55 INT1463 Binding of Pomc 1 129 0.48 15.89 56.27
56 INT5770 Binding of Rbm39 2 88 0.41 13.23 55.5
57 INT2421 Positive_regulation of Positive_regulation of Penk 4 97 0.69 13.38 55.32
58 INT1486 Negative_regulation of Cpe 1 85 0.59 28.78 54.08
59 INT5509 Positive_regulation of Localization of Crh 1 91 0.70 30.65 53.92
60 INT771 Regulation of Nts 1 93 0.61 13.13 53.57
61 INT5704 Binding of Slc3a1 2 78 0.43 8.52 51.78
62 INT2604 Positive_regulation of Got1 2 223 0.70 154.78 49.51
63 INT10304 Binding of OPRK1 1 89 0.48 9.28 49.42
64 INT6823 Negative_regulation of Pdyn 4 68 0.58 13.95 46.12
65 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
66 INT11292 Gene_expression of Mme 1 77 0.78 20.98 35.85
67 INT12537 Positive_regulation of Localization of Prkcg 4 36 0.70 14.57 33.81
68 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
69 INT6762 Binding of Srms 1 56 0.31 6.62 30.27
70 INT15296 Regulation of Rbm39 1 45 0.29 10.66 29.27
71 INT5771 Binding of Oprd1 1 37 0.48 2.6 27.54
72 INT6382 Regulation of Binding of Oprd1 1 36 0.61 7 26.48
73 INT48979 Regulation of Gene_expression of FOS 1 52 0.61 14.4 25.95
74 INT29352 Negative_regulation of Oprd1 1 16 0.58 6.51 14.6
75 INT27266 Regulation of Gene_expression of Pomc 2 41 0.62 6.74 14.59
76 INT7057 Binding of FAIM3 1 19 0.48 4.02 13.78
77 INT1491 Regulation of Rtcd1 1 33 0.53 5.17 13.4
78 INT10433 Positive_regulation of Junb 1 35 0.70 6.55 12.42
79 INT47847 Negative_regulation of Localization of Prkcg 1 11 0.58 4.02 12.36
80 INT5630 Localization of Pdpk1 1 10 0.45 5.21 11.36
81 INT11205 Gene_expression of Prep 2 65 0.77 8.11 10.12
82 INT5854 Regulation of Gene_expression of Penk 2 22 0.61 6.91 10.03
83 INT2339 Positive_regulation of CB 1 30 0.29 10.68 9.12
84 INT15459 Gene_expression of TRH 1 17 0.78 4.89 8.17
85 INT25958 Regulation of Ace 1 26 0.59 11.88 7.87
86 INT32210 Gene_expression of Mif 1 13 0.75 28.48 7.79
87 INT6453 Negative_regulation of Binding of Slc3a1 1 9 0.19 0.81 7.3
88 INT1712 Positive_regulation of Negative_regulation of Penk 1 10 0.67 1.48 7.06
89 INT4208 Regulation of Got1 2 23 0.44 6.72 6.62
90 INT24191 Binding of VIP 1 14 0.40 2.16 6.2
91 INT1243 Regulation of ADRB2 1 16 0.54 1.84 5.66
92 INT12250 Negative_regulation of Mtr 1 19 0.50 6.9 5.35
93 INT15620 Positive_regulation of Negative_regulation of LH 1 13 0.69 2.23 5.08
94 INT29354 Regulation of Binding of OPRK1 1 7 0.60 1.72 5.04
95 INT17103 Negative_regulation of Prep 1 15 0.38 4.95 4.71
96 INT29326 Gene_expression of Calm1 1 17 0.67 3.71 4.53
97 INT24619 Regulation of Thop1 1 11 0.44 1.24 4.5
98 INT29327 Positive_regulation of Ace 1 13 0.67 8.79 4.33
99 INT2453 Positive_regulation of Apoa2 1 20 0.54 3.49 4.08
100 INT5299 Regulation of Tacr3 1 11 0.34 1.51 3.93
101 INT1542 Binding of Prss1 1 8 0.30 4.25 3.74
102 INT29356 Positive_regulation of Binding of YY1 1 8 0.67 0.22 3.49
103 INT6339 Negative_regulation of Ptpn6 1 6 0.14 0.71 3.44
104 INT29322 Negative_regulation of Srms 2 5 0.37 0.31 3.37
105 INT11616 Gene_expression of Thop1 1 10 0.74 0.32 3.34
106 INT29332 Gene_expression of Srms 1 7 0.06 1.21 3.26
107 INT29333 Positive_regulation of Enpep 1 8 0.70 3.22 3.25
108 INT22492 Binding of Enpep 1 10 0.47 0.7 3.2
109 INT6648 Positive_regulation of Atxn2l 1 5 0.07 0.52 2.8
110 INT29331 Positive_regulation of Srms 1 3 0.21 1.65 2.69
111 INT22339 Positive_regulation of Negative_regulation of Crh 2 5 0.67 1.36 2.59
112 INT15622 Positive_regulation of Negative_regulation of Gnrh1 1 4 0.46 1.13 2.27
113 INT29330 Positive_regulation of Thop1 1 6 0.46 1.05 1.8
114 INT35213 Binding of Nptxr 1 2 0.16 0.74 1.77
115 INT22397 Gene_expression of D5Nam12 1 3 0.47 0 1.55
116 INT24190 Binding of Psapl1 1 1 0.00 0 1.19
117 INT11204 Regulation of Gene_expression of Prep 1 11 0.60 1.01 1.12
118 INT32545 Localization of Gsk3b 1 9 0.07 2.88 1.11
119 INT63601 Regulation of Bok 1 1 0.05 0.17 0.97
120 INT35212 Negative_regulation of Atp2b1 1 1 0.51 0 0.96
121 INT17104 Gene_expression of Npvf 1 2 0.18 0.52 0.91
122 INT31551 Negative_regulation of Slc25a1 1 1 0.38 0.72 0.83
123 INT31512 Gene_expression of FEM1B 1 3 0.65 0.43 0.6
124 INT29300 Positive_regulation of Fads1 1 2 0.26 0.35 0.57
125 INT29353 Positive_regulation of Negative_regulation of Oprd1 1 1 0.39 0.36 0.56
126 INT23239 Positive_regulation of Regulation of Got1 1 2 0.10 0.27 0.54
127 INT32618 Regulation of Positive_regulation of Agt 1 2 0.43 0.42 0.52
128 INT35219 Protein_catabolism of Pyy 1 1 0.03 0.17 0.52
129 INT29334 Positive_regulation of Positive_regulation of Enpep 1 2 0.47 1.12 0.44
130 INT29305 Positive_regulation of Pt 1 6 0.37 0.73 0.27
131 INT29313 Regulation of Dtnb 1 1 0.32 0 0.27
132 INT35232 Regulation of Positive_regulation of Apoa2 1 1 0.48 0.18 0.05
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