J:Nat. Neurosci.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT151184 Pdpk1 Positive_regulation of Trpv1 1 1 0.08 0 0.42
2 INT151183 Pdpk1 Positive_regulation of Phosphorylation of Trpv1 1 1 0.08 0 0.42
3 INT139848 Binding of Bace1 and Bace2 2 1 0.28 0.31 0.18
4 INT139849 Binding of App and Bace1 7 1 0.41 0.85 0.13
5 INT150061 Binding of TRPV1 and Trpa1 1 1 0.24 0.1 0.13
6 INT139851 Binding of MBTPS1 and Bace2 1 1 0.00 0.16 0.1
7 INT139847 Binding of App and Bace2 1 1 0.03 0.16 0.1
8 INT139850 Binding of MBTPS1 and App 1 1 0.00 0.16 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
2 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
3 INT76660 Gene_expression of Trpv1 3 691 0.78 329.46 386.42
4 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
5 INT5540 Positive_regulation of Oprm1 1 344 0.70 76.77 319.71
6 INT2365 Positive_regulation of Cck 2 354 0.70 87.8 277.41
7 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
8 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
9 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
10 INT60126 Regulation of Trpv1 2 186 0.62 85.53 133.4
11 INT5595 Positive_regulation of Pdyn 2 223 0.70 48.37 130.14
12 INT1614 Gene_expression of Oprl1 1 164 0.78 31.43 127.74
13 INT6822 Gene_expression of Pdyn 1 215 0.78 35.99 125.76
14 INT5010 Gene_expression of Calca 2 197 0.78 85.76 118.75
15 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
16 INT92518 Gene_expression of Grin2b 3 131 0.78 65.52 80.91
17 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
18 INT24958 Gene_expression of Nkx1-1 1 106 0.74 51.29 76.88
19 INT25363 Negative_regulation of Trpv1 1 144 0.59 64.78 75.7
20 INT96622 Localization of Trpv1 1 110 0.81 59.82 63.25
21 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
22 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
23 INT109430 Positive_regulation of Trpa1 1 119 0.70 44 49.14
24 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
25 INT28265 Positive_regulation of Calca 1 62 0.70 29.1 41.17
26 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
27 INT8746 Negative_regulation of Calca 1 50 0.59 21.22 33.45
28 INT93451 Positive_regulation of Gene_expression of Grin2b 3 43 0.70 29.09 31.89
29 INT112707 Negative_regulation of Akt1 1 89 0.59 28.85 27.76
30 INT127499 Positive_regulation of TRPA1 3 72 0.70 21.7 26.86
31 INT122570 Negative_regulation of Akt1 1 173 0.59 91.44 25.53
32 INT127500 Gene_expression of TRPA1 1 79 0.78 24.58 23.3
33 INT89056 Phosphorylation of Trpv1 1 46 0.82 13.52 22.16
34 INT81210 Positive_regulation of PRKG1 1 71 0.70 26.83 19.89
35 INT62577 Negative_regulation of Creb1 2 55 0.59 19.68 18.1
36 INT73362 Negative_regulation of Abcb1a 1 46 0.59 8.78 17.81
37 INT94650 Gene_expression of Grm5 1 32 0.77 11.26 14.82
38 INT6278 Negative_regulation of Gene_expression of Pomc 1 35 0.59 11.07 14.8
39 INT61635 Positive_regulation of P2ry2 1 35 0.56 12.08 14.68
40 INT69311 Gene_expression of Scn10a 1 31 0.78 15.54 14.64
41 INT30438 Negative_regulation of Gene_expression of Pdyn 1 8 0.57 1.15 10.46
42 INT35284 Positive_regulation of Chrm1 1 14 0.67 5.64 10.11
43 INT81207 Positive_regulation of Lth1 6 10 0.35 5.22 9.81
44 INT89053 Positive_regulation of Phosphorylation of Trpv1 1 16 0.70 8.89 9.39
45 INT50055 Negative_regulation of Rac1 1 36 0.50 19.74 8.98
46 INT106522 Negative_regulation of Phosphorylation of Akt1 1 65 0.58 34.44 7.83
47 INT113705 Gene_expression of Egfr 1 228 0.78 149.05 7.59
48 INT71824 Phosphorylation of Pdpk1 1 14 0.38 4.9 6.86
49 INT94649 Gene_expression of Grm1 1 19 0.77 5.11 6.58
50 INT40962 Localization of Avp 2 40 0.80 20.5 6.38
51 INT67635 Negative_regulation of Gnas 2 29 0.04 11.4 6.32
52 INT85075 Phosphorylation of Mdk 1 22 0.61 10.29 5.55
53 INT70907 Negative_regulation of EDNRA 1 30 0.36 19.68 5.49
54 INT102202 Negative_regulation of Positive_regulation of Creb1 2 11 0.58 4.55 4.99
55 INT49060 Negative_regulation of Camk2a 1 10 0.45 2.59 4.67
56 INT137810 Regulation of Kcnk2 2 5 0.62 3.52 4.4
57 INT32205 Regulation of Positive_regulation of Trib3 1 9 0.11 2.82 4.1
58 INT81213 Binding of Gpm6a 1 6 0.35 0.72 3.87
59 INT41296 Protein_catabolism of Oprd1 1 8 0.85 0.79 3.48
60 INT131748 Binding of Csad 1 5 0.32 5.23 3.32
61 INT131978 Gene_expression of Trpc1 1 15 0.71 4.67 3.19
62 INT93936 Gene_expression of Pgp 1 10 0.59 3.43 3.04
63 INT131670 Gene_expression of Prlhr 4 5 0.78 3.1 2.94
64 INT140378 Negative_regulation of Irs2 2 4 0.57 1.77 2.86
65 INT81208 Negative_regulation of Positive_regulation of Lth1 4 5 0.28 1.01 2.78
66 INT99049 Positive_regulation of Hcn1 1 5 0.43 0.68 2.75
67 INT16025 Gene_expression of Lth1 1 6 0.40 1.89 2.5
68 INT81209 Negative_regulation of Lth1 1 3 0.28 0.97 1.94
69 INT48035 Positive_regulation of NT5C2 1 5 0.67 2.42 1.91
70 INT33400 Regulation of CDS1 1 8 0.29 5.12 1.79
71 INT81827 Positive_regulation of Kcnk2 2 7 0.70 0.42 1.79
72 INT73112 Negative_regulation of Kcnk3 1 7 0.58 1.2 1.55
73 INT81828 Positive_regulation of Kcnk3 2 7 0.45 1.43 1.54
74 INT131671 Negative_regulation of Prlhr 1 3 0.59 1.61 1.48
75 INT83606 Negative_regulation of Gene_expression of Scn10a 1 1 0.43 0.51 1.36
76 INT131977 Positive_regulation of Localization of Avp 1 6 0.55 4.9 1.31
77 INT50141 Gene_expression of Pgs1 1 3 0.49 0.09 1.27
78 INT101994 Positive_regulation of Nrg1 1 10 0.50 1.24 1.05
79 INT129577 Negative_regulation of Positive_regulation of P2ry2 1 4 0.29 0.45 1
80 INT93935 Negative_regulation of Gene_expression of Pgs1 1 1 0.06 0 0.95
81 INT81211 Transcription of Rac1 1 4 0.54 1.05 0.89
82 INT139846 Protein_catabolism of Nrg1 1 5 0.60 1.78 0.74
83 INT101155 Binding of AP1B1 1 2 0.36 0.13 0.56
84 INT81212 Negative_regulation of Transcription of Rac1 1 1 0.01 0 0.46
85 INT130985 Negative_regulation of Positive_regulation of Hcn1 1 1 0.15 0 0.41
86 INT130986 Positive_regulation of Positive_regulation of Hcn1 1 1 0.16 0 0.41
87 INT149780 Negative_regulation of Robo2 2 1 0.27 0.66 0.31
88 INT152712 Negative_regulation of Kcnk9 1 1 0.22 0.14 0.29
89 INT152711 Negative_regulation of Kcnk18 1 1 0.23 0.14 0.29
90 INT149779 Binding of Slit1 1 1 0.13 0.34 0.19
91 INT149776 Binding of Robo2 1 1 0.17 0.34 0.19
92 INT149777 Gene_expression of Slit1 1 1 0.28 0.33 0.16
93 INT149778 Gene_expression of Robo2 1 1 0.35 0.33 0.16
94 INT149781 Negative_regulation of Slit1 1 1 0.18 0.33 0.15
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