J:Naunyn Schmiedebergs Arch. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2714 Pomc Positive_regulation of Localization of Prl 17 2 0.79 0.5 8.18
2 INT1313 Pomc Positive_regulation of Prl 7 2 0.35 0 4.19
3 INT13969 Binding of Calca and Sst 3 2 0.32 0.6 4.02
4 INT69938 Cck Positive_regulation of Localization of Abat 2 3 0.29 0 3.78
5 INT37162 Binding of Calca and Cckar 1 2 0.04 0.55 3.01
6 INT69937 Cck Positive_regulation of Abat 2 2 0.31 0 2.88
7 INT96462 Pnoc Positive_regulation of Pag1 1 2 0.01 0.74 2.45
8 INT96465 Pnoc Positive_regulation of GEM 1 2 0.01 0.74 2.39
9 INT96461 Pnoc Positive_regulation of Oprm1 1 2 0.09 0.73 2.34
10 INT116815 Binding of Pias1 and Ppbp 1 3 0.36 0.86 1.92
11 INT34472 Penk Regulation of Slc3a1 2 1 0.03 0.42 1.74
12 INT79365 Pnoc Negative_regulation of Oprl1 2 1 0.41 0.16 1.72
13 INT101926 Binding of Dio1 and Drd2 4 1 0.28 0.39 1.66
14 INT34393 Oprd1 Negative_regulation of Adcy1 1 1 0.36 0 1.27
15 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 1 0.00 0 1.25
16 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 1 0.05 0.12 1.24
17 INT141244 Fos Regulation of Prkaca 1 1 0.18 0.07 1.24
18 INT34473 Pomc Regulation of Slc3a1 1 1 0.03 0.07 1.23
19 INT141245 Prkaca Regulation of Gene_expression of Th 1 1 0.15 0.17 1.17
20 INT141246 Trib3 Regulation of Gene_expression of Th 1 1 0.02 0.17 1.17
21 INT102570 Abat Regulation of Gene_expression of Penk 3 1 0.13 0 1.12
22 INT70495 CALCA Positive_regulation of CALCB 2 1 0.40 0 1.08
23 INT63543 Binding of Adra2a and Serpini1 1 1 0.13 0 1
24 INT34837 Maob Regulation of Negative_regulation of Mme 1 1 0.48 0.15 0.92
25 INT59396 Tead1 Negative_regulation of Negative_regulation of Man2a2 1 1 0.00 0 0.86
26 INT59395 Tead1 Negative_regulation of Man2a2 1 1 0.00 0 0.86
27 INT63544 Adra2a Regulation of Nisch 1 1 0.18 0 0.79
28 INT15344 Oprd1 Regulation of Localization of Tacr3 1 1 0.00 0 0.76
29 INT105809 ATP8A2 Positive_regulation of P2RX2 1 1 0.13 0.11 0.7
30 INT26230 Binding of GSR and HTR1D 1 2 0.12 0.15 0.69
31 INT26231 Binding of GSR and HTR1B 1 2 0.12 0.15 0.66
32 INT121272 PNOC Negative_regulation of Positive_regulation of TRPV1 1 1 0.27 0 0.66
33 INT31942 Binding of FCGR1A and Oprd1 1 1 0.00 0 0.62
34 INT14387 GAL Regulation of TAC1 1 1 0.10 0 0.56
35 INT24139 Gm8644 Positive_regulation of Dhps 1 1 0.22 0 0.51
36 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 1 0.04 0 0.49
37 INT86089 Foxm1 Regulation of Binding of Crygs 1 1 0.02 0 0.49
38 INT123808 Sst Regulation of Localization of Sstr2 1 1 0.41 0.55 0.46
39 INT12498 Pyy Positive_regulation of Npy 1 1 0.39 0 0.43
40 INT77585 Binding of Htr1a and Ptprg 1 1 0.01 0 0.42
41 INT77584 Negative_regulation of Binding of Htr1a and Ptprg 1 1 0.01 0 0.42
42 INT7625 Man2a2 Regulation of Th 1 1 0.01 0.07 0.4
43 INT109683 NOS1 Positive_regulation of Positive_regulation of ISYNA1 1 1 0.01 0.11 0.38
44 INT77587 Binding of HTR1A and Htr1a 1 1 0.05 0 0.38
45 INT60817 Binding of Sstr1 and Bcl2l11 1 1 0.06 0 0.37
46 INT123807 Binding of Sst and Sstr2 1 1 0.33 0.3 0.36
47 INT109894 Drd2 Positive_regulation of FOS 1 1 0.01 0 0.33
48 INT26235 Binding of GSR and Htr1a 1 1 0.12 0.09 0.31
49 INT23810 Slc47a2 Positive_regulation of Positive_regulation of Itpka 1 1 0.05 0 0.29
50 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 1 0.13 0 0.28
51 INT66682 SFTPA1 Positive_regulation of Localization of B3GAT1 1 1 0.19 0.07 0.24
52 INT66681 Positive_regulation of HTR2A Positive_regulation of Localization of SFTPA1 1 1 0.22 0.07 0.24
53 INT115875 Col5a1 Positive_regulation of Localization of Gcg 1 1 0.08 0 0.23
54 INT89238 Positive_regulation of RUNX1 Positive_regulation of Positive_regulation of CA2 1 1 0.01 0 0.22
55 INT148345 Binding of Drd3 and Adra1a 1 1 0.18 0.12 0.21
56 INT30071 Gm8212 Regulation of Pde3a 1 1 0.00 0 0.2
57 INT76196 Binding of HTR1A and EIF2B3 1 2 0.06 0 0.17
58 INT30068 Tead1 Positive_regulation of Localization of Avp 1 1 0.04 0 0.16
59 INT5737 Hk1 Positive_regulation of Ca2 1 1 0.06 0.16 0.16
60 INT36712 Cd2 Regulation of Localization of Avp 1 1 0.44 0 0.08
61 INT36713 Cd2 Positive_regulation of Avp 1 1 0.26 0 0.08
62 INT84196 Binding of MAOA and FOXI2 1 1 0.03 0 0.05
63 INT84197 Binding of MAOA and NISCH 1 1 0.02 0 0.05
64 INT76195 Binding of HTR1A and HTR1B 1 1 0.40 0 0.04
65 INT57107 Binding of Msh2 and Nts 1 1 0.22 0.22 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 13 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 43 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 6 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 7 2431 0.81 378.96 952.2
5 INT1912 Gene_expression of Calca 12 1152 0.78 453.25 739.84
6 INT3439 Localization of Abat 36 1017 0.78 112.39 727.06
7 INT5202 Positive_regulation of Gene_expression of Fos 12 1163 0.70 319.28 684
8 INT292 Localization of Penk 3 876 0.81 88.44 669.14
9 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
10 INT728 Positive_regulation of Penk 6 1068 0.70 186.9 636.87
11 INT2543 Positive_regulation of Calca 14 787 0.70 331.13 592.08
12 INT797 Regulation of Penk 8 812 0.62 111.13 542.24
13 INT5228 Positive_regulation of Fos 3 934 0.70 209.8 503.87
14 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
15 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
16 INT4758 Positive_regulation of Localization of Calca 9 557 0.70 138.55 411.04
17 INT64202 Positive_regulation of Trpv1 7 643 0.70 249.66 397.42
18 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
19 INT76660 Gene_expression of Trpv1 3 691 0.78 329.46 386.42
20 INT2540 Negative_regulation of Calca 12 538 0.59 172.11 384.38
21 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
22 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
23 INT157 Positive_regulation of Localization of Prl 5 790 0.70 104.54 374.78
24 INT287 Localization of Cck 5 518 0.81 86.84 364.04
25 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
26 INT5660 Binding of Oprd1 3 477 0.48 71.86 342.06
27 INT2649 Regulation of Calca 14 433 0.62 146.05 330.95
28 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
29 INT5979 Gene_expression of Oprd1 3 428 0.78 75.64 320.32
30 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
31 INT5680 Gene_expression of Ngf 1 530 0.78 264.29 310.56
32 INT4941 Positive_regulation of Oprd1 6 345 0.70 74.26 304.41
33 INT477 Localization of Avp 11 813 0.81 131.58 300.4
34 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
35 INT1352 Localization of Acot1 15 728 0.80 73.01 296.01
36 INT5379 Gene_expression of Fos 6 656 0.78 255.5 292.54
37 INT3579 Localization of Oxt 14 555 0.81 43.35 292.44
38 INT2365 Positive_regulation of Cck 1 354 0.70 87.8 277.41
39 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
40 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
41 INT1396 Binding of Penk 3 355 0.48 22.79 269.65
42 INT5591 Regulation of Gene_expression of Fos 4 425 0.62 129.06 265.78
43 INT2909 Positive_regulation of Abat 8 334 0.70 62.1 256.43
44 INT3948 Regulation of Cck 4 291 0.62 58.07 255.88
45 INT5501 Regulation of Oprd1 5 283 0.62 55.1 249.9
46 INT1005 Localization of Sst 6 385 0.81 26.31 244.56
47 INT1902 Gene_expression of Cck 1 348 0.78 70.33 241.92
48 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
49 INT4759 Negative_regulation of Localization of Calca 10 294 0.59 82.62 226.45
50 INT9987 Gene_expression of Abat 4 296 0.78 95.46 226.34
51 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
52 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
53 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
54 INT6665 Gene_expression of FOS 3 520 0.77 165.31 217.66
55 INT1308 Localization of Pomc 3 457 0.81 66.83 217.5
56 INT2651 Positive_regulation of Pomc 2 403 0.70 95.72 206.24
57 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
58 INT798 Positive_regulation of Gene_expression of Penk 3 394 0.70 78.53 203.07
59 INT2211 Negative_regulation of Abat 13 267 0.59 66.51 200.98
60 INT6354 Localization of Gabrg1 2 321 0.74 41.41 186.74
61 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
62 INT3440 Negative_regulation of Localization of Abat 3 221 0.57 33.94 180.36
63 INT943 Negative_regulation of Cck 1 205 0.59 38.42 174.78
64 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
65 INT159 Negative_regulation of Localization of Prl 3 416 0.59 55.34 171.8
66 INT4937 Negative_regulation of Oprd1 2 224 0.59 44.51 171.11
67 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
68 INT1114 Localization of Ins1 6 748 0.80 192.95 165.48
69 INT4768 Positive_regulation of OPRM1 1 212 0.70 31.09 164.28
70 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
71 INT5513 Negative_regulation of Pomc 2 295 0.59 60.9 158.63
72 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
73 INT21185 Binding of Ptprg 3 213 0.47 13.49 157.75
74 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
75 INT1303 Negative_regulation of Npr1 5 278 0.55 35.1 156.78
76 INT2640 Gene_expression of Pomc 2 424 0.78 120.72 155.37
77 INT6042 Binding of Oprm1 3 248 0.48 31.77 154.34
78 INT4740 Gene_expression of Th 3 298 0.78 61.27 154.03
79 INT2910 Regulation of Abat 3 169 0.62 36.95 153.53
80 INT4829 Positive_regulation of Localization of Abat 6 199 0.55 20.91 150.48
81 INT5050 Regulation of Localization of Calca 3 149 0.62 41.25 148.57
82 INT2451 Positive_regulation of Avp 4 355 0.70 102.66 147.69
83 INT1033 Positive_regulation of Ca2 4 507 0.68 131.76 147.64
84 INT812 Localization of INS 5 1026 0.81 515.6 145.31
85 INT3300 Positive_regulation of Gene_expression of Calca 4 179 0.70 77.76 144.2
86 INT2780 Regulation of Gene_expression of Penk 2 265 0.62 32.45 143.88
87 INT1414 Regulation of Oprl1 2 169 0.62 32.05 139.99
88 INT14843 Gene_expression of Gabrg1 1 301 0.77 62.63 139.16
89 INT2867 Gene_expression of CALCA 7 247 0.78 78.78 138.47
90 INT5061 Negative_regulation of Mme 3 306 0.59 51.97 136.9
91 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
92 INT60126 Regulation of Trpv1 5 186 0.62 85.53 133.4
93 INT11012 Positive_regulation of Creb1 1 258 0.70 84.4 132
94 INT5497 Positive_regulation of Crh 2 299 0.70 125.54 131.14
95 INT5380 Positive_regulation of Gene_expression of Fos 4 243 0.70 105.65 131.05
96 INT5931 Regulation of Oprm1 2 149 0.62 18.15 125.93
97 INT6822 Gene_expression of Pdyn 1 215 0.78 35.99 125.76
98 INT6323 Positive_regulation of Gabrg1 2 213 0.70 45.08 124.34
99 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
100 INT4259 Positive_regulation of Npr1 8 262 0.70 49.37 123.11
101 INT218 Positive_regulation of Th 7 245 0.70 40.5 120.1
102 INT64201 Negative_regulation of Trpv1 1 203 0.59 79.18 119.75
103 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
104 INT4207 Regulation of Avp 5 267 0.62 63.72 115.33
105 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
106 INT90 Localization of Gast 1 400 0.81 137.67 113
107 INT49651 Gene_expression of Creb1 1 276 0.78 114.77 111.96
108 INT7327 Regulation of Th 6 164 0.62 29.67 110.14
109 INT65731 Gene_expression of Cnr1 1 234 0.78 63.82 109.34
110 INT5283 Positive_regulation of Npy 2 191 0.70 66.77 109.2
111 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
112 INT47243 Gene_expression of Prkcg 1 195 0.78 58.05 108.44
113 INT4936 Localization of Tacr1 3 125 0.80 35.7 107.7
114 INT9012 Localization of Vip 6 283 0.81 31.71 106.16
115 INT12569 Localization of Oprd1 4 94 0.81 23.81 104.56
116 INT114 Binding of Oprl1 4 139 0.48 23 103.35
117 INT1898 Regulation of Crh 5 220 0.62 61.33 102.64
118 INT5940 Negative_regulation of Avp 3 236 0.59 67.86 101.2
119 INT52651 Positive_regulation of Prkaca 1 136 0.67 40.82 99.16
120 INT4860 Positive_regulation of CALCA 3 148 0.00 73.35 97.61
121 INT17459 Positive_regulation of Gene_expression of FOS 3 182 0.67 53.45 96.38
122 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
123 INT1004 Regulation of Sst 2 140 0.62 18.52 94.84
124 INT2862 Positive_regulation of Localization of Cck 1 108 0.70 20.75 94.25
125 INT1281 Negative_regulation of Maoa 24 203 0.59 22.47 91.66
126 INT69764 Positive_regulation of Cnr1 1 126 0.70 67.8 91.49
127 INT9516 Negative_regulation of Gabrg1 1 149 0.53 27.83 91.02
128 INT6437 Binding of YY1 1 154 0.47 26.3 90.46
129 INT1160 Positive_regulation of Rbm39 3 122 0.57 28.19 90.28
130 INT6214 Negative_regulation of Adarb1 1 123 0.50 26.39 89.57
131 INT1635 Gene_expression of Vip 1 245 0.78 53.36 88.13
132 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
133 INT7885 Positive_regulation of Localization of Oxt 3 160 0.70 14.36 87.7
134 INT3441 Regulation of Localization of Abat 4 117 0.38 8.67 87.59
135 INT1472 Positive_regulation of Ins1 5 349 0.69 146.2 86.36
136 INT2149 Positive_regulation of Oxt 3 181 0.70 24.8 85.43
137 INT4857 Regulation of Tacr1 2 115 0.62 39.01 84.52
138 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
139 INT2520 Negative_regulation of Ca2 3 271 0.57 72.13 83.71
140 INT5590 Negative_regulation of Fos 1 144 0.59 40.94 81.98
141 INT6107 Localization of Npy 7 180 0.81 26.76 81.67
142 INT3214 Localization of Ins1 9 527 0.80 196.9 79.26
143 INT2431 Positive_regulation of Mpo 8 275 0.70 211.99 78.47
144 INT4358 Positive_regulation of Localization of Avp 2 195 0.70 30.79 77.58
145 INT17546 Negative_regulation of Ngf 1 135 0.59 60.28 77.19
146 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
147 INT24958 Gene_expression of Nkx1-1 1 106 0.74 51.29 76.88
148 INT25363 Negative_regulation of Trpv1 2 144 0.59 64.78 75.7
149 INT16654 Gene_expression of Insrr 2 138 0.46 58.96 75.68
150 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
151 INT98621 Regulation of Trpv1 1 121 0.62 79.24 75.23
152 INT1353 Negative_regulation of Localization of Acot1 5 153 0.53 15.05 75.17
153 INT7886 Regulation of Localization of Avp 4 146 0.62 14.53 72.99
154 INT3034 Localization of Ngf 1 126 0.81 50.81 72.84
155 INT49111 Negative_regulation of Prkaca 1 102 0.59 27.44 71.77
156 INT15913 Negative_regulation of CYP2D6 2 174 0.59 22.45 70.91
157 INT66416 Regulation of Pnoc 2 66 0.61 17.32 68.91
158 INT1988 Positive_regulation of Localization of Ins1 3 254 0.69 59.25 68.37
159 INT7344 Gene_expression of TAC1 5 132 0.75 35.48 68.26
160 INT4637 Binding of Adarb1 2 132 0.41 14.48 67.76
161 INT8388 Positive_regulation of Vip 1 142 0.70 39.72 67.61
162 INT65733 Positive_regulation of Cnr1 1 125 0.70 40.27 67.33
163 INT7468 Negative_regulation of Localization of Oxt 1 109 0.59 9.46 66.79
164 INT1603 Negative_regulation of Rtcd1 2 131 0.51 29.99 66.66
165 INT6176 Positive_regulation of Htr1a 7 117 0.67 28.23 66.17
166 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
167 INT480 Negative_regulation of Localization of Avp 1 151 0.59 27.64 63.72
168 INT7280 Positive_regulation of Localization of Sst 1 97 0.70 5.64 63.37
169 INT6894 Gene_expression of CNR1 1 168 0.78 74.07 62.84
170 INT217 Negative_regulation of Th 2 134 0.59 26.83 62.63
171 INT6761 Binding of CALCA 1 100 0.48 26.71 62.05
172 INT8363 Localization of Nts 1 135 0.81 14.29 61.71
173 INT7884 Regulation of Localization of Oxt 3 102 0.62 7.95 61.71
174 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
175 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
176 INT1430 Regulation of PDYN 2 88 0.60 16.99 60.32
177 INT546 Binding of ALB 1 311 0.48 85.98 60.14
178 INT65078 Negative_regulation of Pnoc 6 64 0.59 15.48 59.81
179 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
180 INT6623 Gene_expression of NA 1 231 0.78 45.78 59.36
181 INT3920 Localization of Ldha 2 241 0.81 83.08 58.72
182 INT1307 Positive_regulation of Localization of Pomc 2 120 0.70 24.58 58.48
183 INT5819 Regulation of Localization of Penk 2 64 0.62 6.69 57.68
184 INT5017 Negative_regulation of Tacr1 1 76 0.58 17 57.07
185 INT2148 Negative_regulation of Oxt 3 105 0.59 11.42 57
186 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
187 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
188 INT1463 Binding of Pomc 2 129 0.48 15.89 56.27
189 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
190 INT31186 Negative_regulation of Insrr 2 81 0.37 24.91 55.94
191 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
192 INT8528 Negative_regulation of Gene_expression of Fos 1 100 0.59 41.15 55.6
193 INT314 Positive_regulation of Ren 3 212 0.70 66.68 55.56
194 INT2421 Positive_regulation of Positive_regulation of Penk 2 97 0.69 13.38 55.32
195 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
196 INT49436 Binding of TRPV1 1 145 0.48 38.35 55.08
197 INT1486 Negative_regulation of Cpe 1 85 0.59 28.78 54.08
198 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
199 INT4891 Transcription of Calca 2 81 0.72 35.27 53.75
200 INT7800 Localization of Pag1 1 51 0.56 33.06 53.74
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