J:Neuroimmunomodulation

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT62450 Il2 Positive_regulation of Localization of Crh 1 5 0.43 0.59 2.64
2 INT117821 Binding of Tacr1 and Cd4 1 2 0.34 0.86 2.02
3 INT62448 Il2 Positive_regulation of Crh 1 3 0.59 0.36 1.3
4 INT5518 Pomc Negative_regulation of Crh 2 2 0.36 0.42 1.26
5 INT134971 Positive_regulation of OPRK1 Positive_regulation of Binding of OPRK1 and SP1 1 1 0.00 0 1.07
6 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 1 0.00 0 1.05
7 INT134969 Binding of OPRK1 and SP1 1 1 0.00 0 1.04
8 INT31494 Pomc Regulation of Crh 2 1 0.12 0.13 0.97
9 INT62449 Gnrh1 Regulation of Crh 1 2 0.40 0.34 0.91
10 INT85489 IRF6 Negative_regulation of PLOD1 1 1 0.01 0.16 0.61
11 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 1 0.01 0.16 0.61
12 INT62461 Pomc Regulation of Il2 Positive_regulation of Crh 1 1 0.12 0.13 0.6
13 INT62445 Pomc Negative_regulation of Localization of Crh 1 1 0.12 0.07 0.58
14 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 1 0.05 0.76 0.57
15 INT85487 IL1RN Negative_regulation of IL1R1 1 1 0.02 0 0.57
16 INT70925 Binding of Ifng and Il4 2 1 0.14 0.9 0.5
17 INT62446 Il6 Positive_regulation of Crh 1 1 0.22 0.05 0.5
18 INT62447 Gnrh1 Regulation of Localization of Crh 1 1 0.40 0.17 0.45
19 INT100091 Tlr4 Regulation of Localization of Tnf 1 1 0.01 0.42 0.37
20 INT70924 Binding of Il2 and Il4 1 1 0.07 0.34 0.36
21 INT62451 Il2 Regulation of Localization of Crh 1 2 0.53 0.19 0.2
22 INT100089 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 1 0.01 0 0
23 INT105009 Binding of IFNA1 and Oprm1 1 1 0.01 0 0
24 INT100087 Negative_regulation of Prl Positive_regulation of Localization of Tnf 1 1 0.17 0 0
25 INT134563 Cpe Positive_regulation of Gene_expression of Ifng 1 1 0.39 0 0
26 INT100088 Tlr4 Positive_regulation of Tnf 1 2 0.01 0 0
27 INT134560 Cpe Negative_regulation of Gene_expression of Il2 1 1 0.17 0 0
28 INT134562 Cpe Regulation of Gene_expression of Ifng 1 2 0.30 0 0
29 INT134561 Cpe Negative_regulation of Gene_expression of Il4 1 1 0.11 0 0
30 INT100090 Tlr4 Positive_regulation of Localization of Tnf 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 5 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 3 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
4 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
5 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
6 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
7 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
8 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
9 INT443 Localization of POMC 4 1020 0.81 284.52 443.17
10 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
11 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
12 INT6056 Negative_regulation of Gene_expression of Fos 2 601 0.59 193.05 386.84
13 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
14 INT439 Localization of Gnrh1 5 976 0.81 100.96 363.25
15 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
16 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
17 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
18 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
19 INT5979 Gene_expression of Oprd1 1 428 0.78 75.64 320.32
20 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
21 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
22 INT11624 Gene_expression of OPRM1 2 445 0.78 72.36 294.36
23 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
24 INT16868 Gene_expression of Il6 7 807 0.78 499.48 256.57
25 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
26 INT1562 Localization of Crh 15 499 0.81 126.74 236.68
27 INT6665 Gene_expression of FOS 2 520 0.77 165.31 217.66
28 INT1308 Localization of Pomc 2 457 0.81 66.83 217.5
29 INT4893 Gene_expression of Tacr1 8 366 0.78 129.67 213.92
30 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
31 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
32 INT11313 Positive_regulation of Il6 9 526 0.70 331.27 201.59
33 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
34 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
35 INT5930 Positive_regulation of Oprm1 1 221 0.70 31.19 172.93
36 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
37 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
38 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
39 INT2640 Gene_expression of Pomc 2 424 0.78 120.72 155.37
40 INT13353 Positive_regulation of Tnf 13 332 0.70 248.75 148.1
41 INT2780 Regulation of Gene_expression of Penk 1 265 0.62 32.45 143.88
42 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
43 INT5497 Positive_regulation of Crh 3 299 0.70 125.54 131.14
44 INT695 Binding of POMC 1 304 0.48 56.66 126.85
45 INT4824 Positive_regulation of Tacr1 2 169 0.70 66.1 123.46
46 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
47 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
48 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
49 INT1438 Localization of Pomc 2 360 0.81 101.26 116.47
50 INT1793 Localization of CGA 1 379 0.81 67.38 114.69
51 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
52 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
53 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
54 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
55 INT1898 Regulation of Crh 2 220 0.62 61.33 102.64
56 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
57 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
58 INT293 Protein_catabolism of Penk 1 161 1.00 11.71 98.45
59 INT56130 Gene_expression of MC1R 1 259 0.78 62.7 97.55
60 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
61 INT48408 Gene_expression of ICAM1 3 494 0.78 340.08 88.6
62 INT4857 Regulation of Tacr1 4 115 0.62 39.01 84.52
63 INT920 Localization of PLOD1 5 223 0.81 42.25 78.7
64 INT2431 Positive_regulation of Mpo 6 275 0.70 211.99 78.47
65 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
66 INT5969 Gene_expression of Il1a 2 221 0.75 96.31 71.38
67 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
68 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
69 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
70 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
71 INT7534 Gene_expression of Ifng 8 193 0.78 111.02 68.6
72 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
73 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
74 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
75 INT10706 Regulation of Il6 4 150 0.62 93.23 62.34
76 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
77 INT5016 Negative_regulation of Crh 4 129 0.59 36.74 59.28
78 INT6477 Gene_expression of IL1RN 3 213 0.77 114.69 58.62
79 INT1307 Positive_regulation of Localization of Pomc 1 120 0.70 24.58 58.48
80 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
81 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
82 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
83 INT5509 Positive_regulation of Localization of Crh 2 91 0.70 30.65 53.92
84 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
85 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
86 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
87 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
88 INT29105 Positive_regulation of OPRK1 1 68 0.70 7.06 44.69
89 INT5307 Regulation of Tnf 2 87 0.62 78.71 43.4
90 INT52531 Gene_expression of Nfkb1 1 153 0.75 82.84 42.9
91 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
92 INT2782 Regulation of Gene_expression of Pomc 1 75 0.62 15.04 38.97
93 INT4925 Binding of Tacr1 3 57 0.48 17.39 38.38
94 INT7675 Gene_expression of ENG 1 146 0.77 45.35 34.6
95 INT6302 Binding of IFNA1 4 196 0.48 133.85 32.73
96 INT913 Regulation of Localization of PLOD1 3 71 0.62 8.64 32.72
97 INT5505 Regulation of Localization of Pomc 1 54 0.61 6.96 30.77
98 INT7975 Regulation of PLOD1 2 97 0.62 20.9 30.51
99 INT5507 Regulation of Localization of Crh 2 57 0.61 8.43 30.26
100 INT5514 Negative_regulation of Localization of Crh 2 64 0.58 8.12 29.29
101 INT12751 Gene_expression of Pigm 1 91 0.58 22.42 29.2
102 INT16879 Binding of Crh 2 72 0.48 21.65 28.43
103 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
104 INT8881 Regulation of Gene_expression of Tacr1 3 38 0.61 17.49 27.19
105 INT9647 Gene_expression of PROC 1 163 0.65 89.76 26.75
106 INT1638 Negative_regulation of PLOD1 3 92 0.59 21.69 26.61
107 INT5966 Localization of Il1a 1 50 0.78 22.91 26.54
108 INT69036 Gene_expression of IL18 1 99 0.77 77.92 25.95
109 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
110 INT6115 Positive_regulation of Pigm 2 82 0.64 16.96 25.73
111 INT5948 Regulation of Il1b 2 44 0.60 22.8 25.4
112 INT15511 Gene_expression of Tnfrsf1a 1 84 0.76 63.3 24.03
113 INT7113 Negative_regulation of Localization of CGA 2 71 0.51 17.7 23.42
114 INT14506 Regulation of Sst 1 46 0.62 15.02 22.66
115 INT12114 Positive_regulation of Tnfrsf1a 1 46 0.69 36.26 22.54
116 INT66753 Negative_regulation of Positive_regulation of Tnf 2 45 0.59 35.28 22.33
117 INT78057 Localization of Tlr4 6 140 0.77 67.75 21.72
118 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
119 INT63340 Positive_regulation of Gene_expression of ICAM1 3 109 0.70 90.82 20.61
120 INT14701 Negative_regulation of IFNA1 1 118 0.54 84.19 20.08
121 INT66751 Negative_regulation of Localization of Tnf 3 48 0.59 26 19.36
122 INT19509 Localization of Ifng 1 55 0.78 28.25 18.67
123 INT11628 Regulation of Localization of Pomc 1 44 0.61 10.46 18.66
124 INT35086 Positive_regulation of Gene_expression of Ifng 1 40 0.69 22.55 18.35
125 INT3118 Negative_regulation of Positive_regulation of POMC 1 33 0.59 9.42 18.07
126 INT112017 Regulation of Hand2 1 77 0.36 62.23 18.04
127 INT1642 Negative_regulation of Localization of PLOD1 3 40 0.58 10.67 17.95
128 INT1767 Positive_regulation of PROC 3 83 0.67 54.14 17
129 INT10169 Positive_regulation of Localization of Tnf 2 44 0.70 27.71 16.75
130 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
131 INT104045 Regulation of Hand1 1 65 0.35 51.32 16.26
132 INT50932 Positive_regulation of Positive_regulation of Il6 1 36 0.69 24.9 16.12
133 INT14887 Gene_expression of Mbp 2 55 0.75 36.13 16.11
134 INT25517 Regulation of NFKB1 2 41 0.61 22.28 16.09
135 INT9220 Gene_expression of Ighg1 1 125 0.77 85.74 15.92
136 INT49532 Regulation of Gene_expression of Il6 1 43 0.61 25.8 14.99
137 INT49606 Gene_expression of Il1rn 1 30 0.66 15.78 14.82
138 INT27266 Regulation of Gene_expression of Pomc 1 41 0.62 6.74 14.59
139 INT16919 Gene_expression of IL36RN 1 48 0.48 32.78 13.83
140 INT36177 Binding of Alms1 1 70 0.31 35.47 13.81
141 INT64048 Positive_regulation of Positive_regulation of Tnf 2 32 0.70 21.24 13.74
142 INT76863 Negative_regulation of Gene_expression of OPRM1 1 21 0.57 6.56 13.69
143 INT7532 Negative_regulation of Gene_expression of Ifng 2 33 0.59 18.56 13.14
144 INT20381 Localization of Il2 1 71 0.77 34.23 13.03
145 INT3521 Regulation of Csf2 2 38 0.54 11.09 12.73
146 INT12992 Negative_regulation of Gene_expression of Ptgs1 2 33 0.42 20.47 11.77
147 INT19527 Negative_regulation of Gene_expression of Il1a 2 26 0.51 15.4 11.58
148 INT52625 Regulation of IL1RN 1 30 0.61 19.12 11.31
149 INT9945 Negative_regulation of Csf2 1 35 0.51 17.85 11.22
150 INT14334 Negative_regulation of Il2 1 31 0.58 18.63 11.08
151 INT87863 Positive_regulation of IL18 1 40 0.69 34.08 9.53
152 INT48860 Regulation of Localization of Tnf 2 25 0.61 20.68 8.78
153 INT7924 Negative_regulation of Pigm 1 25 0.40 4.51 8.51
154 INT62452 Regulation of Il2 1 14 0.61 12.11 7.64
155 INT18524 Regulation of Gene_expression of IFNA1 1 37 0.44 18.79 7.62
156 INT19475 Positive_regulation of IL1A 1 20 0.67 17.99 7.57
157 INT39417 Gene_expression of Fcer2a 1 65 0.76 32.1 7.37
158 INT25385 Positive_regulation of Localization of Il2 1 17 0.45 9.53 6.45
159 INT2925 Positive_regulation of Positive_regulation of Mpo 2 21 0.70 16.76 6.36
160 INT60161 Gene_expression of EPHA3 1 43 0.75 3.66 6.25
161 INT3520 Binding of Csf2 2 27 0.43 9.68 6.08
162 INT12066 Localization of Il2 2 16 0.75 3.06 5.7
163 INT63395 Regulation of Regulation of Tacr1 2 6 0.45 2.26 5.39
164 INT1843 Positive_regulation of Hrasls 2 16 0.69 2.16 5.08
165 INT59320 Transcription of Il2 1 32 0.69 6.39 4.95
166 INT44805 Positive_regulation of Mthfs 1 9 0.49 2.32 4.48
167 INT94466 Regulation of Gene_expression of Hand2 1 14 0.28 7.97 4.46
168 INT116011 Positive_regulation of Gata3 1 5 0.31 3.17 4.21
169 INT28544 Regulation of Gene_expression of Pigm 1 6 0.24 1.04 3.96
170 INT70919 Binding of Il4 1 19 0.36 6.58 3.59
171 INT83646 Binding of Il1rn 2 12 0.37 4.41 3.51
172 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 1 6 0.69 3.93 3.42
173 INT81403 Positive_regulation of Regulation of Il6 2 4 0.44 1.81 3.37
174 INT65427 Regulation of Positive_regulation of Tnf 1 7 0.60 3.49 3.22
175 INT17562 Negative_regulation of Lipg 1 32 0.51 16.91 3.17
176 INT15837 Binding of CGA 2 31 0.41 12.06 3.17
177 INT64437 Gene_expression of IL1R1 1 9 0.65 6.22 2.99
178 INT94463 Regulation of Gene_expression of Hand1 1 10 0.36 5.17 2.72
179 INT15197 Regulation of Gene_expression of Ifng 1 8 0.34 2.66 2.69
180 INT22339 Positive_regulation of Negative_regulation of Crh 2 5 0.67 1.36 2.59
181 INT62064 Negative_regulation of Gene_expression of Il1rn 2 6 0.32 4.81 2.53
182 INT100086 Negative_regulation of Localization of Tlr4 2 15 0.37 5.92 2.47
183 INT49930 Binding of Ighg1 1 21 0.37 13.27 2.43
184 INT73980 Transcription of Ifng 1 12 0.72 5.42 2.4
185 INT70918 Positive_regulation of Localization of Ifng 1 5 0.45 2.79 2.33
186 INT66804 Negative_regulation of Negative_regulation of Tnf 1 4 0.56 2.79 2.26
187 INT87497 Positive_regulation of Cadps 1 2 0.22 1.77 2.19
188 INT16461 Negative_regulation of Gene_expression of PROC 1 13 0.24 4.39 2.17
189 INT17688 Positive_regulation of IKZF1 1 5 0.50 0.48 2.11
190 INT56368 Gene_expression of Hspa1a 1 6 0.75 3.76 2.07
191 INT112015 Negative_regulation of Regulation of Hand1 1 5 0.33 3.48 2.05
192 INT89308 Positive_regulation of Binding of IFNA1 1 12 0.49 10.64 2.04
193 INT85492 Localization of IL1R1 1 6 0.72 2.44 1.85
194 INT77368 Regulation of Regulation of Il6 1 3 0.35 1.86 1.45
195 INT62455 Positive_regulation of Positive_regulation of Hrasls 1 3 0.44 0.55 1.42
196 INT128003 Negative_regulation of Gene_expression of MC1R 1 4 0.59 1.56 1.41
197 INT53775 Gene_expression of Hspd1 1 21 0.78 31.25 1.38
198 INT29986 Binding of Fcer2a 1 9 0.27 4.34 1.38
199 INT87498 Regulation of Cadps 1 1 0.23 0.28 1.34
200 INT60741 Regulation of Positive_regulation of IFNA1 1 9 0.16 6.98 1.24
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