J:Neuropsychopharmacology

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT131249 Binding of Bdnf and Ntrk2 11 2 0.41 4 6.25
2 INT18593 Binding of Sst and Fdft1 2 1 0.11 0.08 2.12
3 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 1 0.13 0 1.46
4 INT141676 OPRM1 Positive_regulation of Ltp 1 1 0.04 0 1.46
5 INT141674 Oprm1 Positive_regulation of Ltp 1 1 0.13 0 1.46
6 INT109958 Binding of CRH and HPSE 1 2 0.10 0.72 1.46
7 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 1 0.04 0 1.46
8 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 2 0.01 2.06 1.34
9 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 1 0.39 0.71 1.26
10 INT134534 Binding of Bdnf and Psds1 1 2 0.01 0 1.05
11 INT52435 Positive_regulation of Binding of Sst and Fdft1 1 1 0.09 0.08 0.98
12 INT133616 Map2k1 Regulation of Fadd 1 1 0.04 0.29 0.97
13 INT133614 Map2k1 Regulation of Daxx 1 1 0.02 0.29 0.97
14 INT133615 Regulation of Map2k1 Regulation of Fadd 1 1 0.04 0.29 0.97
15 INT133617 Fas Positive_regulation of Fadd 1 1 0.48 0.07 0.96
16 INT120380 Cnr1 Positive_regulation of Gene_expression of Fos 1 1 0.31 0.45 0.93
17 INT114281 Binding of Oprd1 and Nacc1 1 1 0.03 0 0.74
18 INT120381 Binding of CNR1 and Fos 1 1 0.00 0.52 0.68
19 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 1 0.77 0 0.67
20 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 1 0.77 0 0.67
21 INT134532 Grin2a Regulation of Ngfr 1 1 0.02 0 0.57
22 INT134528 Grin1 Regulation of Ngfr 1 1 0.03 0 0.57
23 INT134531 Gria1 Regulation of Ngfr 1 1 0.01 0 0.57
24 INT134530 Grin1 Regulation of Gria1 1 1 0.12 0 0.56
25 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 1 0.15 0.48 0.56
26 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 1 0.03 0 0.54
27 INT134533 Binding of Ntrk2 and Psds1 1 1 0.01 0 0.5
28 INT143619 Bhlhe22 Positive_regulation of Regulation of Msr1 1 1 0.40 0.93 0.46
29 INT139487 Oprm1 Positive_regulation of Th 1 1 0.26 0.1 0.42
30 INT139488 Oprm1 Positive_regulation of Cnr1 1 1 0.17 0.1 0.42
31 INT139489 Oprm1 Positive_regulation of Penk 1 1 0.23 0.1 0.42
32 INT139486 Oprm1 Positive_regulation of Crh 1 1 0.27 0.1 0.42
33 INT96545 Nacc1 Regulation of Gene_expression of Penk 1 1 0.05 0 0.41
34 INT144795 Binding of Cnr1 and Gm4113 1 1 0.00 0.22 0.38
35 INT66813 Umod Negative_regulation of POMC 1 1 0.03 0.42 0.26
36 INT66812 Foxp4 Negative_regulation of POMC 1 1 0.00 0.42 0.26
37 INT132839 TPT1 Regulation of Mapk1 1 1 0.01 0.07 0.25
38 INT143618 Msr1 Positive_regulation of Adrb3 1 1 0.16 0.85 0.2
39 INT139250 CCKAR Positive_regulation of Localization of POMC 1 1 0.35 0.61 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 16 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 12 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 3 2431 0.81 378.96 952.2
4 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
5 INT5202 Positive_regulation of Gene_expression of Fos 11 1163 0.70 319.28 684
6 INT728 Positive_regulation of Penk 3 1068 0.70 186.9 636.87
7 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
8 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
9 INT5228 Positive_regulation of Fos 10 934 0.70 209.8 503.87
10 INT443 Localization of POMC 6 1020 0.81 284.52 443.17
11 INT5895 Gene_expression of Oprm1 3 525 0.78 120.67 407.29
12 INT64202 Positive_regulation of Trpv1 2 643 0.70 249.66 397.42
13 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
14 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
15 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
16 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
17 INT720 Positive_regulation of POMC 6 807 0.70 237.37 353.83
18 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
19 INT16260 Gene_expression of Bdnf 5 671 0.78 283.44 339.1
20 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
21 INT5540 Positive_regulation of Oprm1 5 344 0.70 76.77 319.71
22 INT9131 Positive_regulation of Prkcg 2 431 0.70 130.8 302.41
23 INT63932 Positive_regulation of Ephb1 1 537 0.70 259.67 296.14
24 INT11624 Gene_expression of OPRM1 2 445 0.78 72.36 294.36
25 INT5379 Gene_expression of Fos 9 656 0.78 255.5 292.54
26 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
27 INT5591 Regulation of Gene_expression of Fos 6 425 0.62 129.06 265.78
28 INT1893 Localization of Gh 1 1041 0.79 340.23 256.58
29 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
30 INT1562 Localization of Crh 2 499 0.81 126.74 236.68
31 INT6406 Binding of Oprm1 4 280 0.48 40.54 226.26
32 INT11009 Phosphorylation of Creb1 6 458 0.82 111.34 221.97
33 INT95787 Positive_regulation of Mapk1 2 568 0.70 226.51 220.94
34 INT6665 Gene_expression of FOS 17 520 0.77 165.31 217.66
35 INT6293 Gene_expression of Oprm1 4 312 0.78 48.73 215.61
36 INT16259 Positive_regulation of Bdnf 2 336 0.70 183.48 209.82
37 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
38 INT798 Positive_regulation of Gene_expression of Penk 3 394 0.70 78.53 203.07
39 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
40 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
41 INT12602 Negative_regulation of Oprm1 4 190 0.59 36.11 177.85
42 INT26472 Regulation of Oprm1 1 191 0.62 35.84 173.1
43 INT5930 Positive_regulation of Oprm1 1 221 0.70 31.19 172.93
44 INT438 Gene_expression of Crh 3 376 0.78 159.11 169.17
45 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
46 INT4768 Positive_regulation of OPRM1 3 212 0.70 31.09 164.28
47 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
48 INT21185 Binding of Ptprg 4 213 0.47 13.49 157.75
49 INT768 Positive_regulation of Oprl1 3 179 0.70 40.05 156.93
50 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
51 INT4740 Gene_expression of Th 6 298 0.78 61.27 154.03
52 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
53 INT425 Localization of PRL 3 455 0.81 189.64 144.8
54 INT2780 Regulation of Gene_expression of Penk 6 265 0.62 32.45 143.88
55 INT1414 Regulation of Oprl1 3 169 0.62 32.05 139.99
56 INT60126 Regulation of Trpv1 1 186 0.62 85.53 133.4
57 INT11012 Positive_regulation of Creb1 6 258 0.70 84.4 132
58 INT5497 Positive_regulation of Crh 5 299 0.70 125.54 131.14
59 INT5380 Positive_regulation of Gene_expression of Fos 5 243 0.70 105.65 131.05
60 INT64161 Positive_regulation of Prkca 1 213 0.70 85.06 129.91
61 INT65600 Positive_regulation of Casp3 3 376 0.70 198.44 128.03
62 INT5842 Gene_expression of Gfap 1 372 0.78 153.71 127.71
63 INT695 Binding of POMC 4 304 0.48 56.66 126.85
64 INT5931 Regulation of Oprm1 4 149 0.62 18.15 125.93
65 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
66 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
67 INT14151 Gene_expression of Casp3 3 311 0.78 140.26 120.68
68 INT1438 Localization of Pomc 2 360 0.81 101.26 116.47
69 INT16253 Positive_regulation of Gene_expression of Bdnf 4 196 0.70 92.67 113.01
70 INT49651 Gene_expression of Creb1 3 276 0.78 114.77 111.96
71 INT65731 Gene_expression of Cnr1 1 234 0.78 63.82 109.34
72 INT5283 Positive_regulation of Npy 3 191 0.70 66.77 109.2
73 INT915 Positive_regulation of PRL 10 342 0.70 141.96 104.31
74 INT1898 Regulation of Crh 2 220 0.62 61.33 102.64
75 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
76 INT5587 Regulation of Fos 5 191 0.62 40.81 99.7
77 INT52651 Positive_regulation of Prkaca 1 136 0.67 40.82 99.16
78 INT65500 Gene_expression of App 3 605 0.78 429.94 98.31
79 INT7944 Positive_regulation of Fos 4 193 0.70 60.69 98.31
80 INT17459 Positive_regulation of Gene_expression of FOS 14 182 0.67 53.45 96.38
81 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
82 INT203 Positive_regulation of Pomc 2 257 0.70 90.56 92.84
83 INT1281 Negative_regulation of Maoa 14 203 0.59 22.47 91.66
84 INT69764 Positive_regulation of Cnr1 2 126 0.70 67.8 91.49
85 INT48767 Negative_regulation of NOS1 5 312 0.59 154.25 90.32
86 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
87 INT74376 Gene_expression of Cnr1 4 173 0.78 73.43 89.7
88 INT18032 Positive_regulation of Oprk1 1 108 0.70 30.78 89.7
89 INT67682 Localization of Bdnf 1 204 0.81 72.36 88.92
90 INT15898 Positive_regulation of Prkaca 2 199 0.70 50.89 87.54
91 INT73340 Negative_regulation of Faah 4 134 0.59 38.67 85.03
92 INT914 Positive_regulation of GH1 2 292 0.69 100.7 84.91
93 INT4289 Positive_regulation of Localization of Gnrh1 1 202 0.70 12.3 84.01
94 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
95 INT7528 Regulation of OPRM1 2 100 0.62 20.63 80.57
96 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
97 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
98 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
99 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
100 INT12536 Localization of Prkcg 5 101 0.80 36.37 73.81
101 INT442 Localization of PDYN 1 99 0.81 11.87 72.75
102 INT31774 Positive_regulation of Vta1 3 67 0.44 14.52 71.79
103 INT8962 Gene_expression of Cpe 1 110 0.71 39.67 71.67
104 INT5843 Positive_regulation of Gfap 3 184 0.70 108.2 70.21
105 INT1377 Positive_regulation of Trh 2 172 0.70 40.55 69.83
106 INT5861 Gene_expression of Egr1 2 203 0.78 49.35 68.13
107 INT65733 Positive_regulation of Cnr1 1 125 0.70 40.27 67.33
108 INT7872 Positive_regulation of P9Ehs1 3 74 0.50 18.54 66.16
109 INT253 Regulation of PRL 4 184 0.62 47.27 65.79
110 INT24989 Positive_regulation of Cfp 5 125 0.61 29.55 64.9
111 INT83419 Gene_expression of Mors1 1 57 0.68 12.11 63.66
112 INT217 Negative_regulation of Th 2 134 0.59 26.83 62.63
113 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
114 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
115 INT65078 Negative_regulation of Pnoc 4 64 0.59 15.48 59.81
116 INT102020 Gene_expression of Creb1 9 190 0.78 57.31 59.77
117 INT5016 Negative_regulation of Crh 4 129 0.59 36.74 59.28
118 INT7340 Regulation of Grin1 2 87 0.62 30.37 57.93
119 INT68813 Transcription of Oprm1 1 93 0.71 20.11 57.65
120 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
121 INT6669 Negative_regulation of Positive_regulation of Fos 2 98 0.59 23.5 56.82
122 INT5356 Positive_regulation of FOS 2 153 0.69 54.21 56.74
123 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
124 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
125 INT31186 Negative_regulation of Insrr 1 81 0.37 24.91 55.94
126 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
127 INT17458 Negative_regulation of Gene_expression of FOS 3 98 0.57 36.77 55.69
128 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
129 INT8528 Negative_regulation of Gene_expression of Fos 2 100 0.59 41.15 55.6
130 INT5598 Negative_regulation of Pdyn 1 95 0.59 14.4 55.43
131 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
132 INT82650 Gene_expression of Bcl2 4 312 0.78 211.71 55.03
133 INT1486 Negative_regulation of Cpe 2 85 0.59 28.78 54.08
134 INT6116 Regulation of Gene_expression of Oprd1 1 69 0.62 16.43 54
135 INT5509 Positive_regulation of Localization of Crh 1 91 0.70 30.65 53.92
136 INT49747 Transcription of Oprm1 2 68 0.72 9.01 53.78
137 INT7898 Gene_expression of Homer1 2 123 0.78 31.52 53.67
138 INT15091 Gene_expression of SLC6A4 1 101 0.78 29.91 53.64
139 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
140 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
141 INT66040 Positive_regulation of Bdnf 2 114 0.69 67.67 51.81
142 INT5704 Binding of Slc3a1 1 78 0.43 8.52 51.78
143 INT5858 Positive_regulation of Drd1a 1 66 0.69 4.51 51.73
144 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
145 INT5957 Positive_regulation of Cpe 3 65 0.69 21.07 51.22
146 INT5136 Negative_regulation of PDYN 1 71 0.59 11.22 51.14
147 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
148 INT921 Regulation of GH1 1 172 0.60 52.88 51.04
149 INT7287 Positive_regulation of Transcription of Penk 1 103 0.70 19.81 50.37
150 INT51163 Gene_expression of Gal 1 119 0.78 67.48 49.23
151 INT32718 Gene_expression of OPRD1 2 82 0.76 9.43 48.38
152 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
153 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
154 INT531 Gene_expression of GH1 1 376 0.75 193.45 46.24
155 INT2783 Gene_expression of Slc3a1 2 86 0.65 8.84 45.4
156 INT6979 Positive_regulation of CA2 1 206 0.67 50.79 44.97
157 INT47683 Negative_regulation of Bdnf 2 92 0.59 47.53 43.55
158 INT4850 Binding of Tac1 1 57 0.47 14.25 42.17
159 INT66867 Gene_expression of Ceacam3 1 58 0.67 30.44 40.7
160 INT16261 Transcription of Bdnf 1 101 0.72 49.41 40.64
161 INT7029 Regulation of Pdyn 1 51 0.61 12.89 40.34
162 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
163 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
164 INT102902 Gene_expression of Ntrk2 2 152 0.78 81.52 39.43
165 INT115 Negative_regulation of Maoa 2 65 0.59 16.27 38.66
166 INT81037 Negative_regulation of Slc6a3 1 70 0.59 15.31 37.01
167 INT17736 Gene_expression of Cfp 3 111 0.65 40.68 36.61
168 INT48959 Positive_regulation of Positive_regulation of Prkcg 1 52 0.70 16.47 36.49
169 INT30169 Negative_regulation of Pde4a 2 107 0.58 81 36.23
170 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
171 INT7326 Transcription of Th 6 83 0.72 13.5 35.33
172 INT7608 Positive_regulation of Adra2a 3 66 0.70 17.81 35.15
173 INT96624 Positive_regulation of Positive_regulation of Trpv1 1 62 0.70 20.5 34.28
174 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
175 INT48924 Positive_regulation of Mapk3 1 107 0.67 50.53 34.05
176 INT12537 Positive_regulation of Localization of Prkcg 3 36 0.70 14.57 33.81
177 INT16714 Regulation of Creb1 3 64 0.62 22.23 33.56
178 INT50308 Binding of Cnr1 3 61 0.48 14.41 33.52
179 INT63933 Negative_regulation of Positive_regulation of Ephb1 1 53 0.58 22.83 33.43
180 INT21560 Positive_regulation of Binding of Oprm1 1 30 0.50 7.16 32.95
181 INT45365 Negative_regulation of Cfp 1 68 0.57 25.44 32.11
182 INT7082 Gene_expression of CRH 2 180 0.78 64.66 31.74
183 INT124860 Gene_expression of Bace1 1 330 0.78 157.11 31.65
184 INT12397 Gene_expression of Oprd1 1 53 0.78 9.1 31.31
185 INT29743 Negative_regulation of App 2 91 0.59 65.56 31.26
186 INT49001 Regulation of Gria1 1 51 0.56 18.28 31.22
187 INT117112 Negative_regulation of Mapk1 1 87 0.56 40.34 31.18
188 INT15347 Positive_regulation of Localization of Pomc 1 81 0.70 28.1 31.01
189 INT6058 Localization of Fos 1 73 0.81 16.7 30.84
190 INT6177 Binding of Htr1a 2 65 0.47 17.65 30.59
191 INT5507 Regulation of Localization of Crh 1 57 0.61 8.43 30.26
192 INT69483 Transcription of OPRM1 4 45 0.72 7.31 30.22
193 INT65597 Negative_regulation of Casp3 1 69 0.59 39.19 29.32
194 INT7956 Regulation of Gene_expression of Th 3 44 0.61 8.26 29.31
195 INT15000 Transcription of Oprd1 2 32 0.72 5.7 29.22
196 INT11010 Regulation of Phosphorylation of Creb1 1 52 0.62 7.26 29.04
197 INT66868 Positive_regulation of Ceacam3 2 40 0.69 26.61 28.9
198 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
199 INT67620 Negative_regulation of Gene_expression of Bdnf 1 53 0.59 22.45 28.5
200 INT16879 Binding of Crh 3 72 0.48 21.65 28.43
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