J:Neuroscience

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT106676 Binding of Trpv1 and Phax 18 1 0.34 4.19 12.36
2 INT158770 Binding of Trpv1 and Trpa1 5 2 0.34 2.07 3.5
3 INT140659 Phax Positive_regulation of Trpv1 3 1 0.49 0.68 2.18
4 INT163266 Crh Negative_regulation of Tyr 1 2 0.01 0.45 1.98
5 INT165284 Positive_regulation of Nts Positive_regulation of Crh 1 2 0.40 1.86 1.93
6 INT165285 Nts Positive_regulation of Crh 1 2 0.40 1.84 1.91
7 INT24157 Binding of CALCA and SFTPA1 2 1 0.07 0.96 1.64
8 INT160578 Binding of CALCA and TAC1 1 3 0.07 0.91 1.61
9 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 1 0.10 0.1 1.44
10 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 1 0.03 0.1 1.32
11 INT160653 Binding of P2rx1 and Ptgfr 1 1 0.28 0.66 1.14
12 INT152490 Slc40a1 Negative_regulation of Faah 1 1 0.01 0.73 0.98
13 INT163265 Sst Negative_regulation of Tyr 1 1 0.00 0.22 0.95
14 INT161412 Pag1 Positive_regulation of Gene_expression of Tens1 1 1 0.11 0.56 0.9
15 INT157297 Npy Regulation of Npy1r 1 1 0.18 0.19 0.82
16 INT164996 Ins1 Regulation of Gria2 1 1 0.05 0.05 0.76
17 INT278490 Negative_regulation of Faah Positive_regulation of Trpv1 1 2 0.38 0.6 0.76
18 INT307754 Ik Negative_regulation of Trpa1 1 1 0.07 0.08 0.71
19 INT161297 Ppp1r1b Negative_regulation of Prkaca 1 1 0.10 0.16 0.7
20 INT161298 Ppp1r1b Negative_regulation of Trib3 1 1 0.05 0.16 0.7
21 INT162878 Agt Regulation of Ang 1 2 0.21 1.15 0.66
22 INT160183 Fbxo23 Regulation of Gabrg1 1 1 0.02 0.07 0.55
23 INT160184 Fbxo23 Positive_regulation of Gabrg1 1 1 0.04 0.06 0.52
24 INT241966 Binding of Ca2 and Acpt 1 1 0.06 0.06 0.33
25 INT263090 Negative_regulation of Binding of FDX1 and LH 1 1 0.02 0.95 0.32
26 INT263091 Binding of FDX1 and LH 1 1 0.02 0.95 0.32
27 INT241971 Ca2 Regulation of Localization of Abat 1 1 0.01 0 0.31
28 INT241969 Grm8 Positive_regulation of Prkaca 1 1 0.05 0.35 0.27
29 INT241965 Prkaca Negative_regulation of Grm8 1 1 0.03 0.36 0.26
30 INT241970 Acpt Positive_regulation of Positive_regulation of Prkaca 1 1 0.05 0.36 0.24
31 INT328896 Scn2a1 Regulation of hb 1 1 0.02 0.27 0.23
32 INT208084 Tlr4 Positive_regulation of Eps8l1 1 1 0.00 0.5 0.23
33 INT165657 Lilrb3 Regulation of Regulation of Bdnf 1 1 0.07 0.72 0.2
34 INT208083 Binding of Arid3b and Eps8l1 1 1 0.01 0.4 0.16
35 INT241967 Binding of Grm7 and Acpt 1 1 0.17 0 0.16
36 INT160929 Chat Positive_regulation of Penk 1 1 0.35 1.18 0.15
37 INT160930 Spn Positive_regulation of Penk 1 1 0.14 1.18 0.15
38 INT160931 Slc18a3 Positive_regulation of Penk 1 1 0.30 1.18 0.15
39 INT241963 Prkaca Positive_regulation of Positive_regulation of Grm8 1 1 0.03 0 0.13
40 INT289049 Binding of Slc38a1 and Sat2 1 1 0.02 0 0.05
41 INT246451 Lta Positive_regulation of nct 1 1 0.14 0 0.04
42 INT246450 Lta Positive_regulation of Ednrb 1 1 0.00 0 0.04
43 INT328898 hb Regulation of Gene_expression of Per2 1 1 0.16 0 0
44 INT328895 hb Regulation of Per1 1 1 0.05 0 0
45 INT241964 Acpt Negative_regulation of Gene_expression of Fig4 1 1 0.10 0 0
46 INT328894 hb Regulation of Gene_expression of Per1 1 1 0.05 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 297 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 140 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 149 1902 0.78 275.47 1057.59
4 INT7114 Positive_regulation of Ltp 7 1192 0.62 290.76 755.77
5 INT1912 Gene_expression of Calca 62 1152 0.78 453.25 739.84
6 INT3439 Localization of Abat 141 1017 0.78 112.39 727.06
7 INT5202 Positive_regulation of Gene_expression of Fos 127 1163 0.70 319.28 684
8 INT58061 Gene_expression of Trpv1 53 1117 0.78 451.54 637.59
9 INT5228 Positive_regulation of Fos 101 934 0.70 209.8 503.87
10 INT4758 Positive_regulation of Localization of Calca 37 557 0.70 138.55 411.04
11 INT5895 Gene_expression of Oprm1 20 525 0.78 120.67 407.29
12 INT64202 Positive_regulation of Trpv1 17 643 0.70 249.66 397.42
13 INT1395 Negative_regulation of Penk 24 537 0.59 87.33 389.81
14 INT6056 Negative_regulation of Gene_expression of Fos 60 601 0.59 193.05 386.84
15 INT76660 Gene_expression of Trpv1 39 691 0.78 329.46 386.42
16 INT18357 Gene_expression of TRPV1 15 825 0.78 307.11 382.81
17 INT16260 Gene_expression of Bdnf 31 671 0.78 283.44 339.1
18 INT5680 Gene_expression of Ngf 11 530 0.78 264.29 310.56
19 INT46460 Gene_expression of NAV1 8 288 0.78 135.51 305.75
20 INT4941 Positive_regulation of Oprd1 18 345 0.70 74.26 304.41
21 INT9131 Positive_regulation of Prkcg 10 431 0.70 130.8 302.41
22 INT1352 Localization of Acot1 23 728 0.80 73.01 296.01
23 INT5379 Gene_expression of Fos 23 656 0.78 255.5 292.54
24 INT94450 Gene_expression of Nav1 8 359 0.78 131.85 275.46
25 INT6852 Localization of TNF 3 883 0.81 705.95 270.84
26 INT5591 Regulation of Gene_expression of Fos 35 425 0.62 129.06 265.78
27 INT9659 Gene_expression of Il6 3 991 0.78 715.11 265.57
28 INT87687 Positive_regulation of Trpv1 16 409 0.70 210.24 257.59
29 INT16868 Gene_expression of Il6 5 807 0.78 499.48 256.57
30 INT2909 Positive_regulation of Abat 29 334 0.70 62.1 256.43
31 INT11377 Positive_regulation of Ngf 5 331 0.70 206.5 238
32 INT4759 Negative_regulation of Localization of Calca 16 294 0.59 82.62 226.45
33 INT9987 Gene_expression of Abat 21 296 0.78 95.46 226.34
34 INT95787 Positive_regulation of Mapk1 16 568 0.70 226.51 220.94
35 INT6481 Binding of TNF 3 624 0.48 510.2 214.82
36 INT4893 Gene_expression of Tacr1 70 366 0.78 129.67 213.92
37 INT9132 Negative_regulation of Prkcg 3 279 0.59 88.05 203.47
38 INT11313 Positive_regulation of Il6 4 526 0.70 331.27 201.59
39 INT2211 Negative_regulation of Abat 30 267 0.59 66.51 200.98
40 INT94952 Positive_regulation of Mapk14 7 305 0.70 197.83 186.61
41 INT3440 Negative_regulation of Localization of Abat 22 221 0.57 33.94 180.36
42 INT5930 Positive_regulation of Oprm1 14 221 0.70 31.19 172.93
43 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
44 INT5127 Localization of Lhb 1 488 0.80 50.48 162.66
45 INT2910 Regulation of Abat 12 169 0.62 36.95 153.53
46 INT120811 Gene_expression of Gopc 3 1174 0.59 428.49 150.55
47 INT4829 Positive_regulation of Localization of Abat 38 199 0.55 20.91 150.48
48 INT5050 Regulation of Localization of Calca 9 149 0.62 41.25 148.57
49 INT7628 Gene_expression of Ltp 2 273 0.77 70.21 147.87
50 INT60694 Gene_expression of Il10 4 567 0.78 369.48 143.69
51 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
52 INT5595 Positive_regulation of Pdyn 41 223 0.70 48.37 130.14
53 INT115386 Gene_expression of Ppara 1 779 0.77 549.99 128.36
54 INT5842 Gene_expression of Gfap 18 372 0.78 153.71 127.71
55 INT5931 Regulation of Oprm1 4 149 0.62 18.15 125.93
56 INT4824 Positive_regulation of Tacr1 24 169 0.70 66.1 123.46
57 INT7533 Gene_expression of Tlr4 1 720 0.78 343.22 121.57
58 INT218 Positive_regulation of Th 17 245 0.70 40.5 120.1
59 INT64201 Negative_regulation of Trpv1 6 203 0.59 79.18 119.75
60 INT12501 Positive_regulation of Adarb1 19 166 0.58 36.94 118.92
61 INT7341 Positive_regulation of Grin1 15 169 0.70 65.86 118.38
62 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
63 INT170025 Gene_expression of Fig4 10 588 0.67 183.27 113.32
64 INT65731 Gene_expression of Cnr1 4 234 0.78 63.82 109.34
65 INT47243 Gene_expression of Prkcg 5 195 0.78 58.05 108.44
66 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
67 INT114 Binding of Oprl1 6 139 0.48 23 103.35
68 INT89054 Positive_regulation of Gene_expression of Trpv1 2 156 0.70 90.78 102.03
69 INT5906 Negative_regulation of Oprm1 4 125 0.59 19.58 101.57
70 INT74826 Gene_expression of Slc1a2 7 131 0.78 61.83 100.84
71 INT97701 Phosphorylation of Mapk14 8 191 0.82 115.33 100.46
72 INT5587 Regulation of Fos 15 191 0.62 40.81 99.7
73 INT52651 Positive_regulation of Prkaca 4 136 0.67 40.82 99.16
74 INT1351 Gene_expression of Pag1 2 131 0.57 89.48 98.76
75 INT65500 Gene_expression of App 4 605 0.78 429.94 98.31
76 INT7944 Positive_regulation of Fos 18 193 0.70 60.69 98.31
77 INT4822 Localization of Ca2 8 417 0.80 99.57 96.45
78 INT74058 Gene_expression of Nos1 8 260 0.78 80.04 95.71
79 INT3537 Positive_regulation of Car2 2 413 0.56 103.51 94.35
80 INT94953 Negative_regulation of Mapk14 2 156 0.59 104.77 91.51
81 INT69764 Positive_regulation of Cnr1 5 126 0.70 67.8 91.49
82 INT1160 Positive_regulation of Rbm39 4 122 0.57 28.19 90.28
83 INT74376 Gene_expression of Cnr1 13 173 0.78 73.43 89.7
84 INT12763 Phosphorylation of Prkcg 4 167 0.82 38.91 89.63
85 INT6214 Negative_regulation of Adarb1 11 123 0.50 26.39 89.57
86 INT67682 Localization of Bdnf 2 204 0.81 72.36 88.92
87 INT1635 Gene_expression of Vip 4 245 0.78 53.36 88.13
88 INT3441 Regulation of Localization of Abat 26 117 0.38 8.67 87.59
89 INT4798 Gene_expression of Nts 13 169 0.77 29.56 86.04
90 INT3766 Positive_regulation of Localization of Acot1 3 192 0.69 21.8 85.35
91 INT4830 Binding of Trpv1 3 158 0.48 45.11 84.2
92 INT2520 Negative_regulation of Ca2 6 271 0.57 72.13 83.71
93 INT99070 Gene_expression of Mapk14 4 147 0.78 103.99 79.59
94 INT29708 Gene_expression of Gria1 11 177 0.78 56.36 77.37
95 INT1335 Negative_regulation of Oprl1 9 123 0.59 18.02 77.13
96 INT24958 Gene_expression of Nkx1-1 8 106 0.74 51.29 76.88
97 INT25363 Negative_regulation of Trpv1 3 144 0.59 64.78 75.7
98 INT98621 Regulation of Trpv1 3 121 0.62 79.24 75.23
99 INT1353 Negative_regulation of Localization of Acot1 5 153 0.53 15.05 75.17
100 INT12536 Localization of Prkcg 2 101 0.80 36.37 73.81
101 INT4153 Binding of Insrr 5 109 0.40 17.99 72.15
102 INT5843 Positive_regulation of Gfap 6 184 0.70 108.2 70.21
103 INT171145 Positive_regulation of Fig4 2 274 0.59 93.55 69.81
104 INT87686 Positive_regulation of Gene_expression of Trpv1 3 101 0.70 72.41 69.15
105 INT9484 Gene_expression of Jun 51 175 0.78 34.89 68.54
106 INT39777 Regulation of Prkcg 3 90 0.62 31.52 68.17
107 INT5861 Gene_expression of Egr1 27 203 0.78 49.35 68.13
108 INT4637 Binding of Adarb1 3 132 0.41 14.48 67.76
109 INT65733 Positive_regulation of Cnr1 1 125 0.70 40.27 67.33
110 INT1046 Gene_expression of LH 4 180 0.77 29.75 66.87
111 INT1425 Gene_expression of Rbm39 3 143 0.58 51.32 65.44
112 INT6926 Regulation of Pag1 5 72 0.39 55.79 65.09
113 INT13286 Gene_expression of Ca2 8 317 0.67 71.58 65.01
114 INT24989 Positive_regulation of Cfp 8 125 0.61 29.55 64.9
115 INT47690 Regulation of Bdnf 6 118 0.62 53.02 64.5
116 INT9304 Negative_regulation of Pag1 3 70 0.39 51.97 64.23
117 INT1951 Positive_regulation of Tlr4 2 345 0.70 176.99 62.42
118 INT2761 Regulation of Gabrg1 1 119 0.61 18.8 60.52
119 INT103924 Positive_regulation of Akt1 3 359 0.69 158.94 60.34
120 INT109431 Gene_expression of Trpa1 16 123 0.78 51.84 59.98
121 INT102020 Gene_expression of Creb1 4 190 0.78 57.31 59.77
122 INT169926 Positive_regulation of Gopc 4 416 0.46 157.8 58.67
123 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
124 INT129303 Positive_regulation of NAV1 1 54 0.70 36.92 57.45
125 INT74389 Gene_expression of Gdnf 3 131 0.78 58.52 57.06
126 INT6669 Negative_regulation of Positive_regulation of Fos 13 98 0.59 23.5 56.82
127 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
128 INT96533 Gene_expression of Slc1a3 8 72 0.78 26.85 55.31
129 INT77855 Gene_expression of Pain1 2 55 0.75 67.42 54.1
130 INT7800 Localization of Pag1 2 51 0.56 33.06 53.74
131 INT3213 Gene_expression of Ins1 1 511 0.76 357.59 53.32
132 INT929 Positive_regulation of Oprl1 8 64 0.70 14.67 52.84
133 INT49028 Positive_regulation of Nos1 9 102 0.70 34.73 51.05
134 INT6165 Gene_expression of Adarb1 10 85 0.58 18.39 51.03
135 INT74827 Positive_regulation of Gene_expression of Slc1a2 3 52 0.70 26.54 50.63
136 INT6796 Positive_regulation of Jun 7 165 0.70 37.18 49.64
137 INT9556 Negative_regulation of NAV1 1 47 0.59 28.49 49.33
138 INT109430 Positive_regulation of Trpa1 5 119 0.70 44 49.14
139 INT17915 Gene_expression of Insr 1 141 0.75 47.45 48.59
140 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
141 INT29144 Gene_expression of Rvm 1 41 0.52 29.23 47.76
142 INT6864 Positive_regulation of Gene_expression of Gfap 5 110 0.70 59.01 47.07
143 INT170646 Negative_regulation of Fig4 3 213 0.37 81.29 46.92
144 INT30170 Gene_expression of Car2 1 330 0.66 77.26 46.76
145 INT1726 Positive_regulation of Kitl 3 65 0.70 38.81 44.85
146 INT2262 Negative_regulation of Lhb 1 142 0.59 25.47 44.81
147 INT17561 Localization of Car2 6 303 0.79 60.95 44.52
148 INT98498 Binding of Trpv1 6 75 0.48 33.67 44.4
149 INT127013 Negative_regulation of Slc1a3 2 37 0.54 14.16 43.97
150 INT1474 Regulation of Localization of Ins1 1 132 0.61 25.96 43.07
151 INT50957 Negative_regulation of Il6 4 134 0.59 79.08 42.67
152 INT12228 Positive_regulation of Gene_expression of Abat 4 44 0.65 17.51 40.55
153 INT103261 Positive_regulation of Nav1 1 68 0.70 24.25 39.27
154 INT16455 Gene_expression of Drd2 4 116 0.78 22.71 38.47
155 INT58062 Negative_regulation of Gene_expression of Trpv1 3 66 0.59 22.34 38.02
156 INT64558 Negative_regulation of Nos1 2 88 0.58 26.76 36.78
157 INT95646 Negative_regulation of Faah 5 63 0.59 25.61 36.78
158 INT17736 Gene_expression of Cfp 3 111 0.65 40.68 36.61
159 INT64436 Gene_expression of P2rx1 3 93 0.78 32.69 36.12
160 INT84260 Positive_regulation of Mapk8 4 124 0.69 72.84 35.98
161 INT14031 Gene_expression of Npy 5 107 0.78 36.48 35.4
162 INT1163 Negative_regulation of Rbm39 2 64 0.29 16.8 34.74
163 INT4892 Positive_regulation of Gene_expression of Tacr1 7 56 0.69 25.64 34.69
164 INT66005 Regulation of Cnr1 1 47 0.61 19.21 34.52
165 INT96624 Positive_regulation of Positive_regulation of Trpv1 2 62 0.70 20.5 34.28
166 INT47710 Negative_regulation of GRIN1 2 71 0.57 25.57 34.24
167 INT5862 Positive_regulation of Egr1 8 82 0.70 30.4 33.96
168 INT81289 Positive_regulation of Gene_expression of Tlr4 2 192 0.69 104.5 33.89
169 INT95789 Positive_regulation of Grm5 1 42 0.55 20.1 33.72
170 INT95734 Phosphorylation of Mapk8 1 108 0.82 49.92 33.52
171 INT14823 Gene_expression of MET 4 103 0.75 51.92 32.48
172 INT45365 Negative_regulation of Cfp 4 68 0.57 25.44 32.11
173 INT6053 Transcription of Fos 3 107 0.72 20.97 31.88
174 INT7787 Positive_regulation of Akr1d1 8 52 0.66 3.55 31.71
175 INT56809 Binding of Tlr4 2 184 0.48 106.02 31.18
176 INT6058 Localization of Fos 8 73 0.81 16.7 30.84
177 INT72252 Gene_expression of Kcnma1 2 63 0.64 20.47 29.56
178 INT67912 Gene_expression of GRIN1 2 75 0.77 28.99 29.28
179 INT15296 Regulation of Rbm39 3 45 0.29 10.66 29.27
180 INT98522 Gene_expression of Accn3 4 68 0.78 26.95 28.6
181 INT122039 Positive_regulation of Gene_expression of Ppara 1 144 0.68 113.55 28.55
182 INT4459 Positive_regulation of Arc 5 74 0.69 33.61 28.29
183 INT83708 Negative_regulation of MAPK1 1 156 0.57 84.93 27.85
184 INT2912 Positive_regulation of Positive_regulation of Abat 5 29 0.66 6.48 27.54
185 INT2650 Positive_regulation of Slc3a1 3 50 0.57 2.95 27.52
186 INT94658 Positive_regulation of F2rl1 3 51 0.70 33.65 27.46
187 INT73314 Gene_expression of Arc 6 133 0.78 67.78 27.44
188 INT8881 Regulation of Gene_expression of Tacr1 10 38 0.61 17.49 27.19
189 INT32826 Positive_regulation of Gene_expression of Ltp 1 52 0.45 10.34 26.8
190 INT4735 Gene_expression of Acot1 5 80 0.71 13.22 26.68
191 INT2261 Gene_expression of Lhb 4 121 0.77 42.78 26.04
192 INT48832 Positive_regulation of Grip2 8 48 0.69 12.13 25.99
193 INT6054 Positive_regulation of Gene_expression of Egr1 8 67 0.70 18.45 25.93
194 INT122570 Negative_regulation of Akt1 2 173 0.59 91.44 25.53
195 INT103320 Positive_regulation of Positive_regulation of Trpv1 1 44 0.70 27.73 25.28
196 INT96904 Regulation of Prkaca 2 33 0.44 10.86 24.51
197 INT64076 Positive_regulation of Kcnma1 1 47 0.40 11.52 24.19
198 INT20003 Gene_expression of Scn2a1 3 125 0.71 8.78 23.94
199 INT6866 Regulation of Gfap 3 51 0.61 19.6 23.56
200 INT48536 Positive_regulation of Grm8 21 46 0.61 14.31 23.56
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