J:Nippon Yakurigaku Zasshi

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 6 0.10 2.91 6.54
2 INT13966 Calca Positive_regulation of Localization of Sst 5 1 0.49 0.75 3.91
3 INT81657 Binding of CPOX and PTGS1 5 2 0.15 1.9 2.37
4 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 1 0.01 0.19 1.24
5 INT95546 KNG1 Positive_regulation of Ptgir 1 1 0.02 0.93 0.64
6 INT95545 Ptgir Regulation of Gene_expression of Il10 1 1 0.04 0.97 0.63
7 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 1 0.10 0 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT158 Localization of Prl 2 2431 0.81 378.96 952.2
3 INT292 Localization of Penk 1 876 0.81 88.44 669.14
4 INT155 Positive_regulation of Prl 3 1233 0.70 317.93 457.82
5 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
6 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
7 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
8 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
9 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
10 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
11 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
12 INT5979 Gene_expression of Oprd1 2 428 0.78 75.64 320.32
13 INT1352 Localization of Acot1 4 728 0.80 73.01 296.01
14 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
15 INT49750 Negative_regulation of CPOX 6 735 0.58 360.06 274.19
16 INT5972 Gene_expression of IL1B 4 948 0.78 510.91 263.97
17 INT87687 Positive_regulation of Trpv1 2 409 0.70 210.24 257.59
18 INT1005 Localization of Sst 3 385 0.81 26.31 244.56
19 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
20 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
21 INT528 Gene_expression of Prl 3 693 0.78 217.18 192.2
22 INT6488 Gene_expression of Tnf 2 484 0.78 339.61 191.58
23 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
24 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
25 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
26 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
27 INT49439 Gene_expression of Cpox 1 508 0.73 326.97 130.17
28 INT416 Regulation of LH 1 253 0.62 31.48 125.55
29 INT5906 Negative_regulation of Oprm1 1 125 0.59 19.58 101.57
30 INT65500 Gene_expression of App 2 605 0.78 429.94 98.31
31 INT940 Negative_regulation of Ptgs1 3 219 0.59 104.34 95.97
32 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
33 INT3537 Positive_regulation of Car2 2 413 0.56 103.51 94.35
34 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
35 INT2149 Positive_regulation of Oxt 1 181 0.70 24.8 85.43
36 INT3766 Positive_regulation of Localization of Acot1 1 192 0.69 21.8 85.35
37 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
38 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
39 INT3214 Localization of Ins1 2 527 0.80 196.9 79.26
40 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
41 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
42 INT57380 Phosphorylation of Creb1 1 213 0.82 66.8 71.26
43 INT451 Regulation of Oxt 1 142 0.62 22.07 69.42
44 INT1046 Gene_expression of LH 2 180 0.77 29.75 66.87
45 INT7280 Positive_regulation of Localization of Sst 1 97 0.70 5.64 63.37
46 INT546 Binding of ALB 4 311 0.48 85.98 60.14
47 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
48 INT102020 Gene_expression of Creb1 1 190 0.78 57.31 59.77
49 INT20964 Gene_expression of OPRK1 1 96 0.78 23.54 58.18
50 INT5017 Negative_regulation of Tacr1 1 76 0.58 17 57.07
51 INT1316 Positive_regulation of Acot1 3 129 0.60 18.86 56.13
52 INT31186 Negative_regulation of Insrr 2 81 0.37 24.91 55.94
53 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
54 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
55 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
56 INT63975 Positive_regulation of Il10 1 175 0.68 134.13 54.69
57 INT3213 Gene_expression of Ins1 1 511 0.76 357.59 53.32
58 INT5704 Binding of Slc3a1 1 78 0.43 8.52 51.78
59 INT2323 Gene_expression of Trh 1 146 0.78 29.92 49.5
60 INT1977 Negative_regulation of Positive_regulation of Prl 1 98 0.59 17.06 47.88
61 INT55670 Negative_regulation of Gene_expression of Tnf 3 83 0.59 57.16 46.33
62 INT29105 Positive_regulation of OPRK1 1 68 0.70 7.06 44.69
63 INT17561 Localization of Car2 8 303 0.79 60.95 44.52
64 INT94029 Positive_regulation of Grin2b 1 58 0.70 24.2 42.52
65 INT2782 Regulation of Gene_expression of Pomc 1 75 0.62 15.04 38.97
66 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
67 INT4925 Binding of Tacr1 1 57 0.48 17.39 38.38
68 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
69 INT3216 Positive_regulation of Localization of Ins1 1 170 0.69 56.78 35.63
70 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
71 INT7282 Regulation of Localization of Sst 1 58 0.62 1.92 34.83
72 INT11764 Positive_regulation of ENG 8 78 0.61 27.65 33.69
73 INT109820 Gene_expression of Trpv4 1 121 0.78 39.69 33.11
74 INT45365 Negative_regulation of Cfp 9 68 0.57 25.44 32.11
75 INT5069 Negative_regulation of Mthfs 2 69 0.57 22.54 31.36
76 INT29743 Negative_regulation of App 1 91 0.59 65.56 31.26
77 INT6177 Binding of Htr1a 1 65 0.47 17.65 30.59
78 INT52690 Positive_regulation of Ptgs2 1 65 0.68 39.51 30.02
79 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
80 INT3217 Regulation of Ins1 1 154 0.62 87.11 27.29
81 INT2569 Gene_expression of Ache 1 120 0.78 26.29 26.89
82 INT5232 Negative_regulation of Enpep 1 56 0.57 3.25 26.7
83 INT1728 Negative_regulation of Cndp2 1 36 0.57 3.76 25.39
84 INT117600 Positive_regulation of Trpm8 1 65 0.70 31.96 24.46
85 INT3028 Negative_regulation of Oxt 1 76 0.58 18.52 24.4
86 INT78675 Gene_expression of Dbi 3 31 0.78 12.93 23.64
87 INT64175 Negative_regulation of Gene_expression of CPOX 1 66 0.38 39.64 23.07
88 INT9282 Gene_expression of HTR1B 1 48 0.75 12.15 22.94
89 INT15326 Phosphorylation of Trib3 1 83 0.55 30.96 22.27
90 INT28728 Regulation of Cfp 1 49 0.46 13.15 21.43
91 INT11625 Localization of App 1 98 0.78 55.46 20.86
92 INT78670 Positive_regulation of Gene_expression of Dbi 2 26 0.70 6.72 19
93 INT2960 Regulation of Dbh 1 32 0.47 10.32 18.94
94 INT2660 Negative_regulation of Fabp6 1 58 0.49 33.74 18.27
95 INT21072 Localization of Adarb1 1 26 0.69 2.76 17.95
96 INT119233 Positive_regulation of Trpv4 1 65 0.70 20.21 17.3
97 INT78233 Positive_regulation of P2rx3 1 36 0.56 21.49 17.25
98 INT3206 Positive_regulation of Got1 1 39 0.69 19.36 17.02
99 INT1767 Positive_regulation of PROC 1 83 0.67 54.14 17
100 INT24225 Gene_expression of Alms1 1 93 0.62 52.75 16.93
101 INT1000 Localization of Ggh 1 31 0.75 2.74 16.41
102 INT4616 Regulation of Maoa 2 40 0.62 6.09 15.94
103 INT3466 Gene_expression of Ptger1 1 39 0.75 18.34 15.75
104 INT12837 Binding of SIGMAR1 2 57 0.48 5.31 15.49
105 INT1284 Negative_regulation of Mmp13 1 20 0.57 36.21 14.91
106 INT61635 Positive_regulation of P2ry2 1 35 0.56 12.08 14.68
107 INT2758 Binding of Dbp 2 36 0.44 8.3 14.47
108 INT7674 Regulation of ENG 1 42 0.30 11.41 14.44
109 INT110 Regulation of Adrb3 1 33 0.60 8.09 13.84
110 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
111 INT69166 Positive_regulation of P2ry1 1 35 0.67 8.41 13.63
112 INT3623 Negative_regulation of CTSB 2 49 0.55 27.39 13.52
113 INT16635 Gene_expression of Ltb4r 1 27 0.64 17.05 13.21
114 INT20715 Binding of Sigmar1 2 45 0.48 4.03 13.17
115 INT65965 Gene_expression of Adcyap1 1 52 0.78 22.53 13.14
116 INT28420 Gene_expression of Ptgds 2 59 0.78 31.72 12.67
117 INT107916 Protein_catabolism of App 1 114 1.00 66.71 12.38
118 INT8629 Positive_regulation of COL7A1 1 72 0.69 40.66 12.09
119 INT122053 Positive_regulation of P2rx4 1 16 0.69 13.02 11.98
120 INT3057 Gene_expression of Ptgfr 1 60 0.58 14.54 11.73
121 INT23122 Gene_expression of Ptger3 1 31 0.72 11.94 11.37
122 INT152 Negative_regulation of MBD2 1 31 0.38 3.95 11.31
123 INT25170 Positive_regulation of Localization of Car2 2 78 0.67 15.25 11.24
124 INT98789 Negative_regulation of Gene_expression of App 1 54 0.58 40.27 11.15
125 INT17826 Positive_regulation of Pla2g1b 1 39 0.70 11.35 10.97
126 INT112037 Negative_regulation of Positive_regulation of Trpv1 1 19 0.59 8.9 10.55
127 INT8188 Positive_regulation of Adrb3 1 27 0.68 7.32 10.44
128 INT71768 Regulation of Gene_expression of Il10 1 27 0.62 19.17 10.4
129 INT33127 Positive_regulation of Phosphorylation of Trib3 1 26 0.17 14.04 10
130 INT80717 Gene_expression of Trpv3 1 20 0.72 10.05 9.96
131 INT2828 Positive_regulation of Ptger3 1 26 0.68 8.01 9.63
132 INT107898 Gene_expression of Trpv2 1 27 0.76 10.55 9.28
133 INT23178 Gene_expression of H1 1 38 0.68 13.37 9.09
134 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
135 INT11732 Negative_regulation of Gtf3a 1 25 0.30 15.73 8.5
136 INT8637 Negative_regulation of Dbp 1 112 0.50 33.28 8.4
137 INT9966 Localization of Htr3a 1 14 0.80 2.28 7.92
138 INT89048 Gene_expression of P2RX2 1 28 0.75 8.75 7.9
139 INT78678 Positive_regulation of Dbi 1 12 0.70 2.13 7.71
140 INT93844 Gene_expression of Ptgir 1 19 0.77 12.12 7.66
141 INT89046 Positive_regulation of P2RX2 1 15 0.67 7.25 7.52
142 INT113 Positive_regulation of MBD2 1 33 0.49 6.76 7.49
143 INT10228 Positive_regulation of PCS 2 49 0.67 28.72 7
144 INT3438 Negative_regulation of Dock7 1 11 0.00 1.03 6.72
145 INT87939 Gene_expression of P2RX3 1 23 0.75 6.15 6.62
146 INT69561 Positive_regulation of GSTM1 1 23 0.50 5.69 6.36
147 INT262 Localization of Ptger3 7 17 0.61 3.03 6.1
148 INT677 Positive_regulation of CST3 1 20 0.67 17.47 6
149 INT1002 Regulation of Localization of Ggh 1 10 0.58 0.63 5.98
150 INT28015 Regulation of Cyp3a23/3a1 1 19 0.40 6.32 5.79
151 INT4282 Regulation of Msr1 4 11 0.45 2.51 5.75
152 INT4613 Positive_regulation of Sirt1 2 32 0.67 18.19 5.53
153 INT62336 Positive_regulation of Hdc 6 38 0.70 14.45 5.51
154 INT38366 Regulation of Cat 1 45 0.62 23.45 5.34
155 INT111470 Positive_regulation of EPRS 1 18 0.44 11.42 5.29
156 INT95099 Gene_expression of SLC22A8 1 14 0.67 1.59 5.14
157 INT74051 Negative_regulation of Localization of Car2 2 27 0.38 9.58 5.1
158 INT7479 Positive_regulation of Ggh 1 13 0.62 5.71 5.02
159 INT3215 Regulation of Gene_expression of Ins1 1 32 0.52 19.83 4.85
160 INT38087 Regulation of Adh1 1 15 0.61 4.56 4.83
161 INT78672 Negative_regulation of Gene_expression of Dbi 1 6 0.43 0.67 4.75
162 INT3128 Negative_regulation of PON1 1 30 0.59 26.19 4.57
163 INT26229 Positive_regulation of ATP8A2 1 6 0.67 2.1 4.48
164 INT29231 Regulation of Dbp 1 44 0.53 10.08 4.47
165 INT1701 Localization of Neu1 3 11 0.69 6.36 4.18
166 INT17324 Negative_regulation of Plg 2 26 0.38 13.5 4.05
167 INT4530 Regulation of Ggh 1 9 0.54 2.5 3.96
168 INT64668 Regulation of SIGMAR1 1 13 0.60 0.54 3.91
169 INT115877 Negative_regulation of Adcyap1 3 14 0.59 5.31 3.74
170 INT86371 Protein_catabolism of Pnoc 1 2 0.98 0.79 3.65
171 INT22009 Negative_regulation of Ctsa 4 12 0.58 3.14 3.59
172 INT10106 Positive_regulation of Msr1 7 16 0.50 5.86 3.52
173 INT39788 Positive_regulation of Scort1 1 3 0.17 1.01 3.47
174 INT1970 Localization of Gusb 1 11 0.75 3.46 3.42
175 INT30192 Regulation of H1 1 10 0.45 4.01 3.3
176 INT25344 Localization of Plg 1 10 0.57 5 3.27
177 INT1972 Negative_regulation of Localization of Gusb 1 8 0.55 3.24 3.27
178 INT19393 Gene_expression of Gfm1 1 31 0.51 18.9 3.2
179 INT94031 Regulation of Gene_expression of Dbi 1 4 0.24 3.36 3.08
180 INT3437 Negative_regulation of Bad 1 5 0.48 1.66 2.99
181 INT45364 Negative_regulation of Negative_regulation of Cfp 3 1 0.30 2.62 2.95
182 INT38250 Negative_regulation of Syt17 1 3 0.38 1.83 2.92
183 INT36835 Regulation of Ctsa 1 5 0.27 3.85 2.87
184 INT2021 Binding of HBG2 1 13 0.36 4.2 2.65
185 INT29064 Gene_expression of Sigmar1 1 9 0.77 2.48 2.65
186 INT122054 Positive_regulation of Positive_regulation of P2rx4 1 3 0.49 2.85 2.65
187 INT119025 Gene_expression of NOTCH1 1 46 0.75 31.32 2.64
188 INT39266 Negative_regulation of Localization of Neu1 2 6 0.30 4.66 2.6
189 INT514 Gene_expression of Adrb2 1 3 0.53 0.23 2.46
190 INT31134 Regulation of Binding of ALB 3 13 0.62 2.51 2.37
191 INT30061 Negative_regulation of Hdc 1 8 0.59 2.14 2.27
192 INT2570 Negative_regulation of Gene_expression of Ache 1 13 0.43 2.88 2.18
193 INT14596 Localization of Ptgds 4 11 0.73 4.41 2.12
194 INT39789 Positive_regulation of Positive_regulation of PCS 1 2 0.32 3.63 2.04
195 INT40647 Gene_expression of Ggh 2 5 0.59 0.24 2.03
196 INT32135 Positive_regulation of Positive_regulation of ENG 1 2 0.02 0.98 1.99
197 INT95544 Negative_regulation of Itpr1 1 4 0.59 1.6 1.85
198 INT10426 Regulation of Myo5a 1 3 0.60 0.85 1.85
199 INT2826 Negative_regulation of Localization of Ptger3 3 6 0.37 0.9 1.64
200 INT107341 Phosphorylation of MAPT 3 19 0.80 14 1.61
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