J:OncoTargets and therapy

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT315829 Binding of EGFR and TKT 1 2 0.03 1.14 0.12
2 INT279417 Binding of PPARA and MLXIPL 3 1 0.00 0.33 0.07
3 INT315803 Binding of FL and Tst 1 1 0.04 0.66 0.04
4 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 1 0.00 1.39 0
5 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 2 0.01 1.15 0
6 INT347257 Binding of LOX and PPARA 1 1 0.15 0.6 0
7 INT318787 Binding of AKT1 and VEGFA 1 1 0.37 0.34 0
8 INT331909 Binding of ALB and SPARC 1 2 0.06 2.01 0
9 INT347226 Hck Regulation of Gene_expression of Lyn 1 1 0.10 0.08 0
10 INT347225 Hck Regulation of Positive_regulation of Bcr 1 1 0.15 0.07 0
11 INT315813 Binding of Tst and KRT20 1 1 0.10 0.35 0
12 INT347258 PPARA Negative_regulation of Localization of VEGFA 1 1 0.16 1.36 0
13 INT315889 Binding of B4GALNT1 and IKBKAP 1 1 0.00 0.68 0
14 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 1 0.01 1.39 0
15 INT318806 Binding of VEGFA and NCOA1 1 1 0.00 0.22 0
16 INT315814 Tst Positive_regulation of Localization of RTEL1 1 1 0.02 2.19 0
17 INT315907 Binding of ALB and Sparc 1 3 0.06 3.67 0
18 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 1 0.14 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
2 INT49750 Negative_regulation of CPOX 7 735 0.58 360.06 274.19
3 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
4 INT68684 Gene_expression of VEGFA 19 2371 0.78 1742.52 259.2
5 INT50670 Gene_expression of CPOX 17 763 0.76 442.13 195.02
6 INT867 Gene_expression of IFNA1 5 930 0.78 594.85 168.03
7 INT86024 Gene_expression of PPARA 6 736 0.78 497.93 91.14
8 INT68682 Positive_regulation of VEGFA 5 640 0.70 454.14 81.65
9 INT79494 Positive_regulation of Gene_expression of VEGFA 5 577 0.70 442.94 69.73
10 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
11 INT67614 Positive_regulation of PPARA 1 438 0.68 293.28 63.61
12 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
13 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
14 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
15 INT546 Binding of ALB 3 311 0.48 85.98 60.14
16 INT50405 Negative_regulation of CYP3A4 2 238 0.59 53.65 51.51
17 INT106525 Phosphorylation of Akt1 3 436 0.82 183.81 47.82
18 INT80124 Negative_regulation of VEGFA 10 450 0.58 311.19 44.53
19 INT77307 Gene_expression of Bcl2 2 399 0.77 319.77 38
20 INT50673 Positive_regulation of Gene_expression of CPOX 3 156 0.54 97.31 37.03
21 INT101992 Localization of VEGFA 2 413 0.81 258.23 36.15
22 INT64171 Regulation of CPOX 1 109 0.36 55.36 32.96
23 INT10248 Gene_expression of KRT20 5 436 0.78 231.96 32.88
24 INT6302 Binding of IFNA1 3 196 0.48 133.85 32.73
25 INT114881 Gene_expression of Akt1 3 227 0.78 102.49 31.81
26 INT48693 Regulation of VEGFA 5 268 0.62 191.88 31.52
27 INT65960 Gene_expression of BCL2 3 352 0.78 312.03 30.73
28 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
29 INT55737 Positive_regulation of MMP2 1 101 0.68 59.11 27.71
30 INT5206 Gene_expression of AR 4 316 0.78 113.83 27.29
31 INT14690 Localization of CSF2 2 124 0.80 85.17 27.26
32 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
33 INT11159 Gene_expression of EGFR 45 698 0.78 548.93 25.69
34 INT122570 Negative_regulation of Akt1 2 173 0.59 91.44 25.53
35 INT64175 Negative_regulation of Gene_expression of CPOX 1 66 0.38 39.64 23.07
36 INT91891 Gene_expression of Kit 5 268 0.78 158.89 22.67
37 INT101517 Negative_regulation of PPARA 4 168 0.57 112.24 21.41
38 INT48692 Binding of VEGFA 21 345 0.48 210.3 21.31
39 INT11157 Binding of EGF 3 88 0.48 53.73 21.25
40 INT73593 Gene_expression of BAX 1 173 0.76 147.81 20.94
41 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
42 INT14701 Negative_regulation of IFNA1 3 118 0.54 84.19 20.08
43 INT8662 Positive_regulation of EDN1 1 144 0.70 125.34 19.59
44 INT712 Positive_regulation of LDHA 3 160 0.70 175.25 19.11
45 INT81194 Binding of CPOX 1 40 0.29 23.7 18.95
46 INT27670 Negative_regulation of Ace 2 122 0.57 79.21 18.08
47 INT50579 Binding of CYP3A4 1 84 0.48 17.52 17.45
48 INT68681 Transcription of VEGFA 5 132 0.71 80.47 17.03
49 INT13510 Gene_expression of ERBB2 3 530 0.78 405.68 16.79
50 INT97245 Gene_expression of AKT1 3 217 0.77 119.63 15.59
51 INT24670 Gene_expression of FGF2 1 121 0.78 85.64 15.12
52 INT7776 Gene_expression of Abcb1b 1 63 0.75 21.35 14.92
53 INT105387 Gene_expression of HIF1A 1 116 0.77 98.62 14.66
54 INT103096 Regulation of PPARA 1 113 0.60 62.47 14.57
55 INT100139 Positive_regulation of Gene_expression of PPARA 2 160 0.63 97.78 14.53
56 INT34904 Negative_regulation of Gtf3a 1 48 0.15 38.88 13.73
57 INT86383 Negative_regulation of EGFR 12 258 0.59 173.94 13.32
58 INT27242 Gene_expression of PGR 2 153 0.75 98.77 12.79
59 INT90673 Gene_expression of LOX 13 66 0.65 69.71 12.18
60 INT19795 Positive_regulation of EGFR 8 161 0.70 103.69 11.55
61 INT119700 Gene_expression of VDR 2 88 0.75 65.33 11.5
62 INT74272 Localization of CPOX 1 39 0.63 25.12 10.53
63 INT173159 Localization of PPARA 2 96 0.74 64.55 10.26
64 INT33099 Negative_regulation of INSRR 1 32 0.40 13.82 9.85
65 INT2036 Localization of EGF 2 42 0.77 21.5 9.74
66 INT75137 Regulation of Akt1 1 74 0.48 37.89 9.7
67 INT70134 Negative_regulation of TXK 1 124 0.23 81.96 9.59
68 INT73596 Positive_regulation of Gene_expression of BAX 1 43 0.67 40.97 9.22
69 INT128159 Positive_regulation of DDIT3 2 29 0.67 29.5 8.99
70 INT14301 Binding of CSF2 1 82 0.48 67.95 8.98
71 INT69264 Gene_expression of KIT 2 207 0.78 179.41 8.95
72 INT90674 Negative_regulation of LOX 9 56 0.57 38.01 8.58
73 INT65959 Positive_regulation of Gene_expression of BCL2 1 75 0.70 77.3 8.27
74 INT106522 Negative_regulation of Phosphorylation of Akt1 1 65 0.58 34.44 7.83
75 INT119411 Negative_regulation of Tst 4 22 0.38 7.84 7.63
76 INT113705 Gene_expression of Egfr 1 228 0.78 149.05 7.59
77 INT96994 Phosphorylation of EGFR 1 99 0.82 52.75 7.33
78 INT70814 Negative_regulation of Il2 2 40 0.56 13.36 7.22
79 INT264641 Binding of AES 1 25 0.42 18.56 6.98
80 INT63057 Regulation of CYP3A4 1 31 0.61 5.75 6.92
81 INT95117 Gene_expression of PDGFA 3 71 0.71 51.17 6.9
82 INT43721 Gene_expression of Vegfa 5 49 0.77 36.18 6.63
83 INT48239 Binding of Gtf3a 1 52 0.33 23.14 6.45
84 INT38672 Binding of KRT20 11 69 0.39 48.01 6.31
85 INT11154 Binding of EGFR 13 149 0.48 96.23 6.29
86 INT163756 Phosphorylation of Stat1 1 45 0.82 14.51 6.11
87 INT93684 Gene_expression of STAT3 2 66 0.78 34.42 5.94
88 INT86111 Positive_regulation of Positive_regulation of VEGFA 1 38 0.69 33.81 5.78
89 INT112124 Positive_regulation of Egfr 1 71 0.70 47.82 5.61
90 INT38671 Positive_regulation of KRT20 1 62 0.53 40.17 5.6
91 INT82611 Negative_regulation of SRC 3 30 0.57 20.16 5.47
92 INT125066 Negative_regulation of HDAC4 2 56 0.49 41.55 5.42
93 INT54617 Positive_regulation of Gene_expression of Abcb1b 1 22 0.67 9.8 5.34
94 INT15376 Positive_regulation of Gene_expression of ERBB2 2 215 0.70 168.54 5.23
95 INT70613 Negative_regulation of Gene_expression of BCL2 2 48 0.59 38.91 5.22
96 INT24080 Negative_regulation of Mtor 6 64 0.37 41.56 5.19
97 INT78914 Positive_regulation of ABCC1 1 19 0.67 7.99 5.18
98 INT128161 Gene_expression of DDIT3 3 20 0.75 17.14 5.13
99 INT201130 Localization of AES 1 31 0.63 25.45 5.12
100 INT89104 Binding of TGFB1 1 29 0.44 13.67 5.12
101 INT73262 Negative_regulation of BCL2 2 67 0.57 61.01 5.07
102 INT68244 Positive_regulation of Ighg1 1 60 0.61 48.86 5.01
103 INT116150 Positive_regulation of Ddit3 1 26 0.67 22.58 5.01
104 INT11158 Positive_regulation of Gene_expression of EGFR 15 165 0.70 131.26 4.93
105 INT60957 Negative_regulation of Abcb1b 1 18 0.57 6 4.73
106 INT26404 Positive_regulation of ATM 3 15 0.49 10.94 4.39
107 INT80983 Regulation of Abcb1b 1 16 0.60 1.95 4.32
108 INT10923 Positive_regulation of Lipg 7 30 0.50 22.87 4.26
109 INT69781 Negative_regulation of FGF2 4 22 0.42 17.25 4.24
110 INT103153 Positive_regulation of Transcription of VEGFA 5 34 0.69 22.16 4.22
111 INT75136 Binding of Akt1 1 27 0.27 8.81 4.15
112 INT88278 Binding of Kit 1 33 0.37 24.45 4.13
113 INT144702 Gene_expression of Tst 9 19 0.68 12.87 4.04
114 INT153666 Gene_expression of CAV1 2 156 0.77 120.99 3.9
115 INT146946 Gene_expression of Lyn 3 16 0.76 8.9 3.75
116 INT124185 Negative_regulation of Kit 2 57 0.59 35.43 3.61
117 INT142483 Positive_regulation of Gene_expression of DDIT3 6 15 0.67 11.39 3.47
118 INT163832 Negative_regulation of Gene_expression of EGFR 1 50 0.59 39.71 3.45
119 INT130295 Gene_expression of Abcg2 3 21 0.75 9.75 3.42
120 INT16969 Negative_regulation of CRS 1 28 0.37 14.77 3.35
121 INT119421 Negative_regulation of RAF1 2 10 0.41 6.94 3.31
122 INT51607 Positive_regulation of DES 1 33 0.67 32.24 3.29
123 INT118035 Positive_regulation of JAK1 1 23 0.67 10.57 3.29
124 INT120562 Negative_regulation of Egfr 2 108 0.59 79.38 3.11
125 INT117348 Regulation of EGFR 4 75 0.61 47.73 3.09
126 INT4488 Gene_expression of TSHB 1 10 0.41 4.69 3.09
127 INT91890 Positive_regulation of Kit 1 36 0.50 25.44 3.06
128 INT105390 Positive_regulation of Gene_expression of HIF1A 1 27 0.49 26.3 2.88
129 INT8095 Gene_expression of ERBB3 1 47 0.77 24.85 2.82
130 INT212394 Gene_expression of Zic2 1 44 0.78 2.88 2.82
131 INT89397 Positive_regulation of PIK3CA 1 33 0.67 16.98 2.78
132 INT121493 Gene_expression of XRCC1 6 55 0.65 73.43 2.76
133 INT27652 Gene_expression of TG 1 36 0.78 22.36 2.74
134 INT179788 Gene_expression of Sparc 3 42 0.77 19.96 2.57
135 INT119838 Positive_regulation of PTEN 2 25 0.67 21.71 2.5
136 INT15540 Positive_regulation of PDGFA 2 24 0.47 19.01 2.5
137 INT163582 Positive_regulation of Tst 3 10 0.43 2.73 2.5
138 INT72782 Positive_regulation of HCC 1 41 0.40 63.74 2.46
139 INT137908 Phosphorylation of Pdgfrb 1 14 0.81 8.44 2.45
140 INT54555 Negative_regulation of CALR 1 10 0.41 4.41 2.4
141 INT102639 Positive_regulation of VDR 1 31 0.69 18.05 2.38
142 INT31134 Regulation of Binding of ALB 1 13 0.62 2.51 2.37
143 INT147349 Localization of Bcl2 1 13 0.65 7.83 2.31
144 INT97973 Positive_regulation of XRCC1 3 24 0.40 30.95 2.26
145 INT35058 Positive_regulation of PLAUR 1 11 0.61 7.21 2.16
146 INT109327 Negative_regulation of KIT 1 42 0.57 43.2 2.15
147 INT38674 Regulation of KRT20 1 32 0.44 19 2.15
148 INT161382 Localization of KRT20 1 25 0.61 12.97 2.13
149 INT14010 Gene_expression of SLC2A1 1 19 0.78 15.22 2.12
150 INT105247 Positive_regulation of Gene_expression of Vegfa 6 12 0.67 12.07 2.05
151 INT287525 Localization of CAV2 1 5 0.47 5.32 2
152 INT70526 Binding of CALR 2 11 0.35 7.09 1.97
153 INT21941 Regulation of CALR 2 7 0.53 3.88 1.96
154 INT118291 Binding of TXK 1 19 0.10 11.77 1.94
155 INT144020 Positive_regulation of Pdgfrb 1 30 0.69 24.8 1.92
156 INT248374 Binding of IKBKAP 1 10 0.42 10.45 1.9
157 INT13907 Gene_expression of SCLC1 1 16 0.59 16.58 1.89
158 INT65545 Localization of EGFR 4 35 0.79 20.8 1.88
159 INT79140 Binding of HCC 1 36 0.31 46.96 1.87
160 INT136503 Negative_regulation of KDR 2 46 0.48 43.1 1.86
161 INT89971 Localization of Sparc 2 10 0.80 10.25 1.85
162 INT15742 Negative_regulation of EPO 2 37 0.59 17.44 1.84
163 INT178130 Binding of EDNRB 1 12 0.36 6.18 1.84
164 INT131916 Negative_regulation of ALPL 1 10 0.42 9.33 1.8
165 INT140175 Regulation of Kit 1 23 0.62 8.59 1.79
166 INT84722 Regulation of Gene_expression of AR 1 20 0.61 7.73 1.69
167 INT164558 Binding of PERP 3 3 0.14 1.55 1.67
168 INT233010 Gene_expression of PERP 3 5 0.26 6.04 1.66
169 INT160105 Binding of Tst 2 6 0.31 1.23 1.56
170 INT118292 Negative_regulation of Phosphorylation of EGFR 1 27 0.59 13.62 1.54
171 INT14048 Negative_regulation of TKT 1 13 0.34 5.05 1.51
172 INT254298 Protein_catabolism of AES 1 6 0.55 9.79 1.43
173 INT2824 Positive_regulation of HTN1 2 10 0.40 10.41 1.4
174 INT199004 Gene_expression of ARMC9 10 43 0.58 17.72 1.32
175 INT92383 Gene_expression of KRAS 3 38 0.65 32.94 1.32
176 INT120722 Gene_expression of TYMP 2 35 0.75 19.26 1.31
177 INT195060 Gene_expression of ALPL 2 9 0.73 4.82 1.3
178 INT95116 Negative_regulation of PDGFA 2 24 0.57 19.56 1.29
179 INT144019 Negative_regulation of Pdgfrb 1 21 0.58 14.93 1.26
180 INT152255 Gene_expression of ATM 1 14 0.71 12.53 1.26
181 INT167056 Gene_expression of CALR 3 29 0.75 20.05 1.25
182 INT86446 Protein_catabolism of Lipg 1 9 0.50 3.52 1.25
183 INT122988 Gene_expression of CLU 19 28 0.75 24.07 1.21
184 INT60060 Positive_regulation of KRAS 1 17 0.67 11.68 1.21
185 INT105270 Positive_regulation of KDR 1 25 0.49 11.49 1.2
186 INT106261 Negative_regulation of DPYD 1 16 0.59 15.02 1.19
187 INT147162 Positive_regulation of Abcb1b 1 13 0.57 7.29 1.15
188 INT158542 Gene_expression of HTN1 1 10 0.75 10.69 1.07
189 INT74020 Negative_regulation of XRCC1 2 16 0.35 17.18 1.06
190 INT263822 Positive_regulation of Gene_expression of LOX 2 8 0.50 11 1.06
191 INT117328 Negative_regulation of Abcb1b 1 4 0.42 1.44 1.04
192 INT197721 Positive_regulation of ARMC9 4 36 0.35 20.08 1.03
193 INT164416 Gene_expression of CDA 1 8 0.64 5.17 1.02
194 INT112717 Negative_regulation of Binding of VEGFA 3 21 0.56 11.07 0.99
195 INT139852 Regulation of HCC 1 14 0.39 14.54 0.97
196 INT158541 Positive_regulation of Gene_expression of HTN1 1 3 0.40 5.88 0.97
197 INT11160 Regulation of Gene_expression of EGFR 4 27 0.62 22.05 0.96
198 INT21940 Positive_regulation of CALR 2 15 0.40 17.42 0.95
199 INT146939 Negative_regulation of Lyn 1 3 0.53 2.97 0.95
200 INT153670 Positive_regulation of Gene_expression of CAV1 1 26 0.69 44.27 0.92
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