J:PLoS Medicine

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 2 0.05 13.45 2.84
2 INT198958 Cnr1 Positive_regulation of Kcnj9 1 2 0.00 0.15 2.24
3 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 1 0.04 2.02 2.08
4 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 1 0.08 1.33 1.89
5 INT215096 Binding of Hmgb1 and Tlr2 9 4 0.38 11.61 1.61
6 INT198957 Binding of Cnr1 and Mastl 1 1 0.00 0 1.31
7 INT197051 Binding of HLA-E and ATP8A1 1 4 0.00 6.52 1.14
8 INT185417 Binding of ALOX5 and PLA2G2A 4 3 0.16 3.13 0.9
9 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 1 0.13 0.5 0.85
10 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 1 0.02 0.5 0.85
11 INT265566 Binding of PDE4D and PTPN5 1 1 0.03 0.81 0.85
12 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 1 0.13 0.45 0.78
13 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 1 0.13 0.45 0.78
14 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 1 0.04 0.44 0.77
15 INT284040 Gtf3a Positive_regulation of Csf3 1 1 0.01 1.7 0.7
16 INT185802 Binding of MMP7 and SPP1 1 3 0.33 1.71 0.68
17 INT284048 Binding of Cia1 and Vtcn1 1 1 0.02 1.37 0.6
18 INT192873 Binding of RS1 and Nktcn1 1 1 0.00 0.8 0.59
19 INT197050 Binding of HLA-DOA and HLA-E 2 1 0.08 1.73 0.58
20 INT185809 Binding of PDX1 and SPP1 1 2 0.02 1.69 0.57
21 INT196585 Mapk14 Regulation of TNF 1 1 0.02 0.36 0.55
22 INT273244 Binding of VCF and Del(7)Tyr<c-23DVT>-p 1 2 0.00 2.94 0.55
23 INT258338 Binding of Aicda and Cr2 1 2 0.24 1.35 0.51
24 INT284041 Negative_regulation of Binding of Vtcn1 and Sh4 1 1 0.07 1.29 0.5
25 INT284045 Binding of Vtcn1 and Sh4 1 1 0.06 1.29 0.5
26 INT284049 Arigm1 Negative_regulation of Cia1 1 1 0.00 1.11 0.5
27 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 2 0.26 1.03 0.49
28 INT206538 Trem2 Regulation of Gene_expression of Cd80 1 2 0.17 1.26 0.44
29 INT206536 Trem2 Positive_regulation of Gene_expression of Cd80 1 2 0.30 1.26 0.44
30 INT284044 Sh4 Positive_regulation of Cia1 1 1 0.20 0.72 0.43
31 INT241679 EIF2AK3 Positive_regulation of Atf4 1 1 0.06 0.46 0.4
32 INT185811 SPP1 Positive_regulation of MMP3 1 1 0.14 0.83 0.38
33 INT185814 Binding of MMP3 and SPP1 1 1 0.15 0.83 0.38
34 INT185804 MMP2 Positive_regulation of SPP1 1 1 0.15 0.88 0.37
35 INT241614 CCNA2 Regulation of PRB3 1 1 0.06 0 0.37
36 INT185795 MMP7 Positive_regulation of SPP1 1 1 0.38 0.81 0.37
37 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 1 0.26 0.87 0.37
38 INT185807 SPP1 Positive_regulation of MMP7 1 1 0.56 0.79 0.36
39 INT284046 Sh4 Negative_regulation of Vtcn1 1 1 0.10 1.13 0.36
40 INT353454 Binding of BRCA1 and IL17A 1 2 0.00 2.55 0.36
41 INT133307 Binding of CD44 and SPP1 5 1 0.26 2.6 0.35
42 INT284039 Binding of fc and Vtcn1 1 1 0.02 0.58 0.35
43 INT353452 Binding of AGRP and BRCA1 1 2 0.00 3.89 0.34
44 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 1 0.02 0.39 0.33
45 INT258339 Binding of Aicda and Scara3 1 1 0.05 0.67 0.32
46 INT241740 Sdhb Regulation of Rapgef5 1 1 0.02 0.34 0.32
47 INT241739 Sdhb Regulation of Adora2b 1 1 0.04 0.63 0.31
48 INT284047 Vtcn1 Negative_regulation of Gene_expression of Ighg2b 1 1 0.05 0.68 0.3
49 INT101810 Binding of NFE2L2 and KEAP1 7 3 0.53 4.12 0.29
50 INT185799 Binding of EGFR and SPP1 1 1 0.19 0.64 0.29
51 INT101813 KEAP1 Negative_regulation of NFE2L2 3 1 0.47 1.63 0.28
52 INT185806 Binding of PDX1 and MMP7 1 1 0.02 0.84 0.28
53 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 1 0.46 0.85 0.28
54 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 2 0.10 0.82 0.28
55 INT196584 Binding of Mapk14 and NeuN 1 2 0.02 0.39 0.27
56 INT206535 Binding of Trem2 and Tg(CAG-EGFP)D4Nagy 1 1 0.03 0.5 0.27
57 INT353448 BRCA1 Positive_regulation of CCL2 1 1 0.01 1.37 0.26
58 INT353449 BRCA1 Positive_regulation of IL4 1 1 0.00 1.37 0.26
59 INT353455 BRCA1 Positive_regulation of IL13 1 1 0.00 1.37 0.26
60 INT258343 Binding of Aicda and Kit 1 1 0.06 0.57 0.26
61 INT206763 Binding of CSF2 and Nqo1 1 1 0.00 1.7 0.25
62 INT321224 TLR4 Positive_regulation of NFKB1 1 1 0.04 1.02 0.25
63 INT321223 CXCR1 Positive_regulation of NFKB1 1 1 0.00 1.02 0.25
64 INT321222 Binding of NFKB1 and NFKBIZ 1 1 0.02 1.11 0.24
65 INT206540 mc Positive_regulation of Gene_expression of Cd80 1 1 0.01 0.62 0.22
66 INT206541 mc Regulation of Gene_expression of Cd80 1 1 0.00 0.62 0.22
67 INT206539 Trem2 Positive_regulation of Phosphorylation of Mapk1 1 1 0.22 0.62 0.2
68 INT258289 Hmgb1 Positive_regulation of Tlr2 4 1 0.48 3.61 0.19
69 INT185805 SPP1 Regulation of MMP7 1 1 0.25 0.38 0.19
70 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 2 0.46 0.36 0.18
71 INT228984 CRP Positive_regulation of IL6 2 1 0.63 0.99 0.17
72 INT185803 Binding of MMP11 and SPP1 1 1 0.06 0.34 0.17
73 INT185815 Binding of MMP1 and SPP1 1 1 0.21 0.34 0.17
74 INT185810 Binding of MMP2 and SPP1 1 1 0.14 0.34 0.17
75 INT185808 SPP1 Positive_regulation of TIMP1 1 3 0.64 0.33 0.16
76 INT258340 Binding of Ms4a1 and Cfb 1 1 0.04 0.32 0.16
77 INT185793 SPP1 Positive_regulation of COL1A2 1 1 0.16 0.33 0.16
78 INT207253 INS Negative_regulation of TXNIP 1 3 0.45 1.2 0.15
79 INT353451 Binding of BRCA1 and CRP 1 1 0.01 1.18 0.14
80 INT353453 Binding of BRCA1 and IL4 1 1 0.00 1.18 0.14
81 INT185455 MUC1 Negative_regulation of Timp1 1 1 0.06 0.84 0.13
82 INT190122 Binding of Luc7l3 and Pls1 1 1 0.00 0.52 0.13
83 INT185454 IGHG1 Negative_regulation of Timp1 1 1 0.04 0.85 0.13
84 INT185416 MUC1 Negative_regulation of TIMP1 1 1 0.18 0.84 0.13
85 INT185418 IGHG1 Negative_regulation of TIMP1 1 1 0.11 0.84 0.13
86 INT258344 Scara3 Positive_regulation of Gene_expression of Aicda 1 1 0.07 0.5 0.12
87 INT207254 ZNF236 Positive_regulation of TXNIP 1 2 0.03 0.68 0.12
88 INT258342 Scara3 Positive_regulation of Cr2 1 1 0.05 0.52 0.12
89 INT211960 Wnt5a Positive_regulation of Car2 1 1 0.13 0.38 0.08
90 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 1 0.07 0.28 0.08
91 INT208555 YWHAQ Positive_regulation of Atxn1 1 1 0.77 1.02 0.08
92 INT208554 Phosphorylation of YWHAQ Positive_regulation of Binding of YWHAQ and Akt1 1 1 0.32 1.04 0.08
93 INT208556 Binding of YWHAQ and Akt1 1 1 0.22 1.02 0.08
94 INT206537 Eae1 Regulation of Trem2 1 1 0.06 0.45 0.06
95 INT197553 Binding of NFE2L2 and LILRA3 1 1 0.03 0.43 0.06
96 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 1 0.46 1.04 0.05
97 INT353450 Binding of BRCA1 and VEGFA 1 1 0.01 0.82 0.05
98 INT199712 Binding of Mkrn1 and 2610029G23Rik 1 1 0.01 0.75 0.04
99 INT197546 NFE2L2 Regulation of Gene_expression of ABCC2 1 1 0.17 0.72 0.04
100 INT198595 Binding of CFH and CFHR1 3 2 0.41 1.36 0.03
101 INT260267 Binding of TFAM and TP53 2 1 0.37 2.1 0.03
102 INT197545 KEAP1 Regulation of NFE2L2 3 2 0.49 0.8 0
103 INT260268 Binding of FGF2 and FGFR1 1 1 0.46 0.94 0
104 INT215432 Binding of IGHG3 and MSMB 1 1 0.01 0.96 0
105 INT207260 INS Negative_regulation of Gene_expression of TXNIP 1 3 0.39 1.71 0
106 INT207256 INS Regulation of Regulation of TXNIP 1 1 0.48 0.25 0
107 INT236071 Binding of pf and Pv 1 1 0.02 2.4 0
108 INT199720 2610029G23Rik Regulation of CYP2B6 1 1 0.02 0.43 0
109 INT207259 Binding of CNBP and TXNIP 1 2 0.01 0.94 0
110 INT204318 NOS3 Regulation of NOS3 Regulation of SIRT1 1 1 0.20 0.1 0
111 INT204325 Binding of PPARGC1A and SIRT1 1 1 0.39 0.19 0
112 INT260269 Binding of FGF1 and FGFBP1 1 1 0.47 0.94 0
113 INT198593 Binding of CFH and VHL 1 1 0.02 0.27 0
114 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 1 0.08 0.12 0
115 INT193014 VHL Regulation of EPAS1 1 1 0.20 0.92 0
116 INT185796 SPP1 Regulation of Gene_expression of COL7A1 1 1 0.06 0 0
117 INT204234 Binding of CDKN2A and TP53 1 1 0.43 1.27 0
118 INT192557 Binding of Tg(Foxn1)E1Hon and ASPM 1 1 0.00 0.43 0
119 INT204320 SOD1 Positive_regulation of Protein_catabolism of ROS1 1 1 0.06 0.05 0
120 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 1 0.30 0.07 0
121 INT197576 Loh1 Positive_regulation of NFE2L2 1 1 0.49 1.1 0
122 INT199717 2610029G23Rik Regulation of CYP2D6 1 1 0.02 0.44 0
123 INT207255 INS Negative_regulation of Gene_expression of NCKIPSD 1 1 0.02 0.94 0
124 INT185817 SPP1 Positive_regulation of Gene_expression of TIMP1 1 2 0.64 0 0
125 INT197544 Binding of KEAP1 and KLHL2 1 1 0.02 0.43 0
126 INT185453 Binding of PRKCB and Lhx1 1 2 0.35 1.99 0
127 INT193013 VHL Regulation of Regulation of EPAS1 1 2 0.14 1.74 0
128 INT180124 Rhob Positive_regulation of Rock1 1 1 0.14 0 0
129 INT199718 2610029G23Rik Regulation of CYP2C19 1 1 0.03 0.44 0
130 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 1 0.51 0.19 0
131 INT207265 ZNF236 Positive_regulation of Gene_expression of TXNIP 1 2 0.04 1.6 0
132 INT198594 Binding of CFH and MIR1197 1 1 0.01 0.48 0
133 INT197547 Binding of PTS and KEAP1 1 1 0.08 1.23 0
134 INT207262 INS Regulation of Gene_expression of TXNIP 1 4 0.48 0.82 0
135 INT197552 GSTK1 Positive_regulation of NQO1 1 1 0.09 1.06 0
136 INT185801 SPP1 Regulation of Gene_expression of TIMP1 1 1 0.25 0 0
137 INT185794 SPP1 Regulation of Gene_expression of MMP1 1 1 0.16 0 0
138 INT180123 Egfl7 Positive_regulation of App 1 1 0.02 0.07 0
139 INT199711 2610029G23Rik Regulation of Cyp2e1 1 1 0.03 0.45 0
140 INT199719 2610029G23Rik Regulation of CYP3A4 1 1 0.01 0.45 0
141 INT185812 SPP1 Negative_regulation of MMP1 1 1 0.26 0 0
142 INT207258 TXNIP Regulation of ZNF236 1 4 0.04 1.87 0
143 INT188164 Binding of ALPP and HIVEP1 1 1 0.02 1.15 0
144 INT207267 INS Positive_regulation of G0S2 1 1 0.47 0.07 0
145 INT260266 Binding of FGF2 and FGFBP1 1 1 0.48 0.94 0
146 INT204321 NOS3 Regulation of SIRT1 1 1 0.23 0.1 0
147 INT190123 Binding of Luc7l3 and Sis 1 1 0.00 0.47 0
148 INT207266 INS Negative_regulation of BCL6 1 1 0.29 0.08 0
149 INT199721 2610029G23Rik Regulation of CYP2A6 1 1 0.02 0.42 0
150 INT180125 Rhoa Positive_regulation of Rock1 1 1 0.14 0 0
151 INT207252 INS Regulation of Gene_expression of ZNF236 1 1 0.02 0.31 0
152 INT207251 TXNIP Positive_regulation of ZNF236 1 1 0.03 0.84 0
153 INT207261 ZNF236 Positive_regulation of Gene_expression of NCKIPSD 1 1 0.00 0.93 0
154 INT200488 Binding of ACE and SUGT1 1 1 0.01 0.28 0
155 INT207263 ZNF236 Positive_regulation of Gene_expression of ROS1 1 1 0.01 0.67 0
156 INT260264 Binding of MTOR and FKBP7 1 1 0.26 0.87 0
157 INT207264 ZNF236 Regulation of Gene_expression of TXNIP 1 4 0.04 0.82 0
158 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 1 0.50 0.12 0
159 INT260265 Binding of FGF1 and FGFR1 1 1 0.45 0.93 0
160 INT321221 Binding of FOSB and SIGLEC11 1 2 0.17 1.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 14 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 16 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 8 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
5 INT63932 Positive_regulation of Ephb1 2 537 0.70 259.67 296.14
6 INT6852 Localization of TNF 6 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 3 1050 0.78 698.72 270
8 INT9659 Gene_expression of Il6 10 991 0.78 715.11 265.57
9 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
10 INT11009 Phosphorylation of Creb1 2 458 0.82 111.34 221.97
11 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
12 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
13 INT63934 Phosphorylation of Ephb1 2 377 0.82 150.52 188.66
14 INT6354 Localization of Gabrg1 1 321 0.74 41.41 186.74
15 INT94952 Positive_regulation of Mapk14 19 305 0.70 197.83 186.61
16 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
17 INT10194 Positive_regulation of IL6 19 702 0.70 600.62 183.38
18 INT49441 Negative_regulation of Cpox 17 494 0.59 303.22 177.46
19 INT15516 Gene_expression of Crp 7 711 0.77 615.33 173.09
20 INT55879 Gene_expression of CCL2 3 421 0.78 240.74 166.02
21 INT66280 Gene_expression of Nos2 6 534 0.78 330.78 157.07
22 INT15515 Positive_regulation of Crp 6 700 0.70 604.24 150.15
23 INT812 Localization of INS 54 1026 0.81 515.6 145.31
24 INT60694 Gene_expression of Il10 2 567 0.78 369.48 143.69
25 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
26 INT14843 Gene_expression of Gabrg1 1 301 0.77 62.63 139.16
27 INT64161 Positive_regulation of Prkca 3 213 0.70 85.06 129.91
28 INT8243 Positive_regulation of Il6 5 451 0.70 358.24 119.28
29 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 43 1138 0.72 311.58 119.18
30 INT17612 Gene_expression of CRP 6 676 0.78 580.61 119.03
31 INT118381 Gene_expression of Il17a 1 405 0.76 306.97 112.06
32 INT11051 Positive_regulation of Gene_expression of IL6 7 415 0.69 319.21 109.3
33 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
34 INT3038 Gene_expression of INS 75 1583 0.78 1174.16 107.01
35 INT69440 Gene_expression of ROS1 21 752 0.78 477.64 103.83
36 INT18009 Positive_regulation of CRP 7 518 0.70 553.03 103.74
37 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
38 INT97701 Phosphorylation of Mapk14 11 191 0.82 115.33 100.46
39 INT65500 Gene_expression of App 41 605 0.78 429.94 98.31
40 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
41 INT94953 Negative_regulation of Mapk14 20 156 0.59 104.77 91.51
42 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
43 INT54571 Positive_regulation of NFKB1 1 263 0.70 138.99 87.32
44 INT82448 Gene_expression of S100a8 2 246 0.77 236.72 84.02
45 INT92434 Phosphorylation of Mapk1 4 287 0.82 91.65 83.46
46 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
47 INT10534 Positive_regulation of Trib3 4 209 0.60 78.75 81.48
48 INT99070 Gene_expression of Mapk14 7 147 0.78 103.99 79.59
49 INT3214 Localization of Ins1 25 527 0.80 196.9 79.26
50 INT63936 Positive_regulation of Phosphorylation of Ephb1 2 131 0.70 49.38 73.16
51 INT56298 Gene_expression of IL4 7 306 0.78 182.18 72.92
52 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
53 INT4153 Binding of Insrr 1 109 0.40 17.99 72.15
54 INT5969 Gene_expression of Il1a 1 221 0.75 96.31 71.38
55 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
56 INT170332 Gene_expression of IFN1@ 1 477 0.75 275.21 69.65
57 INT3375 Gene_expression of IGHE 1 535 0.77 387.47 65.46
58 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
59 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
60 INT11937 Localization of Il6 2 228 0.81 139.83 64.39
61 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
62 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
63 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
64 INT67981 Positive_regulation of CCL2 2 165 0.70 136.84 61.85
65 INT1169 Negative_regulation of Bche 39 322 0.59 149.22 61.27
66 INT11318 Gene_expression of Gtf3a 5 274 0.52 183.82 60.89
67 INT5058 Positive_regulation of IFNA1 3 356 0.70 245.75 60.52
68 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
69 INT55344 Gene_expression of Ros1 23 396 0.54 217.64 59.98
70 INT1759 Gene_expression of TIMP1 7 267 0.77 133.87 59.29
71 INT48232 Gene_expression of MMP1 11 245 0.78 96.31 57.72
72 INT9408 Positive_regulation of Crp 2 296 0.69 242.27 57.35
73 INT4509 Gene_expression of IGG 7 426 0.76 293.69 56.64
74 INT251 Regulation of INS 5 398 0.62 232.47 55.04
75 INT63975 Positive_regulation of Il10 2 175 0.68 134.13 54.69
76 INT84495 Positive_regulation of Positive_regulation of Ephb1 2 85 0.70 46.12 54.11
77 INT8071 Positive_regulation of Gria1 1 102 0.70 26.61 53.37
78 INT3213 Gene_expression of Ins1 17 511 0.76 357.59 53.32
79 INT9234 Negative_regulation of Gene_expression of IL6 2 171 0.59 101.61 53.15
80 INT62543 Gene_expression of Icam1 1 231 0.78 187.58 52.71
81 INT1199 Positive_regulation of INS 10 579 0.70 399.64 50.43
82 INT9210 Regulation of IL6 3 166 0.62 125.61 49.95
83 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
84 INT7093 Negative_regulation of CYP2B6 1 146 0.58 37.3 48.39
85 INT16850 Negative_regulation of Localization of Gabrg1 1 73 0.51 8.28 47.89
86 INT106525 Phosphorylation of Akt1 3 436 0.82 183.81 47.82
87 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
88 INT26500 Gene_expression of MMP2 1 201 0.78 110.57 46.9
89 INT30170 Gene_expression of Car2 3 330 0.66 77.26 46.76
90 INT71786 Phosphorylation of MAPK1 3 256 0.82 110.09 46.17
91 INT1322 Positive_regulation of Localization of INS 3 293 0.70 120.86 45.98
92 INT145266 Gene_expression of IL17A 3 154 0.75 109.83 45.33
93 INT81498 Positive_regulation of Gene_expression of CCL2 1 107 0.70 53.89 45.22
94 INT42980 Gene_expression of GAD1 3 139 0.69 94.77 45.11
95 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
96 INT2774 Binding of Crp 11 241 0.48 195.89 44.39
97 INT4216 Gene_expression of CD40LG 4 328 0.78 256.02 44.23
98 INT73502 Positive_regulation of IL10 3 154 0.69 124.87 43.5
99 INT25383 Gene_expression of Csf2 1 222 0.76 152.93 43.32
100 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
101 INT4004 Gene_expression of IGHG3 8 321 0.71 221.03 42.33
102 INT48929 Regulation of Ephb1 1 71 0.62 24.42 42.11
103 INT29496 Gene_expression of MMP3 1 136 0.75 49.49 41.78
104 INT13556 Gene_expression of CD4 4 367 0.78 230.82 41.74
105 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
106 INT57442 Phosphorylation of Prkca 1 98 0.70 31.58 41.04
107 INT69437 Positive_regulation of ROS1 7 328 0.58 222.83 40.56
108 INT97596 Localization of S100a8 2 94 0.78 90.69 40.41
109 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
110 INT92437 Positive_regulation of Phosphorylation of Mapk1 1 113 0.70 32.19 40.29
111 INT3252 Negative_regulation of INS 5 428 0.59 271.65 39.52
112 INT77434 Positive_regulation of Gene_expression of Nos2 1 151 0.69 96.76 38.94
113 INT9094 Gene_expression of COL7A1 3 277 0.77 143.42 38.73
114 INT16323 Gene_expression of pr 3 62 0.66 36.14 38.26
115 INT43507 Gene_expression of Gabbr1 1 79 0.78 28.53 38.22
116 INT97702 Positive_regulation of Phosphorylation of Mapk14 3 69 0.69 49.21 36.81
117 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
118 INT9082 Positive_regulation of ESR1 3 238 0.69 148.51 36.69
119 INT3253 Negative_regulation of Localization of INS 12 205 0.59 130.39 36.61
120 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
121 INT3216 Positive_regulation of Localization of Ins1 1 170 0.69 56.78 35.63
122 INT10796 Gene_expression of CYP2B6 2 131 0.77 30.14 35.27
123 INT60710 Gene_expression of Col7a1 2 217 0.78 113.2 35.2
124 INT8747 Positive_regulation of Ins1 2 221 0.69 154.28 35.15
125 INT72651 Gene_expression of TH1L 2 114 0.75 80.15 35.15
126 INT118343 Positive_regulation of Eae1 4 121 0.39 136.06 34.87
127 INT2274 Regulation of Localization of INS 2 101 0.62 41.55 34.79
128 INT74563 Positive_regulation of Gene_expression of ROS1 8 258 0.61 168.18 34.08
129 INT16960 Gene_expression of Crp 3 166 0.76 116.21 34.07
130 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
131 INT67039 Positive_regulation of Cpox 1 144 0.65 98.4 33.77
132 INT11325 Gene_expression of HLA-E 1 209 0.76 98.05 33.72
133 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
134 INT40160 Positive_regulation of Adora1 1 74 0.70 26.36 33.03
135 INT234 Binding of Alb 1 151 0.48 52.34 32.97
136 INT73498 Gene_expression of IL13 4 117 0.44 83.85 32.26
137 INT22939 Gene_expression of Csf2 5 164 0.78 85.1 32.22
138 INT92837 Negative_regulation of Gene_expression of Nos2 4 116 0.59 59.67 31.82
139 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
140 INT124860 Gene_expression of Bace1 2 330 0.78 157.11 31.65
141 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
142 INT166203 Positive_regulation of Cia1 9 62 0.43 75.94 31.37
143 INT29743 Negative_regulation of App 5 91 0.59 65.56 31.26
144 INT1179 Negative_regulation of Ace 4 157 0.59 67.03 30.46
145 INT34729 Positive_regulation of IFN1@ 2 233 0.67 128.04 30.38
146 INT90792 Localization of Il10 2 144 0.80 87.88 30.03
147 INT6660 Positive_regulation of Jun 1 148 0.69 67.58 29.73
148 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
149 INT169180 Binding of SNRNP70 9 204 0.47 119.1 29.3
150 INT86437 Binding of IL6 4 154 0.48 121.22 29.3
151 INT15174 Gene_expression of Itgam 1 238 0.73 104.92 29.26
152 INT11010 Regulation of Phosphorylation of Creb1 2 52 0.62 7.26 29.04
153 INT28361 Gene_expression of TP53 4 443 0.78 384.86 28.8
154 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
155 INT66200 Gene_expression of Gfap 1 215 0.78 88.04 28.25
156 INT55737 Positive_regulation of MMP2 2 101 0.68 59.11 27.71
157 INT21900 Gene_expression of Mthfd1 1 150 0.75 69.47 27.03
158 INT59449 Negative_regulation of Timp1 1 76 0.42 54.86 26.99
159 INT16428 Positive_regulation of Gtf3a 5 135 0.20 106.44 26.67
160 INT12681 Regulation of Trib3 1 76 0.53 23.92 26.58
161 INT73047 Positive_regulation of MMP9 1 133 0.68 73.22 26.42
162 INT9682 Positive_regulation of IGF1 1 238 0.70 120.03 26.36
163 INT86062 Positive_regulation of Tnfrsf1a 1 51 0.69 40.69 26.2
164 INT20044 Negative_regulation of Gpi1 1 50 0.59 29.96 26
165 INT130176 Positive_regulation of Gene_expression of CRP 6 125 0.66 137.06 25.9
166 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
167 INT70048 Positive_regulation of Gene_expression of IL10 1 90 0.55 71.34 25.66
168 INT89662 Positive_regulation of Gene_expression of App 11 169 0.70 133.36 25.62
169 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
170 INT140413 Gene_expression of AQP4 6 113 0.78 139.25 25.53
171 INT68758 Positive_regulation of Ros1 3 125 0.46 82.72 25.27
172 INT93717 Gene_expression of Mmp3 2 85 0.78 33.95 24.89
173 INT106272 Positive_regulation of Positive_regulation of Mapk14 3 39 0.70 32.08 24.71
174 INT22708 Gene_expression of MUC1 1 297 0.78 232.71 24.19
175 INT72370 Gene_expression of Timp1 1 82 0.65 57.52 24.16
176 INT89854 Regulation of Nos2 1 49 0.61 42.58 24.1
177 INT17275 Gene_expression of HIVEP1 6 267 0.75 232.07 24.06
178 INT44954 Gene_expression of APP 6 191 0.78 105.86 23.9
179 INT114362 Localization of Hmgb1 32 127 0.78 120.28 23.26
180 INT99069 Positive_regulation of Gene_expression of Mapk14 1 42 0.53 29.84 23.16
181 INT18323 Negative_regulation of Localization of Ins1 4 122 0.58 45.74 23.04
182 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
183 INT6868 Gene_expression of GFAP 3 136 0.78 84.65 22.7
184 INT91891 Gene_expression of Kit 10 268 0.78 158.89 22.67
185 INT18322 Negative_regulation of Ins1 7 132 0.58 88.49 22.59
186 INT16996 Gene_expression of PRTN3 40 113 0.75 85.61 22.57
187 INT823 Negative_regulation of ESR1 1 144 0.58 63.72 22.52
188 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
189 INT15326 Phosphorylation of Trib3 2 83 0.55 30.96 22.27
190 INT142594 Gene_expression of Tlr2 7 165 0.78 139.73 22.26
191 INT3299 Positive_regulation of AGT 2 126 0.68 79.45 21.91
192 INT23257 Regulation of CRP 1 127 0.62 100.05 21.87
193 INT34488 Negative_regulation of MMP2 1 85 0.59 41.98 21.72
194 INT73593 Gene_expression of BAX 2 173 0.76 147.81 20.94
195 INT72060 Positive_regulation of Gene_expression of Ros1 8 127 0.41 76.76 20.91
196 INT11625 Localization of App 8 98 0.78 55.46 20.86
197 INT101537 Gene_expression of Vta1 2 19 0.50 1.88 20.76
198 INT86751 Negative_regulation of Il10 2 62 0.59 40.1 20.51
199 INT137767 Gene_expression of Eae1 2 74 0.34 89.32 20.48
200 INT62042 Positive_regulation of Gene_expression of IL4 3 67 0.56 42.05 20.39
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