J:PLoS ONE

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 21 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 10 0.09 0.22 12.65
3 INT106676 Binding of Trpv1 and Phax 18 2 0.34 4.19 12.36
4 INT145775 Ngf Positive_regulation of Trpv1 11 2 0.72 7.71 11.25
5 INT77646 Binding of Ngf and Ntrk1 23 2 0.40 7.85 9.26
6 INT106559 Binding of Bdnf and Ntrk2 23 4 0.43 11.09 7.33
7 INT259228 Binding of Oprm1 and Glul 1 5 0.00 0.08 7.22
8 INT254001 Binding of Cxcr4 and Mif 1 27 0.52 14.17 7.18
9 INT179502 Binding of Cd14 and Tlr4 29 7 0.39 13.77 5.73
10 INT227157 Binding of PEBP1 and Gpm6a 1 5 0.00 1.28 5.52
11 INT211710 Binding of Mc1r and a 7 4 0.44 0.37 4.78
12 INT122567 Mog Positive_regulation of Eae1 8 2 0.31 10.18 4.26
13 INT259209 Binding of Glul and Flna 1 3 0.03 0 4.2
14 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 3 0.02 0 4.15
15 INT95730 Binding of CP and SPINK1 2 6 0.19 5.65 4.02
16 INT127128 Binding of CNR1 and CNR2 8 2 0.39 3.98 3.97
17 INT317511 Ppp1r9b Regulation of Oprm1 3 2 0.27 0.33 3.85
18 INT317517 Binding of Nos1 and Oprm1 1 4 0.17 0.22 3.85
19 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 3 0.18 1.57 3.59
20 INT85743 Pdyn Positive_regulation of Oprk1 3 1 0.32 2.12 3.52
21 INT180984 IRF6 Positive_regulation of Localization of IL8 7 5 0.11 2.13 3.47
22 INT340118 Binding of Sugt1 and Pain1 1 2 0.00 3.53 3.44
23 INT349584 Binding of Cyp2e1 and Aap 1 3 0.10 1.56 3.24
24 INT166134 Binding of Cxcl12 and Cxcr4 3 7 0.49 5.69 3.17
25 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 4 0.43 0.4 3.13
26 INT309150 Edc4 Positive_regulation of Creb1 1 8 0.03 3.46 3.09
27 INT317563 Binding of Hint1 and Oprm1 1 4 0.20 0.25 3.03
28 INT229497 Binding of Vim and Ndel1 1 18 0.33 3.5 2.81
29 INT317551 Binding of Akt1 and Oprm1 1 3 0.19 0.21 2.74
30 INT226118 Ghrl Regulation of Prkag1 1 9 0.08 0.72 2.72
31 INT349589 Aap Positive_regulation of Cyp2e1 1 4 0.21 1.84 2.71
32 INT259231 Binding of Oprm1 and Ppp1r9b 1 2 0.01 0 2.67
33 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 2 0.00 0 2.64
34 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 2 0.01 0 2.64
35 INT351444 Grin1 Positive_regulation of Gria2 1 2 0.22 1.5 2.64
36 INT340117 Binding of Bdnf and Pain1 1 2 0.01 2.48 2.55
37 INT253988 Binding of Cd74 and Mif 1 6 0.36 6.57 2.52
38 INT317528 Ppp1r9b Regulation of Grin1 1 2 0.18 0.2 2.48
39 INT314141 Binding of Tacr3 and SFTPA1 1 3 0.00 3.02 2.48
40 INT122163 Binding of TNF and TNFRSF1B 6 1 0.44 6.06 2.41
41 INT317526 Binding of Hint1 and Gipc1 1 3 0.00 0.25 2.38
42 INT211748 Binding of Pag1 and Mors1 2 1 0.07 0.2 2.26
43 INT197379 Tbs1 Positive_regulation of Ltp 6 1 0.07 1.87 2.21
44 INT317524 Binding of Camk2a and Grin1 1 2 0.17 0.06 2.21
45 INT140659 Phax Positive_regulation of Trpv1 3 1 0.49 0.68 2.18
46 INT49242 Binding of Mc1r and Pomc 10 1 0.38 3.79 2.15
47 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
48 INT273120 NOVA2 Regulation of Gene_expression of MET 1 1 0.23 1.17 2.11
49 INT221181 Binding of GOPC and Flna 1 2 0.03 0.06 2.08
50 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 2 0.04 0.64 2.07
51 INT70043 IL6 Regulation of IL10 3 1 0.18 3.59 2.01
52 INT281381 FSCN1 Positive_regulation of Gene_expression of Gfap 1 2 0.06 1.13 1.98
53 INT317540 Camk2a Negative_regulation of Oprm1 1 2 0.19 0 1.98
54 INT157767 Binding of TLR4 and LY96 8 2 0.54 4.05 1.95
55 INT217042 IRF6 Positive_regulation of TNF 4 1 0.27 3.03 1.95
56 INT349585 Aap Positive_regulation of Etf1 1 2 0.00 1.68 1.94
57 INT283050 Binding of Gad2 and Trpm8 1 2 0.23 2.02 1.93
58 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 1 0.01 0.06 1.86
59 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 1 0.04 0.06 1.86
60 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 2 0.06 0.73 1.85
61 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 2 0.63 2.86 1.84
62 INT302646 ARSA Positive_regulation of TGFB1 1 4 0.10 0.52 1.76
63 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 6 0.08 1.87 1.76
64 INT86997 Binding of HIVEP1 and NGF 2 1 0.03 1.75 1.73
65 INT282398 Binding of Mefv and Nlrp3 1 6 0.40 6.8 1.72
66 INT215100 Binding of Hmgb1 and Tlr4 5 5 0.29 3.21 1.68
67 INT101926 Binding of Dio1 and Drd2 4 1 0.28 0.39 1.66
68 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 1 0.47 1.01 1.63
69 INT215096 Binding of Hmgb1 and Tlr2 9 5 0.38 11.61 1.61
70 INT174503 Binding of HLA-B and KIR3DL1 6 1 0.37 3.48 1.61
71 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 8 0.08 4.21 1.61
72 INT317558 Binding of Oprm1 and Rgs17 1 1 0.18 0 1.59
73 INT355254 Ltp Regulation of Cacna1a 1 1 0.04 0 1.58
74 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 1 0.07 0 1.57
75 INT208991 Binding of CALM1 and Ca2 10 4 0.06 1.34 1.55
76 INT208980 Binding of Ca2 and Trpv1 4 3 0.32 0.67 1.55
77 INT333150 Tlx2 Regulation of asa 1 4 0.04 2.17 1.55
78 INT252633 Binding of TNF and Tnfrsf1b 4 1 0.05 3.66 1.54
79 INT284785 Gch1 Regulation of Bh4p 1 1 0.00 1.48 1.54
80 INT241750 Binding of CD4 and ITIH4 14 1 0.18 5.72 1.53
81 INT69031 IL12A Positive_regulation of IFNA1 9 1 0.13 4.23 1.52
82 INT317538 Binding of Neu3 and Mors1 1 1 0.00 0 1.51
83 INT256360 Car2 Positive_regulation of Localization of Rela 1 2 0.14 0 1.51
84 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 1 0.04 0.66 1.49
85 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 1 0.12 0.66 1.49
86 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 1 0.00 0 1.46
87 INT150392 Binding of MEFV and PSTPIP1 2 39 0.51 10.49 1.44
88 INT329451 Binding of Oprd1 and Tacr1 1 1 0.05 0.23 1.41
89 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 4 0.27 0.54 1.4
90 INT329452 Binding of Tac1 and Oprd1 1 1 0.01 0.23 1.4
91 INT227152 Positive_regulation of Binding of Mop3 and Gpm6a 1 1 0.00 0 1.39
92 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 1 0.03 0 1.39
93 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 1 0.04 0 1.39
94 INT227151 Binding of Mop3 and Gpm6a 1 1 0.00 0 1.38
95 INT218309 Binding of CRP and IL6 3 2 0.23 4.78 1.36
96 INT290542 Crh Positive_regulation of Insr 1 2 0.02 0.36 1.36
97 INT229496 Binding of Ndel1 and Gopc 1 9 0.08 2.05 1.36
98 INT355248 Ltp Positive_regulation of Localization of Trpv1 1 1 0.51 0 1.35
99 INT355253 Ltp Positive_regulation of Cacna1a 1 1 0.05 0 1.34
100 INT178986 Binding of MMP9 and TIMP1 4 1 0.47 2.58 1.33
101 INT259211 Binding of Ppp1r9b and Flna 1 1 0.06 0 1.33
102 INT281382 FSCN1 Positive_regulation of Sds 1 1 0.02 0.84 1.33
103 INT300864 Ngf Positive_regulation of Mapk14 2 1 0.60 1.38 1.32
104 INT265213 Binding of Ctla4 and Cd86 2 1 0.13 1.93 1.31
105 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 1 0.14 0 1.31
106 INT355252 Binding of Cacna1a and Cnr1 1 1 0.04 0 1.31
107 INT281479 Drd2 Positive_regulation of Penk 1 3 0.23 0.4 1.3
108 INT330124 Positive_regulation of Bdkrb1 Positive_regulation of RT1-O2-ps 1 2 0.02 1.97 1.3
109 INT186393 Binding of TNF and Tnfrsf1a 9 1 0.37 8.55 1.29
110 INT107858 PRSS1 Positive_regulation of F2RL1 6 2 0.12 4.23 1.29
111 INT242623 Binding of Ntf3 and Ntrk3 5 1 0.22 1.31 1.29
112 INT121096 Binding of Calca and Trpv1 3 1 0.37 1.23 1.29
113 INT208990 Binding of CALM1 and Trpv1 1 3 0.10 0.07 1.29
114 INT276282 Binding of Atrn and Mc1r 1 2 0.32 0.41 1.29
115 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 1 0.00 1.58 1.26
116 INT239640 Sst Positive_regulation of Ltp 1 3 0.04 0.23 1.26
117 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 1 0.11 0 1.25
118 INT236835 Binding of CISH and CSF2 1 2 0.06 1.43 1.25
119 INT161508 Tlr4 Positive_regulation of Mapk14 2 3 0.19 0.46 1.24
120 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 1 0.02 0 1.23
121 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 1 0.03 1.32 1.23
122 INT237207 LGALS4 Regulation of Localization of Ik 1 5 0.00 0.9 1.23
123 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 1 0.02 1.32 1.23
124 INT197092 TNF Regulation of VEGFA 4 1 0.21 2.78 1.22
125 INT83422 Binding of FANCB and IGHG3 3 10 0.12 5.09 1.22
126 INT310068 Pain1 Positive_regulation of Faah 1 1 0.03 1.3 1.22
127 INT253999 Binding of Cxcl12 and Mif 1 3 0.41 2.26 1.22
128 INT197231 Grik1 Regulation of Gabrg1 1 1 0.19 0.13 1.22
129 INT310067 Pain1 Positive_regulation of Mgll 1 1 0.02 1.29 1.21
130 INT224410 Binding of CRP and CIMT 3 17 0.42 10.46 1.2
131 INT210982 Binding of Cnr1 and Cfp 2 1 0.22 1.27 1.2
132 INT281373 Tcf21 Regulation of Fig4 1 1 0.03 0.67 1.2
133 INT228681 Fkbp4 Negative_regulation of Trib3 1 1 0.00 0.57 1.2
134 INT281383 FSCN1 Positive_regulation of Fig4 1 2 0.02 0.44 1.19
135 INT281379 Tcf21 Regulation of FSCN1 1 1 0.01 0.66 1.19
136 INT351715 Pax3 Negative_regulation of Adarb1 1 1 0.00 0 1.19
137 INT201067 Binding of Edn1 and Ednra 2 3 0.18 1.36 1.18
138 INT349587 Binding of Aap and Csf2 1 1 0.04 0.41 1.18
139 INT228680 Fkbp1a Negative_regulation of Trib3 1 1 0.01 0.56 1.18
140 INT225067 Binding of ETF1 and IGHG3 1 6 0.03 4.52 1.17
141 INT349586 Aap Regulation of Gene_expression of Ros1 1 1 0.03 0.56 1.17
142 INT353338 F2r Positive_regulation of Localization of Mif 1 8 0.68 1.25 1.16
143 INT280949 Binding of Fst and Inhbe 3 2 0.01 2.51 1.15
144 INT336559 SLC6A3 Positive_regulation of GOPC 1 4 0.08 1 1.15
145 INT349590 Aap Positive_regulation of Cytl1 1 1 0.13 1.31 1.15
146 INT225104 CNR1 Positive_regulation of Gene_expression of RETNLB 1 1 0.01 1.41 1.14
147 INT317553 Binding of Car2 and Grin1 1 1 0.07 0 1.14
148 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 1 0.19 0 1.14
149 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 1 0.02 0.82 1.13
150 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 1 0.25 1.3 1.12
151 INT208621 Binding of Prph and Nmbr 1 3 0.05 0.43 1.12
152 INT221183 Binding of OPRM1 and Mors1 1 1 0.00 0 1.12
153 INT242624 Binding of Ngf and Ntrk2 5 1 0.24 0.48 1.11
154 INT99577 Binding of KITLG and Kit 3 2 0.34 2.33 1.11
155 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 1 0.15 0 1.11
156 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 1 0.17 0.1 1.11
157 INT317527 Binding of Hint1 and Nos1 1 1 0.27 0.1 1.11
158 INT173059 Binding of KDR and VEGFA 43 8 0.43 29.63 1.1
159 INT317512 Binding of Oprm1 and Prkca 1 1 0.07 0.13 1.1
160 INT323175 PRKCA Positive_regulation of Akt1 1 2 0.02 0 1.1
161 INT317561 Binding of Grin1 and Oprm1 1 1 0.14 0.09 1.08
162 INT161011 Binding of Cpe and St13 2 1 0.03 0.61 1.07
163 INT282712 Binding of MUC5AC and Csf2 1 2 0.01 2.63 1.07
164 INT218846 Ppp1r9a Regulation of Ltp 1 2 0.15 2.24 1.07
165 INT218840 Cysltr1 Positive_regulation of Ltp 2 1 0.02 1.04 1.06
166 INT314136 Binding of TAC1 and SFTPA1 2 1 0.03 0.78 1.06
167 INT331108 Mc1r Positive_regulation of Mc4r 1 1 0.44 1.05 1.06
168 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 1 0.17 1.5 1.05
169 INT317552 Binding of Calm3 and Car2 2 1 0.06 0.07 1.05
170 INT317531 Regulation of Binding of Grin1 and Mors1 1 1 0.08 0.06 1.05
171 INT317534 Regulation of Binding of Camk2a and Grin1 1 1 0.20 0.06 1.05
172 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 1 0.05 0.5 1.05
173 INT214875 Ap3d1 Negative_regulation of Gene_expression of Fos 1 1 0.00 0.39 1.04
174 INT317535 Binding of Grin1 and Mors1 1 1 0.07 0.06 1.04
175 INT349576 Binding of Ugt2b and Sult1a1 1 1 0.00 0.45 1.03
176 INT293014 IRF6 Positive_regulation of Localization of CA2 1 1 0.04 0.71 1.02
177 INT230594 Binding of Hrh1 and Hrh2 1 1 0.24 0.99 1.02
178 INT218310 IL6 Positive_regulation of Localization of CRP 1 2 0.29 3.33 1.02
179 INT178663 Binding of CXCR3 and TH1L 2 1 0.04 2.24 1.01
180 INT293008 IL8 Positive_regulation of Localization of CA2 1 1 0.11 0.71 1.01
181 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 1 0.21 0.07 1
182 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 1 0.18 0.07 1
183 INT317518 Src Regulation of Negative_regulation of Oprm1 1 1 0.16 0.07 1
184 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 1 0.21 0.07 1
185 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 1 0.20 0.07 1
186 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 1 0.13 0.07 1
187 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 1 0.10 0.07 1
188 INT351443 Cnr1 Regulation of Positive_regulation of Vta1 1 1 0.12 0.93 0.99
189 INT308804 Pld1 Positive_regulation of TNF 1 3 0.05 2.42 0.99
190 INT103928 Binding of Cd28 and Trav6-3 3 1 0.03 0.55 0.98
191 INT238091 Binding of GRIP1 and Mmp24 1 2 0.00 0 0.98
192 INT317550 Binding of Hint1 and Rgs20 1 1 0.32 0.07 0.98
193 INT267886 Arl10 Positive_regulation of Insrr 1 2 0.00 0.07 0.98
194 INT311102 IL8 Positive_regulation of CXCR7 1 2 0.00 1.74 0.98
195 INT238092 Binding of SHBG and Mmp24 1 2 0.04 0 0.98
196 INT317529 Binding of Hint1 and Rgs17 1 1 0.32 0.07 0.98
197 INT311143 IL8 Positive_regulation of Cxcr1 1 2 0.04 1.74 0.98
198 INT349592 GTF2H5 Negative_regulation of Cyp2c22 1 1 0.00 0.64 0.98
199 INT353372 Dio1 Positive_regulation of Grin1 1 1 0.16 0 0.98
200 INT307100 Trpv1 Regulation of Binding of Trpa1 1 1 0.31 1.81 0.97

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 195 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 11 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 7 1902 0.78 275.47 1057.59
4 INT6483 Gene_expression of TNF 185 3152 0.78 2515.62 929.82
5 INT7114 Positive_regulation of Ltp 188 1192 0.62 290.76 755.77
6 INT1912 Gene_expression of Calca 12 1152 0.78 453.25 739.84
7 INT3439 Localization of Abat 32 1017 0.78 112.39 727.06
8 INT5202 Positive_regulation of Gene_expression of Fos 50 1163 0.70 319.28 684
9 INT292 Localization of Penk 2 876 0.81 88.44 669.14
10 INT58061 Gene_expression of Trpv1 91 1117 0.78 451.54 637.59
11 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
12 INT2543 Positive_regulation of Calca 3 787 0.70 331.13 592.08
13 INT5228 Positive_regulation of Fos 31 934 0.70 209.8 503.87
14 INT155 Positive_regulation of Prl 5 1233 0.70 317.93 457.82
15 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
16 INT443 Localization of POMC 6 1020 0.81 284.52 443.17
17 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
18 INT9238 Gene_expression of IL6 160 1575 0.78 1135.66 424.22
19 INT4758 Positive_regulation of Localization of Calca 2 557 0.70 138.55 411.04
20 INT5895 Gene_expression of Oprm1 19 525 0.78 120.67 407.29
21 INT64202 Positive_regulation of Trpv1 58 643 0.70 249.66 397.42
22 INT467 Gene_expression of POMC 11 1048 0.78 332.8 394.16
23 INT6056 Negative_regulation of Gene_expression of Fos 26 601 0.59 193.05 386.84
24 INT76660 Gene_expression of Trpv1 29 691 0.78 329.46 386.42
25 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
26 INT18357 Gene_expression of TRPV1 57 825 0.78 307.11 382.81
27 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
28 INT439 Localization of Gnrh1 8 976 0.81 100.96 363.25
29 INT720 Positive_regulation of POMC 4 807 0.70 237.37 353.83
30 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
31 INT16260 Gene_expression of Bdnf 114 671 0.78 283.44 339.1
32 INT5235 Negative_regulation of TNF 40 924 0.59 772.91 331.98
33 INT2649 Regulation of Calca 2 433 0.62 146.05 330.95
34 INT5059 Positive_regulation of TNF 62 1050 0.70 896.51 322.81
35 INT162 Regulation of Prl 5 794 0.62 165.01 322.24
36 INT5979 Gene_expression of Oprd1 16 428 0.78 75.64 320.32
37 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
38 INT5540 Positive_regulation of Oprm1 12 344 0.70 76.77 319.71
39 INT5680 Gene_expression of Ngf 38 530 0.78 264.29 310.56
40 INT46460 Gene_expression of NAV1 3 288 0.78 135.51 305.75
41 INT9131 Positive_regulation of Prkcg 23 431 0.70 130.8 302.41
42 INT63932 Positive_regulation of Ephb1 34 537 0.70 259.67 296.14
43 INT1352 Localization of Acot1 4 728 0.80 73.01 296.01
44 INT886 Gene_expression of Pomc 8 676 0.78 129.87 295.98
45 INT11624 Gene_expression of OPRM1 13 445 0.78 72.36 294.36
46 INT5379 Gene_expression of Fos 88 656 0.78 255.5 292.54
47 INT97367 Gene_expression of Nav1 22 243 0.78 132.97 286.66
48 INT9158 Gene_expression of Tnf 5 722 0.78 522.01 277.68
49 INT9381 Positive_regulation of TRPV1 13 523 0.70 187.4 276.05
50 INT94450 Gene_expression of Nav1 10 359 0.78 131.85 275.46
51 INT49750 Negative_regulation of CPOX 19 735 0.58 360.06 274.19
52 INT6852 Localization of TNF 73 883 0.81 705.95 270.84
53 INT10832 Gene_expression of IL8 107 1050 0.78 698.72 270
54 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
55 INT5591 Regulation of Gene_expression of Fos 18 425 0.62 129.06 265.78
56 INT9659 Gene_expression of Il6 108 991 0.78 715.11 265.57
57 INT5972 Gene_expression of IL1B 16 948 0.78 510.91 263.97
58 INT68684 Gene_expression of VEGFA 263 2371 0.78 1742.52 259.2
59 INT87687 Positive_regulation of Trpv1 52 409 0.70 210.24 257.59
60 INT1893 Localization of Gh 19 1041 0.79 340.23 256.58
61 INT16868 Gene_expression of Il6 37 807 0.78 499.48 256.57
62 INT2909 Positive_regulation of Abat 5 334 0.70 62.1 256.43
63 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
64 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
65 INT11377 Positive_regulation of Ngf 7 331 0.70 206.5 238
66 INT1562 Localization of Crh 4 499 0.81 126.74 236.68
67 INT5597 Gene_expression of Pdyn 1 433 0.78 62.97 235.47
68 INT1665 Positive_regulation of Pag1 11 270 0.68 186.63 229.87
69 INT9987 Gene_expression of Abat 18 296 0.78 95.46 226.34
70 INT6406 Binding of Oprm1 24 280 0.48 40.54 226.26
71 INT11009 Phosphorylation of Creb1 23 458 0.82 111.34 221.97
72 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
73 INT95787 Positive_regulation of Mapk1 90 568 0.70 226.51 220.94
74 INT6665 Gene_expression of FOS 20 520 0.77 165.31 217.66
75 INT6481 Binding of TNF 36 624 0.48 510.2 214.82
76 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
77 INT22548 Positive_regulation of Casp3 34 483 0.70 258.78 213.07
78 INT6482 Positive_regulation of Gene_expression of TNF 48 659 0.70 569.88 210
79 INT16259 Positive_regulation of Bdnf 48 336 0.70 183.48 209.82
80 INT48955 Gene_expression of Nos2 54 753 0.78 403.87 208.08
81 INT2391 Negative_regulation of PTGS1 7 501 0.59 207.62 205.6
82 INT9132 Negative_regulation of Prkcg 6 279 0.59 88.05 203.47
83 INT798 Positive_regulation of Gene_expression of Penk 1 394 0.70 78.53 203.07
84 INT11313 Positive_regulation of Il6 24 526 0.70 331.27 201.59
85 INT2211 Negative_regulation of Abat 7 267 0.59 66.51 200.98
86 INT50670 Gene_expression of CPOX 19 763 0.76 442.13 195.02
87 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
88 INT528 Gene_expression of Prl 5 693 0.78 217.18 192.2
89 INT6488 Gene_expression of Tnf 9 484 0.78 339.61 191.58
90 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
91 INT63934 Phosphorylation of Ephb1 19 377 0.82 150.52 188.66
92 INT6354 Localization of Gabrg1 25 321 0.74 41.41 186.74
93 INT94952 Positive_regulation of Mapk14 17 305 0.70 197.83 186.61
94 INT1652 Regulation of Pomc 5 387 0.62 61.01 186.51
95 INT24326 Gene_expression of Ngf 28 346 0.78 218.67 184.71
96 INT10194 Positive_regulation of IL6 72 702 0.70 600.62 183.38
97 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
98 INT3440 Negative_regulation of Localization of Abat 1 221 0.57 33.94 180.36
99 INT12602 Negative_regulation of Oprm1 10 190 0.59 36.11 177.85
100 INT49441 Negative_regulation of Cpox 74 494 0.59 303.22 177.46
101 INT7506 Negative_regulation of Ltp 42 267 0.46 91.01 176.8
102 INT1429 Gene_expression of PDYN 5 308 0.78 61.33 175.65
103 INT19472 Gene_expression of Il1 10 554 0.76 419.75 175.35
104 INT26472 Regulation of Oprm1 10 191 0.62 35.84 173.1
105 INT15516 Gene_expression of Crp 17 711 0.77 615.33 173.09
106 INT5930 Positive_regulation of Oprm1 1 221 0.70 31.19 172.93
107 INT4937 Negative_regulation of Oprd1 3 224 0.59 44.51 171.11
108 INT438 Gene_expression of Crh 9 376 0.78 159.11 169.17
109 INT867 Gene_expression of IFNA1 198 930 0.78 594.85 168.03
110 INT55879 Gene_expression of CCL2 28 421 0.78 240.74 166.02
111 INT1114 Localization of Ins1 9 748 0.80 192.95 165.48
112 INT4768 Positive_regulation of OPRM1 17 212 0.70 31.09 164.28
113 INT5127 Localization of Lhb 13 488 0.80 50.48 162.66
114 INT3448 Positive_regulation of Gh 4 521 0.69 180.03 161.18
115 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
116 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
117 INT66280 Gene_expression of Nos2 66 534 0.78 330.78 157.07
118 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
119 INT2640 Gene_expression of Pomc 16 424 0.78 120.72 155.37
120 INT4740 Gene_expression of Th 24 298 0.78 61.27 154.03
121 INT2910 Regulation of Abat 3 169 0.62 36.95 153.53
122 INT120811 Gene_expression of Gopc 392 1174 0.59 428.49 150.55
123 INT4829 Positive_regulation of Localization of Abat 6 199 0.55 20.91 150.48
124 INT15515 Positive_regulation of Crp 16 700 0.70 604.24 150.15
125 INT49134 Gene_expression of Grin1 25 270 0.78 84.78 148.61
126 INT5050 Regulation of Localization of Calca 1 149 0.62 41.25 148.57
127 INT6108 Gene_expression of Npy 5 292 0.78 110.65 148.21
128 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
129 INT7628 Gene_expression of Ltp 54 273 0.77 70.21 147.87
130 INT1033 Positive_regulation of Ca2 71 507 0.68 131.76 147.64
131 INT9852 Positive_regulation of Gpt 21 563 0.70 364.64 146.82
132 INT5116 Gene_expression of IL2 43 670 0.78 291.13 146.69
133 INT812 Localization of INS 59 1026 0.81 515.6 145.31
134 INT425 Localization of PRL 10 455 0.81 189.64 144.8
135 INT3300 Positive_regulation of Gene_expression of Calca 1 179 0.70 77.76 144.2
136 INT60694 Gene_expression of Il10 110 567 0.78 369.48 143.69
137 INT9660 Regulation of TNF 16 363 0.62 312.94 139.99
138 INT90910 Phosphorylation of Grin1 1 150 0.82 68.23 139.24
139 INT14843 Gene_expression of Gabrg1 24 301 0.77 62.63 139.16
140 INT48895 Gene_expression of Il10 7 333 0.78 221.2 138.52
141 INT5061 Negative_regulation of Mme 6 306 0.59 51.97 136.9
142 INT4658 Binding of OPRM1 19 188 0.48 25.96 136.24
143 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
144 INT60126 Regulation of Trpv1 12 186 0.62 85.53 133.4
145 INT11012 Positive_regulation of Creb1 35 258 0.70 84.4 132
146 INT48953 Positive_regulation of Nos2 23 486 0.70 239.85 131.87
147 INT5497 Positive_regulation of Crh 2 299 0.70 125.54 131.14
148 INT5380 Positive_regulation of Gene_expression of Fos 36 243 0.70 105.65 131.05
149 INT49439 Gene_expression of Cpox 24 508 0.73 326.97 130.17
150 INT5595 Positive_regulation of Pdyn 1 223 0.70 48.37 130.14
151 INT64161 Positive_regulation of Prkca 11 213 0.70 85.06 129.91
152 INT115386 Gene_expression of Ppara 45 779 0.77 549.99 128.36
153 INT65600 Positive_regulation of Casp3 77 376 0.70 198.44 128.03
154 INT5842 Gene_expression of Gfap 79 372 0.78 153.71 127.71
155 INT1878 Binding of HLA-B 4 440 0.48 321.16 127.36
156 INT695 Binding of POMC 7 304 0.48 56.66 126.85
157 INT65054 Positive_regulation of Nfkb1 5 285 0.70 149.33 126.73
158 INT5931 Regulation of Oprm1 2 149 0.62 18.15 125.93
159 INT6822 Gene_expression of Pdyn 5 215 0.78 35.99 125.76
160 INT6323 Positive_regulation of Gabrg1 18 213 0.70 45.08 124.34
161 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
162 INT7533 Gene_expression of Tlr4 108 720 0.78 343.22 121.57
163 INT14151 Gene_expression of Casp3 23 311 0.78 140.26 120.68
164 INT218 Positive_regulation of Th 2 245 0.70 40.5 120.1
165 INT64201 Negative_regulation of Trpv1 29 203 0.59 79.18 119.75
166 INT8243 Positive_regulation of Il6 81 451 0.70 358.24 119.28
167 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 363 1138 0.72 311.58 119.18
168 INT1026 Binding of Lbp 2 207 0.48 150.96 119.16
169 INT17612 Gene_expression of CRP 79 676 0.78 580.61 119.03
170 INT12501 Positive_regulation of Adarb1 1 166 0.58 36.94 118.92
171 INT5010 Gene_expression of Calca 3 197 0.78 85.76 118.75
172 INT9235 Negative_regulation of Gene_expression of TNF 23 346 0.59 252.98 118.61
173 INT50674 Gene_expression of PTGS2 6 459 0.78 253.33 118.51
174 INT7341 Positive_regulation of Grin1 14 169 0.70 65.86 118.38
175 INT7395 Localization of GNRH1 5 399 0.81 62.88 117.68
176 INT12339 Localization of IL8 82 437 0.81 251.87 117.39
177 INT92669 Gene_expression of Bdnf 37 309 0.78 178.26 116.68
178 INT1438 Localization of Pomc 5 360 0.81 101.26 116.47
179 INT62124 Gene_expression of NOS1 18 444 0.78 218.08 114.85
180 INT48593 Positive_regulation of NOS1 20 420 0.68 226.15 114.71
181 INT1793 Localization of CGA 17 379 0.81 67.38 114.69
182 INT20374 Gene_expression of Il4 32 515 0.76 306.15 114.12
183 INT170025 Gene_expression of Fig4 153 588 0.67 183.27 113.32
184 INT16253 Positive_regulation of Gene_expression of Bdnf 33 196 0.70 92.67 113.01
185 INT1530 Regulation of Gh 3 382 0.61 115.96 112.47
186 INT118381 Gene_expression of Il17a 86 405 0.76 306.97 112.06
187 INT11011 Positive_regulation of Phosphorylation of Creb1 3 190 0.70 49.25 112.01
188 INT49651 Gene_expression of Creb1 30 276 0.78 114.77 111.96
189 INT7362 Gene_expression of Sst 1 185 0.78 41.73 111.37
190 INT7327 Regulation of Th 11 164 0.62 29.67 110.14
191 INT48923 Gene_expression of Ephb1 13 211 0.77 106.23 109.9
192 INT65731 Gene_expression of Cnr1 47 234 0.78 63.82 109.34
193 INT11051 Positive_regulation of Gene_expression of IL6 58 415 0.69 319.21 109.3
194 INT27096 Positive_regulation of Nfkb1 5 325 0.70 195.11 109.06
195 INT47243 Gene_expression of Prkcg 17 195 0.78 58.05 108.44
196 INT60526 Gene_expression of IL10 42 449 0.78 292.71 107.84
197 INT3038 Gene_expression of INS 71 1583 0.78 1174.16 107.01
198 INT7627 Negative_regulation of Positive_regulation of Ltp 18 162 0.50 41.2 106.27
199 INT9012 Localization of Vip 5 283 0.81 31.71 106.16
200 INT12082 Localization of IL6 47 365 0.81 241.78 105.78
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