J:Pain

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 1 0.43 11.09 7.33
2 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 8 0.10 3.92 7.2
3 INT132228 Negative_regulation of Binding of Pik3cg and Sh2d6 1 4 0.07 1.96 3.6
4 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 4 0.34 1.96 3.6
5 INT106560 Binding of Ntf3 and Ntrk2 3 2 0.14 2.47 2.84
6 INT69059 Klkb1 Regulation of H2-M3 Regulation of Klkb1 1 2 0.00 0.42 2.71
7 INT69057 H2-M3 Regulation of Klkb1 1 2 0.00 0.42 2.71
8 INT107578 Kitl Negative_regulation of Grin2b 1 4 0.12 2.05 2.36
9 INT106558 Binding of Ntrk2 and Ntrk3 3 2 0.52 2.51 2.28
10 INT91860 Npy Regulation of Npy1r 2 1 0.28 1.13 2.24
11 INT39108 Binding of PDYN and YY1 2 1 0.50 0.44 2.14
12 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 2 0.00 2.11 2.08
13 INT87891 Agt Regulation of Cck 1 2 0.28 0 1.97
14 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 2 0.36 1.11 1.96
15 INT93293 Ngf Regulation of Trpv1 2 1 0.28 0.71 1.9
16 INT132229 Binding of Akt1 and Sh2d6 1 2 0.09 0.98 1.8
17 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 1 0.28 0.31 1.58
18 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 1 0.41 0.33 1.58
19 INT27932 Binding of CCK and NCOR2 1 2 0.01 0.91 1.47
20 INT39109 Binding of INSRR and PDYN 1 1 0.15 0.45 1.46
21 INT95325 HTR1B Negative_regulation of Calca 1 1 0.47 0.69 1.43
22 INT13756 Binding of Oprd1 and Scn4a 1 1 0.02 0 1.32
23 INT13755 Binding of Oprd1 and Ap2m1 1 1 0.20 0 1.32
24 INT66428 Dcc Positive_regulation of Fos 2 1 0.05 0.39 1.29
25 INT121000 Binding of PAG1 and Nrm 1 1 0.13 0.67 1.25
26 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 1 0.58 0.81 1.23
27 INT93294 Ngf Regulation of Transcription of Trpv1 1 1 0.01 0.36 1.19
28 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 1 0.30 0.17 1.18
29 INT107579 Kitl Negative_regulation of Grin2a 1 2 0.10 1.02 1.18
30 INT93290 Ngf Regulation of Transcription of Trpv1 1 1 0.02 0.34 1.16
31 INT93289 Ngf Regulation of Trpv1 1 1 0.05 0.34 1.16
32 INT125284 FSCN1 Positive_regulation of Positive_regulation of EPHB2 1 1 0.04 0.4 1.14
33 INT122369 Tacr1 Positive_regulation of Ngf 1 1 0.30 0.16 1.14
34 INT123387 Binding of Camk2a and Gria2 1 1 0.13 0.32 1.14
35 INT87320 Ngf Regulation of Gene_expression of Bdnf 2 1 0.38 0.97 1.06
36 INT100564 CRX Positive_regulation of Fos 1 2 0.04 0.89 1.06
37 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 1 0.00 1.05 1.04
38 INT125301 Nts Positive_regulation of Unc5c 1 1 0.00 0 1.03
39 INT130607 Hcrt Positive_regulation of H1 1 1 0.59 0.39 1.02
40 INT86662 Ngf Regulation of SCN10A 1 1 0.27 1.24 0.99
41 INT125300 Nts Positive_regulation of Ntsr1 1 1 0.04 0 0.99
42 INT122380 Pnoc Positive_regulation of Oprl1 1 1 0.36 0.55 0.98
43 INT90385 EXTL3 Regulation of Ctsl 1 1 0.00 1.1 0.98
44 INT85485 Phax Regulation of Gene_expression of Cck 1 1 0.07 0.61 0.91
45 INT132226 Binding of Akt1 and Pik3cg 1 1 0.30 0.49 0.9
46 INT132227 Binding of Pik3cg and Sh2d6 1 1 0.06 0.49 0.9
47 INT120999 Binding of Oprm1 and Ifng 1 1 0.22 0.57 0.84
48 INT100559 Binding of Grin1 and LOC502940 1 1 0.13 0.61 0.8
49 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 1 0.02 0.98 0.79
50 INT127585 Binding of CNR2 and Ctbp1 1 1 0.00 0.6 0.76
51 INT83868 Oprd1 Positive_regulation of Gene_expression of Fos 1 1 0.01 0 0.75
52 INT127584 Binding of CNR1 and Ctbp1 1 1 0.00 0.6 0.75
53 INT102086 TRNAI1 Negative_regulation of Positive_regulation of P2rx3 1 1 0.00 0.47 0.74
54 INT86657 TNF Regulation of H2-Ab1 1 1 0.02 0.84 0.74
55 INT63557 Binding of Edn1 and Edn3 1 1 0.23 0.63 0.7
56 INT114036 Binding of Grin1 and Psd 1 2 0.24 0.45 0.68
57 INT120484 ITIH4 Positive_regulation of Il1 1 1 0.01 0.62 0.68
58 INT31861 Cd79b Regulation of Sst 1 1 0.49 0.31 0.56
59 INT31862 Pdyn Regulation of Sst 1 1 0.45 0.31 0.56
60 INT132242 NR3C1 Regulation of Gene_expression of Slc1a1 1 1 0.09 0.62 0.49
61 INT99160 Binding of Mpo and Nrm 1 1 0.38 0.92 0.45
62 INT118889 Phax Regulation of Localization of Calca 1 1 0.05 0.18 0.42
63 INT118890 Phax Positive_regulation of Localization of Calca 1 1 0.05 0.18 0.42
64 INT99159 Nrm Positive_regulation of Mpo 1 1 0.44 0.85 0.36
65 INT83869 Oprm1 Regulation of Gene_expression of Fos 1 1 0.01 0 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 8 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 2 2431 0.81 378.96 952.2
3 INT292 Localization of Penk 4 876 0.81 88.44 669.14
4 INT728 Positive_regulation of Penk 6 1068 0.70 186.9 636.87
5 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
6 INT155 Positive_regulation of Prl 5 1233 0.70 317.93 457.82
7 INT64202 Positive_regulation of Trpv1 4 643 0.70 249.66 397.42
8 INT467 Gene_expression of POMC 13 1048 0.78 332.8 394.16
9 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
10 INT6580 Negative_regulation of Ptgs1 9 929 0.59 381.53 376.26
11 INT720 Positive_regulation of POMC 11 807 0.70 237.37 353.83
12 INT5660 Binding of Oprd1 3 477 0.48 71.86 342.06
13 INT876 Localization of Gh1 3 843 0.80 67.75 340.82
14 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
15 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
16 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
17 INT5540 Positive_regulation of Oprm1 4 344 0.70 76.77 319.71
18 INT5680 Gene_expression of Ngf 28 530 0.78 264.29 310.56
19 INT886 Gene_expression of Pomc 5 676 0.78 129.87 295.98
20 INT97367 Gene_expression of Nav1 9 243 0.78 132.97 286.66
21 INT2365 Positive_regulation of Cck 11 354 0.70 87.8 277.41
22 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
23 INT3948 Regulation of Cck 5 291 0.62 58.07 255.88
24 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
25 INT738 Regulation of POMC 6 459 0.62 111.19 243.74
26 INT1902 Gene_expression of Cck 8 348 0.78 70.33 241.92
27 INT11377 Positive_regulation of Ngf 17 331 0.70 206.5 238
28 INT1562 Localization of Crh 12 499 0.81 126.74 236.68
29 INT1665 Positive_regulation of Pag1 12 270 0.68 186.63 229.87
30 INT9987 Gene_expression of Abat 2 296 0.78 95.46 226.34
31 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
32 INT11009 Phosphorylation of Creb1 12 458 0.82 111.34 221.97
33 INT1308 Localization of Pomc 6 457 0.81 66.83 217.5
34 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
35 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
36 INT2651 Positive_regulation of Pomc 4 403 0.70 95.72 206.24
37 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
38 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
39 INT2211 Negative_regulation of Abat 7 267 0.59 66.51 200.98
40 INT528 Gene_expression of Prl 2 693 0.78 217.18 192.2
41 INT1652 Regulation of Pomc 2 387 0.62 61.01 186.51
42 INT4803 Transcription of Penk 3 435 0.72 59.09 182.4
43 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
44 INT19472 Gene_expression of Il1 6 554 0.76 419.75 175.35
45 INT5930 Positive_regulation of Oprm1 2 221 0.70 31.19 172.93
46 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
47 INT438 Gene_expression of Crh 14 376 0.78 159.11 169.17
48 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
49 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
50 INT4768 Positive_regulation of OPRM1 2 212 0.70 31.09 164.28
51 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
52 INT768 Positive_regulation of Oprl1 7 179 0.70 40.05 156.93
53 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
54 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
55 INT425 Localization of PRL 1 455 0.81 189.64 144.8
56 INT2780 Regulation of Gene_expression of Penk 2 265 0.62 32.45 143.88
57 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
58 INT14843 Gene_expression of Gabrg1 2 301 0.77 62.63 139.16
59 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
60 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
61 INT2541 Binding of Calca 6 200 0.48 67.14 134.62
62 INT11012 Positive_regulation of Creb1 5 258 0.70 84.4 132
63 INT5497 Positive_regulation of Crh 4 299 0.70 125.54 131.14
64 INT5595 Positive_regulation of Pdyn 4 223 0.70 48.37 130.14
65 INT64161 Positive_regulation of Prkca 2 213 0.70 85.06 129.91
66 INT695 Binding of POMC 4 304 0.48 56.66 126.85
67 INT5931 Regulation of Oprm1 6 149 0.62 18.15 125.93
68 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
69 INT5008 Localization of Calca 6 204 0.81 80.35 125.16
70 INT4824 Positive_regulation of Tacr1 14 169 0.70 66.1 123.46
71 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
72 INT252 Localization of GH1 1 529 0.80 227.4 122.05
73 INT2555 Positive_regulation of Localization of Penk 2 116 0.70 24.35 119.73
74 INT12501 Positive_regulation of Adarb1 4 166 0.58 36.94 118.92
75 INT5010 Gene_expression of Calca 5 197 0.78 85.76 118.75
76 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
77 INT92669 Gene_expression of Bdnf 6 309 0.78 178.26 116.68
78 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
79 INT16253 Positive_regulation of Gene_expression of Bdnf 5 196 0.70 92.67 113.01
80 INT11011 Positive_regulation of Phosphorylation of Creb1 13 190 0.70 49.25 112.01
81 INT49651 Gene_expression of Creb1 3 276 0.78 114.77 111.96
82 INT7327 Regulation of Th 1 164 0.62 29.67 110.14
83 INT5283 Positive_regulation of Npy 6 191 0.70 66.77 109.2
84 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
85 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
86 INT4936 Localization of Tacr1 5 125 0.80 35.7 107.7
87 INT7627 Negative_regulation of Positive_regulation of Ltp 2 162 0.50 41.2 106.27
88 INT49171 Gene_expression of Nos1 3 241 0.78 140.7 104.76
89 INT12569 Localization of Oprd1 1 94 0.81 23.81 104.56
90 INT915 Positive_regulation of PRL 1 342 0.70 141.96 104.31
91 INT4742 Gene_expression of Tac1 2 177 0.78 69.99 102.66
92 INT1898 Regulation of Crh 5 220 0.62 61.33 102.64
93 INT97701 Phosphorylation of Mapk14 2 191 0.82 115.33 100.46
94 INT5587 Regulation of Fos 6 191 0.62 40.81 99.7
95 INT1351 Gene_expression of Pag1 3 131 0.57 89.48 98.76
96 INT874 Positive_regulation of Gh1 1 244 0.70 27.17 97.98
97 INT1760 Gene_expression of PTGER2 1 524 0.57 226.94 96.4
98 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
99 INT1004 Regulation of Sst 2 140 0.62 18.52 94.84
100 INT2862 Positive_regulation of Localization of Cck 1 108 0.70 20.75 94.25
101 INT11587 Gene_expression of CSF2 2 645 0.78 544.38 93.89
102 INT203 Positive_regulation of Pomc 2 257 0.70 90.56 92.84
103 INT81417 Gene_expression of PAG1 1 94 0.58 90.85 92.79
104 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
105 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
106 INT48767 Negative_regulation of NOS1 7 312 0.59 154.25 90.32
107 INT67682 Localization of Bdnf 4 204 0.81 72.36 88.92
108 INT1635 Gene_expression of Vip 1 245 0.78 53.36 88.13
109 INT3441 Regulation of Localization of Abat 1 117 0.38 8.67 87.59
110 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
111 INT73340 Negative_regulation of Faah 1 134 0.59 38.67 85.03
112 INT875 Regulation of Localization of Gh1 1 166 0.62 12.87 84.97
113 INT4857 Regulation of Tacr1 4 115 0.62 39.01 84.52
114 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
115 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
116 INT8534 Localization of Pax3 10 85 0.59 28.71 82.82
117 INT16254 Positive_regulation of Gene_expression of Ngf 4 144 0.70 80.61 82.08
118 INT5590 Negative_regulation of Fos 13 144 0.59 40.94 81.98
119 INT8650 Gene_expression of Gal 5 152 0.78 61.97 81.72
120 INT6107 Localization of Npy 13 180 0.81 26.76 81.67
121 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
122 INT7528 Regulation of OPRM1 2 100 0.62 20.63 80.57
123 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
124 INT2289 Gene_expression of PENK 2 203 0.78 55.62 79.49
125 INT2893 Localization of Oxt 1 219 0.80 28.96 79.43
126 INT2431 Positive_regulation of Mpo 8 275 0.70 211.99 78.47
127 INT2155 Negative_regulation of Sst 4 111 0.59 16.58 77.74
128 INT17546 Negative_regulation of Ngf 5 135 0.59 60.28 77.19
129 INT1335 Negative_regulation of Oprl1 2 123 0.59 18.02 77.13
130 INT12001 Regulation of Ngf 10 97 0.62 54.64 76.25
131 INT100965 Positive_regulation of Nav1 1 85 0.70 37.74 75.35
132 INT12536 Localization of Prkcg 8 101 0.80 36.37 73.81
133 INT7028 Localization of Pdyn 4 90 0.81 8.89 73.54
134 INT3034 Localization of Ngf 3 126 0.81 50.81 72.84
135 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
136 INT14049 Positive_regulation of GRIN1 1 102 0.70 48.31 71.06
137 INT58400 Negative_regulation of Tnf 3 182 0.59 129.97 71
138 INT1376 Binding of Trh 1 121 0.48 20 69.86
139 INT1377 Positive_regulation of Trh 1 172 0.70 40.55 69.83
140 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
141 INT14624 Gene_expression of Pax3 2 100 0.38 33.22 69.47
142 INT87686 Positive_regulation of Gene_expression of Trpv1 3 101 0.70 72.41 69.15
143 INT66416 Regulation of Pnoc 2 66 0.61 17.32 68.91
144 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
145 INT9484 Gene_expression of Jun 1 175 0.78 34.89 68.54
146 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
147 INT39777 Regulation of Prkcg 2 90 0.62 31.52 68.17
148 INT5861 Gene_expression of Egr1 2 203 0.78 49.35 68.13
149 INT6489 Positive_regulation of Gene_expression of Tnf 2 140 0.70 92.31 67.85
150 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
151 INT19511 Localization of Il6 3 212 0.81 118.17 67.67
152 INT55224 Gene_expression of DRGX 1 99 0.31 67.55 67.63
153 INT8388 Positive_regulation of Vip 3 142 0.70 39.72 67.61
154 INT102546 Gene_expression of Ccl2 1 197 0.78 192.8 67.41
155 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
156 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
157 INT66531 Gene_expression of Pnoc 2 88 0.78 22.9 65.11
158 INT6926 Regulation of Pag1 1 72 0.39 55.79 65.09
159 INT11807 Gene_expression of Il2 3 266 0.78 112 64.97
160 INT5573 Negative_regulation of Gene_expression of Penk 1 113 0.59 21.83 64.66
161 INT9304 Negative_regulation of Pag1 1 70 0.39 51.97 64.23
162 INT2212 Binding of Abat 7 89 0.48 18.36 63.99
163 INT9664 Binding of LBP 2 127 0.48 94.9 63.42
164 INT6894 Gene_expression of CNR1 2 168 0.78 74.07 62.84
165 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
166 INT50971 Gene_expression of Ntrk1 1 180 0.75 73.52 62.28
167 INT12175 Positive_regulation of PDYN 1 86 0.69 18.27 62.04
168 INT48934 Positive_regulation of Mapk1 1 157 0.70 60.61 61.72
169 INT11318 Gene_expression of Gtf3a 2 274 0.52 183.82 60.89
170 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
171 INT4760 Negative_regulation of Gene_expression of Calca 1 93 0.59 34.19 60.3
172 INT65078 Negative_regulation of Pnoc 1 64 0.59 15.48 59.81
173 INT5016 Negative_regulation of Crh 1 129 0.59 36.74 59.28
174 INT16258 Gene_expression of Ntf3 2 121 0.78 53.93 59.03
175 INT49170 Negative_regulation of Nos1 7 116 0.59 60.66 58.87
176 INT7032 Positive_regulation of Pdyn 2 94 0.66 26.51 58.83
177 INT11491 Positive_regulation of KNG1 2 128 0.67 60.41 58.74
178 INT20964 Gene_expression of OPRK1 1 96 0.78 23.54 58.18
179 INT6436 Positive_regulation of Positive_regulation of Fos 2 101 0.70 18.71 57.96
180 INT7340 Regulation of Grin1 2 87 0.62 30.37 57.93
181 INT5017 Negative_regulation of Tacr1 2 76 0.58 17 57.07
182 INT6669 Negative_regulation of Positive_regulation of Fos 5 98 0.59 23.5 56.82
183 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
184 INT20266 Positive_regulation of Bdkrb1 3 60 0.69 63.64 56.59
185 INT83602 Positive_regulation of Gene_expression of TRPV1 1 114 0.70 51.19 56.35
186 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
187 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
188 INT13277 Regulation of Positive_regulation of Ltp 2 83 0.52 19.68 55.78
189 INT1782 Regulation of Gh1 1 125 0.62 22 55.74
190 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
191 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
192 INT5770 Binding of Rbm39 1 88 0.41 13.23 55.5
193 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
194 INT2421 Positive_regulation of Positive_regulation of Penk 1 97 0.69 13.38 55.32
195 INT49436 Binding of TRPV1 3 145 0.48 38.35 55.08
196 INT8153 Regulation of Localization of Cck 1 52 0.62 11.22 54.83
197 INT119528 Positive_regulation of Camk2a 1 135 0.70 26.13 54.7
198 INT5034 Negative_regulation of Insr 1 100 0.55 28.08 54.5
199 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
200 INT77855 Gene_expression of Pain1 1 55 0.75 67.42 54.1
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