J:Pediatr Nephrol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 2 0.31 1.25 0.32
2 INT255044 GLP1R Positive_regulation of Localization of INS 3 2 0.49 1.47 0.22
3 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 2 0.10 1.16 0.17
4 INT125770 GLP1R Negative_regulation of Localization of GCG 2 1 0.29 0.65 0.16
5 INT311226 DPP4 Negative_regulation of GLP1R 1 1 0.31 0.65 0.16
6 INT311227 INS Negative_regulation of HBA1 1 1 0.01 0.52 0.16
7 INT226204 Nfkb1 Positive_regulation of Gene_expression of Trim63 1 1 0.04 0.65 0.14
8 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 1 0.04 0.71 0.14
9 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 1 0.11 1.08 0.14
10 INT226208 Nfkb1 Positive_regulation of Protein_catabolism of Trim63 1 1 0.04 0.66 0.14
11 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 1 0.00 0.53 0.12
12 INT226210 Akt1 Regulation of Mul1 1 1 0.04 0.6 0.1
13 INT311225 GLP1R Positive_regulation of Gene_expression of INS 1 1 0.49 0.33 0.06
14 INT283226 Binding of ACE and CC2D1A 1 1 0.11 2.37 0.04
15 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 1 0.17 1.04 0
16 INT311229 DPP4 Positive_regulation of Gene_expression of INS 1 1 0.32 0.57 0
17 INT311223 GLP1R Regulation of Localization of GCG 1 1 0.16 0.74 0
18 INT226206 Gtf3a Positive_regulation of Akt1 1 1 0.00 1.02 0
19 INT226207 Binding of Ins1 and Positive_regulation of Pik3cb 1 2 0.01 2.08 0
20 INT226193 Gtf3a Positive_regulation of Pik3cb 1 1 0.00 1.02 0
21 INT283062 ERCC8 Positive_regulation of CFH 1 1 0.02 1.88 0
22 INT283061 Binding of ERCC8 and LDLR 1 1 0.00 0.44 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
2 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
3 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
4 INT22548 Positive_regulation of Casp3 5 483 0.70 258.78 213.07
5 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
6 INT120811 Gene_expression of Gopc 2 1174 0.59 428.49 150.55
7 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
8 INT812 Localization of INS 14 1026 0.81 515.6 145.31
9 INT14151 Gene_expression of Casp3 1 311 0.78 140.26 120.68
10 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
11 INT48593 Positive_regulation of NOS1 2 420 0.68 226.15 114.71
12 INT20374 Gene_expression of Il4 3 515 0.76 306.15 114.12
13 INT3038 Gene_expression of INS 6 1583 0.78 1174.16 107.01
14 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
15 INT3214 Localization of Ins1 1 527 0.80 196.9 79.26
16 INT1724 Negative_regulation of ACE 2 437 0.59 315.64 74.48
17 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
18 INT103924 Positive_regulation of Akt1 2 359 0.69 158.94 60.34
19 INT251 Regulation of INS 2 398 0.62 232.47 55.04
20 INT3213 Gene_expression of Ins1 4 511 0.76 357.59 53.32
21 INT106525 Phosphorylation of Akt1 7 436 0.82 183.81 47.82
22 INT1322 Positive_regulation of Localization of INS 3 293 0.70 120.86 45.98
23 INT27493 Negative_regulation of Casp3 1 114 0.56 56.89 44.63
24 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
25 INT3758 Gene_expression of ALB 3 326 0.78 184.65 38.75
26 INT385 Gene_expression of Agt 3 182 0.78 63.62 37.91
27 INT390 Positive_regulation of Agt 3 170 0.70 61.47 36.08
28 INT1361 Negative_regulation of Gnrhr 2 118 0.58 57.77 35.54
29 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
30 INT14559 Gene_expression of Igf1 1 254 0.78 112 34.17
31 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
32 INT13186 Positive_regulation of Il4 3 113 0.68 71.22 31.4
33 INT54302 Positive_regulation of Gene_expression of Il4 3 126 0.68 86.18 30.75
34 INT6624 Gene_expression of Pth 2 135 0.76 110.27 27.54
35 INT3217 Regulation of Ins1 1 154 0.62 87.11 27.29
36 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
37 INT20585 Gene_expression of Gfra1 1 39 0.77 26.94 26.69
38 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
39 INT122570 Negative_regulation of Akt1 3 173 0.59 91.44 25.53
40 INT17625 Localization of GCG 4 210 0.80 55.69 24.97
41 INT23937 Gene_expression of EDNRA 2 103 0.65 55.63 24.67
42 INT79061 Positive_regulation of NOS2 1 92 0.65 58.89 23.96
43 INT18323 Negative_regulation of Localization of Ins1 1 122 0.58 45.74 23.04
44 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
45 INT18322 Negative_regulation of Ins1 3 132 0.58 88.49 22.59
46 INT20379 Localization of Il4 1 85 0.73 51.22 20.55
47 INT138696 Positive_regulation of Ccl2 2 57 0.67 59.57 19.58
48 INT756 Gene_expression of C3 3 138 0.75 100.6 19.2
49 INT27670 Negative_regulation of Ace 1 122 0.57 79.21 18.08
50 INT84464 Gene_expression of DPP4 3 101 0.78 56.15 17.53
51 INT32515 Negative_regulation of B4GALNT1 1 82 0.43 28.1 17.46
52 INT170051 Positive_regulation of Gene_expression of Gopc 1 150 0.43 56.75 16.93
53 INT120966 Positive_regulation of Pik3cb 1 34 0.68 15.15 16.59
54 INT94573 Negative_regulation of Pik3cb 1 42 0.50 15.83 15.4
55 INT74449 Positive_regulation of B4GALNT1 1 53 0.30 34.49 14.96
56 INT65263 Positive_regulation of Gene_expression of Igf1 1 61 0.69 25.69 14.49
57 INT20665 Gene_expression of ACE 2 87 0.78 51.71 14.19
58 INT109304 Positive_regulation of Phosphorylation of Akt1 1 113 0.69 40.92 13.49
59 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
60 INT10585 Localization of NAGLU 2 53 0.80 23.32 12.75
61 INT4137 Positive_regulation of C3 1 73 0.69 48.57 12.63
62 INT119892 Gene_expression of Cftr 1 54 0.77 23.76 9.73
63 INT87863 Positive_regulation of IL18 1 40 0.69 34.08 9.53
64 INT132036 Negative_regulation of DPP4 21 126 0.59 63.24 9.51
65 INT26492 Negative_regulation of Localization of GCG 3 73 0.58 22.2 9.48
66 INT102106 Positive_regulation of Bax 1 48 0.67 30.62 9.28
67 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
68 INT22083 Regulation of Pth 3 55 0.62 22.32 8.9
69 INT386 Positive_regulation of Gene_expression of Agt 2 37 0.70 15.92 8.73
70 INT11732 Negative_regulation of Gtf3a 1 25 0.30 15.73 8.5
71 INT670 Gene_expression of B2m 1 31 0.66 27.32 8.49
72 INT15529 Gene_expression of GCG 1 51 0.75 18.55 8.35
73 INT18583 Positive_regulation of Gene_expression of Ins1 1 67 0.50 49.72 8.26
74 INT106522 Negative_regulation of Phosphorylation of Akt1 2 65 0.58 34.44 7.83
75 INT17996 Binding of Crp 1 40 0.37 31.4 7.8
76 INT98178 Localization of Casp3 1 32 0.65 21.01 7.77
77 INT83006 Gene_expression of AGTR1 1 59 0.75 54.46 7.27
78 INT32709 Negative_regulation of Hbb 1 30 0.54 18.27 6.97
79 INT11826 Positive_regulation of LDLR 1 62 0.62 45.09 6.21
80 INT16359 Positive_regulation of Gene_expression of AGT 2 30 0.49 28.27 6.14
81 INT9321 Transcription of Igf1 2 25 0.69 10.2 6.08
82 INT52814 Negative_regulation of Nr3c1 1 9 0.57 5.69 5.41
83 INT60776 Regulation of EDNRA 2 20 0.51 16.62 5.36
84 INT30738 Negative_regulation of Gene_expression of ALB 3 32 0.59 19.01 5.04
85 INT673 Positive_regulation of B2m 1 24 0.68 24.24 4.82
86 INT134657 Localization of Akt1 1 37 0.68 11.58 4.62
87 INT23045 Positive_regulation of Hbb 10 31 0.64 19.35 4.54
88 INT14557 Negative_regulation of Igf1 3 96 0.59 54.83 4.45
89 INT4097 Localization of Pth 2 66 0.81 47.17 4.36
90 INT95512 Transcription of Ghr 1 24 0.69 3.1 4.12
91 INT22838 Gene_expression of Fgg 1 26 0.25 19.9 3.88
92 INT13451 Positive_regulation of DPP4 3 23 0.68 9.33 3.62
93 INT201959 Positive_regulation of Gene_expression of DPP4 1 13 0.53 6.24 3.4
94 INT16236 Negative_regulation of CFH 1 31 0.57 19.59 3.36
95 INT16234 Positive_regulation of CFH 1 25 0.50 26.05 3.33
96 INT23044 Gene_expression of Hbb 1 13 0.43 5.77 3.1
97 INT92814 Negative_regulation of NOS3 1 25 0.51 20.67 3.07
98 INT9884 Localization of CD79A 1 41 0.78 21.75 3.06
99 INT146758 Gene_expression of LCN2 2 45 0.78 38.29 2.97
100 INT226178 Gene_expression of thd 1 14 0.23 8.29 2.92
101 INT51377 Localization of Hexb 1 10 0.80 3.02 2.8
102 INT88852 Protein_catabolism of Casp3 1 28 0.65 23.57 2.74
103 INT17033 Positive_regulation of Trf 1 21 0.62 11.76 2.68
104 INT4647 Regulation of Hbb 1 10 0.60 5.28 2.66
105 INT1829 Gene_expression of CFH 4 71 0.75 64.24 2.49
106 INT91999 Transcription of Gfra1 1 10 0.67 4.67 2.45
107 INT66544 Binding of Igf1 1 23 0.46 8.33 2.44
108 INT35643 Positive_regulation of BPIFA4P 4 7 0.67 4.87 2.39
109 INT165841 Gene_expression of BPIFA4P 2 17 0.65 6.48 2.38
110 INT95898 Gene_expression of CAPG 3 14 0.39 10.51 2.33
111 INT133567 Regulation of IL18 1 11 0.50 9.54 2.31
112 INT52052 Positive_regulation of SDHB 1 14 0.68 14.07 2.27
113 INT28739 Binding of Ins1 2 35 0.37 22.43 2.14
114 INT664 Positive_regulation of Fgg 1 14 0.46 8.75 2.11
115 INT88701 Gene_expression of MMD 1 15 0.44 6.04 1.94
116 INT138844 Positive_regulation of CC2D1A 8 25 0.41 41.36 1.92
117 INT15980 Positive_regulation of Positive_regulation of Agt 1 6 0.50 2.99 1.76
118 INT14149 Binding of C6orf25 1 11 0.48 9.04 1.71
119 INT77415 Localization of GLP1R 4 23 0.63 11.1 1.69
120 INT97434 Positive_regulation of Positive_regulation of Il4 1 8 0.40 3.51 1.66
121 INT242212 Gene_expression of GLP1R 9 29 0.65 11.36 1.52
122 INT103799 Positive_regulation of CAPG 1 8 0.34 5.16 1.52
123 INT139263 Gene_expression of Mstn 4 10 0.62 6.67 1.51
124 INT262293 Gene_expression of CC2D1A 15 21 0.40 44.64 1.5
125 INT182514 Binding of AGTR1 2 18 0.47 13.35 1.48
126 INT23938 Positive_regulation of Gene_expression of EDNRA 1 8 0.45 9.82 1.47
127 INT226175 Regulation of thd 1 8 0.14 6.8 1.42
128 INT16239 Negative_regulation of Trf 1 9 0.32 4.06 1.35
129 INT102747 Gene_expression of Hmbs 1 17 0.78 10.53 1.34
130 INT39500 Positive_regulation of Positive_regulation of Pth 1 14 0.48 9.75 1.28
131 INT264798 Binding of GLP1R 3 9 0.40 2.95 1.27
132 INT138843 Binding of CC2D1A 7 19 0.33 33.06 1.25
133 INT36226 Gene_expression of GIP 1 13 0.67 3.05 1.25
134 INT145960 Positive_regulation of GLP1R 5 19 0.58 7.25 1.19
135 INT201955 Regulation of DPP4 1 18 0.45 11.91 1.18
136 INT23199 Binding of LDLR 1 22 0.47 17.08 1.16
137 INT46044 Positive_regulation of Gene_expression of C3 1 23 0.53 20.07 1.06
138 INT77555 Positive_regulation of thd 4 8 0.05 7.82 1.06
139 INT29372 Localization of GIP 1 18 0.69 7.23 1.01
140 INT174705 Phosphorylation of Gtf3a 2 7 0.02 4.11 0.97
141 INT226478 Protein_catabolism of DPP4 3 11 0.85 5.52 0.95
142 INT82702 Positive_regulation of Positive_regulation of LDLR 1 4 0.45 1.08 0.95
143 INT204156 Gene_expression of HAMP 1 7 0.75 8.1 0.94
144 INT44972 Negative_regulation of Gfra1 4 16 0.58 10.17 0.93
145 INT157686 Gene_expression of Fbxo32 2 14 0.75 8.68 0.9
146 INT27919 Positive_regulation of Mbis1 1 6 0.02 2.28 0.9
147 INT132883 Gene_expression of Slc11a2 1 5 0.75 2.96 0.89
148 INT171460 Protein_catabolism of Gtf3a 1 4 0.02 3.28 0.87
149 INT254143 Negative_regulation of CC2D1A 5 10 0.35 13.81 0.82
150 INT21246 Negative_regulation of ATP1A4 1 3 0.10 3.3 0.79
151 INT102745 Positive_regulation of Hmbs 8 17 0.61 12.41 0.78
152 INT102746 Negative_regulation of Hmbs 1 11 0.59 8.35 0.77
153 INT176445 Protein_catabolism of Gopc 3 23 0.76 7.57 0.75
154 INT23146 Negative_regulation of Aprt 2 8 0.56 7.53 0.71
155 INT129490 Negative_regulation of Protein_catabolism of Casp3 1 4 0.22 3.91 0.71
156 INT226179 Phosphorylation of Foxo1 1 15 0.68 3.14 0.7
157 INT62067 Negative_regulation of Gene_expression of Pth 2 13 0.41 8.24 0.61
158 INT242210 Positive_regulation of Gene_expression of GLP1R 2 6 0.58 3.59 0.61
159 INT145957 Positive_regulation of Localization of GLP1R 1 5 0.43 2.12 0.61
160 INT44080 Positive_regulation of HBA1 1 7 0.25 2.23 0.6
161 INT238245 Gene_expression of Atp5s 3 4 0.75 7.57 0.6
162 INT226176 Protein_catabolism of Hmbs 7 15 0.61 13.17 0.56
163 INT19395 Negative_regulation of Localization of Pth 1 11 0.58 10.16 0.55
164 INT149394 Positive_regulation of Mul1 1 4 0.12 1.89 0.53
165 INT47095 Positive_regulation of Naglu 1 3 0.66 1.5 0.53
166 INT250743 Localization of CC2D1A 7 12 0.51 20.97 0.51
167 INT89217 Negative_regulation of ADAMTS13 1 8 0.50 12.32 0.51
168 INT226164 Gene_expression of Trim63 4 5 0.68 4.77 0.49
169 INT102108 Protein_catabolism of Bax 1 8 0.64 5.69 0.48
170 INT116460 Negative_regulation of HBA1 8 11 0.42 5.6 0.47
171 INT36770 Positive_regulation of Localization of Pth 1 14 0.70 10.42 0.46
172 INT226196 Positive_regulation of Gene_expression of Mstn 2 3 0.54 2.68 0.46
173 INT311230 Regulation of GLP1R 5 6 0.38 3.2 0.45
174 INT226198 Regulation of Mstn 2 3 0.48 2.99 0.45
175 INT204147 Negative_regulation of Localization of Flot2 2 1 0.02 0.71 0.45
176 INT57643 Negative_regulation of Binding of Ins1 1 6 0.43 3.51 0.43
177 INT201307 Negative_regulation of Vcan 1 4 0.41 1.71 0.43
178 INT283239 Negative_regulation of Localization of CC2D1A 5 1 0.29 10.4 0.41
179 INT158463 Regulation of Hmbs 2 7 0.31 4.87 0.4
180 INT226184 Protein_catabolism of Cftr 1 3 0.87 1.52 0.38
181 INT101790 Positive_regulation of Positive_regulation of Hbb 2 2 0.25 1.82 0.38
182 INT102744 Positive_regulation of Gene_expression of Hmbs 1 4 0.70 2.97 0.35
183 INT218294 Positive_regulation of Gene_expression of Fbxo32 2 7 0.49 5.84 0.34
184 INT118264 Binding of Hmbs 2 6 0.37 4.87 0.33
185 INT226170 Positive_regulation of Gene_expression of Trim63 4 5 0.44 3.96 0.31
186 INT226172 Transcription of Fbxo32 2 3 0.52 1.56 0.31
187 INT262297 Negative_regulation of Gene_expression of CC2D1A 1 2 0.25 2.95 0.31
188 INT95446 Gene_expression of PHC2 3 2 0.32 1.59 0.3
189 INT226167 Positive_regulation of Transcription of Fbxo32 2 3 0.45 1.42 0.28
190 INT226476 Positive_regulation of Protein_catabolism of DPP4 2 2 0.45 1.64 0.28
191 INT102111 Positive_regulation of Protein_catabolism of Bax 1 2 0.45 1.14 0.27
192 INT242211 Negative_regulation of GLP1R 1 9 0.36 3.4 0.26
193 INT283235 Localization of KCNAB2 1 1 0.02 0.94 0.26
194 INT283232 Negative_regulation of Localization of KCNAB2 1 1 0.01 0.95 0.26
195 INT201308 Binding of Vcan 1 5 0.34 1.05 0.24
196 INT47550 Gene_expression of Naglu 1 4 0.44 2.02 0.23
197 INT204142 Positive_regulation of Localization of Flot2 1 1 0.03 0.35 0.23
198 INT218287 Positive_regulation of Fbxo32 1 3 0.49 0.51 0.22
199 INT204141 Localization of Flot2 1 1 0.04 0.35 0.22
200 INT226195 Regulation of Gene_expression of Mstn 1 2 0.48 1.23 0.2
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