J:Pediatr Rheumatol Online J

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
2 INT101942 Binding of CD40 and CD40LG 16 3 0.23 15.24 4.01
3 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
4 INT236365 Binding of CD40LG and IL6 3 2 0.20 4.16 1.42
5 INT340439 Binding of HLA-DMA and SUGT1 1 3 0.00 4.1 1.16
6 INT230019 Binding of HLA-B and ERAL1 1 1 0.00 2.23 1.1
7 INT209881 Binding of TNFRSF11B and TNFSF11 8 1 0.36 8.92 0.86
8 INT182636 Binding of TNFSF11 and TNFRSF11A 16 1 0.29 17.5 0.84
9 INT340437 Binding of SERPINH1 and HLA-DRB4 1 1 0.00 2.26 0.84
10 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 1 0.25 1.37 0.72
11 INT139069 Binding of CTLA4 and Cd86 3 1 0.16 0.65 0.7
12 INT321598 Binding of MLL and TNF 1 1 0.05 1.07 0.49
13 INT340440 Binding of HLA-B and BTG3 1 1 0.05 1.57 0.47
14 INT340438 Binding of HLA-DMA and MRAP 1 1 0.02 1.69 0.43
15 INT299041 SPARC Regulation of Gene_expression of NPEPPS 1 1 0.01 0.83 0.42
16 INT299040 Binding of COL7A1 and SPARC 1 1 0.02 0.7 0.42
17 INT296945 ADIPOQ Negative_regulation of TNF 1 1 0.03 1.13 0.4
18 INT285746 IL6 Regulation of Localization of PRL 1 1 0.08 1.51 0.39
19 INT285749 IL6 Positive_regulation of Localization of PRL 1 1 0.08 1.51 0.39
20 INT285750 IL1B Positive_regulation of Localization of PRL 1 1 0.05 1.51 0.39
21 INT285744 IL1B Regulation of Localization of PRL 1 1 0.05 1.51 0.39
22 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 1 0.01 1.01 0.31
23 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 1 0.19 1.04 0.22
24 INT233324 SHE Positive_regulation of HIVEP1 1 1 0.00 2.72 0.14
25 INT260099 Binding of COMP and IL4 1 1 0.00 0.18 0.09
26 INT260127 Binding of CD4 and Trav6-3 1 1 0.03 0 0
27 INT260128 Binding of ISG20 and Trav6-3 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 19 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 7 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 8 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 5 1050 0.70 896.51 322.81
5 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
6 INT6852 Localization of TNF 7 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
8 INT5972 Gene_expression of IL1B 9 948 0.78 510.91 263.97
9 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
10 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
11 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
12 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
13 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
14 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
15 INT5116 Gene_expression of IL2 5 670 0.78 291.13 146.69
16 INT425 Localization of PRL 7 455 0.81 189.64 144.8
17 INT60694 Gene_expression of Il10 2 567 0.78 369.48 143.69
18 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
19 INT1878 Binding of HLA-B 8 440 0.48 321.16 127.36
20 INT17612 Gene_expression of CRP 3 676 0.78 580.61 119.03
21 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
22 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
23 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
24 INT60526 Gene_expression of IL10 2 449 0.78 292.71 107.84
25 INT12082 Localization of IL6 3 365 0.81 241.78 105.78
26 INT915 Positive_regulation of PRL 6 342 0.70 141.96 104.31
27 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
28 INT11381 Positive_regulation of IL1B 3 330 0.70 209.31 100.9
29 INT749 Gene_expression of HLA-B 4 341 0.75 224.12 77.37
30 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
31 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
32 INT56298 Gene_expression of IL4 4 306 0.78 182.18 72.92
33 INT170332 Gene_expression of IFN1@ 1 477 0.75 275.21 69.65
34 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
35 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
36 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
37 INT9664 Binding of LBP 1 127 0.48 94.9 63.42
38 INT6477 Gene_expression of IL1RN 1 213 0.77 114.69 58.62
39 INT9408 Positive_regulation of Crp 3 296 0.69 242.27 57.35
40 INT1579 Gene_expression of PRL 10 279 0.78 119.2 55.41
41 INT82650 Gene_expression of Bcl2 1 312 0.78 211.71 55.03
42 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
43 INT22112 Positive_regulation of Localization of TNF 2 164 0.70 115.66 52.18
44 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
45 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
46 INT145266 Gene_expression of IL17A 1 154 0.75 109.83 45.33
47 INT3361 Positive_regulation of Esr1 4 273 0.69 208.53 44.81
48 INT80124 Negative_regulation of VEGFA 2 450 0.58 311.19 44.53
49 INT4216 Gene_expression of CD40LG 14 328 0.78 256.02 44.23
50 INT73502 Positive_regulation of IL10 2 154 0.69 124.87 43.5
51 INT60695 Positive_regulation of Gene_expression of Il10 1 154 0.70 120.28 43.07
52 INT4004 Gene_expression of IGHG3 2 321 0.71 221.03 42.33
53 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
54 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
55 INT13556 Gene_expression of CD4 14 367 0.78 230.82 41.74
56 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
57 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
58 INT88322 Gene_expression of CCR5 1 111 0.78 77.36 39.84
59 INT916 Regulation of Localization of PRL 1 92 0.62 22.98 38.13
60 INT9239 Regulation of Gene_expression of IL6 1 106 0.61 75.24 36.53
61 INT6484 Binding of IL1B 2 122 0.47 75.84 35.07
62 INT11325 Gene_expression of HLA-E 1 209 0.76 98.05 33.72
63 INT10763 Localization of IL2 2 157 0.80 81.11 33.21
64 INT10248 Gene_expression of KRT20 1 436 0.78 231.96 32.88
65 INT132161 Gene_expression of MTX1 2 48 0.58 26.55 32.32
66 INT73498 Gene_expression of IL13 1 117 0.44 83.85 32.26
67 INT88318 Gene_expression of CXCR4 1 208 0.77 189.67 31.72
68 INT29503 Gene_expression of Mmp2 1 95 0.77 56.92 31.68
69 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
70 INT56072 Negative_regulation of NFKB1 2 94 0.59 53.16 28.19
71 INT69157 Gene_expression of IL5 3 127 0.77 102.58 26.81
72 INT2609 Localization of ELANE 1 111 0.81 50.22 26.63
73 INT17739 Gene_expression of S100B 1 226 0.78 132.7 26.4
74 INT2614 Gene_expression of CGA 2 187 0.78 105.89 24.77
75 INT10835 Regulation of IL8 1 79 0.49 53.04 24.14
76 INT15511 Gene_expression of Tnfrsf1a 2 84 0.76 63.3 24.03
77 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
78 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
79 INT5328 Positive_regulation of CD4 12 191 0.69 133.43 21.31
80 INT11346 Binding of Mtx1 1 39 0.41 24.88 21.21
81 INT955 Gene_expression of GHRH 2 126 0.78 59.91 20.74
82 INT62042 Positive_regulation of Gene_expression of IL4 1 67 0.56 42.05 20.39
83 INT105021 Binding of GOPC 1 187 0.40 60.39 20.38
84 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
85 INT756 Gene_expression of C3 1 138 0.75 100.6 19.2
86 INT70614 Gene_expression of FAS 1 118 0.75 112.33 19.01
87 INT18010 Positive_regulation of CD40LG 10 122 0.70 100.8 18.46
88 INT9900 Positive_regulation of Vwf 1 80 0.69 51.85 18.13
89 INT70145 Gene_expression of Trav6-3 1 136 0.76 69.6 18.05
90 INT112017 Regulation of Hand2 1 77 0.36 62.23 18.04
91 INT80755 Gene_expression of CD40 7 88 0.75 53.68 17.86
92 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
93 INT116978 Gene_expression of CCR6 1 53 0.78 56 17.73
94 INT1578 Negative_regulation of Localization of PRL 2 52 0.59 20.62 17.18
95 INT6480 Positive_regulation of IL1RN 1 59 0.69 33.7 16.66
96 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
97 INT10000 Regulation of Gene_expression of IL2 1 56 0.45 15.33 16.2
98 INT7970 Gene_expression of PLOD1 1 120 0.71 44.42 15.54
99 INT2064 Positive_regulation of BTG3 1 29 0.49 25.58 15.37
100 INT16167 Negative_regulation of DMD 4 186 0.57 108.71 15.25
101 INT5333 Gene_expression of NPEPPS 1 45 0.65 26.34 15.25
102 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
103 INT16166 Positive_regulation of DMD 7 348 0.67 133.22 15.06
104 INT89293 Positive_regulation of Gene_expression of CCR5 1 29 0.70 22.14 15
105 INT3002 Binding of SUGT1 1 62 0.24 55.9 14.91
106 INT10709 Negative_regulation of CD4 3 106 0.59 95.6 14.89
107 INT3545 Positive_regulation of Mtx1 1 27 0.42 11.97 14.83
108 INT20665 Gene_expression of ACE 1 87 0.78 51.71 14.19
109 INT70265 Regulation of MRI1 1 42 0.39 30.95 14.18
110 INT2005 Positive_regulation of Gene_expression of PRL 2 55 0.70 21.4 13.44
111 INT10016 Negative_regulation of CD8A 1 81 0.42 56.68 13.15
112 INT4145 Gene_expression of FSHR 2 124 0.77 44.98 13.04
113 INT81629 Positive_regulation of Fas 3 58 0.70 59.63 12.94
114 INT1827 Gene_expression of Aap 2 11 0.67 9.37 12.66
115 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
116 INT4137 Positive_regulation of C3 1 73 0.69 48.57 12.63
117 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
118 INT541 Positive_regulation of MBP 1 31 0.67 28.56 12.24
119 INT148207 Gene_expression of CTLA4 2 53 0.77 29.13 12.07
120 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
121 INT87844 Binding of IL1RN 1 40 0.41 24.37 11.92
122 INT36287 Binding of CD4 3 96 0.47 58.93 11.88
123 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
124 INT28872 Positive_regulation of CSRP1 2 49 0.70 47.23 11.7
125 INT102272 Regulation of TH1L 1 41 0.44 30.89 11.63
126 INT24816 Binding of CD40LG 5 68 0.47 45.48 11.56
127 INT65713 Localization of ICAM1 3 42 0.81 39.55 11.49
128 INT49266 Positive_regulation of Arigg4 19 37 0.47 53.79 11.2
129 INT15804 Gene_expression of ISG20 14 83 0.75 44.33 10.58
130 INT58904 Localization of TH1L 1 40 0.68 27.11 10.52
131 INT94454 Gene_expression of CD68 1 73 0.72 63.94 10.43
132 INT130867 Gene_expression of TNFSF11 1 106 0.77 45.15 10.34
133 INT16404 Regulation of CD4 11 54 0.61 33.05 10.29
134 INT103554 Positive_regulation of MTX1 2 19 0.45 11.23 10
135 INT5788 Gene_expression of IL2RA 4 60 0.75 40.67 9.98
136 INT2378 Negative_regulation of SERPINE1 1 47 0.59 34.55 9.9
137 INT170333 Binding of IFN1@ 1 68 0.47 49.01 9.72
138 INT64346 Positive_regulation of S100B 1 95 0.70 63.11 9.17
139 INT27551 Gene_expression of SERPINH1 2 45 0.62 42.87 9.04
140 INT8903 Gene_expression of IFNA2 1 58 0.71 38.23 8.68
141 INT89292 Positive_regulation of CCR5 2 27 0.70 15.12 8.59
142 INT2921 Positive_regulation of F8 4 53 0.59 41.56 8.56
143 INT169015 Gene_expression of FOXP3 8 50 0.60 33.18 8.4
144 INT13085 Positive_regulation of ACE 3 50 0.70 44.2 8.31
145 INT17024 Gene_expression of COL1A2 1 69 0.77 36.38 8.29
146 INT86705 Gene_expression of BTG3 1 41 0.65 37.29 8.29
147 INT67374 Gene_expression of Mefv 1 15 0.74 49.1 8.07
148 INT24232 Localization of Mtx1 3 24 0.65 8.06 7.99
149 INT573 Negative_regulation of C3 1 60 0.59 41.37 7.78
150 INT182320 Binding of MTX1 1 14 0.18 8.5 7.65
151 INT74520 Positive_regulation of CD68 1 30 0.61 31.68 7.59
152 INT91667 Localization of IL12A 1 39 0.74 25.51 7.36
153 INT102572 Gene_expression of Ccnd1 1 79 0.69 56.37 7.34
154 INT6596 Positive_regulation of HLA-DRB1 1 33 0.61 27.01 7.26
155 INT93003 Binding of CD40 3 28 0.47 20.25 7.13
156 INT1124 Negative_regulation of CD40LG 1 53 0.57 36.26 7
157 INT11747 Positive_regulation of IL2RA 1 22 0.67 16.55 6.95
158 INT17049 Localization of CD4 3 57 0.75 35.33 6.89
159 INT117186 Positive_regulation of CXCR4 2 29 0.69 24.19 6.84
160 INT2111 Gene_expression of LIF 1 34 0.77 16.82 6.76
161 INT13520 Binding of HLA-DRB4 1 30 0.42 32.65 6.74
162 INT23246 Gene_expression of HLA-DRB4 1 37 0.64 36.79 6.61
163 INT73499 Positive_regulation of IL13 1 23 0.39 20.03 6.53
164 INT23174 Gene_expression of NLRP3 1 51 0.72 35.49 6.47
165 INT11048 Gene_expression of CD69 1 59 0.67 42.85 6.4
166 INT38672 Binding of KRT20 1 69 0.39 48.01 6.31
167 INT83451 Positive_regulation of Gene_expression of CD40LG 4 26 0.60 22.81 6.25
168 INT122653 Positive_regulation of Gene_expression of CD4 1 48 0.68 22.5 5.96
169 INT67060 Negative_regulation of Transcription of TNF 1 17 0.59 12.94 5.88
170 INT59384 Gene_expression of Il7 1 23 0.75 11.42 5.87
171 INT141151 Regulation of PSMD1 1 16 0.40 8.19 5.86
172 INT69153 Positive_regulation of Gene_expression of IL5 1 22 0.32 23.59 5.7
173 INT81049 Positive_regulation of CASP1 1 44 0.67 19.97 5.69
174 INT88935 Positive_regulation of SPP1 2 36 0.70 31.07 5.49
175 INT13396 Gene_expression of DMD 2 125 0.75 57.81 5.45
176 INT77146 Binding of IL4 1 23 0.36 13.69 5.39
177 INT69156 Localization of IL5 1 21 0.68 14.95 5.37
178 INT45753 Localization of CD40LG 3 45 0.79 32.31 5.28
179 INT19271 Binding of Aap 1 6 0.30 0.88 5.27
180 INT121801 Binding of Aip 5 18 0.36 24.1 5.26
181 INT29290 Regulation of Gene_expression of PRL 2 13 0.49 6.46 5.23
182 INT10889 Gene_expression of F8 3 60 0.78 41.36 5.06
183 INT129856 Positive_regulation of TNFRSF11A 1 26 0.68 16.21 4.75
184 INT105114 Gene_expression of Arigg4 5 16 0.52 21.88 4.56
185 INT84911 Gene_expression of SUGT1 2 43 0.11 19.85 4.54
186 INT36221 Positive_regulation of Nlrp3 1 25 0.68 19.7 4.5
187 INT1901 Binding of Mefv 1 24 0.48 32.26 4.5
188 INT36502 Positive_regulation of asp1 2 10 0.40 6.26 4.45
189 INT6021 Binding of PRL 2 18 0.48 12.55 4.3
190 INT93016 Binding of TNFRSF11A 1 29 0.47 19.67 4.17
191 INT115889 Binding of Fas 1 27 0.36 28.87 4.08
192 INT15802 Positive_regulation of Gene_expression of ISG20 1 16 0.42 8.16 4.03
193 INT17548 Negative_regulation of Serpine1 2 30 0.57 24.69 3.93
194 INT148671 Gene_expression of Aip 3 26 0.63 24.32 3.91
195 INT92653 Gene_expression of IL12B 2 21 0.75 17.28 3.89
196 INT172677 Gene_expression of SHE 1 65 0.59 25.86 3.85
197 INT149332 Gene_expression of CD163 1 19 0.75 13.63 3.65
198 INT16165 Regulation of DMD 2 114 0.60 35.13 3.64
199 INT3564 Positive_regulation of Aip 4 11 0.58 15.38 3.62
200 INT170528 Negative_regulation of Gene_expression of CD4 1 25 0.41 17.98 3.6
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