J:Pflugers Arch

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT208980 Binding of Ca2 and Trpv1 4 2 0.32 0.67 1.55
2 INT285185 Binding of Ca2 and Cd2 1 3 0.25 0.24 1.21
3 INT158399 Binding of Preb and Frg1 1 1 0.01 0.3 0.62
4 INT302731 Binding of Gfm1 and Hk 1 1 0.01 1 0.2
5 INT302732 Positive_regulation of Binding of Gfm1 and Hk 1 1 0.01 1 0.2
6 INT285183 Cd2 Regulation of Ca2 1 1 0.30 0.23 0.18
7 INT315030 Binding of Cav1 and Tmie 1 1 0.03 0.25 0.14
8 INT315032 Binding of Cav1 and Ryr1 1 1 0.27 0.2 0.14
9 INT205955 Gopc Regulation of Tdrd6 1 1 0.06 0.27 0.13
10 INT285184 Negative_regulation of Atp2a2 Negative_regulation of Localization of Ca2 1 1 0.04 0.66 0.05
11 INT315034 Ass1 Positive_regulation of Cacna1f 1 1 0.00 0 0.03
12 INT315033 Binding of Calm3 and Vsig2 1 1 0.00 0 0
13 INT314986 Ins1 Negative_regulation of CACNA1S 1 1 0.00 0.08 0
14 INT315029 Binding of Calm3 and Cacna1f 1 1 0.04 0 0
15 INT315035 Binding of NAE1 and Cav1 1 1 0.01 0.7 0
16 INT315031 Binding of Cacna1f and Vsig2 1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 4 2008 0.81 518.3 1408.65
2 INT58061 Gene_expression of Trpv1 3 1117 0.78 451.54 637.59
3 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
4 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
5 INT4758 Positive_regulation of Localization of Calca 3 557 0.70 138.55 411.04
6 INT64202 Positive_regulation of Trpv1 6 643 0.70 249.66 397.42
7 INT76660 Gene_expression of Trpv1 2 691 0.78 329.46 386.42
8 INT97367 Gene_expression of Nav1 1 243 0.78 132.97 286.66
9 INT87687 Positive_regulation of Trpv1 1 409 0.70 210.24 257.59
10 INT6354 Localization of Gabrg1 2 321 0.74 41.41 186.74
11 INT120811 Gene_expression of Gopc 8 1174 0.59 428.49 150.55
12 INT1033 Positive_regulation of Ca2 15 507 0.68 131.76 147.64
13 INT60126 Regulation of Trpv1 2 186 0.62 85.53 133.4
14 INT60126 Regulation of Trpv1 2 186 0.62 85.53 133.4
15 INT64201 Negative_regulation of Trpv1 4 203 0.59 79.18 119.75
16 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 9 1138 0.72 311.58 119.18
17 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
18 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
19 INT4822 Localization of Ca2 8 417 0.80 99.57 96.45
20 INT3537 Positive_regulation of Car2 7 413 0.56 103.51 94.35
21 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
22 INT2520 Negative_regulation of Ca2 12 271 0.57 72.13 83.71
23 INT100965 Positive_regulation of Nav1 1 85 0.70 37.74 75.35
24 INT13286 Gene_expression of Ca2 11 317 0.67 71.58 65.01
25 INT97368 Negative_regulation of Nav1 1 62 0.59 41.56 60.27
26 INT169926 Positive_regulation of Gopc 2 416 0.46 157.8 58.67
27 INT1032 Regulation of Ca2 5 202 0.52 54.91 53.03
28 INT121416 Gene_expression of Trpm8 1 101 0.78 52.7 47.85
29 INT111051 Negative_regulation of Nav1 1 64 0.59 25.51 47.27
30 INT170646 Negative_regulation of Fig4 1 213 0.37 81.29 46.92
31 INT30170 Gene_expression of Car2 5 330 0.66 77.26 46.76
32 INT17561 Localization of Car2 13 303 0.79 60.95 44.52
33 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
34 INT173693 Localization of Gopc 4 249 0.65 70.49 38.81
35 INT58062 Negative_regulation of Gene_expression of Trpv1 2 66 0.59 22.34 38.02
36 INT109820 Gene_expression of Trpv4 2 121 0.78 39.69 33.11
37 INT102429 Negative_regulation of Gene_expression of Nav1 1 19 0.59 20.09 28.09
38 INT85395 Gene_expression of Scn11a 4 62 0.78 17.97 26.89
39 INT11014 Phosphorylation of CREB1 2 72 0.81 26.35 25.64
40 INT17962 Regulation of Car2 3 124 0.41 33.98 22.71
41 INT4369 Gene_expression of Ldha 1 157 0.76 88.12 22.45
42 INT11893 Positive_regulation of Ptger2 1 96 0.69 31.49 21.92
43 INT23564 Negative_regulation of Car2 1 103 0.50 27.28 21.86
44 INT171820 Localization of Fig4 1 144 0.65 27.38 20.88
45 INT170444 Binding of Gopc 2 172 0.39 45.05 20.71
46 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 134 0.61 34.87 20.15
47 INT96511 Negative_regulation of Positive_regulation of Trpv1 1 35 0.59 10.95 19.79
48 INT1278 Negative_regulation of Ldha 1 93 0.59 37.66 19.36
49 INT14546 Positive_regulation of Localization of Ca2 1 93 0.67 31.09 18.72
50 INT145971 Localization of Nav1 1 20 0.81 10.3 18.11
51 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
52 INT119233 Positive_regulation of Trpv4 3 65 0.70 20.21 17.3
53 INT170051 Positive_regulation of Gene_expression of Gopc 2 150 0.43 56.75 16.93
54 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 1 95 0.43 24.83 15.69
55 INT16266 Gene_expression of Chat 4 80 0.67 16.14 15.01
56 INT113625 Positive_regulation of Gene_expression of Ca2 2 47 0.50 9.82 14.07
57 INT142941 Negative_regulation of Scn11a 3 14 0.43 12.2 13.38
58 INT19799 Binding of Ca2 1 71 0.48 13.69 12.92
59 INT30101 Regulation of Cacna1a 1 25 0.45 14.38 12.43
60 INT98524 Positive_regulation of Accn2 1 15 0.49 9.48 11.57
61 INT373 Regulation of Ldha 1 37 0.61 17.86 11.41
62 INT25170 Positive_regulation of Localization of Car2 7 78 0.67 15.25 11.24
63 INT13240 Gene_expression of TF 3 94 0.76 57.81 10.99
64 INT11794 Gene_expression of Cd2 2 27 0.76 17.31 10.99
65 INT7458 Negative_regulation of Kcnma1 1 30 0.43 6.61 10.4
66 INT29967 Positive_regulation of Positive_regulation of Car2 1 40 0.40 8.03 10.13
67 INT109578 Positive_regulation of Accn3 1 16 0.70 9.09 10.05
68 INT33094 Regulation of Localization of Ca2 1 28 0.38 8.65 9.96
69 INT80717 Gene_expression of Trpv3 3 20 0.72 10.05 9.96
70 INT23094 Positive_regulation of Positive_regulation of Ca2 1 29 0.49 6.8 9.35
71 INT170504 Positive_regulation of Gene_expression of Car2 1 60 0.41 19.1 8.45
72 INT45234 Binding of Ldha 1 20 0.37 9.8 8.18
73 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 1 61 0.55 13.63 8.17
74 INT87271 Positive_regulation of Phosphorylation of CREB1 1 27 0.66 12.87 7.91
75 INT200874 Positive_regulation of Localization of Gopc 1 27 0.38 5.69 7.5
76 INT134864 Binding of Calm3 3 20 0.27 1.86 6.86
77 INT170381 Transcription of Gopc 1 59 0.60 15.96 6.82
78 INT9289 Gene_expression of Htr3a 2 15 0.75 4.43 6.69
79 INT6913 Negative_regulation of Amelx 1 6 0.32 2.32 5.95
80 INT147263 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 3 51 0.53 15.32 5.86
81 INT149739 Regulation of Gene_expression of Ca2 1 25 0.38 7.22 5.53
82 INT22597 Positive_regulation of TF 2 43 0.68 27.27 5.17
83 INT74051 Negative_regulation of Localization of Car2 2 27 0.38 9.58 5.1
84 INT58060 Negative_regulation of HMI 2 30 0.44 11.9 5.06
85 INT205954 Regulation of Psmd1 2 8 0.33 3.72 4.52
86 INT8624 Positive_regulation of Scn11a 1 7 0.46 3.56 4.41
87 INT15851 Positive_regulation of Trpv3 4 11 0.60 4.6 4.35
88 INT109821 Negative_regulation of Trpv4 1 19 0.55 6.86 3.98
89 INT147028 Negative_regulation of Accn2 1 6 0.14 2.06 3.92
90 INT14091 Binding of Vsig2 4 8 0.42 3.21 3.91
91 INT192129 Gene_expression of P2rx2 5 24 0.67 7.62 3.68
92 INT18396 Positive_regulation of Ryr1 1 10 0.58 2.45 3.38
93 INT92632 Gene_expression of Vsig2 3 48 0.50 19.93 3.04
94 INT9569 Negative_regulation of Trpv3 2 6 0.40 0.84 3.03
95 INT181804 Negative_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 2 57 0.50 12.54 3
96 INT30171 Gene_expression of Calm3 2 13 0.73 0.58 2.96
97 INT100344 Regulation of Gene_expression of Scn11a 1 4 0.44 1.6 2.82
98 INT70253 Negative_regulation of Gene_expression of Ca2 6 29 0.49 16.31 2.69
99 INT127385 Gene_expression of Elk1 1 10 0.41 2.75 2.64
100 INT140091 Gene_expression of Ctgf 4 26 0.78 14.21 2.39
101 INT15127 Regulation of Cd2 1 4 0.44 1.06 2.38
102 INT67737 Negative_regulation of Pam 1 6 0.51 4.08 2.19
103 INT127386 Positive_regulation of Elk1 2 8 0.42 3.63 2.15
104 INT54234 Binding of Cd2 2 6 0.35 2.14 1.99
105 INT148715 Gene_expression of HCN1 4 4 0.78 1.29 1.98
106 INT112089 Gene_expression of Cav1 27 73 0.75 23.8 1.97
107 INT153207 Transcription of Elk1 3 3 0.24 0.39 1.75
108 INT6904 Negative_regulation of Cd2 1 5 0.42 1.37 1.64
109 INT135955 Positive_regulation of Cav1 4 17 0.48 7.73 1.61
110 INT154730 Regulation of Slc6a5 2 3 0.43 1.91 1.56
111 INT111808 Negative_regulation of Hk 8 3 0.32 5.18 1.46
112 INT242532 Positive_regulation of Gene_expression of Chat 1 14 0.50 2.38 1.44
113 INT42391 Positive_regulation of BCR 1 7 0.49 4.93 1.44
114 INT166485 Gene_expression of Slc6a5 2 2 0.64 1.51 1.36
115 INT73938 Gene_expression of Cd36 5 20 0.76 12.27 1.35
116 INT170507 Localization of Tmie 8 27 0.43 6.25 1.31
117 INT205952 Gene_expression of Shbdp1 1 14 0.24 2.46 1.27
118 INT132453 Binding of TF 1 31 0.36 12.98 1.22
119 INT205995 Gene_expression of SLC7A7 1 11 0.75 10.61 1.21
120 INT49536 Regulation of Regulation of Ca2 1 6 0.38 3.89 1.13
121 INT249305 Negative_regulation of Preb 2 7 0.39 0.62 1.12
122 INT222968 Negative_regulation of Gene_expression of Chat 1 8 0.42 1.1 1.1
123 INT111807 Positive_regulation of Hk 3 5 0.37 2.1 1.1
124 INT170511 Regulation of Localization of Car2 1 11 0.21 2.18 1.09
125 INT148710 Negative_regulation of HCN1 1 3 0.43 0 1.09
126 INT25451 Negative_regulation of Gfm1 1 13 0.27 8.22 1.06
127 INT148714 Regulation of HCN1 2 2 0.45 0.53 1.02
128 INT152809 Negative_regulation of Hk2 4 2 0.57 1.95 0.98
129 INT88466 Regulation of Gene_expression of Ldha 1 5 0.33 4.07 0.97
130 INT192124 Positive_regulation of P2rx2 2 5 0.60 1.36 0.96
131 INT89085 Transcription of Slco1a1 1 2 0.67 0 0.95
132 INT249303 Regulation of Preb 1 7 0.41 1.12 0.93
133 INT116831 Binding of Ryr1 1 11 0.47 0.12 0.9
134 INT214709 Gene_expression of Hk2 12 5 0.76 9.11 0.86
135 INT205949 Positive_regulation of Shbdp1 5 7 0.15 1.58 0.85
136 INT200900 Localization of Mapk8 1 9 0.40 5.76 0.84
137 INT112090 Negative_regulation of Gene_expression of Cav1 2 8 0.57 3.5 0.78
138 INT236517 Gene_expression of Cacna1f 12 8 0.65 5.18 0.77
139 INT73429 Negative_regulation of Atp2a2 3 20 0.20 9.05 0.74
140 INT146549 Negative_regulation of Ephx2 2 10 0.54 3.55 0.74
141 INT285167 Binding of PSMC4 1 2 0.04 0.56 0.72
142 INT282365 Positive_regulation of Trpm5 1 4 0.68 0.53 0.69
143 INT68385 Binding of Preb 1 2 0.20 0.37 0.69
144 INT70104 Positive_regulation of CACNA1S 1 6 0.47 5.92 0.68
145 INT248968 Regulation of Csn2 1 2 0.20 0.09 0.68
146 INT108713 Negative_regulation of Kcnn4 2 4 0.31 1.57 0.66
147 INT158398 Binding of Frg1 1 1 0.01 0.3 0.62
148 INT170503 Positive_regulation of Localization of Tmie 5 11 0.29 3.27 0.61
149 INT285165 Binding of MIR377 5 1 0.00 0 0.58
150 INT315028 Regulation of Cav2 1 2 0.43 0.86 0.54
151 INT32137 Regulation of Negative_regulation of Ca2 1 7 0.36 2.17 0.49
152 INT158296 Positive_regulation of Gene_expression of Ctgf 1 5 0.47 4.82 0.47
153 INT75024 Positive_regulation of Gstm1 1 4 0.31 0.49 0.46
154 INT111810 Regulation of Hk 2 2 0.24 1.21 0.46
155 INT220504 Positive_regulation of Gene_expression of Cav1 1 11 0.39 6.26 0.43
156 INT302730 Localization of Hk 2 1 0.44 1.59 0.42
157 INT262546 Positive_regulation of Binding of Calm3 2 2 0.11 0.3 0.39
158 INT220506 Binding of Cav1 2 13 0.45 5.46 0.38
159 INT315006 Regulation of Localization of Tmie 1 2 0.04 0.26 0.37
160 INT159139 Positive_regulation of MALAT1 2 3 0.41 1.73 0.33
161 INT153465 Regulation of Gene_expression of Ctgf 1 3 0.61 2.5 0.33
162 INT285182 Negative_regulation of Accn1 2 1 0.04 1.06 0.31
163 INT302727 Binding of Hk 5 1 0.30 3.22 0.31
164 INT75006 Gene_expression of Gstm1 3 6 0.45 2.19 0.29
165 INT315011 Gene_expression of Cacna1d 9 1 0.57 4.47 0.29
166 INT136840 Positive_regulation of Ctgf 2 2 0.35 1.34 0.27
167 INT166753 Gene_expression of Cacna2d1 1 2 0.21 1.41 0.25
168 INT205950 Negative_regulation of Positive_regulation of Shbdp1 1 1 0.13 0.38 0.25
169 INT258890 Positive_regulation of Positive_regulation of Shbdp1 3 1 0.13 0.71 0.23
170 INT135956 Phosphorylation of Cav1 1 5 0.64 2.24 0.22
171 INT135954 Positive_regulation of Phosphorylation of Cav1 1 2 0.40 0.64 0.22
172 INT282364 Positive_regulation of Trpm2 1 1 0.14 0 0.22
173 INT282366 Positive_regulation of Trpm4 1 1 0.15 0 0.22
174 INT205953 Regulation of Shbdp1 1 2 0.14 0.61 0.21
175 INT205951 Regulation of Tdrd6 1 1 0.11 0.15 0.21
176 INT273279 Negative_regulation of Localization of Tmie 1 2 0.07 1.72 0.2
177 INT302729 Positive_regulation of Gene_expression of Hk2 7 1 0.68 2.86 0.2
178 INT220497 Regulation of Gene_expression of Cav1 1 4 0.36 1.84 0.18
179 INT315025 Gene_expression of Cacna1s 1 3 0.48 2.3 0.18
180 INT179406 Binding of Elk1 1 2 0.12 1.07 0.18
181 INT315024 Positive_regulation of Cacna1f 4 1 0.41 0.5 0.17
182 INT258892 Gene_expression of Angle1 1 2 0.19 0.24 0.16
183 INT258891 Positive_regulation of Gene_expression of Angle1 1 1 0.14 0.1 0.16
184 INT315022 Regulation of Cacna1d 1 1 0.20 0.32 0.16
185 INT258893 Positive_regulation of Angle1 1 1 0.20 0.1 0.16
186 INT145253 Negative_regulation of Cav1 2 9 0.46 3.02 0.15
187 INT314985 Positive_regulation of Negative_regulation of Pam 1 1 0.05 2.1 0.15
188 INT285175 Binding of MALAT1 1 1 0.06 0 0.15
189 INT302728 Transcription of Hk 1 1 0.43 0.71 0.15
190 INT285171 Localization of HCN1 1 1 0.60 0 0.15
191 INT302724 Negative_regulation of Binding of Hk 1 1 0.36 0.79 0.15
192 INT214975 Localization of Cav1 1 7 0.75 2.7 0.13
193 INT315023 Transcription of Cacna1d 1 1 0.50 0.26 0.13
194 INT170514 Gene_expression of Ryr1 2 4 0.49 0.56 0.12
195 INT285174 Gene_expression of MIR377 1 1 0.01 0 0.12
196 INT315026 Gene_expression of Csn2 2 1 0.30 0.24 0.12
197 INT285168 Gene_expression of MALAT1 1 1 0.11 0 0.12
198 INT315027 Positive_regulation of Gene_expression of Cacna1f 2 1 0.41 0.27 0.12
199 INT315018 Positive_regulation of Gene_expression of Csn2 1 1 0.22 0 0.12
200 INT315016 Negative_regulation of Csn2 1 1 0.19 0 0.12
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