J:Pflugers Arch.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT63519 Hrh1 Regulation of H2 1 1 0.02 0.36 0.39
2 INT126942 Binding of PKD2 and ZACN 1 2 0.00 1.38 0.28
3 INT5874 Pitx1 Positive_regulation of Ina 1 1 0.17 0 0.21
4 INT5873 Pitx1 Negative_regulation of Ina 1 1 0.15 0 0.21
5 INT126944 Binding of PKD2 and Pkd1 2 1 0.08 2.09 0.19
6 INT109805 LOC685542 Negative_regulation of Dnase1l1 1 1 0.00 0 0.19
7 INT126943 Binding of Pkd1 and ZACN 1 1 0.00 0.69 0.14
8 INT44815 Sct Positive_regulation of Npr1 1 1 0.06 0 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 4 3083 0.78 894.43 1639.02
2 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
3 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
4 INT18357 Gene_expression of TRPV1 4 825 0.78 307.11 382.81
5 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
6 INT477 Localization of Avp 2 813 0.81 131.58 300.4
7 INT886 Gene_expression of Pomc 2 676 0.78 129.87 295.98
8 INT97367 Gene_expression of Nav1 14 243 0.78 132.97 286.66
9 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
10 INT5591 Regulation of Gene_expression of Fos 2 425 0.62 129.06 265.78
11 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
12 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
13 INT2451 Positive_regulation of Avp 2 355 0.70 102.66 147.69
14 INT1033 Positive_regulation of Ca2 3 507 0.68 131.76 147.64
15 INT812 Localization of INS 2 1026 0.81 515.6 145.31
16 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
17 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
18 INT47243 Gene_expression of Prkcg 3 195 0.78 58.05 108.44
19 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
20 INT67682 Localization of Bdnf 1 204 0.81 72.36 88.92
21 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
22 INT2520 Negative_regulation of Ca2 4 271 0.57 72.13 83.71
23 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
24 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
25 INT9304 Negative_regulation of Pag1 2 70 0.39 51.97 64.23
26 INT46 Localization of Ren 11 233 0.81 46.15 62.44
27 INT97368 Negative_regulation of Nav1 2 62 0.59 41.56 60.27
28 INT1536 Negative_regulation of NA 3 244 0.55 52.67 59.79
29 INT6623 Gene_expression of NA 7 231 0.78 45.78 59.36
30 INT62960 Gene_expression of P2rx2 1 149 0.77 58.31 59.16
31 INT83602 Positive_regulation of Gene_expression of TRPV1 2 114 0.70 51.19 56.35
32 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
33 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
34 INT12717 Binding of Pck1 1 85 0.47 12.49 54.81
35 INT1032 Regulation of Ca2 1 202 0.52 54.91 53.03
36 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
37 INT929 Positive_regulation of Oprl1 2 64 0.70 14.67 52.84
38 INT5338 Regulation of Npy 1 92 0.62 25.54 51.24
39 INT8690 Localization of Tac1 2 71 0.80 22.98 50.75
40 INT7059 Regulation of Adra2a 1 89 0.62 18.24 48.43
41 INT654 Localization of REN 5 250 0.81 75.12 47.86
42 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
43 INT789 Positive_regulation of YY1 1 69 0.67 14.07 47.06
44 INT5781 Gene_expression of Edn1 1 190 0.78 99.1 46
45 INT6979 Positive_regulation of CA2 2 206 0.67 50.79 44.97
46 INT117675 Transcription of Nav1 1 46 0.72 30.23 44.01
47 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
48 INT2531 Positive_regulation of Cebpz 2 166 0.00 43.08 38.86
49 INT1596 Negative_regulation of Oprl1 1 61 0.57 13.5 38.41
50 INT4449 Positive_regulation of NA 2 179 0.55 40.26 37.82
51 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
52 INT49 Negative_regulation of Ren 4 129 0.59 37.48 35.62
53 INT23330 Binding of Chrna7 3 79 0.48 10.06 35.5
54 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
55 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
56 INT1116 Regulation of Ren 1 103 0.62 27.66 33.26
57 INT51698 Positive_regulation of Gene_expression of Prkcg 1 44 0.68 14.02 32.9
58 INT2330 Regulation of CB 1 78 0.10 20.46 32.6
59 INT1495 Positive_regulation of Rtcd1 4 91 0.54 22.93 32.43
60 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
61 INT50 Negative_regulation of Localization of Ren 1 87 0.59 14.94 30.22
62 INT72252 Gene_expression of Kcnma1 1 63 0.64 20.47 29.56
63 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
64 INT5440 Negative_regulation of Ina 2 85 0.58 10.52 28.98
65 INT6364 Gene_expression of Edn1 1 123 0.78 73.76 28.43
66 INT102429 Negative_regulation of Gene_expression of Nav1 2 19 0.59 20.09 28.09
67 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
68 INT127499 Positive_regulation of TRPA1 2 72 0.70 21.7 26.86
69 INT9647 Gene_expression of PROC 2 163 0.65 89.76 26.75
70 INT2140 Regulation of REN 2 104 0.62 28.24 24.49
71 INT64076 Positive_regulation of Kcnma1 1 47 0.40 11.52 24.19
72 INT127500 Gene_expression of TRPA1 1 79 0.78 24.58 23.3
73 INT103842 Gene_expression of Cftr 2 53 0.78 59.59 21.82
74 INT3589 Positive_regulation of SCN5A 1 101 0.57 46.01 21.73
75 INT15796 Regulation of IL2 2 66 0.61 25.43 20.62
76 INT7017 Regulation of Npr1 1 45 0.52 3.38 20.05
77 INT48 Positive_regulation of Localization of Ren 3 69 0.70 12.47 18.03
78 INT101501 Phosphorylation of TRPV1 1 31 0.82 9.26 17.27
79 INT653 Negative_regulation of Localization of REN 2 67 0.59 20.33 16.7
80 INT1214 Gene_expression of PGE 1 70 0.72 29.07 16.22
81 INT52591 Gene_expression of KCNMA1 3 78 0.76 13.95 15.55
82 INT92839 Regulation of P2rx2 2 36 0.45 13.19 15.38
83 INT36554 Gene_expression of PRSS1 2 70 0.78 50.25 15.33
84 INT81088 Gene_expression of ASIC1 1 26 0.77 17.8 15.07
85 INT13118 Positive_regulation of Ina 3 48 0.69 7.39 13.85
86 INT6365 Localization of Edn1 1 56 0.81 18.84 13.83
87 INT11996 Gene_expression of Ina 1 34 0.67 4.8 13.82
88 INT53070 Regulation of Rtn4 2 15 0.22 9.35 13.77
89 INT655 Positive_regulation of Localization of REN 2 86 0.70 32.41 13.56
90 INT2673 Negative_regulation of PROC 1 93 0.57 50.34 12.79
91 INT11793 Negative_regulation of CA2 1 78 0.57 19.63 12.35
92 INT83894 Positive_regulation of TRPM8 1 37 0.70 18.28 11.7
93 INT127981 Gene_expression of Trpc1 1 25 0.77 10.51 11.67
94 INT18001 Positive_regulation of Htr2c 1 21 0.67 7.63 11.39
95 INT686 Negative_regulation of Sct 2 35 0.59 9.59 11.32
96 INT48691 Negative_regulation of Tacr1 1 20 0.59 4.96 11.25
97 INT36715 Gene_expression of Trpc4 1 50 0.68 4.18 11.13
98 INT15546 Localization of Pyy 19 70 0.81 4.23 10.87
99 INT3535 Regulation of CA2 1 61 0.32 16.48 10.8
100 INT19155 Binding of Adora1 1 25 0.47 6.41 10.72
101 INT1180 Gene_expression of Ren 8 63 0.77 27.33 10.51
102 INT7458 Negative_regulation of Kcnma1 1 30 0.43 6.61 10.4
103 INT43009 Gene_expression of Scn7a 3 45 0.68 7.85 10.29
104 INT127978 Gene_expression of Trpc5 1 58 0.67 3.11 10.21
105 INT1372 Regulation of Localization of REN 3 50 0.62 5.76 9.81
106 INT6361 Localization of Edn1 3 30 0.81 19.09 9.7
107 INT23676 Gene_expression of Chrna7 1 47 0.75 23.66 9.51
108 INT4903 Regulation of Ina 1 23 0.50 3.03 9.46
109 INT44378 Gene_expression of GSTM1 1 69 0.76 34.61 8.81
110 INT22383 Binding of IL2 1 59 0.48 39.06 8.56
111 INT136177 Gene_expression of P2rx4 1 8 0.75 6.74 8.05
112 INT66460 Negative_regulation of Cabin1 2 15 0.43 8.98 8.03
113 INT21502 Gene_expression of Scn4a 2 22 0.78 4.47 7.97
114 INT18025 Binding of Pah 1 32 0.45 30.72 7.93
115 INT20705 Positive_regulation of Scn4a 2 18 0.68 4.34 7.85
116 INT21685 Gene_expression of ras 3 115 0.66 85.6 7.76
117 INT30729 Binding of Ptger2 1 36 0.29 7.66 7.35
118 INT17029 Regulation of Scn7a 1 23 0.45 3.89 7.02
119 INT69289 Negative_regulation of Cftr 2 44 0.57 13.28 6.97
120 INT110605 Gene_expression of KCNK2 2 24 0.78 5.71 6.85
121 INT9818 Positive_regulation of Pdia4 1 12 0.34 0.67 6.65
122 INT27325 Positive_regulation of Pyy 1 15 0.62 13.69 6.54
123 INT51137 Negative_regulation of GSTM1 3 39 0.43 14.74 6.5
124 INT539 Negative_regulation of Chrna7 1 14 0.42 4.59 6.42
125 INT24946 Binding of PRSS1 1 23 0.47 16.75 6.41
126 INT69561 Positive_regulation of GSTM1 2 23 0.50 5.69 6.36
127 INT3905 Positive_regulation of Positive_regulation of Rtcd1 1 10 0.27 1.76 5.82
128 INT86119 Regulation of Cftr 1 13 0.45 14.08 5.75
129 INT26112 Positive_regulation of Hrh2 1 10 0.69 4.28 5.54
130 INT5490 Binding of CA2 1 52 0.36 9.73 5.53
131 INT13370 Negative_regulation of Scn4a 2 11 0.57 4.05 5.47
132 INT21933 Regulation of Negative_regulation of Pag1 1 5 0.28 5.48 5.29
133 INT75682 Regulation of Chrna7 1 14 0.45 10.24 5.25
134 INT13051 Regulation of Kcnma1 1 12 0.12 2.09 5.06
135 INT1317 Negative_regulation of Sds 1 23 0.48 6.97 5.03
136 INT6983 Negative_regulation of Positive_regulation of Ca2 1 18 0.41 4.29 5.03
137 INT7479 Positive_regulation of Ggh 1 13 0.62 5.71 5.02
138 INT106131 Negative_regulation of Abcc3 1 8 0.58 3.17 4.86
139 INT27326 Positive_regulation of Localization of Pyy 8 27 0.70 1.59 4.81
140 INT10551 Negative_regulation of Positive_regulation of Cebpz 1 14 0.38 3.22 4.6
141 INT3097 Binding of Ren 1 12 0.48 3.15 4.4
142 INT141841 Negative_regulation of Transcription of Nav1 1 3 0.43 3.15 4.38
143 INT21686 Positive_regulation of Gene_expression of ras 4 19 0.42 13.79 4.28
144 INT136179 Positive_regulation of P2RX4 1 9 0.67 7.06 4.27
145 INT27158 Negative_regulation of Positive_regulation of Rtcd1 1 7 0.13 1.84 4.25
146 INT24146 Negative_regulation of Pirt 1 9 0.02 0.15 4.14
147 INT144 Positive_regulation of H1 1 10 0.64 2.77 4.13
148 INT48993 Positive_regulation of Cftr 2 17 0.57 6.02 4.12
149 INT89113 Regulation of Cftr 1 11 0.62 6.83 4.01
150 INT100995 Gene_expression of KCNK5 1 10 0.78 0.09 4.01
151 INT4530 Regulation of Ggh 1 9 0.54 2.5 3.96
152 INT16189 Regulation of Pls1 1 7 0.24 1.82 3.71
153 INT127980 Gene_expression of Trpc3 1 13 0.75 2.53 3.52
154 INT14558 Regulation of Positive_regulation of Oprl1 1 6 0.43 2.49 3.5
155 INT18073 Positive_regulation of TYRP1 2 11 0.67 1.98 3.36
156 INT4479 Negative_regulation of Positive_regulation of REN 1 17 0.56 6.1 3.27
157 INT93308 Gene_expression of PIRT 3 13 0.09 2 2.92
158 INT16188 Positive_regulation of Pls1 1 4 0.19 3.07 2.85
159 INT1213 Positive_regulation of Gene_expression of PGE 1 12 0.46 4.85 2.83
160 INT19689 Regulation of Tes 1 5 0.24 1.01 2.76
161 INT99049 Positive_regulation of Hcn1 1 5 0.43 0.68 2.75
162 INT48539 Positive_regulation of Cabin1 1 8 0.32 0.63 2.68
163 INT33996 Positive_regulation of Negative_regulation of Oprl1 1 4 0.53 1.34 2.68
164 INT136176 Positive_regulation of Gene_expression of P2rx4 1 5 0.60 3.18 2.64
165 INT69290 Localization of Cftr 2 11 0.75 3.69 2.52
166 INT129161 Binding of TRPM8 1 7 0.48 1.32 2.48
167 INT23788 Negative_regulation of Kcne1 2 7 0.39 0.73 2.38
168 INT5756 Gene_expression of KCNN1 1 7 0.59 1.07 2.29
169 INT23808 Positive_regulation of Itpka 1 8 0.68 0 2.28
170 INT28576 Binding of MLN 1 18 0.48 5.45 2.26
171 INT59680 Binding of Lynx1 1 10 0.12 1.53 2.19
172 INT34413 Negative_regulation of Pia1 1 4 0.12 0.24 2.17
173 INT24196 Positive_regulation of Binding of Chrna7 1 8 0.45 0.79 2.13
174 INT55642 Negative_regulation of Pls1 1 4 0.07 1.16 2.08
175 INT5415 Negative_regulation of Pdia4 3 6 0.36 0.94 1.93
176 INT47857 Negative_regulation of Localization of Pyy 3 12 0.59 1.67 1.76
177 INT106984 Regulation of P2RX1 1 12 0.60 2.05 1.75
178 INT72982 Regulation of Chga 1 4 0.44 0.4 1.72
179 INT38207 Positive_regulation of Tes 1 7 0.40 3.47 1.7
180 INT1500 Negative_regulation of Gene_expression of Ren 2 10 0.43 4.44 1.68
181 INT1215 Negative_regulation of PGE 1 19 0.47 4.6 1.52
182 INT84763 Regulation of P2RX6 1 2 0.26 0.37 1.47
183 INT109940 Negative_regulation of Siafq1 1 1 0.10 1.22 1.43
184 INT21011 Positive_regulation of P2RY6 1 7 0.37 3.58 1.38
185 INT99050 Regulation of Hcn1 1 2 0.42 0.66 1.33
186 INT120521 Negative_regulation of Gene_expression of Scn11a 1 2 0.42 2.12 1.3
187 INT1846 Positive_regulation of RPS6KB2 1 6 0.50 1.77 1.21
188 INT60286 Gene_expression of PKLR 1 5 0.65 2.14 1.04
189 INT10625 Regulation of Positive_regulation of Avp 1 4 0.44 1.06 1.04
190 INT131840 Transcription of KCNK2 4 5 0.70 0.74 0.99
191 INT64654 Localization of IFNW1 1 2 0.10 0.29 0.89
192 INT87903 Positive_regulation of ASIC5 1 1 0.36 0 0.88
193 INT17034 Positive_regulation of Slc10a2 1 4 0.41 2.79 0.87
194 INT90291 Gene_expression of LMNB1 1 6 0.38 7.75 0.86
195 INT131838 Transcription of KCNK5 4 1 0.69 0.36 0.8
196 INT131839 Transcription of KCNK6 4 1 0.69 0.36 0.8
197 INT131837 Transcription of KCNK1 4 1 0.67 0.36 0.8
198 INT20704 Negative_regulation of Positive_regulation of Scn4a 1 2 0.57 0 0.68
199 INT66461 Binding of Ppia 1 2 0.21 1.44 0.68
200 INT49617 Negative_regulation of Slc9a1 1 3 0.42 0.67 0.66
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