J:Pharm Res

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 1 0.28 0.88 0.56
2 INT210363 Binding of ALB and M6PR 1 1 0.00 1.19 0.1
3 INT325654 Binding of Nab1 and Gopc 1 1 0.04 0.63 0.09
4 INT325653 Positive_regulation of Binding of Nab1 and Gopc 1 1 0.05 0.63 0.09
5 INT210364 Binding of FUT1 and GOPC 1 1 0.01 0.53 0.08
6 INT210365 Binding of FUT1 and GPM6A 1 2 0.00 1.1 0.08
7 INT271493 Ctbs Negative_regulation of Hand1 1 1 0.04 0.63 0.07
8 INT215188 Binding of Ntrk2 and Nnat 1 1 0.00 0.15 0.07
9 INT350486 Cebpb Positive_regulation of IgG2a 1 1 0.00 0.42 0
10 INT210362 Binding of GPM6A and IGF2R 1 1 0.00 0.57 0
11 INT300664 Binding of Gla and Thra 1 1 0.08 0 0
12 INT215207 Binding of Gopc and Tg(GH)3Mi 1 2 0.01 0 0
13 INT215206 Gh Positive_regulation of Transcription of Igf1 1 1 0.03 0 0
14 INT215209 Binding of Igf1 and Igfbp3 1 1 0.11 0 0
15 INT215205 Binding of Igf2 and Igfbp3 1 1 0.04 0 0
16 INT350487 Cebpb Positive_regulation of Cebpb Positive_regulation of IgG2a 1 1 0.00 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
4 INT5680 Gene_expression of Ngf 3 530 0.78 264.29 310.56
5 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
6 INT68684 Gene_expression of VEGFA 5 2371 0.78 1742.52 259.2
7 INT1893 Localization of Gh 1 1041 0.79 340.23 256.58
8 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
9 INT120811 Gene_expression of Gopc 5 1174 0.59 428.49 150.55
10 INT62124 Gene_expression of NOS1 2 444 0.78 218.08 114.85
11 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
12 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
13 INT16254 Positive_regulation of Gene_expression of Ngf 1 144 0.70 80.61 82.08
14 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
15 INT749 Gene_expression of HLA-B 1 341 0.75 224.12 77.37
16 INT3034 Localization of Ngf 2 126 0.81 50.81 72.84
17 INT79494 Positive_regulation of Gene_expression of VEGFA 2 577 0.70 442.94 69.73
18 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
19 INT50971 Gene_expression of Ntrk1 1 180 0.75 73.52 62.28
20 INT17401 Gene_expression of IGF1 1 475 0.78 232.18 62.07
21 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
22 INT546 Binding of ALB 1 311 0.48 85.98 60.14
23 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
24 INT74389 Gene_expression of Gdnf 4 131 0.78 58.52 57.06
25 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
26 INT20375 Gene_expression of Hand1 2 213 0.60 148.51 54.53
27 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
28 INT17881 Gene_expression of LEP 1 278 0.78 221.61 48.31
29 INT18522 Positive_regulation of Gene_expression of IFNA1 1 248 0.67 160.85 44.87
30 INT25383 Gene_expression of Csf2 2 222 0.76 152.93 43.32
31 INT97596 Localization of S100a8 1 94 0.78 90.69 40.41
32 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
33 INT173693 Localization of Gopc 7 249 0.65 70.49 38.81
34 INT101992 Localization of VEGFA 2 413 0.81 258.23 36.15
35 INT14559 Gene_expression of Igf1 5 254 0.78 112 34.17
36 INT84825 Gene_expression of CD36 1 121 0.78 43.73 33.23
37 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
38 INT22939 Gene_expression of Csf2 1 164 0.78 85.1 32.22
39 INT64113 Positive_regulation of Gene_expression of NOS1 2 110 0.60 71.03 29.72
40 INT15610 Localization of GOPC 2 223 0.65 68.26 28.7
41 INT9682 Positive_regulation of IGF1 1 238 0.70 120.03 26.36
42 INT14556 Positive_regulation of Igf1 1 105 0.69 52.21 24.04
43 INT171820 Localization of Fig4 3 144 0.65 27.38 20.88
44 INT170444 Binding of Gopc 7 172 0.39 45.05 20.71
45 INT105021 Binding of GOPC 2 187 0.40 60.39 20.38
46 INT65907 Negative_regulation of Gene_expression of Ngf 1 36 0.59 19.5 20.03
47 INT12265 Positive_regulation of IgG 5 168 0.63 104.89 19.76
48 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
49 INT112017 Regulation of Hand2 1 77 0.36 62.23 18.04
50 INT96155 Gene_expression of Cd86 1 134 0.77 50.56 17.13
51 INT24225 Gene_expression of Alms1 4 93 0.62 52.75 16.93
52 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
53 INT93361 Gene_expression of Trp53 2 208 0.78 175.35 16.65
54 INT109110 Positive_regulation of Pde5a 2 29 0.63 11.16 16.65
55 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
56 INT104045 Regulation of Hand1 1 65 0.35 51.32 16.26
57 INT9220 Gene_expression of Ighg1 3 125 0.77 85.74 15.92
58 INT96775 Gene_expression of Pdgfa 2 42 0.54 29.78 15.46
59 INT152730 Positive_regulation of S100a8 1 48 0.68 47.67 15.4
60 INT85964 Gene_expression of Pecam1 1 109 0.78 69.73 15.21
61 INT65263 Positive_regulation of Gene_expression of Igf1 2 61 0.69 25.69 14.49
62 INT36177 Binding of Alms1 8 70 0.31 35.47 13.81
63 INT5207 Negative_regulation of Alms1 1 70 0.41 41.56 13.68
64 INT55874 Binding of GPM6A 5 20 0.34 4.2 13.63
65 INT69878 Positive_regulation of Gene_expression of Gtf3a 1 48 0.29 36.78 13.57
66 INT18720 Localization of Csf2 3 72 0.67 13.65 13.41
67 INT53747 Positive_regulation of Cyp2e1 1 34 0.70 29.03 13.39
68 INT89395 Negative_regulation of AKT1 1 127 0.58 70.27 12.54
69 INT27268 Localization of Gtf3a 3 71 0.21 56.93 12.51
70 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
71 INT94464 Negative_regulation of Hand1 1 44 0.41 31.5 12.39
72 INT35801 Regulation of Alms1 1 34 0.38 20.88 12.38
73 INT28952 Negative_regulation of Gene_expression of IGF1 1 75 0.58 41.11 12.32
74 INT48335 Negative_regulation of NOSTRIN 1 38 0.56 16.22 12.05
75 INT149985 Gene_expression of Tlr9 2 32 0.75 29.83 11.86
76 INT48912 Localization of NOS1 4 52 0.77 24.14 10.92
77 INT22132 Positive_regulation of CAT 1 41 0.67 18.64 10.67
78 INT178306 Negative_regulation of Gene_expression of Gopc 2 71 0.37 26.43 9.74
79 INT101105 Positive_regulation of FUT1 13 62 0.30 55.96 9.28
80 INT132586 Negative_regulation of Hand2 1 40 0.30 26.58 9.28
81 INT93490 Gene_expression of GPM6A 3 14 0.69 3.14 9.08
82 INT182137 Gene_expression of TLR9 1 137 0.78 48.48 9.05
83 INT77795 Localization of Gdnf 1 26 0.81 6.29 8.55
84 INT91370 Phosphorylation of STAT3 1 123 0.82 49.25 8.42
85 INT95414 Positive_regulation of Alms1 3 40 0.41 20.3 8.1
86 INT13675 Gene_expression of Cyp2c22 1 23 0.39 4.52 7.71
87 INT55185 Binding of Sert1 1 26 0.48 4.43 7.57
88 INT200874 Positive_regulation of Localization of Gopc 1 27 0.38 5.69 7.5
89 INT1123 Positive_regulation of CD79A 1 74 0.70 51.96 7.14
90 INT8793 Gene_expression of H2 1 58 0.75 26.36 7.07
91 INT132860 Binding of BDNF 1 33 0.47 14.7 6.99
92 INT36960 Gene_expression of vs 1 33 0.43 20.77 6.97
93 INT95117 Gene_expression of PDGFA 2 71 0.71 51.17 6.9
94 INT142344 Transcription of Igf1 1 22 0.69 7.55 6.77
95 INT11591 Gene_expression of IgG2a 4 53 0.65 23.14 6.73
96 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
97 INT8101 Binding of INCENP 4 42 0.31 16.2 6.68
98 INT92001 Regulation of Gene_expression of Gdnf 2 12 0.62 6.62 6.65
99 INT207892 Binding of Tlr9 2 35 0.46 26.66 6.61
100 INT39516 Gene_expression of Alb 1 81 0.75 30.08 6.59
101 INT25022 Binding of PAEP 1 66 0.42 22.83 6.59
102 INT93359 Positive_regulation of Trp53 2 90 0.70 69.77 6.24
103 INT3819 Positive_regulation of Apc 1 36 0.69 27.03 6.02
104 INT57719 Localization of GPM6A 1 7 0.44 0.95 5.97
105 INT75501 Gene_expression of CCND1 1 90 0.76 60.86 5.93
106 INT151032 Localization of Igf1 2 49 0.76 26.32 5.71
107 INT145888 Negative_regulation of Mthfd1 1 27 0.41 8.98 5.4
108 INT164656 Negative_regulation of Gene_expression of CD36 1 24 0.57 6.51 5.39
109 INT96778 Positive_regulation of Pdgfa 1 22 0.46 12.7 5.31
110 INT60585 Regulation of TP53 1 59 0.59 54.55 5.21
111 INT95099 Gene_expression of SLC22A8 2 14 0.67 1.59 5.14
112 INT73262 Negative_regulation of BCL2 1 67 0.57 61.01 5.07
113 INT68244 Positive_regulation of Ighg1 3 60 0.61 48.86 5.01
114 INT83680 Gene_expression of FUT1 1 40 0.26 25.45 4.98
115 INT104356 Negative_regulation of Pgp 2 15 0.43 6.64 4.89
116 INT105923 Binding of FUT1 9 34 0.14 17.81 4.79
117 INT65056 Binding of Ntrk2 1 20 0.36 3.72 4.42
118 INT63113 Positive_regulation of HRAS 2 30 0.67 22.85 4.28
119 INT10923 Positive_regulation of Lipg 1 30 0.50 22.87 4.26
120 INT20981 Binding of HRAS 1 42 0.48 24.49 4.23
121 INT84686 Regulation of BAX 1 26 0.49 28.54 4.13
122 INT156416 Gene_expression of Lipg 1 38 0.67 18.35 4.07
123 INT101857 Negative_regulation of BCL2L1 1 22 0.57 23.56 3.95
124 INT96776 Positive_regulation of Gene_expression of Pdgfa 1 8 0.40 7.79 3.93
125 INT44323 Positive_regulation of F8 1 32 0.60 24.88 3.89
126 INT142174 Regulation of Gene_expression of Igf1 1 28 0.60 11.86 3.77
127 INT55907 Binding of Ngfr 1 13 0.47 5.79 3.75
128 INT108761 Localization of Alms1 1 24 0.70 13.92 3.74
129 INT71602 Negative_regulation of Trp53 1 84 0.59 67.77 3.68
130 INT97126 Regulation of CASP3 1 9 0.40 8.15 3.6
131 INT96777 Localization of Pdgfa 3 12 0.79 5.86 3.52
132 INT111482 Gene_expression of Cd24a 1 23 0.72 13.74 3.37
133 INT76869 Localization of PAEP 1 15 0.73 6.57 3.36
134 INT168003 Localization of Fgf2 1 24 0.80 12.52 3.31
135 INT92632 Gene_expression of Vsig2 2 48 0.50 19.93 3.04
136 INT93936 Gene_expression of Pgp 1 10 0.59 3.43 3.04
137 INT75114 Gene_expression of Ntsr1 1 5 0.52 1.42 2.97
138 INT3682 Binding of Ppr1 2 10 0.42 1.87 2.96
139 INT68235 Positive_regulation of IgG2a 4 39 0.49 30.96 2.75
140 INT215185 Localization of Nnat 1 7 0.69 3.62 2.75
141 INT192964 Positive_regulation of Hp 1 7 0.28 2 2.75
142 INT90875 Negative_regulation of CCND1 1 31 0.42 26.22 2.66
143 INT169987 Transcription of GOPC 1 45 0.60 21.88 2.61
144 INT72782 Positive_regulation of HCC 1 41 0.40 63.74 2.46
145 INT24129 Positive_regulation of ZAK 1 13 0.70 2.29 2.39
146 INT94002 Regulation of Lox 1 13 0.38 8.41 2.29
147 INT113438 Positive_regulation of GPM6A 3 3 0.11 3.26 2.29
148 INT103327 Gene_expression of F8 1 45 0.71 32.5 2.12
149 INT135258 Gene_expression of Pgp 1 4 0.47 1.28 1.96
150 INT142341 Positive_regulation of Transcription of Igf1 1 8 0.49 2.44 1.95
151 INT76993 Regulation of HRAS 1 8 0.60 7.81 1.95
152 INT122195 Regulation of Localization of VEGFA 1 13 0.57 10.61 1.92
153 INT228401 Positive_regulation of Cd86 2 24 0.53 6.46 1.8
154 INT145878 Positive_regulation of Negative_regulation of Pgp 1 2 0.30 1.2 1.75
155 INT281639 Binding of Map3k12 1 2 0.02 3.05 1.68
156 INT161097 Gene_expression of Epc1 1 36 0.45 7.76 1.64
157 INT145879 Positive_regulation of Gene_expression of Pgp 1 2 0.30 1.23 1.63
158 INT88195 Gene_expression of ZAK 3 15 0.74 4.79 1.55
159 INT64233 Regulation of Trp53 2 35 0.62 27.11 1.53
160 INT147692 Localization of Epc1 1 22 0.40 7.17 1.51
161 INT120227 Binding of Cxadr 1 17 0.45 8.02 1.51
162 INT204530 Positive_regulation of Gene_expression of TLR9 1 14 0.70 6.85 1.48
163 INT129099 Negative_regulation of Hbegf 1 4 0.36 1.2 1.46
164 INT61068 Gene_expression of Igfbp3 1 15 0.75 8.48 1.41
165 INT105921 Localization of FUT1 3 13 0.23 3.92 1.39
166 INT201463 Negative_regulation of CCNE2 1 7 0.39 3.31 1.36
167 INT187888 Binding of Pgp 2 5 0.32 0.4 1.35
168 INT181526 Positive_regulation of Apcs 1 13 0.49 4.09 1.3
169 INT2681 Binding of Thra 1 11 0.32 5.98 1.27
170 INT86446 Protein_catabolism of Lipg 3 9 0.50 3.52 1.25
171 INT210399 Gene_expression of IGF2R 6 22 0.65 17.1 1.23
172 INT210392 Regulation of PDGFA 1 10 0.36 11.41 1.12
173 INT112082 Regulation of Vsig2 1 13 0.40 1.89 0.98
174 INT170106 Binding of Nnat 1 3 0.31 1.65 0.98
175 INT135260 Negative_regulation of Pgp 1 4 0.42 1.13 0.95
176 INT188317 Positive_regulation of Gene_expression of PDGFA 2 15 0.46 12.7 0.91
177 INT215202 Localization of Igfbp3 1 3 0.62 2.5 0.91
178 INT7147 Localization of Vsig2 2 7 0.49 4.42 0.86
179 INT101103 Positive_regulation of Positive_regulation of FUT1 2 5 0.27 4.25 0.85
180 INT98017 Protein_catabolism of Gtf3a 1 10 0.11 6.16 0.83
181 INT204852 Gene_expression of Cd83 1 7 0.48 3.15 0.76
182 INT24128 Negative_regulation of ZAK 1 3 0.39 0 0.7
183 INT39999 Gene_expression of Gla 2 7 0.59 3.27 0.69
184 INT43922 Gene_expression of Epgn 1 3 0.58 1.45 0.69
185 INT2395 Binding of MB 1 18 0.36 7.53 0.68
186 INT271488 Negative_regulation of Negative_regulation of Hand2 1 3 0.18 2.36 0.67
187 INT210390 Binding of PDGFA 2 12 0.36 6.78 0.63
188 INT247751 Positive_regulation of Binding of Gopc 1 8 0.25 0.75 0.61
189 INT80257 Positive_regulation of OXA1L 1 8 0.40 0.74 0.58
190 INT18631 Positive_regulation of H2 2 9 0.29 3.24 0.55
191 INT61067 Positive_regulation of Igfbp3 1 3 0.41 1.21 0.5
192 INT126683 Localization of Lipg 1 7 0.70 3.87 0.46
193 INT136750 Gene_expression of SCARF1 1 3 0.65 1.48 0.43
194 INT144263 Gene_expression of KCNK1 1 3 0.58 0.14 0.43
195 INT215204 Gene_expression of Tg(GH)3Mi 15 1 0.09 0.36 0.4
196 INT215198 Localization of Tg(GH)3Mi 31 1 0.11 0.6 0.39
197 INT210405 Negative_regulation of Binding of FUT1 1 5 0.14 1.97 0.38
198 INT139450 Binding of IGF2R 1 3 0.19 1.75 0.36
199 INT154243 Positive_regulation of Binding of Alms1 1 4 0.42 1.86 0.32
200 INT75628 Gene_expression of Dst 1 4 0.60 0.78 0.31
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