J:Pharmacol. Toxicol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT1151 Binding of CCK and GAST 7 4 0.49 0.73 3.08
2 INT24796 ACE Positive_regulation of Localization of HMMR 1 2 0.00 0.58 1.16
3 INT9824 Binding of Agtr2 and Bcl2a1a 1 1 0.16 0.24 0.64
4 INT63459 Binding of Calca and Phax 1 1 0.00 0.12 0.49
5 INT74713 Binding of Gria1 and Olr1868 1 1 0.00 0 0.42
6 INT109784 GAST Positive_regulation of CCK 1 1 0.51 0.06 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 6 2008 0.81 518.3 1408.65
2 INT158 Localization of Prl 6 2431 0.81 378.96 952.2
3 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
4 INT155 Positive_regulation of Prl 3 1233 0.70 317.93 457.82
5 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
6 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
7 INT157 Positive_regulation of Localization of Prl 4 790 0.70 104.54 374.78
8 INT287 Localization of Cck 3 518 0.81 86.84 364.04
9 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
10 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
11 INT1352 Localization of Acot1 12 728 0.80 73.01 296.01
12 INT3579 Localization of Oxt 1 555 0.81 43.35 292.44
13 INT2909 Positive_regulation of Abat 4 334 0.70 62.1 256.43
14 INT3948 Regulation of Cck 2 291 0.62 58.07 255.88
15 INT5501 Regulation of Oprd1 3 283 0.62 55.1 249.9
16 INT1902 Gene_expression of Cck 1 348 0.78 70.33 241.92
17 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
18 INT767 Localization of Gnrhr 12 565 0.80 106.68 214.57
19 INT943 Negative_regulation of Cck 1 205 0.59 38.42 174.78
20 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
21 INT4768 Positive_regulation of OPRM1 1 212 0.70 31.09 164.28
22 INT2366 Binding of Cck 2 192 0.48 30.64 163.46
23 INT2910 Regulation of Abat 3 169 0.62 36.95 153.53
24 INT5050 Regulation of Localization of Calca 1 149 0.62 41.25 148.57
25 INT425 Localization of PRL 1 455 0.81 189.64 144.8
26 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
27 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
28 INT7327 Regulation of Th 1 164 0.62 29.67 110.14
29 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
30 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
31 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
32 INT214 Localization of AVP 1 370 0.81 208.51 91.09
33 INT2149 Positive_regulation of Oxt 1 181 0.70 24.8 85.43
34 INT3766 Positive_regulation of Localization of Acot1 7 192 0.69 21.8 85.35
35 INT1309 Positive_regulation of Localization of Gnrhr 5 152 0.69 24.25 81.56
36 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
37 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
38 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
39 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
40 INT1376 Binding of Trh 2 121 0.48 20 69.86
41 INT1377 Positive_regulation of Trh 2 172 0.70 40.55 69.83
42 INT451 Regulation of Oxt 1 142 0.62 22.07 69.42
43 INT7468 Negative_regulation of Localization of Oxt 1 109 0.59 9.46 66.79
44 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
45 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
46 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
47 INT217 Negative_regulation of Th 6 134 0.59 26.83 62.63
48 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
49 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
50 INT2761 Regulation of Gabrg1 2 119 0.61 18.8 60.52
51 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
52 INT2148 Negative_regulation of Oxt 1 105 0.59 11.42 57
53 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
54 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
55 INT5858 Positive_regulation of Drd1a 2 66 0.69 4.51 51.73
56 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
57 INT7093 Negative_regulation of CYP2B6 2 146 0.58 37.3 48.39
58 INT2463 Localization of CCK 3 101 0.81 37.54 47.59
59 INT2406 Gene_expression of CCK 3 85 0.78 28.04 46.67
60 INT683 Positive_regulation of AVP 2 173 0.70 74.55 46.41
61 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
62 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
63 INT685 Regulation of AVP 1 124 0.62 34.9 39.91
64 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
65 INT7824 Regulation of Cck 8 39 0.62 5.31 39.28
66 INT3188 Regulation of Localization of Acot1 6 84 0.59 8.94 38.56
67 INT1354 Negative_regulation of Acot1 1 87 0.43 15.01 36.44
68 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
69 INT7608 Positive_regulation of Adra2a 1 66 0.70 17.81 35.15
70 INT7833 Positive_regulation of Cck 1 33 0.70 8.54 34.21
71 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
72 INT9796 Gene_expression of Cck 1 63 0.78 11.44 32.09
73 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
74 INT23222 Binding of Phax 3 52 0.31 7.61 30.4
75 INT1079 Positive_regulation of Ache 1 104 0.70 23.52 30.28
76 INT7664 Negative_regulation of Grip2 1 68 0.49 10.11 29.93
77 INT2408 Regulation of CCK 1 37 0.61 10.01 26.66
78 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
79 INT19986 Negative_regulation of Cck 1 31 0.59 4.32 24.99
80 INT5690 Negative_regulation of Binding of Oprd1 1 36 0.59 8.29 24.52
81 INT7827 Binding of Cck 2 32 0.48 4.66 23.73
82 INT250 Regulation of GHRH 1 65 0.61 17.46 23.19
83 INT39914 Negative_regulation of Cyp1a2 1 44 0.58 10.04 22
84 INT47859 Negative_regulation of Cyp2e1 3 41 0.59 16.92 21.72
85 INT1561 Negative_regulation of Dnahc8 1 59 0.59 18.12 20.99
86 INT1156 Binding of CCK 1 27 0.48 8.71 20.58
87 INT6699 Positive_regulation of ADRA1D 1 65 0.70 22.72 20.31
88 INT2165 Localization of Cga 1 41 0.80 4.02 19.53
89 INT9128 Regulation of Gene_expression of Cck 1 27 0.62 6.55 19.45
90 INT12031 Negative_regulation of Car1 1 44 0.59 20.46 19.36
91 INT7680 Regulation of Drd1a 1 27 0.45 4.52 18.86
92 INT6129 Positive_regulation of Localization of AVP 1 63 0.70 30.44 16.64
93 INT2243 Localization of GAST 2 67 0.81 34.54 16.19
94 INT4769 Regulation of OPRD1 1 20 0.44 2.05 15.97
95 INT5859 Positive_regulation of Positive_regulation of Drd1a 1 20 0.55 2.05 15.61
96 INT1154 Negative_regulation of CCK 3 24 0.59 9.3 15.32
97 INT14131 Regulation of HTR1A 1 34 0.60 9.61 14.74
98 INT22301 Positive_regulation of Gene_expression of CSF2 1 66 0.63 59.49 14.24
99 INT19408 Negative_regulation of Cyp2c22 1 37 0.59 6.23 14.22
100 INT8088 Regulation of Localization of Cga 1 28 0.60 2.37 13.91
101 INT18658 Regulation of Adra1a 1 34 0.62 5.69 13.78
102 INT1491 Regulation of Rtcd1 1 33 0.53 5.17 13.4
103 INT49538 Binding of Gria1 1 22 0.47 2.66 13.35
104 INT20715 Binding of Sigmar1 1 45 0.48 4.03 13.17
105 INT13338 Regulation of Sigmar1 1 22 0.57 2.91 11.35
106 INT14780 Regulation of Binding of Cck 1 9 0.49 4.33 10.83
107 INT22210 Gene_expression of CYP1A2 4 45 0.78 4.95 10.66
108 INT98130 Positive_regulation of CASP8 1 79 0.67 65.29 10.08
109 INT2407 Regulation of GAST 1 26 0.62 5.31 10.04
110 INT47860 Negative_regulation of Cyp1a2 2 20 0.57 6.06 10
111 INT1224 Gene_expression of Fabp6 1 34 0.64 23.69 9.08
112 INT19947 Negative_regulation of B3GAT2 1 10 0.57 4.2 7.95
113 INT9932 Positive_regulation of Positive_regulation of Trh 1 13 0.50 1.8 7.63
114 INT17867 Positive_regulation of Cyp1a2 1 39 0.69 2.58 7.57
115 INT102749 Positive_regulation of Positive_regulation of CASP3 1 32 0.67 26.07 6.93
116 INT63057 Regulation of CYP3A4 1 31 0.61 5.75 6.92
117 INT20840 Negative_regulation of Car3 1 14 0.47 4.35 6.83
118 INT17143 Regulation of Cyp2c22 1 18 0.60 3.02 6.7
119 INT23221 Negative_regulation of Binding of Phax 1 10 0.37 1.57 5.97
120 INT87420 Gene_expression of BCL2L1 1 56 0.75 48.84 5.32
121 INT73262 Negative_regulation of BCL2 1 67 0.57 61.01 5.07
122 INT14027 Positive_regulation of Prep 2 29 0.69 3.63 4.99
123 INT55419 Regulation of CYP1A2 1 19 0.62 5.3 4.75
124 INT65514 Gene_expression of Cyp1a2 3 25 0.77 6.12 4.6
125 INT59041 Negative_regulation of CYP2E1 1 17 0.59 5.47 4.51
126 INT37912 Negative_regulation of Chd7 1 10 0.26 5.84 4.46
127 INT26404 Positive_regulation of ATM 1 15 0.49 10.94 4.39
128 INT2242 Negative_regulation of Localization of GAST 1 12 0.58 5.55 4.22
129 INT521 Negative_regulation of Lrtomt 1 8 0.55 2.83 3.96
130 INT9822 Binding of Agtr2 2 9 0.36 3 3.93
131 INT77823 Negative_regulation of Negative_regulation of Th 1 9 0.59 1.56 3.79
132 INT28389 Negative_regulation of Ptpra 1 5 0.37 0.4 3.69
133 INT20011 Regulation of NEUROD1 1 10 0.44 3.83 3.53
134 INT1155 Binding of GAST 1 12 0.36 3.64 3.5
135 INT28802 Binding of F2 1 15 0.47 8.8 3.47
136 INT9821 Binding of Bcl2a1a 1 9 0.33 4.32 3.47
137 INT22517 Gene_expression of Mop3 1 5 0.03 0.18 3.43
138 INT28390 Negative_regulation of Mt1a 1 4 0.36 1.13 3.39
139 INT24797 Localization of HMMR 2 5 0.45 1.4 3.03
140 INT73263 Negative_regulation of MYC 1 20 0.57 12.86 2.95
141 INT90818 Gene_expression of Cckar 3 1 0.77 0 2.93
142 INT38504 Negative_regulation of Regulation of Cck 1 2 0.42 0.17 2.89
143 INT11769 Regulation of Mptp1 1 8 0.60 6.38 2.68
144 INT755 Regulation of HRH2 2 7 0.45 2.87 2.68
145 INT29064 Gene_expression of Sigmar1 1 9 0.77 2.48 2.65
146 INT18432 Positive_regulation of RGD735065 1 3 0.12 0.66 2.5
147 INT41789 Negative_regulation of Moxd2 1 6 0.57 4.03 2.49
148 INT61805 Positive_regulation of Dpp4 1 4 0.44 0.41 2.49
149 INT113081 Negative_regulation of Gene_expression of Cyp1a2 2 6 0.58 1.68 2.39
150 INT97748 Positive_regulation of BCL2L1 1 12 0.67 9.83 2.26
151 INT91836 Negative_regulation of Gene_expression of BCL2L1 1 9 0.49 8.59 2.25
152 INT102752 Positive_regulation of Gene_expression of BCL2L1 1 14 0.67 13.8 2.19
153 INT65424 Positive_regulation of Gene_expression of CYP1A2 2 6 0.70 2.01 2.01
154 INT102751 Positive_regulation of polymerase 1 7 0.10 3.06 1.81
155 INT15969 Negative_regulation of Ar 1 11 0.43 2.77 1.59
156 INT20690 Regulation of Cnnm2 1 2 0.10 0.18 1.28
157 INT20752 Binding of Dspp 1 2 0.09 0.1 1.26
158 INT37913 Negative_regulation of Ptpra 1 2 0.29 0.15 1.06
159 INT102750 Positive_regulation of Protein_catabolism of LMNB1 1 1 0.54 0.69 1
160 INT37914 Regulation of Negative_regulation of Chd7 1 1 0.12 0 1
161 INT102748 Protein_catabolism of LMNB1 1 1 0.78 0.66 0.95
162 INT68265 Positive_regulation of Negative_regulation of Ptgs2 1 3 0.46 0.08 0.92
163 INT94194 Transcription of Gclc 2 1 0.58 0.53 0.87
164 INT44100 Regulation of Cga 1 2 0.60 0.35 0.86
165 INT94193 Transcription of Cyp1a2 1 4 0.65 1.29 0.74
166 INT37490 Negative_regulation of Cyp1b1 1 3 0.30 1.57 0.68
167 INT63458 Negative_regulation of Binding of Sigmar1 1 2 0.36 0.39 0.52
168 INT65774 Regulation of Positive_regulation of Prep 1 1 0.22 0.17 0.52
169 INT74710 Binding of Olr1868 1 1 0.00 0 0.42
170 INT65423 Negative_regulation of PTPRN 1 1 0.57 0.08 0.38
171 INT63456 Negative_regulation of Car4 1 1 0.18 0.07 0.37
172 INT20689 Binding of Isyna1 1 1 0.07 0 0.34
173 INT63457 Positive_regulation of Gene_expression of Sigmar1 1 1 0.36 0.09 0.23
174 INT23200 Negative_regulation of Fam102b 1 1 0.41 0.08 0.2
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