J:Pharmacol Rep

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT167319 Binding of OPRM1 and PCSK2 1 2 0.22 0.63 1.77
2 INT167320 Binding of CPE and OPRM1 1 2 0.14 0.63 1.77
3 INT167321 Binding of ENG and OPRM1 1 2 0.27 0.63 1.76
4 INT151679 Ifng Negative_regulation of Oas1b 1 2 0.12 1.24 0.71
5 INT151676 Ifng Negative_regulation of Art2a-ps 1 2 0.00 1.25 0.71
6 INT151681 Il2 Negative_regulation of Art2a-ps 1 2 0.00 1.23 0.7
7 INT151678 Il2 Negative_regulation of Oas1b 1 2 0.13 1.23 0.7
8 INT145491 PROC Positive_regulation of Cpox 1 1 0.00 1.08 0.58
9 INT151677 Il4 Negative_regulation of Art2a-ps 1 1 0.00 0.61 0.35
10 INT151680 Il4 Negative_regulation of Oas1b 1 1 0.07 0.61 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 4 3083 0.78 894.43 1639.02
2 INT5228 Positive_regulation of Fos 6 934 0.70 209.8 503.87
3 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
4 INT50058 Negative_regulation of Cpox 5 907 0.58 426.28 428.29
5 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
6 INT6580 Negative_regulation of Ptgs1 9 929 0.59 381.53 376.26
7 INT16260 Gene_expression of Bdnf 2 671 0.78 283.44 339.1
8 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
9 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
10 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
11 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
12 INT5591 Regulation of Gene_expression of Fos 4 425 0.62 129.06 265.78
13 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
14 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
15 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
16 INT16259 Positive_regulation of Bdnf 1 336 0.70 183.48 209.82
17 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
18 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
19 INT48895 Gene_expression of Il10 2 333 0.78 221.2 138.52
20 INT5008 Localization of Calca 1 204 0.81 80.35 125.16
21 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
22 INT16253 Positive_regulation of Gene_expression of Bdnf 3 196 0.70 92.67 113.01
23 INT60526 Gene_expression of IL10 2 449 0.78 292.71 107.84
24 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
25 INT5587 Regulation of Fos 3 191 0.62 40.81 99.7
26 INT6437 Binding of YY1 1 154 0.47 26.3 90.46
27 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
28 INT56291 Gene_expression of Ros1 1 503 0.63 274.12 81.5
29 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
30 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
31 INT10359 Gene_expression of Ifng 1 159 0.78 79.6 72.14
32 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
33 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
34 INT9657 Positive_regulation of Gene_expression of Il6 2 237 0.70 180.45 63.6
35 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
36 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
37 INT16258 Gene_expression of Ntf3 1 121 0.78 53.93 59.03
38 INT6436 Positive_regulation of Positive_regulation of Fos 1 101 0.70 18.71 57.96
39 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
40 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
41 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
42 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
43 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
44 INT1564 Localization of OPRM1 1 41 0.80 8.03 44.67
45 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
46 INT115384 Positive_regulation of Mmp9 1 121 0.68 94.74 43.02
47 INT50957 Negative_regulation of Il6 2 134 0.59 79.08 42.67
48 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
49 INT65889 Gene_expression of RETNLB 2 73 0.34 60.98 38.3
50 INT48896 Positive_regulation of Gene_expression of Il10 2 73 0.70 43.14 35.5
51 INT11764 Positive_regulation of ENG 1 78 0.61 27.65 33.69
52 INT8746 Negative_regulation of Calca 1 50 0.59 21.22 33.45
53 INT9658 Negative_regulation of Gene_expression of Il6 1 110 0.59 66.29 32.58
54 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
55 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
56 INT10799 Localization of ENG 1 63 0.78 18.67 27.28
57 INT86062 Positive_regulation of Tnfrsf1a 1 51 0.69 40.69 26.2
58 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
59 INT40776 Gene_expression of Akt1 3 99 0.77 34.91 24.39
60 INT16721 Negative_regulation of Cat 2 56 0.59 44.44 22.84
61 INT76336 Negative_regulation of PDE5A 2 192 0.59 112.02 20.09
62 INT25222 Positive_regulation of Gene_expression of Ifng 2 32 0.50 24.18 19.58
63 INT64442 Regulation of Mc4r 2 6 0.62 5.22 19.09
64 INT12875 Regulation of Adra2a 1 26 0.45 7.51 17.35
65 INT2480 Negative_regulation of Got1 2 43 0.51 14.47 16.09
66 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
67 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
68 INT79149 Gene_expression of CSE 1 26 0.58 11.76 14.16
69 INT5806 Regulation of Edn1 1 63 0.62 23.46 13.88
70 INT75224 Positive_regulation of Gene_expression of Ntf3 1 23 0.69 11.79 13.08
71 INT64445 Gene_expression of Mc4r 1 17 0.78 5.06 12.91
72 INT26534 Regulation of Akt1 3 34 0.61 14.47 11.86
73 INT41313 Gene_expression of Gpx1 1 68 0.78 34.24 11.77
74 INT18001 Positive_regulation of Htr2c 1 21 0.67 7.63 11.39
75 INT85017 Positive_regulation of Mc4r 4 13 0.67 7.56 10.86
76 INT53201 Negative_regulation of gr 1 35 0.50 17.76 10.62
77 INT94004 Negative_regulation of Lox 1 31 0.59 13.76 10.45
78 INT158863 Negative_regulation of Ros1 1 84 0.35 40.3 10.14
79 INT79720 Positive_regulation of Cat 2 57 0.70 31.81 10.11
80 INT130497 Gene_expression of Cbs 1 5 0.77 16.93 9.34
81 INT121599 Negative_regulation of Gene_expression of RETNLB 1 7 0.21 9.28 8.8
82 INT6573 Regulation of Negative_regulation of Ptgs1 1 19 0.45 6.16 8.71
83 INT26751 Regulation of Nr3c1 1 13 0.61 6.58 8.65
84 INT142783 Gene_expression of Ccdc88a 6 14 0.40 3.52 8.46
85 INT70572 Gene_expression of Fst 1 33 0.78 5.22 8.24
86 INT76427 Regulation of Negative_regulation of Cpox 2 17 0.31 6.75 7.93
87 INT7378 Negative_regulation of Efs 1 17 0.37 1.93 7.78
88 INT17867 Positive_regulation of Cyp1a2 1 39 0.69 2.58 7.57
89 INT19475 Positive_regulation of IL1A 1 20 0.67 17.99 7.57
90 INT49749 Negative_regulation of Nr3c1 2 13 0.43 6.25 7.36
91 INT60931 Negative_regulation of Fst 1 15 0.57 5.44 7.21
92 INT800 Negative_regulation of Grhpr 1 21 0.42 10.3 7.17
93 INT104909 Binding of Pias1 2 11 0.37 3.67 6.72
94 INT59079 Transcription of PTGS2 1 30 0.72 14.21 6.52
95 INT64444 Negative_regulation of Mc4r 1 9 0.58 5.12 6.44
96 INT116641 Phosphorylation of Gsk3a 1 12 0.71 4.3 6.22
97 INT117721 Positive_regulation of Gene_expression of Akt1 1 22 0.69 6.26 6.08
98 INT142793 Positive_regulation of Ccdc88a 5 7 0.41 0.93 5.98
99 INT107386 Negative_regulation of AGTR1 1 37 0.55 35.94 5.15
100 INT58766 Gene_expression of ANGPT2 1 41 0.67 21.65 4.82
101 INT61245 Positive_regulation of Cyp2b2 4 9 0.64 0.41 4.7
102 INT114988 Negative_regulation of Ccdc88a 1 3 0.22 0.14 4.29
103 INT7560 Transcription of gr 1 14 0.69 4.21 4.09
104 INT158864 Negative_regulation of Aldh2 1 25 0.58 10.92 3.81
105 INT6956 Gene_expression of PTGIS 1 29 0.76 12.1 3.8
106 INT54886 Negative_regulation of ANGPT2 1 25 0.42 9.33 3.79
107 INT129746 Positive_regulation of Gene_expression of Tfrc 1 4 0.18 2.15 3.74
108 INT32353 Regulation of Lct 1 7 0.52 1.37 3.16
109 INT68846 Gene_expression of Tfrc 1 22 0.32 10.1 3.06
110 INT49971 Regulation of Ednra 1 10 0.35 2.4 3.06
111 INT33237 Regulation of Fst 1 10 0.39 1.3 3
112 INT66716 Negative_regulation of BDKRB1 1 4 0.48 1.31 3
113 INT142788 Transcription of Rgs19 3 1 0.32 0.28 2.42
114 INT80391 Negative_regulation of Cyp2b2 2 4 0.54 0.12 2.36
115 INT97876 Gene_expression of Pias1 2 4 0.59 1.62 2.18
116 INT21611 Negative_regulation of RASGRP1 1 20 0.35 11.76 2.15
117 INT153718 Gene_expression of ANGPT1 1 15 0.45 10.82 2.13
118 INT35689 Localization of C3 1 17 0.75 5.3 1.98
119 INT142786 Transcription of Ccdc88a 2 3 0.42 0.17 1.94
120 INT123873 Positive_regulation of Negative_regulation of Cat 1 7 0.50 2.86 1.86
121 INT22335 Regulation of Negative_regulation of ACE 1 10 0.44 7.01 1.77
122 INT154727 Regulation of Cyp2b2 2 2 0.25 0 1.76
123 INT142790 Gene_expression of Rgs19 2 1 0.30 0.18 1.67
124 INT79699 Regulation of Cyp2a 2 1 0.55 0.46 1.62
125 INT142784 Regulation of Transcription of Rgs19 2 1 0.20 0.19 1.61
126 INT142787 Regulation of Transcription of Ccdc88a 2 1 0.36 0.17 1.59
127 INT38292 Negative_regulation of COX1 1 3 0.41 1.57 1.43
128 INT132500 Negative_regulation of Cyp2a 2 1 0.59 0 1.37
129 INT32039 Positive_regulation of CPE 1 3 0.37 1.92 1.32
130 INT163506 Binding of Gsk3a 2 4 0.32 1.41 1.31
131 INT161648 Gene_expression of TAs 1 9 0.58 3.57 1.28
132 INT169363 Negative_regulation of PTGIS 1 4 0.20 3.35 1.22
133 INT41628 Positive_regulation of PCSK2 1 2 0.31 0.58 1.21
134 INT79598 Regulation of PDE5A 1 16 0.60 8.68 1.17
135 INT132499 Positive_regulation of Cyp2a 2 1 0.69 0 1.15
136 INT103043 Binding of PDE5A 1 16 0.37 7.79 1.12
137 INT149035 Positive_regulation of Cyp2c11 1 5 0.62 3.35 1.08
138 INT132505 Regulation of Si 1 3 0.06 0.68 1.06
139 INT142785 Positive_regulation of Positive_regulation of Ccdc88a 1 1 0.27 0.14 1.04
140 INT163508 Regulation of Gene_expression of Akt1 2 3 0.45 1.65 0.92
141 INT61241 Gene_expression of Cyp2b2 1 1 0.56 0 0.92
142 INT153292 Localization of C5AR1 1 2 0.68 0.79 0.91
143 INT142791 Positive_regulation of Rgs19 1 1 0.21 0.1 0.86
144 INT157981 Binding of Cyp2b2 1 1 0.44 0 0.86
145 INT142782 Positive_regulation of Transcription of Rgs19 1 1 0.21 0.1 0.86
146 INT142792 Positive_regulation of Gene_expression of Rgs19 1 1 0.22 0.1 0.86
147 INT142789 Regulation of Gene_expression of Rgs19 1 1 0.20 0.1 0.86
148 INT157982 Positive_regulation of Gene_expression of Cyp2b2 1 1 0.43 0 0.85
149 INT109080 Negative_regulation of ANGPT1 2 8 0.14 3.17 0.82
150 INT17865 Regulation of Positive_regulation of Cyp1a2 1 2 0.45 0 0.74
151 INT116379 Protein_catabolism of Lox 1 2 0.77 0.64 0.72
152 INT132497 Negative_regulation of Negative_regulation of Got1 1 1 0.20 0 0.71
153 INT58764 Negative_regulation of Gene_expression of ANGPT2 1 7 0.34 2.64 0.69
154 INT149036 Regulation of Positive_regulation of Cyp2c11 1 1 0.45 0 0.69
155 INT151670 Negative_regulation of Protein_catabolism of Lox 1 1 0.37 0.41 0.6
156 INT78495 Negative_regulation of Art2a-ps 1 2 0.23 1.03 0.59
157 INT78494 Negative_regulation of Oas1b 1 2 0.22 1.02 0.59
158 INT132501 Positive_regulation of Binding of Cyp2a 1 1 0.50 0 0.56
159 INT132498 Binding of Cyp2a 1 1 0.48 0 0.56
160 INT132503 Negative_regulation of Positive_regulation of Cyp2a 1 1 0.43 0 0.55
161 INT129748 Transcription of Nr3c1 1 1 0.58 0.53 0.48
162 INT129747 Regulation of Transcription of Nr3c1 1 1 0.22 0.53 0.48
163 INT163507 Negative_regulation of Phosphorylation of Gsk3a 1 3 0.51 0.96 0.45
164 INT107385 Regulation of Negative_regulation of AGTR1 1 2 0.15 1.26 0.42
165 INT151675 Positive_regulation of Negative_regulation of Oas1b 1 1 0.25 0.79 0.39
166 INT151672 Positive_regulation of Negative_regulation of Art2a-ps 1 1 0.01 0.79 0.39
167 INT132506 Regulation of Gaa 1 1 0.06 0.16 0.39
168 INT151674 Negative_regulation of Localization of Oas1b 1 1 0.22 0.61 0.36
169 INT151673 Localization of Oas1b 1 1 0.38 0.61 0.36
170 INT156590 Negative_regulation of Negative_regulation of ANGPT1 1 1 0.10 0.33 0.16
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