J:Pharmacotherapy

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT92803 Binding of CYP1A2 and VKORC1 1 1 0.31 0.12 0.48
2 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 1 0.41 0.12 0.48
3 INT92802 Binding of PPIG and GRHPR 1 1 0.03 0.11 0.47
4 INT92801 Binding of CYP2B6 and GRHPR 1 1 0.03 0.1 0.47
5 INT118136 Binding of HTR1A and HTR2A 1 1 0.36 0.77 0.45

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
2 INT50058 Negative_regulation of Cpox 7 907 0.58 426.28 428.29
3 INT6580 Negative_regulation of Ptgs1 5 929 0.59 381.53 376.26
4 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
5 INT49750 Negative_regulation of CPOX 1 735 0.58 360.06 274.19
6 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
7 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
8 INT9852 Positive_regulation of Gpt 5 563 0.70 364.64 146.82
9 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
10 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
11 INT15913 Negative_regulation of CYP2D6 1 174 0.59 22.45 70.91
12 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
13 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
14 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
15 INT7093 Negative_regulation of CYP2B6 3 146 0.58 37.3 48.39
16 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
17 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
18 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
19 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
20 INT11246 Binding of Grin1 1 65 0.48 14.53 36.93
21 INT234 Binding of Alb 1 151 0.48 52.34 32.97
22 INT20307 Positive_regulation of Cyp2e1 2 70 0.70 23.59 32.49
23 INT10285 Binding of ADRA1D 1 102 0.47 25.82 31.11
24 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
25 INT22211 Positive_regulation of CYP3A4 1 110 0.70 22 28.27
26 INT37296 Binding of Esr1 2 117 0.43 62.51 27.33
27 INT97 Negative_regulation of Adrb1 1 102 0.59 32.44 26.9
28 INT2040 Positive_regulation of CYP2B6 2 95 0.69 34.3 25.6
29 INT4369 Gene_expression of Ldha 1 157 0.76 88.12 22.45
30 INT7535 Negative_regulation of Tlr4 1 111 0.56 56.84 21.37
31 INT60779 Negative_regulation of CYP3A 1 63 0.59 8.38 21.27
32 INT712 Positive_regulation of LDHA 1 160 0.70 175.25 19.11
33 INT667 Negative_regulation of Hrh2 1 38 0.58 18.11 18.01
34 INT50403 Negative_regulation of CYP2C19 1 55 0.59 8.97 17.79
35 INT13790 Binding of HTR1A 1 52 0.47 18.83 17.59
36 INT50404 Negative_regulation of CYP1A2 1 49 0.59 8.61 17.35
37 INT899 Gene_expression of F13A1 2 122 0.70 78.02 16.26
38 INT20336 Positive_regulation of CYP2E1 1 48 0.70 19.26 15.66
39 INT59929 Negative_regulation of CYP2C9 2 60 0.59 16.33 15.39
40 INT23212 Positive_regulation of Rac1 1 46 0.55 32.85 15.1
41 INT7475 Positive_regulation of Hdl1 2 138 0.67 175.81 15.05
42 INT170 Negative_regulation of Adrb1 1 52 0.55 13.46 14.78
43 INT67855 Negative_regulation of PPIG 2 64 0.57 17.83 13.54
44 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
45 INT50580 Binding of PPIG 1 39 0.36 11.17 12.34
46 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
47 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
48 INT1190 Positive_regulation of F2 1 53 0.70 46.41 11.64
49 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
50 INT11679 Negative_regulation of F13A1 1 55 0.54 33.69 9.43
51 INT36449 Negative_regulation of G6PD 3 74 0.59 54.15 8.85
52 INT66819 Binding of CYP2C9 1 41 0.48 8.23 8.76
53 INT197 Gene_expression of Hrh2 1 24 0.63 12.35 8.37
54 INT61599 Positive_regulation of CYP2C9 1 43 0.69 11.1 8.33
55 INT107129 Positive_regulation of RLS 2 46 0.60 40.1 8.09
56 INT12334 Positive_regulation of CYP3A 1 34 0.70 6.77 7.85
57 INT26115 Gene_expression of Adrb1 1 14 0.64 5.13 7.78
58 INT17686 Negative_regulation of Hdl1 1 72 0.36 81.85 7.74
59 INT17867 Positive_regulation of Cyp1a2 1 39 0.69 2.58 7.57
60 INT11823 Positive_regulation of GGT1 2 53 0.67 45.84 7.55
61 INT17501 Negative_regulation of F2 1 70 0.58 32.23 7.51
62 INT10344 Localization of Jun 1 23 0.73 6.36 7.46
63 INT15490 Negative_regulation of Gene_expression of COL7A1 1 40 0.58 25.97 7.18
64 INT7743 Binding of Hrh2 2 19 0.47 7.75 7.11
65 INT22024 Negative_regulation of HBG1 1 45 0.58 26 6.8
66 INT24800 Negative_regulation of AMPD1 1 44 0.59 21.19 6.76
67 INT31582 Gene_expression of Hdl1 1 103 0.66 118.95 6.42
68 INT48270 Negative_regulation of RNF130 1 44 0.57 21.31 6.14
69 INT20331 Positive_regulation of CYP1A2 1 31 0.69 8.6 5.92
70 INT9895 Binding of GHR 1 18 0.36 4.8 5.65
71 INT28088 Binding of Alb 1 34 0.47 11.06 5.48
72 INT22907 Positive_regulation of Ggt1 1 33 0.67 17.82 5.28
73 INT39900 Positive_regulation of Gene_expression of Ldha 1 36 0.50 20.35 5.22
74 INT19993 Negative_regulation of Ren1 1 43 0.58 20.89 5.04
75 INT7346 Localization of Hrh2 2 15 0.69 5.78 4.79
76 INT50581 Regulation of PPIG 1 26 0.55 8.96 4.32
77 INT10923 Positive_regulation of Lipg 1 30 0.50 22.87 4.26
78 INT24332 Regulation of Hdl1 4 28 0.45 45.45 4.26
79 INT16478 Positive_regulation of Plg 1 29 0.45 18.07 4.07
80 INT31580 Negative_regulation of Cyp11a1 2 14 0.57 3.48 3.61
81 INT54840 Localization of HTR4 1 6 0.73 2.67 3.42
82 INT63025 Gene_expression of BHLHE22 1 10 0.75 3.79 3.3
83 INT16390 Regulation of Plg 1 13 0.48 6.72 3.2
84 INT21299 Negative_regulation of Hp 1 14 0.44 10.97 2.97
85 INT48688 Positive_regulation of HTR4 1 12 0.67 1.94 2.81
86 INT19669 Positive_regulation of SPANXA1 1 4 0.22 1.93 2.29
87 INT19668 Regulation of SPANXA1 1 4 0.16 1.21 2.26
88 INT18654 Gene_expression of HRH2 1 9 0.67 5.73 2.19
89 INT17399 Positive_regulation of Positive_regulation of REN 1 13 0.69 7.05 1.9
90 INT23884 Negative_regulation of Negative_regulation of Adrb1 1 7 0.38 2.3 1.83
91 INT59077 Transcription of PTGS1 1 11 0.43 2.37 1.65
92 INT128051 Gene_expression of FGF10 1 9 0.78 2.31 1.56
93 INT3164 Positive_regulation of GUSB 1 4 0.49 2.67 1.47
94 INT23278 Negative_regulation of Binding of F13A1 1 6 0.39 3.54 1.37
95 INT19578 Negative_regulation of Gene_expression of F13A1 1 8 0.42 7.71 1.23
96 INT57504 Positive_regulation of Positive_regulation of GUSB 1 2 0.33 1.25 1.16
97 INT4311 Negative_regulation of Ces2a 1 5 0.44 1.24 1.14
98 INT66651 Negative_regulation of SLC45A2 1 3 0.57 1.31 1.12
99 INT17813 Positive_regulation of Hdl2 1 11 0.36 12.23 1.04
100 INT4609 Gene_expression of Klkb1 1 5 0.47 0.81 1.03
101 INT106023 Localization of PPIG 1 8 0.57 4.08 0.96
102 INT31583 Positive_regulation of Hdl3 1 6 0.39 5.14 0.92
103 INT44122 Positive_regulation of AMPD1 1 4 0.44 1.88 0.92
104 INT144390 Positive_regulation of Negative_regulation of CYP2C9 1 4 0.49 2.03 0.72
105 INT63024 Positive_regulation of Gene_expression of BHLHE22 1 1 0.49 1.28 0.71
106 INT107779 Negative_regulation of F7 1 3 0.30 2.99 0.66
107 INT19584 Negative_regulation of Ptafr 1 3 0.56 1.82 0.61
108 INT62881 Positive_regulation of Positive_regulation of HTR4 1 2 0.49 0.96 0.59
109 INT55532 Binding of Cyp4b1 1 1 0.09 0.05 0.45
110 INT144386 Positive_regulation of Negative_regulation of CYP2D6 1 3 0.49 1.01 0.4
111 INT76728 Binding of Vkorc1 1 1 0.01 0.1 0.36
112 INT31581 Regulation of Hdl2 1 3 0.22 4.55 0.28
113 INT144387 Positive_regulation of Negative_regulation of CYP1A2 1 2 0.39 0.64 0.28
114 INT31584 Regulation of Hdl3 1 2 0.22 1.89 0.28
115 INT144388 Positive_regulation of Negative_regulation of CYP3A 1 1 0.40 0.24 0.18
116 INT144389 Positive_regulation of Negative_regulation of CYP2C19 1 2 0.43 0.37 0.17
117 INT144926 Binding of NCKAP1 1 1 0.10 1.32 0.13
118 INT44040 Negative_regulation of Gene_expression of Adrb1 1 1 0.35 0.34 0.09
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