J:Philosophical Transactions of the Royal Society B: Biological Sciences

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT263776 Grin1 Positive_regulation of Ltp 2 1 0.17 0.17 0.54
2 INT268473 Negative_regulation of CNR1 Negative_regulation of Cysltr1 1 1 0.00 1.02 0.48
3 INT268493 Binding of Dnm1 and Szt2 1 1 0.01 0.8 0.07
4 INT268492 Binding of Arc and Dnm1 1 1 0.33 0.79 0.07
5 INT251944 Binding of GH1 and PRNP 1 1 0.09 1.14 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT7114 Positive_regulation of Ltp 9 1192 0.62 290.76 755.77
2 INT5228 Positive_regulation of Fos 1 934 0.70 209.8 503.87
3 INT95787 Positive_regulation of Mapk1 2 568 0.70 226.51 220.94
4 INT7506 Negative_regulation of Ltp 3 267 0.46 91.01 176.8
5 INT7628 Gene_expression of Ltp 2 273 0.77 70.21 147.87
6 INT92669 Gene_expression of Bdnf 2 309 0.78 178.26 116.68
7 INT214 Localization of AVP 1 370 0.81 208.51 91.09
8 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
9 INT92434 Phosphorylation of Mapk1 2 287 0.82 91.65 83.46
10 INT92518 Gene_expression of Grin2b 2 131 0.78 65.52 80.91
11 INT13036 Positive_regulation of Positive_regulation of Ltp 1 105 0.51 23.71 77.66
12 INT31774 Positive_regulation of Vta1 1 67 0.44 14.52 71.79
13 INT57380 Phosphorylation of Creb1 1 213 0.82 66.8 71.26
14 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
15 INT102020 Gene_expression of Creb1 1 190 0.78 57.31 59.77
16 INT82055 Positive_regulation of Creb1 7 176 0.70 60.2 58.39
17 INT13277 Regulation of Positive_regulation of Ltp 1 83 0.52 19.68 55.78
18 INT7898 Gene_expression of Homer1 1 123 0.78 31.52 53.67
19 INT61873 Gene_expression of Arc 7 128 0.78 128.25 52.24
20 INT66040 Positive_regulation of Bdnf 2 114 0.69 67.67 51.81
21 INT94029 Positive_regulation of Grin2b 1 58 0.70 24.2 42.52
22 INT92517 Gene_expression of Grin1 3 105 0.78 29.53 39.43
23 INT92515 Gene_expression of Grin2a 2 84 0.76 26.68 38.37
24 INT52194 Positive_regulation of Grin1 3 83 0.69 25.09 34.76
25 INT33768 Positive_regulation of Cysltr1 10 87 0.46 54.66 33.52
26 INT93451 Positive_regulation of Gene_expression of Grin2b 1 43 0.70 29.09 31.89
27 INT117112 Negative_regulation of Mapk1 1 87 0.56 40.34 31.18
28 INT64918 Gene_expression of Gria2 2 108 0.74 29.95 29.67
29 INT102206 Regulation of Bdnf 1 37 0.62 28.54 28.78
30 INT3217 Regulation of Ins1 1 154 0.62 87.11 27.29
31 INT32826 Positive_regulation of Gene_expression of Ltp 2 52 0.45 10.34 26.8
32 INT57192 Binding of Ltp 1 43 0.41 17.48 24.96
33 INT107577 Negative_regulation of Grin2b 1 32 0.59 12.35 24.88
34 INT47818 Positive_regulation of Homer1 1 48 0.70 11.11 24.05
35 INT14556 Positive_regulation of Igf1 3 105 0.69 52.21 24.04
36 INT5055 Positive_regulation of IFNG 1 89 0.69 64.03 23.05
37 INT76249 Gene_expression of Gria1 1 67 0.75 15.07 22.78
38 INT18322 Negative_regulation of Ins1 1 132 0.58 88.49 22.59
39 INT16996 Gene_expression of PRTN3 1 113 0.75 85.61 22.57
40 INT102112 Gene_expression of Prnp 4 440 0.78 209.32 22.5
41 INT11625 Localization of App 1 98 0.78 55.46 20.86
42 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
43 INT10442 Negative_regulation of CNR1 1 47 0.59 20.88 20.2
44 INT69592 Positive_regulation of PSMD1 1 27 0.70 17.83 18.98
45 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
46 INT62577 Negative_regulation of Creb1 1 55 0.59 19.68 18.1
47 INT106556 Negative_regulation of Gene_expression of Bdnf 1 42 0.59 34.71 17.64
48 INT92514 Regulation of Grin2b 2 22 0.50 11.07 16.92
49 INT54077 Gene_expression of Adcyap1 2 62 0.78 23.17 16.75
50 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
51 INT95790 Regulation of Mapk1 1 55 0.61 21.17 16.31
52 INT20966 Positive_regulation of Arc 1 30 0.70 24.38 15.62
53 INT129 Localization of OXTR 1 51 0.80 11.08 15.36
54 INT4851 Positive_regulation of Chat 1 53 0.70 9.21 15.11
55 INT82929 Gene_expression of Plat 2 58 0.78 26.96 13.85
56 INT69878 Positive_regulation of Gene_expression of Gtf3a 1 48 0.29 36.78 13.57
57 INT69569 Positive_regulation of Prnp 1 175 0.70 96.31 13.34
58 INT22030 Negative_regulation of Cysltr1 2 31 0.39 21.83 12.49
59 INT100799 Negative_regulation of Grin2a 5 27 0.57 7.33 12.2
60 INT118676 Positive_regulation of Camk4 1 34 0.70 16.67 10.9
61 INT1708 Gene_expression of OXTR 2 56 0.78 6.92 10.69
62 INT64193 Regulation of Grin2a 3 19 0.54 2.98 10.31
63 INT4297 Negative_regulation of CFP 1 21 0.42 12.7 10.29
64 INT120509 Gene_expression of Cat 1 65 0.77 50.9 9.75
65 INT46273 Gene_expression of PRNP 14 103 0.78 110.34 9.25
66 INT78570 Negative_regulation of Grm5 1 15 0.57 5.45 9.17
67 INT52243 Phosphorylation of Ltp 1 13 0.54 2.84 8.7
68 INT126314 Positive_regulation of OFC1 2 25 0.54 7.65 7.39
69 INT110705 Positive_regulation of Positive_regulation of Grin1 1 11 0.69 4.7 7.33
70 INT116619 Positive_regulation of Positive_regulation of Creb1 2 25 0.69 8.32 7.3
71 INT55957 Positive_regulation of PRNP 7 57 0.67 37.87 7.11
72 INT28861 Binding of Gh 1 61 0.46 25.61 6.38
73 INT79425 Gene_expression of SMN1 1 42 0.65 36.37 6.1
74 INT179810 Protein_catabolism of Ecm1 3 30 0.11 18.28 5.75
75 INT166765 Localization of PYCARD 1 21 0.70 3.89 5.66
76 INT251958 Gene_expression of VTA1 2 9 0.58 7.26 5.6
77 INT11837 Positive_regulation of MHB 5 8 0.69 1.07 5.55
78 INT69572 Localization of Prnp 1 96 0.81 38.11 5.45
79 INT208108 Localization of Grin2a 2 19 0.70 1.5 5.22
80 INT111947 Positive_regulation of Gene_expression of Grin2a 1 7 0.68 1.75 4.84
81 INT17110 Gene_expression of PSMD1 3 60 0.65 19.57 4.69
82 INT266250 Gene_expression of Lhb 13 28 0.64 10.75 4.66
83 INT63880 Positive_regulation of FLNA 2 29 0.59 13.88 3.97
84 INT92516 Positive_regulation of Gene_expression of Grin1 2 8 0.45 2.53 3.77
85 INT22354 Positive_regulation of Lhb 8 13 0.63 2.15 3.74
86 INT64539 Gene_expression of Gpx3 1 14 0.58 9.42 3.64
87 INT116623 Localization of Prkaca 1 15 0.73 2.89 3.59
88 INT78284 Positive_regulation of PTPRC 1 40 0.49 27.17 3.45
89 INT170351 Positive_regulation of Gene_expression of Gria2 1 13 0.67 3.67 3.27
90 INT171368 Regulation of Phosphorylation of Mapk1 1 14 0.61 4.77 3.14
91 INT24443 Gene_expression of PSMD2 2 20 0.54 7.29 2.77
92 INT50080 Binding of APOE 1 38 0.45 29.61 2.67
93 INT99550 Regulation of FLNA 1 51 0.54 27.88 2.58
94 INT189122 Positive_regulation of Positive_regulation of Cysltr1 1 8 0.17 5.11 2.26
95 INT266251 Positive_regulation of Gene_expression of Lhb 2 4 0.42 3.26 2.13
96 INT40104 Binding of Cysltr1 1 11 0.38 4.56 1.95
97 INT246723 Localization of Arc 1 10 0.63 7.27 1.92
98 INT102205 Negative_regulation of Positive_regulation of Bdnf 1 6 0.50 3.77 1.91
99 INT167203 Binding of PRNP 4 25 0.48 20.09 1.84
100 INT11836 Regulation of MHB 2 2 0.23 0.07 1.67
101 INT12062 Positive_regulation of Gene_expression of OXTR 1 9 0.69 1.04 1.63
102 INT22785 Negative_regulation of PRNP 1 12 0.57 5.09 1.57
103 INT105535 Gene_expression of Myoz1 1 27 0.13 3.94 1.5
104 INT59040 Regulation of Positive_regulation of Grin1 1 3 0.27 1.61 1.42
105 INT10069 Negative_regulation of Lhb 3 2 0.49 0 1.36
106 INT118677 Positive_regulation of Positive_regulation of Camk4 1 3 0.33 0.83 1.24
107 INT11838 Gene_expression of MHB 3 3 0.52 0.38 1.2
108 INT142616 Negative_regulation of Positive_regulation of Igf1 2 5 0.43 1.56 1.16
109 INT85621 Regulation of PRNP 3 16 0.60 8.7 1.15
110 INT107592 Gene_expression of SMG1 1 42 0.74 11.16 1.13
111 INT154018 Binding of Lhb 2 5 0.31 1.39 1.13
112 INT46470 Positive_regulation of Regulation of Ins1 1 8 0.46 4.51 1.01
113 INT105697 Negative_regulation of KLK4 1 7 0.43 2.78 0.93
114 INT68788 Localization of CFP 1 7 0.63 1.07 0.93
115 INT118590 Binding of OFC1 2 7 0.32 1.14 0.9
116 INT214999 Positive_regulation of Gene_expression of Myoz1 1 12 0.12 1.42 0.85
117 INT216456 Positive_regulation of Ghr 1 6 0.41 4.96 0.85
118 INT266254 Regulation of Lhb 1 4 0.31 0.43 0.76
119 INT66961 Regulation of Localization of OXTR 1 3 0.24 0 0.73
120 INT100601 Localization of PRNP 3 17 0.66 13.61 0.71
121 INT198898 Protein_catabolism of Gpx3 1 6 0.02 2.49 0.71
122 INT228172 Negative_regulation of RNU1-1 1 14 0.15 7.53 0.62
123 INT219681 Regulation of CD96 1 2 0.29 0.13 0.57
124 INT268472 Negative_regulation of Aoc2 1 1 0.12 0.93 0.56
125 INT144701 Gene_expression of Cdkn2a 2 15 0.75 8.42 0.53
126 INT99502 Gene_expression of Tnfrsf17 1 2 0.51 0.29 0.41
127 INT255851 Positive_regulation of Tauph 1 2 0.02 1.51 0.39
128 INT266252 Negative_regulation of Positive_regulation of Lhb 1 1 0.35 0 0.39
129 INT233917 Gene_expression of MED1 1 2 0.20 0.17 0.38
130 INT238902 Binding of TGS1 1 3 0.07 2.86 0.36
131 INT150322 Gene_expression of RNU1-1 2 6 0.75 2.45 0.35
132 INT240825 Gene_expression of Irs2 4 14 0.78 3.88 0.32
133 INT210766 Gene_expression of Igf1r 2 6 0.65 2.15 0.31
134 INT266248 Negative_regulation of Binding of Lhb 1 1 0.35 0 0.31
135 INT251949 Negative_regulation of Gene_expression of PRNP 1 6 0.43 4.16 0.3
136 INT164993 Positive_regulation of Gene_expression of SMG1 1 4 0.66 0.69 0.29
137 INT115708 Phosphorylation of PRNP 1 2 0.71 1.61 0.26
138 INT268478 Negative_regulation of Positive_regulation of Igfbp5 2 1 0.26 0.64 0.26
139 INT268477 Positive_regulation of Igfbp5 2 1 0.31 0.63 0.25
140 INT250513 Negative_regulation of Irs2 2 8 0.56 4.04 0.23
141 INT251975 Positive_regulation of Pkhd1 2 5 0.10 8.98 0.15
142 INT268476 Protein_catabolism of Igfbp5 1 1 0.40 0.25 0.13
143 INT227763 Positive_regulation of KLK4 2 8 0.47 1.39 0.1
144 INT308826 Gene_expression of CD96 1 1 0.43 0 0.1
145 INT210673 Gene_expression of Gpx4 2 2 0.48 3.54 0.09
146 INT266241 Regulation of Wnt1 1 1 0.26 0.59 0.09
147 INT349622 Negative_regulation of Negative_regulation of Irs2 2 1 0.41 1.98 0.09
148 INT255790 Protein_catabolism of Plat 1 2 0.32 0.68 0.08
149 INT349623 Negative_regulation of Binding of Igf1r 2 1 0.39 0.51 0.08
150 INT349620 Binding of Igf1r 2 1 0.34 0.51 0.08
151 INT251976 Positive_regulation of TLE1 1 3 0.52 0.95 0.07
152 INT268474 Protein_catabolism of Galns 1 1 0.05 0 0.07
153 INT202864 Negative_regulation of Positive_regulation of Camk4 1 2 0.27 0.83 0.06
154 INT268475 Binding of Nus1 1 1 0.03 0.08 0.04
155 INT212458 Binding of Mtor 1 8 0.04 6.77 0.03
156 INT194250 Gene_expression of Rrs1 3 4 0.58 0.12 0.03
157 INT266258 Regulation of FSI 1 1 0.05 0.43 0.03
158 INT266257 Binding of FSI 1 1 0.07 0.43 0.03
159 INT194249 Positive_regulation of Rrs1 2 4 0.60 0.7 0
160 INT251978 Gene_expression of TLE1 2 3 0.51 0.45 0
161 INT194247 Regulation of Rrs1 1 2 0.24 0 0
162 INT266253 Localization of Lhb 1 2 0.62 0.1 0
163 INT322218 Binding of SCGB1D4 1 2 0.05 1.88 0
164 INT194248 Positive_regulation of Gene_expression of Rrs1 1 2 0.44 0.05 0
165 INT266262 Regulation of Strs1 1 1 0.13 0 0
166 INT266264 Binding of Strs1 1 1 0.15 0 0
167 INT266259 Gene_expression of Strs2 2 1 0.41 0 0
168 INT266256 Negative_regulation of FSI 1 1 0.08 0.38 0
169 INT266265 Localization of Rrs1 1 1 0.09 0 0
170 INT349621 Positive_regulation of Gpx4 1 1 0.36 2.26 0
171 INT266266 Positive_regulation of Localization of Rrs1 1 1 0.06 0 0
172 INT266261 Regulation of Strs2 1 1 0.19 0 0
173 INT266249 Regulation of Gene_expression of Lhb 1 1 0.37 0.15 0
174 INT266263 Positive_regulation of Strs2 1 1 0.28 0 0
175 INT251977 Gene_expression of RNU2-2 2 1 0.15 0.52 0
176 INT266260 Transcription of Strs2 1 1 0.48 0 0
177 INT251490 Localization of TSE2 1 1 0.04 1.71 0
178 INT251979 Negative_regulation of RNU2-2 1 1 0.08 0 0
179 INT251948 Binding of PRND 1 1 0.35 0.86 0
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