J:Proc. Soc. Exp. Biol. Med.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT26468 Ghrh Positive_regulation of Localization of Gh 21 2 0.37 3.26 9.21
2 INT20133 Trh Positive_regulation of Localization of Prl 23 1 0.78 2.04 5.44
3 INT16221 Ghrh Positive_regulation of Gh 8 1 0.21 1.89 4.08
4 INT20411 Ghrh Positive_regulation of Gh1 6 1 0.56 0.62 2.47
5 INT38936 Binding of Avp and Crh 7 2 0.40 0.82 1.04
6 INT16222 Ghrh Positive_regulation of Ghrh Positive_regulation of Gh 2 1 0.02 0.51 0.99
7 INT28921 Adra2a Positive_regulation of Localization of Prl 1 2 0.24 0 0.9
8 INT44589 Negative_regulation of Oprl1 Positive_regulation of Gh1 1 1 0.22 0.53 0.87
9 INT44590 Oprl1 Positive_regulation of Gh1 1 1 0.23 0.53 0.87
10 INT12883 Binding of IL2 and POMC 1 1 0.01 0 0.81
11 INT54800 Grin1 Regulation of Gene_expression of Gh 1 1 0.01 0 0.79
12 INT54799 SST Negative_regulation of Ghrh Positive_regulation of Gh 1 1 0.00 0 0.75
13 INT54802 SST Negative_regulation of Localization of Gh 1 1 0.01 0 0.75
14 INT54801 SST Negative_regulation of Positive_regulation of Gh 1 1 0.01 0 0.75
15 INT31306 Ghrh Regulation of Localization of Gnrhr 2 1 0.14 1 0.73
16 INT45849 Nts Regulation of Localization of LH 2 1 0.35 0 0.65
17 INT17463 Trh Regulation of Localization of Prl 2 1 0.30 0.22 0.47
18 INT78121 Positive_regulation of Binding of App and 20S 1 1 0.23 0.61 0.4
19 INT78122 Binding of App and 20S 1 1 0.16 0.61 0.4
20 INT78123 Positive_regulation of App Positive_regulation of Binding of App and 20S 1 1 0.05 0.61 0.4
21 INT4638 Binding of Agt and Adarb1 3 2 0.01 0 0.34
22 INT39299 Binding of Prl and Dlst 1 1 0.20 0 0.27
23 INT32636 Slc12a3 Regulation of Localization of Nppa 1 1 0.00 0.41 0.23
24 INT45987 GRP Positive_regulation of Localization of Prl 1 1 0.18 0 0.2
25 INT45985 GRP Regulation of Localization of Prl 1 1 0.21 0 0.18
26 INT45986 GRP Negative_regulation of Localization of Prl 1 1 0.16 0 0.17
27 INT31848 SST Regulation of Localization of Gnrhr 1 1 0.01 0 0.14
28 INT31849 Ghrh Regulation of SST 1 1 0.09 0 0.14
29 INT31847 Ghrh Positive_regulation of Positive_regulation of Gh1 1 1 0.20 0 0.08
30 INT31845 Negative_regulation of Ghrh Positive_regulation of Gh1 1 1 0.18 0 0.08
31 INT45848 Nts Regulation of Localization of Prl 1 1 0.31 0 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 39 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 22 1233 0.70 317.93 457.82
3 INT1045 Localization of LH 10 1211 0.81 87.04 456.25
4 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
5 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
6 INT157 Positive_regulation of Localization of Prl 17 790 0.70 104.54 374.78
7 INT287 Localization of Cck 1 518 0.81 86.84 364.04
8 INT439 Localization of Gnrh1 5 976 0.81 100.96 363.25
9 INT720 Positive_regulation of POMC 5 807 0.70 237.37 353.83
10 INT876 Localization of Gh1 9 843 0.80 67.75 340.82
11 INT162 Regulation of Prl 7 794 0.62 165.01 322.24
12 INT477 Localization of Avp 9 813 0.81 131.58 300.4
13 INT161 Regulation of Localization of Prl 6 615 0.62 65.37 298.66
14 INT1893 Localization of Gh 8 1041 0.79 340.23 256.58
15 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
16 INT1212 Binding of Oprl1 1 312 0.48 28.6 225.15
17 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
18 INT767 Localization of Gnrhr 11 565 0.80 106.68 214.57
19 INT22548 Positive_regulation of Casp3 3 483 0.70 258.78 213.07
20 INT156 Negative_regulation of Prl 10 542 0.59 131.97 192.24
21 INT528 Gene_expression of Prl 10 693 0.78 217.18 192.2
22 INT2085 Positive_regulation of LH 3 441 0.70 60.15 191.02
23 INT1652 Regulation of Pomc 7 387 0.62 61.01 186.51
24 INT159 Negative_regulation of Localization of Prl 12 416 0.59 55.34 171.8
25 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
26 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
27 INT1114 Localization of Ins1 6 748 0.80 192.95 165.48
28 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
29 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
30 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
31 INT1044 Negative_regulation of Localization of LH 2 358 0.59 25.95 151.31
32 INT880 Positive_regulation of Localization of Gh1 6 304 0.70 14.79 150.23
33 INT2451 Positive_regulation of Avp 3 355 0.70 102.66 147.69
34 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
35 INT2379 Positive_regulation of Localization of LH 2 349 0.70 27.86 144.53
36 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
37 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
38 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
39 INT416 Regulation of LH 2 253 0.62 31.48 125.55
40 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
41 INT2106 Regulation of Localization of LH 2 279 0.62 22.37 122.77
42 INT7395 Localization of GNRH1 1 399 0.81 62.88 117.68
43 INT4207 Regulation of Avp 3 267 0.62 63.72 115.33
44 INT1793 Localization of CGA 5 379 0.81 67.38 114.69
45 INT1530 Regulation of Gh 5 382 0.61 115.96 112.47
46 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
47 INT397 Localization of SST 1 232 0.81 58.05 101.19
48 INT65500 Gene_expression of App 1 605 0.78 429.94 98.31
49 INT874 Positive_regulation of Gh1 11 244 0.70 27.17 97.98
50 INT5865 Positive_regulation of Localization of Gh 4 282 0.69 84.86 93.5
51 INT1160 Positive_regulation of Rbm39 2 122 0.57 28.19 90.28
52 INT6585 Positive_regulation of Insrr 1 110 0.52 40.67 89.9
53 INT1472 Positive_regulation of Ins1 2 349 0.69 146.2 86.36
54 INT875 Regulation of Localization of Gh1 2 166 0.62 12.87 84.97
55 INT4289 Positive_regulation of Localization of Gnrh1 2 202 0.70 12.3 84.01
56 INT5617 Localization of Nppa 15 266 0.81 83.51 83.89
57 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
58 INT339 Regulation of Trh 2 156 0.62 39.27 83.55
59 INT1309 Positive_regulation of Localization of Gnrhr 4 152 0.69 24.25 81.56
60 INT403 Localization of Trh 3 241 0.81 28.55 81.45
61 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
62 INT148 Positive_regulation of Gnrhr 3 182 0.70 47.44 79.64
63 INT2155 Negative_regulation of Sst 1 111 0.59 16.58 77.74
64 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
65 INT3657 Gene_expression of Ins1 3 514 0.78 321.69 75.76
66 INT881 Negative_regulation of Localization of Gh1 2 164 0.58 15.1 75.28
67 INT7886 Regulation of Localization of Avp 4 146 0.62 14.53 72.99
68 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
69 INT2123 Positive_regulation of Gnrh1 5 209 0.70 24.2 68.97
70 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
71 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
72 INT1046 Gene_expression of LH 2 180 0.77 29.75 66.87
73 INT1425 Gene_expression of Rbm39 1 143 0.58 51.32 65.44
74 INT480 Negative_regulation of Localization of Avp 1 151 0.59 27.64 63.72
75 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
76 INT46 Localization of Ren 9 233 0.81 46.15 62.44
77 INT5095 Localization of Ghrh 12 185 0.81 28.09 62.08
78 INT3161 Regulation of Localization of Gh 3 163 0.61 35.43 59.45
79 INT1794 Regulation of Localization of CGA 2 136 0.57 13.39 59.07
80 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
81 INT1463 Binding of Pomc 1 129 0.48 15.89 56.27
82 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
83 INT314 Positive_regulation of Ren 4 212 0.70 66.68 55.56
84 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
85 INT5623 Positive_regulation of Nppa 4 174 0.70 69.96 52.33
86 INT1781 Negative_regulation of Gh1 3 127 0.59 16.94 51.77
87 INT1977 Negative_regulation of Positive_regulation of Prl 2 98 0.59 17.06 47.88
88 INT873 Gene_expression of Gh1 2 130 0.76 26.15 46.75
89 INT20345 Gene_expression of Dbi 2 136 0.78 56.41 46.2
90 INT619 Positive_regulation of Positive_regulation of Prl 2 116 0.70 22.69 45.06
91 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
92 INT49552 Negative_regulation of Positive_regulation of Casp3 1 76 0.55 36.04 44.78
93 INT989 Negative_regulation of Trh 1 90 0.59 15.45 43.63
94 INT1894 Negative_regulation of Localization of Gh 1 168 0.58 64.12 43.56
95 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
96 INT1474 Regulation of Localization of Ins1 2 132 0.61 25.96 43.07
97 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
98 INT7824 Regulation of Cck 1 39 0.62 5.31 39.28
99 INT1931 Positive_regulation of Gene_expression of POMC 1 116 0.70 37.26 38.67
100 INT385 Gene_expression of Agt 2 182 0.78 63.62 37.91
101 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
102 INT5620 Positive_regulation of Localization of Nppa 4 105 0.70 30.23 36.45
103 INT1976 Regulation of Gene_expression of Prl 2 80 0.62 20.19 36
104 INT49 Negative_regulation of Ren 1 129 0.59 37.48 35.62
105 INT1361 Negative_regulation of Gnrhr 2 118 0.58 57.77 35.54
106 INT2296 Positive_regulation of Gene_expression of Prl 5 137 0.70 36.96 35.39
107 INT7833 Positive_regulation of Cck 2 33 0.70 8.54 34.21
108 INT11764 Positive_regulation of ENG 3 78 0.61 27.65 33.69
109 INT1116 Regulation of Ren 3 103 0.62 27.66 33.26
110 INT5989 Positive_regulation of Dbi 3 79 0.49 24.38 32.56
111 INT1159 Negative_regulation of Agt 2 133 0.59 40.14 31.67
112 INT1158 Regulation of Agt 2 106 0.61 29.4 30.29
113 INT50 Negative_regulation of Localization of Ren 2 87 0.59 14.94 30.22
114 INT5100 Positive_regulation of Ghrh 5 100 0.64 24.2 30.21
115 INT6196 Regulation of Nppa 4 83 0.62 30.31 30.18
116 INT7397 Negative_regulation of Localization of GNRH1 1 86 0.59 15.45 29.78
117 INT894 Binding of Avp 2 84 0.48 29.16 29.63
118 INT47712 Positive_regulation of App 2 135 0.69 101.38 28.94
119 INT7035 Regulation of CGA 2 87 0.45 29.04 28.45
120 INT16879 Binding of Crh 4 72 0.48 21.65 28.43
121 INT4861 Localization of GRP 2 84 0.80 8.26 28.03
122 INT6174 Regulation of Gene_expression of POMC 1 49 0.61 9.75 27.69
123 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
124 INT10799 Localization of ENG 8 63 0.78 18.67 27.28
125 INT7832 Localization of Cck 2 39 0.81 6.81 26.54
126 INT3559 Negative_regulation of Localization of Gnrhr 3 73 0.58 18.89 26.41
127 INT5426 Negative_regulation of RTCA 1 58 0.51 12.34 25.74
128 INT8205 Negative_regulation of Nppa 1 77 0.59 26.43 25.72
129 INT6385 Regulation of Man2a2 1 48 0.61 7.8 24.68
130 INT5988 Localization of Dbi 1 74 0.81 17.52 24.09
131 INT9155 Gene_expression of Glul 1 60 0.77 17.97 23.95
132 INT1792 Positive_regulation of CGA 1 123 0.70 64.73 20.79
133 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
134 INT1512 Binding of Prl 1 73 0.48 26.22 20.63
135 INT65502 Regulation of App 1 77 0.62 52.05 19.44
136 INT9179 Positive_regulation of Localization of Ghrh 2 42 0.70 7.05 18.1
137 INT48 Positive_regulation of Localization of Ren 4 69 0.70 12.47 18.03
138 INT5618 Regulation of Localization of Nppa 6 36 0.62 13.42 17.46
139 INT3656 Positive_regulation of Gene_expression of Ins1 1 74 0.54 44.94 17.36
140 INT18660 Binding of Gnrhr 1 45 0.41 10.6 16.85
141 INT10056 Positive_regulation of Fabp6 3 77 0.59 36.99 16.8
142 INT10000 Regulation of Gene_expression of IL2 1 56 0.45 15.33 16.2
143 INT4242 Negative_regulation of Positive_regulation of Gh1 2 26 0.58 1.47 15.75
144 INT54052 Gene_expression of App 3 33 0.78 25.08 14.7
145 INT11762 Regulation of Dbi 3 40 0.62 7.83 14.48
146 INT7674 Regulation of ENG 1 42 0.30 11.41 14.44
147 INT2490 Regulation of Sct 1 44 0.62 9.45 13.11
148 INT481 Regulation of Localization of Ren 1 37 0.62 5.95 11.61
149 INT65501 Regulation of Gene_expression of App 1 56 0.62 32.51 11.48
150 INT686 Negative_regulation of Sct 1 35 0.59 9.59 11.32
151 INT18412 Binding of PLEK 1 49 0.47 17.82 10.72
152 INT3637 Positive_regulation of Localization of Trh 1 33 0.70 2.13 10.55
153 INT19010 Negative_regulation of Localization of Ghrh 2 27 0.57 4.85 10.5
154 INT50615 Positive_regulation of Positive_regulation of Insrr 1 11 0.19 5.5 10.05
155 INT3431 Negative_regulation of Positive_regulation of Oprl1 1 14 0.46 2.55 9.65
156 INT2059 Positive_regulation of Negative_regulation of Prl 1 24 0.70 5.7 9.37
157 INT5512 Negative_regulation of Dbi 1 32 0.36 7.33 9.1
158 INT1224 Gene_expression of Fabp6 1 34 0.64 23.69 9.08
159 INT386 Positive_regulation of Gene_expression of Agt 2 37 0.70 15.92 8.73
160 INT7673 Negative_regulation of ENG 1 31 0.42 7.9 8.61
161 INT1138 Positive_regulation of IgG-2a 2 16 0.68 5.59 8.11
162 INT113 Positive_regulation of MBD2 3 33 0.49 6.76 7.49
163 INT56031 Positive_regulation of App 4 25 0.69 13.46 7.37
164 INT9785 Negative_regulation of Positive_regulation of Gnrh1 1 18 0.43 1.88 7.35
165 INT4299 Positive_regulation of Gene_expression of Gh1 1 27 0.50 5.24 7.31
166 INT11150 Positive_regulation of Dlst 1 31 0.51 9.01 6.63
167 INT84965 Gene_expression of MAOA 1 15 0.75 6.9 6.06
168 INT71220 Positive_regulation of Casp1 1 15 0.38 10.23 5.84
169 INT3614 Negative_regulation of Gene_expression of Gh1 1 16 0.42 6.8 5.74
170 INT18345 Positive_regulation of Positive_regulation of Gnrhr 1 16 0.42 4.99 4.91
171 INT11298 Gene_expression of Ido1 1 6 0.58 6.71 4.85
172 INT78116 Positive_regulation of Gene_expression of App 3 12 0.70 10.78 4.52
173 INT205 Negative_regulation of Cbr1 1 10 0.58 4.23 4.29
174 INT10842 Transcription of Gh 1 18 0.64 2.94 4.13
175 INT4360 Gene_expression of Hypism 1 29 0.22 38.1 4.07
176 INT9013 Localization of Grp 1 9 0.73 0.63 3.99
177 INT26368 Positive_regulation of S100A6 2 30 0.45 9.72 3.89
178 INT17620 Positive_regulation of Gnrh1 1 23 0.70 9.77 3.79
179 INT10168 Positive_regulation of Localization of Gtf3a 1 16 0.60 3.55 3.75
180 INT27642 Regulation of Gene_expression of Dbi 1 10 0.44 2.55 3.66
181 INT56916 Positive_regulation of Mir125b-1 2 3 0.10 1.14 3.22
182 INT21679 Negative_regulation of PTGER1 1 10 0.26 4.59 2.85
183 INT32983 Localization of Lct 2 8 0.47 0.42 2.6
184 INT14877 Positive_regulation of Localization of GRP 2 8 0.46 0.1 2.47
185 INT3608 Regulation of Cbr1 1 6 0.45 2.28 2.44
186 INT12133 Regulation of Localization of ENG 3 3 0.03 0.57 2.24
187 INT16527 Negative_regulation of Positive_regulation of Ghrh 2 6 0.43 1.01 2.23
188 INT25461 Negative_regulation of Regulation of Nppa 1 2 0.43 0.22 1.97
189 INT35370 Negative_regulation of Dlst 1 6 0.32 2.58 1.9
190 INT81169 Localization of Nr4a2 1 1 0.68 0 1.71
191 INT45719 Positive_regulation of Transcription of Gh 1 5 0.47 0.68 1.66
192 INT60053 Regulation of Hibch 2 1 0.06 1.98 1.65
193 INT3607 Gene_expression of Cbr1 1 4 0.59 1.17 1.48
194 INT25544 Positive_regulation of Hapln1 1 3 0.12 8.58 1.44
195 INT32519 Positive_regulation of Terc 1 5 0.36 4.41 1.41
196 INT56914 Gene_expression of Mir125b-1 1 2 0.14 0.47 1.36
197 INT43815 Localization of Mapre1 2 1 0.14 0.16 1.21
198 INT56915 Positive_regulation of Positive_regulation of IgG-2a 1 1 0.09 0.13 1.09
199 INT3609 Regulation of Gene_expression of Cbr1 1 1 0.27 0.74 1.08
200 INT40249 Regulation of Regulation of Ren 1 4 0.36 0.83 1.05
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